Laura Christine Norris, Ph.D Clemson Dr., Davis, CA (410)

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1 Laura Christine Norris, Ph.D Clemson Dr., Davis, CA (410) EDUCATION Johns Hopkins School of Public Health Ph.D. in Molecular Microbiology and Immunology September 2006-March 2011 Dissertation Title: The Effects of Insecticide-treated Bed Net Introduction on Anopheline and Culicine Mosquito Behavior and Insecticide Resistance in Southern Zambia Thesis Committee: Douglas Norris, Gregory Glass, William Moss, Peter Winch University of Maryland, Baltimore County B.S. in Biological Sciences, Minor in Chemistry, Summa cum Laude September 2002-May 2006 RESEARCH EXPERIENCE Pathology, Microbiology, and Immunology Department Davis, California UC Davis School of Veterinary Medicine June 2012-present Postdoctoral Fellow Advisors: Dr. Anthony Cornel and Dr. Gregory Lanzaro Next-generation sequencing project investigating speciation islands and reproductive isolation between An. gambiae chromosomal forms Investigated mitochondrial genetic variation in island and mainland populations of Anopheles gambiae MMI and Epidemiology Dept. Johns Hopkins School of Public Health Postdoctoral Fellow April 2011-May 2012 Advisors: Dr. Douglas Norris and Dr. William Moss Assisted in logistics for setting up two new field study sites in Nchelenge, Zambia, and Mutasa, Zimbabwe, as part of the International Centers of Excellence in Malaria Research. Carried out preliminary investigations identifying An. funestus as the primary malaria vector species and An. gambiae s.s as the secondary vector in Nchelenge; as well as studying their feeding habits and insecticide resistance status. Conducted a pilot study on gene flow between the An. gambiae s.s. populations in northern Zambia. Trained visiting scientists from Ndola, Zambia in entomological laboratory techniques. Recruited and trained the epidemiology/entomology field team for the Nchelenge, Zambia, and Mutasa, Zimbabwe study sites. Used molecular diagnostics to screen ticks for pathogens including Borrelia species, Rickettsia species, Anaplasma phagocytophilum, Ehrlichia chaffeensis, and Babesia microti, as part of a collaboration with the Fairfax, Virginia Health Department. MMI Dept., Johns Hopkins School of Public Health Ph.D. Candidate March 2007 March 2011 Research advisor: Dr. Douglas Norris

2 Laura C. Norris 2 Conducted integrated field and laboratory research to determine the efficacy of insecticidetreated bed nets (ITNs) against the local vector mosquito populations in a rural area of Southern Zambia Characterized the insecticide susceptibility status and mechanisms of insecticide resistance in the mosquito vectors Anopheles arabiensis and Culex quinquefasciatus Characterized the effects of ITN introduction on Anopheles arabiensis feeding behavior and finescale heterogeneity in malaria risk Constructed a molecular phylogeny of anopheline mosquitoes of southern Africa Managed an 8-12 person field team and organized and carried out mosquito collections Reared mosquitoes in an insectary for laboratory bioassays Developed novel PCR-based diagnostic assays for malaria detection and insecticide-resistance target site mutations Cooperated with the Zambian Ministry of Health, National Malaria Control Council, and Malaria Institute at Macha, assisted the Choma District Health Department in epidemiological investigations of malaria outbreaks Statistically analyzed large data sets using STATA MMI Dept., Johns Hopkins School of Public Health Ph.D. Lab rotation November 2006 February 2007 Research advisor: Dr. Clive Shiff Conducted behavioral assays for chemical compounds as mosquito attractants for Anopheles stephensi and Anopheles gambiae. MMI Dept., Johns Hopkins School of Public Health Ph.D. Lab rotation September 2006 November 2006 Research advisor: Dr. Sean Prigge Created and compared expression patterns of malaria protein constructs in Escherichia coli. Conducted laboratory investigations using molecular cloning and sequencing techniques, fast protein liquid chromatography, and radio-labeled enzyme assays. UMBC Department of Biological Sciences Research Assistant January 2005 May 2006 Research advisor: Dr. Philip Farabaugh Investigated translational accuracy and molecular mechanisms of translational frameshifting in Escherichia coli and Saccharomyces cerevisiae. Conducted laboratory investigations using molecular cloning, mutagenesis, and sequencing techniques, conducted enzyme activity assays. Center for Urban Environmental Research and Education Research Intern May 2004 December 2004 Research advisor: Dr. Richard Pouyat Conducted tree and vegetation surveys as part of the Long-Term Ecological Research Network, in order to provide data on changes in the health of the urban Baltimore ecosystem. Collected and tested soil samples for environmental indicators and heavy metal contamination. Conducted hydrology surveys in urban waterways.

3 Laura C. Norris 3 PUBLICATIONS Norris LC, Norris DE. Phylogeny of anopheline (Diptera: Culicidae) species in Southern Africa, based upon nuclear and mitochondrial genes. [in review in Journal of Medical Entomology] Norris LC, Norris DE. Heterogeneity and Changes in Inequality of Malaria Risk After the Introduction of Insecticide-Treated Bed Nets in Macha, Zambia. [accepted by American Journal of Tropical Medicine and Hygiene] Alam MS, Chakma S, Khan WA, Glass GE, Mohon AN, Elahi R, Norris LC, Podder MP, Ahmed S, Haque R, Sack DA, Sullivan DJ Jr., Norris DE. Diversity of anopheline species and their Plasmodium infection status in rural Bandarban. Parasites and Vectors, 2012 Jul;5:150. Norris LC, Norris DE. Insecticide resistance in Culex quinquefasciatus mosquitoes after the introduction of ITNs in Macha, Zambia. Journal of Vector Ecology, 2011 Dec; 36(2): Norris LC, Norris DE. Efficacy of long-lasting insecticidal nets in use in Macha, Zambia, against the local Anopheles arabiensis population. Malaria Journal, 2011 Aug; 10:254 Fornadel CM, Norris LC, Franco V, Norris DE. Unexpected anthropophily in the potential secondary malaria vectors Anopheles coustani s.l. and Anopheles squamosus in Macha, Zambia. Vector Borne and Zoonotic Diseases, 2011 Aug;11(8) Fornadel CM, Norris LC, Glass GE, Norris DE. Analysis of Anopheles arabiensis blood feeding behavior in southern Zambia during the two years after the introduction of insecticide-treated bed nets. American Journal of Tropical Medicine and Hygiene Oct; 83(4): Fornadel CM, Norris LC, Norris, DE. CDC light traps as an efficient replacement for human landing catches to monitor Anopheles arabiensis behavior in an area with high insecticide treated bed net use in Southern Zambia. American Journal of Tropical Medicine and Hygiene Oct; 83(4): Norris LC, Fornadel CM, Pineda J, Norris DE. Frequency of multiple human blood meals taken in a single gonotrophic cycle by Anopheles arabiensis mosquitoes in Macha, Zambia. American Journal of Tropical Medicine and Hygiene Jul; 83(1): 33-7 Guarraia C, Norris L, Raman A, Farabaugh PJ. Saturation mutagenesis of a +1 programmed frameshift-inducing mrna sequence derived from a yeast retrotransposon. RNA Nov; 13(11): PRESENTATIONS Heterogeneity and Changes in Inequality of Malaria Risk After the Introduction of Insecticide- Treated Bed Nets in Macha, Zambia American Society for Tropical Medicine and Hygiene (poster presentation).

4 Laura C. Norris 4 Insecticide resistance in the anthropophilic mosquitoes Anopheles arabiensis and Culex quinquefasciatus in Macha, Zambia American Society for Tropical Medicine and Hygiene (poster presentation). Insecticide resistance in the anthropophilic mosquitoes Anopheles arabiensis and Culex quinquefasciatus in Macha, Zambia Society for Vector Ecology Meeting (invited talk). Unexpected anthropophily in the potential malaria vectors Anopheles coustani and Anopheles squamosus in Macha, Zambia American Society of Tropical Medicine and Hygiene Meeting (oral presentation). Anopheles arabiensis feeding behavior and its relationship to the demographics of insecticide treated bed net use in Macha, Zambia American Society of Tropical Medicine and Hygiene Meeting (poster presentation). Frequency of multiple human blood meals taken by Anopheles arabiensis mosquitoes in Macha, Zambia American Society of Tropical Medicine and Hygiene Meeting (poster presentation). Complexities in the recognition and differentiation of vectors and non-vectors of malaria in Macha, Zambia American Society of Tropical Medicine and Hygiene Meeting (poster presentation). TEACHING EXPERIENCE Johns Hopkins School of Public Health Co-Instructor Spring Term, 2012 Vector Biology and Vector-borne Diseases, for Masters and Ph.D. students. Teaching Assistant Spring Term, 2011 Vector Biology and Vector-borne Diseases, for Masters and Ph.D. students. Teaching Assistant Fall Term, 2010 Public Health Ecology, for Masters and Ph.D. students. Teaching Assistant Fall Term, 2010 Evolution of Infectious Disease, for undergraduate and Masters students. Research Mentor June 2011 August 2011 Mentored two undergraduate students on their research projects, focusing on mosquito species diversity in Baltimore and bacterial pathogens in Ixodes scapularis. Research Mentor November 2010 Present Mentored two Sc.M. and one Ph.D. student on their research projects, focusing on transcription levels of Culex quinquefasciatus esterase detoxification genes, genetic diversity of tick-borne pathogens in Amblyomma americanum, and entomological aspects of malaria transmission in Nchelenge, Zambia. Research Mentor January 2010 Present Mentored an Sc.M. student on his Masters thesis, focusing on population distribution and transovarial transmission of CxFV virus in Culex quinquefasciatus in Macha, Zambia. Research Mentor February-March 2009 and January-February 2010

5 Laura C. Norris 5 Taught field ecology techniques, mosquito species identification, insect rearing, and lab techniques to resident technicians and scientists from the Malaria Institute at Macha and the Tropical Disease Research Center in Ndola, Zambia. Research Mentor May 2009 Present Mentored a post-baccalaureate student on her project, focusing on feeding behavior of secondary malaria vectors and identification of new vector species in Macha, Zambia. Research Mentor May 2009 Led a one-day class introducing 8 th and 9 th grade students to molecular biology techniques. Research Mentor September 2008 August 2009 Mentored three students on their undergraduate thesis projects, including Culiseta melanura host choice in New Jersey, prevalence of tick-borne pathogens in Virginia and Maryland, and multiple paternity of Norway rats. Teaching Assistant Spring Term, 2008 Vector Biology and Vector-Borne Diseases, for Masters and Ph.D. students. FIELD EXPERIENCE Southern Africa International Center of Excellence in Malaria Research Mutasa, Zimbabwe April 2012 Trained a 7-person joint entomology/epidemiology field team for a long-term observational malaria epidemiology project. Met with representatives of the District Health Office and Rural Health Clinics to introduce the project and obtain their permission to work in the community. Southern Africa International Center of Excellence in Malaria Research Nchelenge, Zambia October 2011 and March 2012 Recruited and trained a 7-person joint entomology/epidemiology field team for a long-term observational malaria epidemiology project. Met with the local chief, headmen, representatives of the District Health Office and Rural Health Clinics to introduce the project and obtain their permission to work in the community. Organized community mobilization meetings to explain the project to residents of the selected catchment areas. Initiated field collections for epidemiological and entomological samples. Malaria Institute at Macha Macha, Zambia March April 2008, February March 2009, January March 2010 Organized and participated in mosquito collections, including human landing catches, pyrethroid spray catches, CDC light trap collections, cattle-baited collections, larval collections, and oviposition trap collections. Morphologically identified genus and species of mosquitoes from collections. Reared mosquitoes from the field in an insectary facility for oviposition and bioassays. Conducted surveys of ITN use in nearby villages. Assisted in malaria screening and mass drug administration in villages. Valles Caldera National Preserve August 2007 Valles Caldera, New Mexico

6 Laura C. Norris 6 Collected and identified insects and screened potential mosquito vectors for West Nile Virus. Trapped small mammals and tested retro-orbital blood samples for Hantavirus. Center for Urban Environmental Research and Education May 2004 December 2004 Collected, processed, and tested soil samples for carbon content and heavy metal contamination. Collected and tested water samples from urban streams for bacteria content. Conducted tree and vegetation surveys throughout the city of Baltimore. SPECIAL TRAINING Human Subjects training JHSPH, 2007 Blood-borne Pathogen training JHSPH, 2006 MANUSCRIPT REVIEW Peer reviewer for: Parasitology Research Journal of Vector Ecology Journal of Medical Entomology February 2012 present October 2011 present May 2011 present VOLUNTEER EXPERIENCE Intersession Volunteer Trip, New Orleans, LA January 2007 and January 2008 Assisted with organization and grant-writing to fund a student volunteer trip to New Orleans, post- Hurricane Katrina. Worked with Habitat for Humanity, ACORN, and the New Orleans City Health Department. Gave presentations on the impact of Hurricane Katrina to students at Johns Hopkins and the Community College of Baltimore County. Rose Street Tutoring Program, Baltimore, MD Fall 2006 Spring 2007 Participated in after-school tutoring of at-risk children from East Baltimore. HONORS AND AWARDS Sylvia and Ralph Barr Fellowship in Vector Biology (2009), Eleanor A. Bliss. Fellowship (2008), Golden Key Honor Society Member (2006), UMBC University Scholar (2006), Maryland Distinguished Scholar (2002) SOCIETY MEMBERSHIPS American Society of Tropical Medicine and Hygiene Maryland Tropical Medicine Dinner Club REFERENCES Dr. Douglas Norris, Associate Professor, MMI Dept., Johns Hopkins School of Public Health dnorris@jhsph.edu Dr. Gregory Glass, Professor, MMI Dept., Johns Hopkins School of Public Health gglass@jhsph.edu

7 Laura C. Norris 7 Dr. William Moss, Associate Professor, Epidemiology Dept., Johns Hopkins School of Public Health wmoss@jhsph.edu Dr. Jason Rasgon, Associate Professor, Center for Infectious Disease Dynamics, Penn State jlr54@jhsph.edu