Cancer and AAA: Causal role for chronic inflammation?
|
|
- Angelina Gwenda Rodgers
- 5 years ago
- Views:
Transcription
1 Cancer and AAA: Causal role for chronic inflammation? Sakalihasan Natzi MD,PhD Department of Cardiovascular and Thoracic Surgery University hospital of Liège, Experimental Research Center of the Cardiovascular Surgery Department, GIGA-Cardiovascular Science Unit, University of Liège, Liège, BELGIUM
2 Disclosure Speaker name:...sakalihasan Natzi... Collaborative Project large-scale focused research project EU.Health Grant Agreement Number 2006 Aneurysmal Pathology Foundation, Belgium 2
3 Prevalence of cancer in AAA patients The frequency of neoplasia in AAA patients is reported to vary between 0.5% and 26%. Chan E., et al. Incidence of cancer and Abdominal Aortic Aneurysms, a logistic regression analysis. Annals New York Academy Of Sciences;1996; 800: Tilson, M.D., E.L. Fieg, M. Harvey. Malignant neoplasia in patients with abdominal aortic aneurysms. 1984; Arch. Surg. ;119: Robinson G, Hughes W, Lippey E. Abdominal aortic aneurysm and associated colorectal carcinoma: a management problem. Aust N Z J Surg 1994; 64: Morris DM, Colquitt J. Concomitant abdominal aortic aneurysm and malignant disease: a difficult management problem. J Surg Oncol 1988; 39: Veraldi GF, et al. Treatment of AAA associated with colorectal cancer: presentation of 14 cases and literature review. Int. J. Colorectal 2008; 23: Sakalihasan N, et al. Emission Tomography (PET) Evaluation of Abdominal Aortic Aneurysm (AAA) ; Eur. J. Vasc. Endovasc. Surg. 2002;23: (26% ofpatients with concomitant AAAandcancer) EVAR Trial investigators. N Engl J Med 2010;362: (25% of patients suffered from cancer followed after EVAR) DREAM study Group N Engl J Med 2010;362: (Cancer related mortality during FU 10.8%)
4 Abdominal aortic aneurism and neoplasia: a prospective cohort study Material and Methods (ongoing study) 187 consecutive patients referred to our department with confirmed AAA with (-) PET/CT for cancer ( ) 563 control patients with Coronary Artery Disease (CAD) during same period Patients were followed up for 96 months (8 years) At baseline, all patients were free of cancer
5 Primary endpoints 1. Occurrence of neoplasia within 96 months FU 2. Neoplasia free survival (NFS, days) defined as the time difference between occurrence of neoplasia and baseline (study entry)
6 Characteristics of AAA and CAD patients at Baseline
7 96-month incidence of neoplasia Total Neoplasia % CAD AAA RR = 1.54 (95%CI: ) RR adjusted = 1.48 (95% CI : )
8 Type of cancer Lung Digestive Urologic Breast Other Total AAA (187) (27.3%) CAD (563) (17.8%)
9 Incidence of neoplasia with respect to AAA treatment Non-operated (N=45) Number (%) Operated (N=142) Number (%) P value Incidence of neoplasia 16 (35.6%) 35 (24.7%) P=0.15 EVAR (N=46) Number (%) Open Surgery (N=96) Number (%) P value 12 (26.1%) 23 (24.0%) P= / /2006 Open surgery 150 patients (5-year FU) Occurrence of neoplasia 30/150 (20.5%)
10 Overall survival in CAD and AAA patients (P=0.0012) HR = 1.62 (95%CI: ). The Kaplan-Meier overall survival (OS) curves. Cox regression analysis evidenced a significant difference between the two groups (P=0.0012) and yielded the following hazard ratio HR = 1.62 (95%CI: ).
11 Neoplasia free survival in CAD and AAA patients HR = 1.56 (95% CI: ) HR adjusted = 1.42 (95% CI: )
12 Relative Risk (RR) of neoplasia in AAA vs CAD according to baseline CRP levels CRP low* : RR=1.26 (95%CI: ) CRP high**: RR=2.12 (95%CI: ) * < 6mg/L **>6mg/L
13 AAA is Chronic Inflammatory Disease Thrombus aortic wall media & adventitia Natzi Sakalihasan et al, Journal of Vascular Surgery Volume 24, Issue 1, Pages (July 1996) DOI: /S0741 Nchimi A,.Sakalihasan N, Radiology 2010 Mar ;254(3):973-81
14 Representative example of MMP-2 and MMP-9 activity under latent or activated forms measured by gelatin zymography in extracts of normal (CAA) and diseased aortic wall (AAA and AOD). Olivier D Defawe, Natzi Sakalihasan. Cardiovasc Res 2003;60: Copyright 2003, European Society of Cardiology
15 ADVENTITIA PET 0 PET + - site + site MMP * MMP2 1 MMP3 1 3 MMP9 1 MMP12 nd nd nd MMP13 nd 1 8 * # MMP ** # MMP15 1 TIMP1 1 TIMP2 1 RECK 1 PAI * TIMP3 1 upa * # EMMPRI N # COL1A1 1 5 ** # ELN 1 MCP1 1 IL1α # IL IL8 1 4 COX2 1 TNFα 1 0.6* 0.5 * TGFα * 0.7 * HIF1α * CD * VEGF 1 0.6* # TSP1 1 αsma 1
16 Preoperative circulating CRP: median concentration (mg/l) in PET0 patients (and in PET+ patients (*P < 0.01, Mann Whitney U test. Audrey Courtois et al. J Nucl Med 2013;54: (c) Copyright 2014 SNMMI; all rights reserved
17 Mol Med. 2014; 20(1):
18 Fig 1. Circulating micrornas (mirnas) modulated in patients with aneurysms displaying positive[18f]fluorodeoxyglucose (FDG) uptake (A.) on positron emission tomography (PET) compared with patients displaying no uptake (A0) were measured by polymerase chain reaction (PCR) array. Seventeen mirnas are modulated in the three pools of plasmatic RNA from 17 A. patients compared with the four pools of RNA from 24 A0 patients. Nine are downregulated and eight are upregulated. Results are expressed as the fold-change relative to the median of mirnas expression in the A0 pools. P <.05 by Mann-Whitney U test.
19 Conclusion The present study purposed to draw attention on the possible association between AAA and cancer and to hypothesize some potential mechanisms. Based on these preliminary study results, EVAR and DREAM trials we believe that the incidence of cancer in AAA patients is higher than that published for the general population. In the present study, this finding is not only occasional or related to the age of both patient groups but may be due to the presence of chronic inflammatory cells and cytokines in AAA patients as well as their angiogenesis status. Further investigations are needed to test these hypotheses.
Management of graft infection after EVAR-TEVAR. Can PET-CT predict the outcome of prosthetic graft infections?
Management of graft infection after EVAR-TEVAR. Can PET-CT predict the outcome of Imane El hassani, Martin Moïse, Roland Hustinx Jean-Olivier Defraigne & Natzi Sakalihasan Department of Cardiovascular
More informationImportance of changes in thoracic and abdominal aortic stiffness following stent graft implantation
14/9/2018 Importance of changes in thoracic and abdominal aortic stiffness following stent graft implantation Christos D. Liapis, MD, FACS, FRCS, FEBVS Professor (Em) of Vascular Surgery National & Kapodistrian
More information5cm. 5cm AAA. 5cm. 5cm. 8 4cm. 5cm 0.6. abdominal aortic aneurysm; AAA. Tel:
15 3 9 2006 5cm 5cm AAA 5cm5cm 8 4cm AAA 5cm 4cm5cm 5cm AAA 261 1 260 99.6 125 135 52 5cm 14 5cm5cm 4cm 5 77.8 58.34cm 0.6 76.8 75.1 4cm 5cm 4cm 74.8 5cm 78.6 5cm 5cm 15 3 9 2006 abdominal aortic aneurysm;
More informationCorrelation of pretreatment surgical staging and PET SUV(max) with outcomes in NSCLC. Giancarlo Moscol, MD PGY-5 Hematology-Oncology UTSW
Correlation of pretreatment surgical staging and PET SUV(max) with outcomes in NSCLC Giancarlo Moscol, MD PGY-5 Hematology-Oncology UTSW BACKGROUND AJCC staging 1 gives valuable prognostic information,
More informationRatio of maximum standardized uptake value to primary tumor size is a prognostic factor in patients with advanced non-small cell lung cancer
Original Article Ratio of maximum standardized uptake value to primary tumor size is a prognostic factor in patients with advanced non-small cell lung cancer Fangfang Chen 1 *, Yanwen Yao 2 *, Chunyan
More informationEVAR follow up: answers to uncertainties Moderators F. Moll, Y. Alimi, M. Bjorck. Inflammatory response after EVAR: causes and clinical implication
39 th Annual Meeting, Boston, Sept. 2012 EVAR follow up: answers to uncertainties Moderators F. Moll, Y. Alimi, M. Bjorck Inflammatory response after EVAR: causes and clinical implication Christos D. Liapis,
More informationInsights from the PROTAGORAS/PERICLES Registries: impact on ChEVAR results
Insights from the PROTAGORAS/PERICLES Registries: impact on ChEVAR results Konstantinos P. Donas, Giovanni Torsello Department of Vascular Surgery St. Franziskus Hospital Münster, Germany Disclosure Speaker
More informationReduction in cardiovascular related adverse events following active sac management with Nellix vs. EVAR: Are there biological advantages?
February 1, 2018 Reduction in cardiovascular related adverse events following active sac management with Nellix vs. EVAR: Are there biological advantages? Patrick Berg M.D. Marienhospital Kevelaer Germany
More informationPreliminary data from the Liège Screening Programme Suggests the Reported Decline in AAA Prevalence is not Global
Preliminary data from the Liège Screening Programme Suggests the Reported Decline in AAA Prevalence is not Global Georgios Makrygiannis, MD Department of Cardiovascular Surgery, and Surgical Research Center,
More informationDisclosures. EVAR follow-up: actual recommendation. EVAR follow-up: critical issues
Disclosures is it time to discuss individualized follow-up schemes based on preoperative anatomy and high quality completion angiography? Consultant / Speaker / Proctor Cook Cordis Medtronic Invatec W.L.
More informationSpontaneous embolisation on TCD and carotid plaque features
Spontaneous embolisation on TCD and carotid plaque features J. David Spence Stroke Prevention & Atherosclerosis Research Centre Robarts Research Institute London, Canada dspence@robarts.ca www.imaging.robarts.ca/sparc
More informationEVAS is Associated with Lower All-Cause Mortality
EVAS is Associated with Lower All-Cause Mortality Marc L Schermerhorn, MD Chief, Division of Vascular and Endovascular Surgery Beth Israel Deaconess Medical Center Professor of Surgery Harvard Medical
More informationGORE EXCLUDER AAA Endoprosthesis demonstrates long-term durability. Michel Reijnen Rijnstate Hospital Arnhem, The Netherlands
GORE EXCLUDER AAA Endoprosthesis demonstrates long-term durability Michel Reijnen Rijnstate Hospital Arnhem, The Netherlands Disclosure Speaker name: Michel Reijnen I have the following potential conflicts
More informationDissection de type B: l étude Instead et corollaire stratégique
Dissection de type B: l étude Instead et corollaire stratégique Christoph A. Nienaber, MD, FACC University Rostock Heartcenter Med. Clinic I Cardiology christoph.nienaber@med.uni-rostock.de Type B aortic
More informationDisclosure. I do not have any potential conflict of interest
Endovascular repair of ruptured abdominal aortic aneurysms is superior to open repair in risk stratified patients: a look at the United States experience through the SVS Vascular Quality Initiative 2003
More informationGene Expression Study in Positron Emission Tomography Positive Abdominal Aortic Aneurysms Identifies CCL18 as a Potential Biomarker for Rupture Risk
Gene Expression Study in Positron Emission Tomography Positive Abdominal Aortic Aneurysms Identifies CCL18 as a Potential Biomarker for Rupture Risk Audrey Courtois, 1,2,3 Betty V Nusgens, 2 Roland Hustinx,
More informationEvaluation of Lung Cancer Response: Current Practice and Advances
Evaluation of Lung Cancer Response: Current Practice and Advances Jeremy J. Erasmus I have no financial relationships, arrangements or affiliations and this presentation will not include discussion of
More informationPositron Emission Tomography (PET) Evaluation of Abdominal Aortic Aneurysm (AAA)
Eur J Vasc Endovasc Surg 23, 431±436 (2002) doi:10.1006/ejvs.2002.1646, available online at http://www.idealibrary.com on Positron Emission Tomography (PET) Evaluation of Abdominal Aortic Aneurysm (AAA)
More informationF-Fludeoxyglucose Positron Emission Tomography (FDG-PET) in Patients with Large Vessel Vasculitis (LVV)
Assessment of Treatment Response by 18 F-Fludeoxyglucose Positron Emission Tomography (FDG-PET) in Patients with Large Vessel Vasculitis (LVV) Shubhasree Banerjee 1, Sara Alehashemi 1, Mark A. Ahlman 2,
More informationImproving Endograft Durability with EndoAnchors
Improving Endograft Durability with EndoAnchors William D. Jordan, Jr., M.D. John E. Skandalakis Chair in Surgery Professor and Chief Division of Vascular Surgery and Endovascular Therapy Emory University
More informationAcute non-complicated TBD Do need TEVAR treatment
Acute non-complicated TBD Do need TEVAR treatment Prof. Dr. med. Christoph A. Nienaber Universität Rostock Universitäres Herzzentrum christoph.nienaber@med.uni-rostock.de Survival in type B dissection
More informationENCORE, a Study to Investigate the Durability of Polymer EVAR with Ovation A Contemporary Review of 1296 Patients
ENCORE, a Study to Investigate the Durability of Polymer EVAR with Ovation A Contemporary Review of 1296 Patients The Ovation System is approved to treat infrarenal abdominal aortic aneurysms and is not
More informationLocoregional treatment Session Oral Abstract Presentation Saulo Brito Silva
Locoregional treatment Session Oral Abstract Presentation Saulo Brito Silva Background Post-operative radiotherapy (PORT) improves disease free and overall suvivallin selected patients with breast cancer
More informationLos Angeles Radiological Society 62 nd Annual Midwinter Radiology Conference January 31, 2010
Los Angeles Radiological Society 62 nd Annual Midwinter Radiology Conference January 31, 2010 Self Assessment Module on Nuclear Medicine and PET/CT Case Review FDG PET/CT IN LYMPHOMA AND MELANOMA Submitted
More informationUC SF An Algorithm to Choose Which Uncomplicated (Asymptomatic) Acute Type B Dissection Patients Should Undergo TEVAR. Disclosures.
An Algorithm to Choose Which Uncomplicated (Asymptomatic) Acute Type B Dissection Patients Should Undergo TEVAR Disclosures Royalties and research grant support from Cook Medical, Inc. Jade S. Hiramoto,
More informationInterpretation of the CAESAR trial: when should we (if at all) treat small AAA?
Interpretation of the CAESAR trial: when should we (if at all) treat small AAA? Piergiorgio Cao, MD, FRCS Chief of Vascular Surgery Azienda Ospedaliera S. Camillo Forlanini, Rome Professor of Vascular
More informationBest Papers. F. Fusco
Best Papers UROLOGY F. Fusco Best papers - 2015 RP/RT Oncological outcomes RP/RT IN ct3 Utilization trends RP/RT Complications Evolving role of elnd /Salvage LND This cohort reflects the current clinical
More informationAndrogen Receptor Expression in Renal Cell Carcinoma: A New Actionable Target?
Androgen Receptor Expression in Renal Cell Carcinoma: A New Actionable Target? New Frontiers in Urologic Oncology Juan Chipollini, MD Clinical Fellow Department of Genitourinary Oncology Moffitt Cancer
More informationEndovascular Treatment of Symptomatic Abdominal Aortic Aneurysms
춘계심장학회, April 2013 Endovascular Treatment of Symptomatic Abdominal Aortic Aneurysms Seung-Hyuk Choi Division of Cardiology Samsung Medical Center SungKyunKwan Univ. Contents Introduction EVAR vs. Open
More informationmicrorna PCR System (Exiqon), following the manufacturer s instructions. In brief, 10ng of
SUPPLEMENTAL MATERIALS AND METHODS Quantitative RT-PCR Quantitative RT-PCR analysis was performed using the Universal mircury LNA TM microrna PCR System (Exiqon), following the manufacturer s instructions.
More informationTreatment options of late failures of EVAS. Michel Reijnen Rijnstate Arnhem The Netherlands
Treatment options of late failures of EVAS Michel Reijnen Rijnstate Arnhem The Netherlands Disclosure Speaker name: Michel Reijnen I have the following potential conflicts of interest to report: Consulting
More informationJohn J.P. Kastelein MD PhD Professor of Medicine Dept. of Vascular Medicine Academic Medial Center / University of Amsterdam
Latest Insights from the JUPITER Study John J.P. Kastelein MD PhD Professor of Medicine Dept. of Vascular Medicine Academic Medial Center / University of Amsterdam Inflammation, hscrp, and Vascular Prevention
More informationUtility of 18 F-FDG PET/CT in metabolic response assessment after CyberKnife radiosurgery for early stage non-small cell lung cancer
Utility of F-FDG PET/CT in metabolic response assessment after CyberKnife radiosurgery for early stage non-small cell lung cancer Ngoc Ha Le 1*, Hong Son Mai 1, Van Nguyen Le 2, Quang Bieu Bui 2 1 Department
More informationAortic Neck Issues Associated Clinical Sequelae/Implications for Graft Choice
Aortic Neck Issues Associated Clinical Sequelae/Implications for Graft Choice Eric Verhoeven, MD, PhD, A. Katsargyris, MD Department of Vascular and Endovascular Surgery, Paracelsus Medical University,
More informationThree juxta renal parallel grafts is not too many FOR. Frans Moll
Three juxta renal parallel grafts is not too many FOR Frans Moll Why do we ask this question? bail out? standard procedure? Answer: To bail out in complicated cases, but also durable enough for 5 year
More informationElderly men with prostate cancer + ADT
Elderly men with prostate cancer + ADT Background and Rationale ADT and Osteoporosis Proportion of Patients With Fractures 1-5 Yrs After Cancer Diagnosis 21 18 +6.8%; P
More informationPhysician Follow-Up and Guideline Adherence in Post- Treatment Surveillance of Colorectal Cancer
Physician Follow-Up and Guideline Adherence in Post- Treatment Surveillance of Colorectal Cancer Gabriela M. Vargas, MD Kristin M. Sheffield, PhD, Abhishek Parmar, MD, Yimei Han, MS, Kimberly M. Brown,
More information感染性腹部大動脈瘤の診断における PET-CT 検査の有用性について
Online publication December 27, 2011 総 説 第 51 回総会シンポジウム 5 各種脈管画像診断の進歩と将来展望 感染性腹部大動脈瘤の診断における PET-CT 検査の有用性について 1 1 1 1 1 2 1 要旨 : CT 2007 6 2010 5 97 6 PET-CT CT PET-CT 6 4 2 SUVmax 5.0 FDP SUVmax 3.0 2
More informationThe Management and Treatment of Ruptured Abdominal Aortic Aneurysm (RAAA)
The Management and Treatment of Ruptured Abdominal Aortic Aneurysm (RAAA) Disclosure Speaker name: Ren Wei, Li Zhui, Li Fenghe, Zhao Yu Department of Vascular Surgery, The First Affiliated Hospital of
More informationCardiopulmonary exercise testing provides a predictive tool for early and late outcomes in abdominal aortic aneurysm patients
Vascular surgery doi 10.1308/003588411X587235 Cardiopulmonary exercise testing provides a predictive tool for early and late outcomes in abdominal aortic AR Thompson, N Peters, RE Lovegrove, S Ledwidge,
More informationConsiderations for a Durable Repair
Considerations for a Durable Repair Eric Verhoeven, MD, PhD, A. Katsargyris, MD Department of Vascular and Endovascular Surgery, Paracelsus Medical University, Nuremberg, Germany Disclosures William Cook
More informationDr Sneha Shah Tata Memorial Hospital, Mumbai.
Dr Sneha Shah Tata Memorial Hospital, Mumbai. Topics covered Lymphomas including Burkitts Pediatric solid tumors (non CNS) Musculoskeletal Ewings & osteosarcoma. Neuroblastomas Nasopharyngeal carcinomas
More informationAfter primary tumor treatment, 30% of patients with malignant
ESTS METASTASECTOMY SUPPLEMENT Alberto Oliaro, MD, Pier L. Filosso, MD, Maria C. Bruna, MD, Claudio Mossetti, MD, and Enrico Ruffini, MD Abstract: After primary tumor treatment, 30% of patients with malignant
More informationAre stent-grafts for acute type B dissection durable? Est-ce que les stents graft pour la dissection aigue de type B sont efficaces à moyen terme?
Are stent-grafts for acute type B dissection durable? Est-ce que les stents graft pour la dissection aigue de type B sont efficaces à moyen terme? Martin Björck, Johnny Steuer, Anders Wanhainen Uppsala
More informationMortality After Elective and Ruptured Abdominal Aortic Aneurysm Surgical Repair: 12-Year Single-Center Experience of Estonia
738923SJS0010.1177/1457496917738923J. Lieberg, L-L. Pruks, M. Kals, K. Paapstel, A. Aavik, J. KalsAbdominal Aortic Aneurysm Repair and Mortality research-article2017 Original Research Article SJS SCANDINAVIAN
More informationFeasibility of aortic neck anatomy for endovascular aneurysm repair in Korean patients with abdominal aortic aneurysm
LINC 2019 Leipzig, Germany Feasibility of aortic neck anatomy for endovascular aneurysm repair in Korean patients with abdominal aortic aneurysm Deokbi Hwang, Sujin Park, Hyung-Kee Kim, Seung Huh Division
More informationHow to Categorize the Infrarenal Neck Properly? I Van Herzeele Dept. Thoracic and Vascular Surgery, Ghent University, Belgium
How to Categorize the Infrarenal Neck Properly? I Van Herzeele Dept. Thoracic and Vascular Surgery, Ghent University, Belgium Disclosure Speaker name: Isabelle Van Herzeele I have the following potential
More informationExpert Review The Role of Molecular Imaging in Response Prediction in Metastatic Breast Cancer
Expert Review The Role of Molecular Imaging in Response Prediction in Metastatic Breast Cancer Geraldine Gebhart, MD Institut Jules Bordet Brussels, Belgium Discussants Moderator Lee Lokey, MD prime Oncology
More informationManaging Dyslipidemia in Disclosures. Learning Objectives 03/05/2018. Speaker Disclosures
Managing Dyslipidemia in 2018 Glen J. Pearson, BSc, BScPhm, PharmD, FCSHP, FCCS Professor of Medicine (Cardiology) Co-Director, Cardiac Transplant Clinic; Associate Chair, Health Research Ethics Boards;
More informationApplications of PET/CT in Rheumatology. Role of PET/CT. Annibale Versari, MD Nuclear Medicine PET Center S.Maria Nuova Hospital Reggio Emilia Italy
CME Session Associazione Italiana di Medicina Nucleare ed Imaging Molecolare Applications of PET/CT in Rheumatology Role of PET/CT Annibale Versari, MD Nuclear Medicine PET Center S.Maria Nuova Hospital
More informationIndex. Surg Oncol Clin N Am 16 (2007) Note: Page numbers of article titles are in boldface type.
Surg Oncol Clin N Am 16 (2007) 465 469 Index Note: Page numbers of article titles are in boldface type. A Adjuvant therapy, preoperative for gastric cancer, staging and, 339 B Breast cancer, metabolic
More informationZurich, January 19, 2018
Brain metastases as first presentation of malignancy: Immediate management, differential diagnosis; prevalence of primaries and suggested work-up Symposium on Brain Metastasis Cancer Center Zurich Zurich,
More informationNon alcoholic fatty liver disease and atherosclerosis Raul Santos, MD
Non alcoholic fatty liver disease and atherosclerosis Raul Santos, MD Sao Paulo Medical School Hospital Sao Paulo, Brazil Disclosure Honoraria received for consult and/or speaker : Astra Zeneca, Amgen,
More informationCentral pressures and prediction of cardiovascular events in erectile dysfunction patients
Central pressures and prediction of cardiovascular events in erectile dysfunction patients N. Ioakeimidis, K. Rokkas, A. Angelis, Z. Kratiras, M. Abdelrasoul, C. Georgakopoulos, D. Terentes-Printzios,
More informationIndeterminate Pulmonary Nodules in Patients with Colorectal Cancer
Indeterminate Pulmonary Nodules in Patients with Colorectal Cancer Jai Sule 1, Kah Wai Cheong 2, Stella Bee 2, Bettina Lieske 2,3 1 Dept of Cardiothoracic and Vascular Surgery, University Surgical Cluster,
More informationFrom 1996 to 1999, a total of 1,193 patients with
THE ANEURX CLINICAL TRIAL AT 8 YEARS Lessons learned following the US AneuRx clinical trial from 1996 to 2004. BY CHRISTOPHER K. ZARINS, MD From 1996 to 1999, a total of 1,193 patients with infrarenal
More informationEndocarditis: Medical vs. Surgical Treatment. Nabin K. Shrestha, MD, MPH Infectious Diseases
Endocarditis: Medical vs. Surgical Treatment Nabin K. Shrestha, MD, MPH Infectious Diseases Conflicts of interest Nothing to disclose 2 Complications of infective endocarditis Local complications Heart
More informationPET FDG *** (cost-effectiveness) FDG-PET (fluorodeoxyglucose-positron emission tomography) PET PET PET/PET-CT PET PET FDG PET FDG PET PET PET
119 PET FDG * *, ** * * *** PET 10 PET 2005 FDG PET FDG FDG 3 PET PET FDG A B C 3 PET 1,591 1,637 914 1 110,262 111,091 134,192 2,583 2,679 2,081 FDG PET PET PET PET ( 45: 119 123, 2008) FDG-PET (fluorodeoxyglucose-positron
More informationLessons learned from Ch-EVAR for the treatment of. Miltos Matsagkas MD, PhD, FEBVS Professor of Vascular Surgery University of Thessaly
Lessons learned from Ch-EVAR for the treatment of pararenal AAAs Miltos Matsagkas MD, PhD, FEBVS Professor of Vascular Surgery University of Thessaly Ch-EVAR Ch-EVAR = Chimney-EVAR Placement of single
More informationEVAR FOR ANEURYSM RUPTURE IS SUPERIOR
EVAR FOR ANEURYSM RUPTURE IS SUPERIOR RUPTURED AAA Tenth leading cause of death in humans over 55 years Rupture is the most common cause of death in patients with AAA Girma Tefera, MD University of Wisconsin
More informationWhat is the best treatment for False Lumen growth after type B Dissection
What is the best treatment for False Lumen growth after type B Dissection Nikolaos Tsilimparis, Fiona Rohlffs, Yuk Law, Sebastian Debus, Tilo Kölbel N. Tsilimparis, MD, PhD, FEBVS Deputy Head of German
More informationRetrograde Embolization of a Symptomatic Hypogastric Artery Aneurysm
Retrograde Embolization of a Symptomatic Hypogastric Artery Aneurysm Andrew Unzeitig MD Piedmont Atlanta Hospital Georgia Vascular Society 2017 Annual Meeting Lake Oconee, Georgia Disclosures None Case
More informationNo Disclosure. Aortic Dissection in Japan. This. The Challenge of Acute and Chronic Type B Aortic Dissections with Endovascular Aortic Repair
No Disclosure The Challenge of Acute and Chronic Type B Aortic Dissections with Endovascular Aortic Repair Toru Kuratani Department of Cardiovascular Surgery Osaka University Graduate School of Medicine,
More informationResearch Article Survival Comparison of Patients Undergoing Secondary Aortic Repair
Advances in Vascular Medicine Volume 2015, Article ID 395921, 5 pages http://dx.doi.org/10.1155/2015/395921 Research Article Survival Comparison of Patients Undergoing Secondary Aortic Repair Dean J. Yamaguchi,
More informationResearch Article Abdominal Aortic Aneurysms and Coronary Artery Disease in a Small Country with High Cardiovascular Burden
ISRN Cardiology, Article ID 825461, 4 pages http://dx.doi.org/10.1155/2014/825461 Research Article Abdominal Aortic Aneurysms and Coronary Artery Disease in a Small Country with High Cardiovascular Burden
More informationTakayasu disease Is it still a room for intervention? NO YES. BUT
Takayasu disease Is it still a room for intervention? NO YES. BUT Z. Tazi Mezalek Internal Medicine Department Mohammed V University Ibn Sina Hospital - Rabat - Maroc Disclosure Speaker name: TAZI MEZALEK
More informationCLI: Patient level Risk Factors and CLI Outcomes
Disclosures CLI: Patient level Risk Factors and CLI Outcomes CHRISTOPHER D. OWENS MD, MSC UCSF VASCULAR SURGERY I am paid to talk about peripheral interventions by BARD and Medtronic CLI Natural Evolution:
More informationOsimertinib Activity in Patients With Leptomeningeal Disease From Non-Small Cell Lung Cancer: Updated Results From the BLOOM Study
Osimertinib Activity in Patients With Leptomeningeal Disease From Non-Small Cell Lung Cancer: Updated Results From the BLOOM Study Abstract 9002 Yang JC, Kim DW, Kim SW, Cho BC, Lee JS, Ye X, Yin X, Yang
More informationStatistical analysis plan
Statistical analysis plan Prepared and approved for the BIOMArCS 2 glucose trial by Prof. Dr. Eric Boersma Dr. Victor Umans Dr. Jan Hein Cornel Maarten de Mulder Statistical analysis plan - BIOMArCS 2
More informationClinical and Economic Value of Rivaroxaban in Coronary Artery Disease
CHRISTOPHER B. GRANGER, MD Professor of Medicine Division of Cardiology, Department of Medicine; Director, Cardiac Care Unit Duke University Medical Center, Durham, NC Clinical and Economic Value of Rivaroxaban
More informationJUPITER NEJM Poll. Panel Discussion: Literature that Should Have an Impact on our Practice: The JUPITER Study
Panel Discussion: Literature that Should Have an Impact on our Practice: The Study Kaiser COAST 11 th Annual Conference Maui, August 2009 Robert Blumberg, MD, FACC Ralph Brindis, MD, MPH, FACC Primary
More informationPREDICTORS OF PROLONGED HOSPITAL STAY
PREDICTORS OF PROLONGED HOSPITAL STAY IN CARDIAC SURGERY Zuraida Khairudin Faculty of Science Computer and Mathematics, Universiti Teknologi MARA, Malaysia zurai405@salam.uitm.edu.my ABSTRACT quality of
More informationWhy EVAR? A review of the literature. (or What did the EVAR trials EVER teach us?)
Why EVAR? A review of the literature (or What did the EVAR trials EVER teach us?) Because we can? How did we get here? Parodi 1991 1 Homemade devices initially 2,3 Commercial devices 1994 4 Registries
More informationTumor necrosis is a strong predictor for recurrence in patients with pathological T1a renal cell carcinoma
ONCOLOGY LETTERS 9: 125-130, 2015 Tumor necrosis is a strong predictor for recurrence in patients with pathological T1a renal cell carcinoma KEIICHI ITO 1, KENJI SEGUCHI 1, HIDEYUKI SHIMAZAKI 2, EIJI TAKAHASHI
More informationEndovascular aneurysm repair (EVAR) is universally accepted as an
Diagn Interv Radiol 2012; 18:307 313 Turkish Society of Radiology 2012 INTERVENTIONAL RADIOLOGY ORIGINAL ARTICLE Risk factors for the development of persistent type II endoleaks after endovascular repair
More informationPET Features of Aortic Diseases
Nuclear Medicine/Molecular Imaging Pictorial Essay Hayashida et al. PET of ortic iseases Nuclear Medicine/Molecular Imaging Pictorial Essay ownloaded from www.ajronline.org by 148.251.232.83 on 05/01/18
More informationClinical Trials of Acute and Chronic Dissections. Gregory Landry MD
Clinical Trials of Acute and Chronic Dissections Gregory Landry MD No disclosures Acute vs chronic dissection: Definitions 1950s: Acute < 2 weeks, Chronic > 2 weeks 2013: European Interdisciplinary Consensus
More informationSupplementary Online Content
1 Supplementary Online Content Friedman DJ, Piccini JP, Wang T, et al. Association between left atrial appendage occlusion and readmission for thromboembolism among patients with atrial fibrillation undergoing
More informationClinical Policy Title: Abdominal aortic aneurysm screening
Clinical Policy Title: Abdominal aortic aneurysm screening Clinical Policy Number: 08.01.10 Effective Date: August 1, 2017 Initial Review Date: June 22, 2017 Most Recent Review Date: June 5, 2018 Next
More informationSally Barrington Martin Hutchings
Sally Barrington Martin Hutchings Therapeutic implications of BMI Bone marrow involvement means extranodal disease and by definition stage IV BMI detected by BMB is a poor prognostic feature in most lymphomas
More informationKHP Who are We? NVR Data
The VASCULAR Unit KHP Who are We? NVR Data 2013-2017 AAA Mortality the answers: Centralise Standardise DO EVAR!! All Aortic Surgery Elective Infra-Renal EVAR What are we trying to do? Fix those AAAs that
More informationClinical Policy Title: Abdominal aortic aneurysm screening
Clinical Policy Title: Abdominal aortic aneurysm screening Clinical Policy Number: 08.01.10 Effective Date: August 1, 2017 Initial Review Date: June 22, 2017 Most Recent Review Date: July 20, 2017 Next
More informationThe Auckland Experience with the Nellix EVAS System. Andrew Holden, MBChB, FRANZCR
The Auckland Experience with the Nellix EVAS System Andrew Holden, MBChB, FRANZCR Disclosure Speaker name: Associate Professor Andrew Holden I have the following potential conflicts of interest to report:
More informationSupplementary Online Content
Supplementary Online Content Venook AP, Niedzwiecki D, Lenz H-J, et al. Effect of first-line chemotherapy combined with cetuximab or bevacizumab on overall survival in patients with KRAS wild-type advanced
More informationCurrent and Future Imaging Trends in Risk Stratification for CAD
Current and Future Imaging Trends in Risk Stratification for CAD Brian P. Griffin, MD FACC Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic Disclosures: None Introduction
More informationClinical Outcome in Patients with Aortic Stenosis
Clinical Outcome in Patients with Aortic Stenosis Is the Prognosis Worse in Patients with Low-Gradient Severe Aortic Stenosis? Yoel Angel BSc, Shemy Carasso MD, Diab Mutlak MD, Jonathan Lessick MD Dsc,
More informationFDG-PET Findings in an Ovarian Endometrioma: A Case Report
FDG-PET Findings in an Ovarian Endometrioma: A Case Report Jia-Huei Lin 1, Victor Chit-kheng Kok 2, Jian-Chiou Su 3 1 Department of Nuclear medicine, Kuang Tien General Hospital, Sha-Lu, Taichung, Taiwan
More informationClinical Policy Title: Abdominal aortic aneurysm screening
Clinical Policy Title: Abdominal aortic aneurysm screening Clinical Policy Number: 08.01.10 Effective Date: August 1, 2017 Initial Review Date: June 22, 2017 Most Recent Review Date: June 5, 2018 Next
More informationAntiangiogenic Agents in NSCLC Where are we? Which biomarkers? VEGF Is the Only Angiogenic Factor Present Throughout the Tumor Life Cycle
Antiangiogenic Agents in NSCLC Where are we? Which biomarkers? Martin Reck Department e t of Thoracic c Oncology ogy Hospital Grosshansdorf Germany VEGF Is the Only Angiogenic Factor Present Throughout
More informationFasting or non fasting?
Vascular harmony Robert Chilton Professor of Medicine University of Texas Health Science Center Director of Cardiac Catheterization labs Director of clinical proteomics Which is best to measure Lower continues
More informationAnimesh Rathore, MD 4/22/17. The Great Debate 45yo Man With Uncomplicated Acute TBAD: The Case For Medical Management
Animesh Rathore, MD 4/22/17 The Great Debate 45yo Man With Uncomplicated Acute TBAD: The Case For Medical Management Disclosures Just a young vascular surgeon who would like to keep his job My opponent
More informationImportance of the third arterial graft in multiple arterial grafting strategies
Research Highlight Importance of the third arterial graft in multiple arterial grafting strategies David Glineur Department of Cardiovascular Surgery, Cliniques St Luc, Bouge and the Department of Cardiovascular
More informationThe Use of PET Scanning in Urologic Oncology
The Use of PET Scanning in Urologic Oncology Dr Nicholas C. Buchan Uro-oncology Fellow 1 2 Aims To understand the basic concepts underlying PET scanning. Understand the emerging role of PET Scanning for
More informationThe conundrum about complicated and uncomplicated type B dissection New concepts?
The conundrum about complicated and uncomplicated type B dissection New concepts? Professor Christoph A. Nienaber The Royal Brompton and Harefield NHS Trust Cardiology and Aortic Centre C.Nienaber@rbht.nhs.uk
More informationAll biomarkers at higher level in HIV group
Supplemental Table S1: Summary of studies assessing mainly inflammatory biomarkers and their association with mortality and clinical endpoints in HIV infection First author, year, country Biomarkers measured
More informationThe Society for Vascular Surgery Patient Safety Organization: Use of A Quality Registry for Practice Improvement
The Society for Vascular Surgery Patient Safety Organization: Use of A Quality Registry for Practice Improvement Georgia Vascular Society Adam W. Beck, MD, FACS September 9, 2017 Disclosures No relevant
More informationMedical management of abdominal aortic aneurysms
Medical management of abdominal aortic aneurysms Definition of AAA - Generally a 50% increase in native vessel diameter - Diameter 3 cm - Relative measures compared with nondiseased aortic segments less
More informationPioneering EVAR techniques in aortic dissection
Pioneering EVAR techniques in aortic dissection Jianing Yue, Weiguo Fu Department of Vascular Surgery Zhongshan Hospital Fudan University Shanghai, China LINC Asia-Pacific 2016 March 8-10, 2016 Hong Kong
More informationRole of Gender in TEVAR and EVAR results from the GREAT registry
Role of Gender in TEVAR and EVAR results from the GREAT registry Mauro Gargiulo Vascular Surgery University of Bologna - DIMES Policlinico S.Orsola-Malpighi Bologna, Italy mauro.gargiulo2@unibo.it Disclosure
More informationEarly outcomes of acute retrograde dissection in the aortic arch and the ascending aorta data from IRAD
Early outcomes of acute retrograde dissection in the aortic arch and the ascending aorta data from IRAD Foeke JH Nauta, MD, PhD Resident Cardiothoracic Surgery, Academic Medical Center, Amsterdam Disclosure
More information