BBMRI-ERIC and BBMRI.fi

Transcription

1 BBMRI-ERIC and BBMRI.fi Connecting Biobanks at the European and National level to proviede hiqh quality samples and associated data for health Anu Jalanko Terveystalo Biobank Finland 31/05/2018 1

2 BBMRI-ERIC BBMRI- ERIC Biobanking and BioMolecular resources Research Infrastructure European Research Infrastructure Consortium ESFRI Roadmap & EU project application: Preparatory Phase: funded EU Project, Interim Phase: ERIC application, Establisment as an ERIC: 2013 Host country: Austria 2

3 BBMRI-ERIC BBMRI-ERIC - largest infrastructure for health in Europe Members Austria Belgium Bulgaria Czech Republic Estonia Finland France Germany Greece Italy Latvia Malta Netherlands Norway Poland Sweden United Kingdom Observers Cyprus Switzerland Turkey IARC/WHO 3

4 BBMRI-ERIC GOVERNANCE STRUCTURE 31/05/2018 4

5 BBMRI-ERIC BBMRI-ERIC Services Priority Areas for Finland Common Services IT ELSI (Ethical and legal issues) Central Service: Sample Quality 5

6 IT Common Services Directory & Negotiator Availability requests Direct negotiation between biobanks and researchers 2017: Negotiator Connector DB Directory v 4.0 Central MDR 2018: Sample locator Mapping tool/s

7 BBMRI-ERIC Directory A biobank registry (yellow pages), to provide a directory of relevant biobanks 626 biobanks Directory 2.0 delivered at collections estimated Continuous development toward >100,000,000 samples Directory 3.0 until spring 2017 switch to MOLGENIS framework Directory 3.1 integrated with the Negotiator (summer 2017)

8 BBMRI-ERIC Quality Management Services FOR BASIC AND APPLIED RESEARCH KNOWLEDGE HUB TRAINING & SUPPORT AUDITING International standards (ISO 9001, ISO 20387, ISO 15189, CEN Technical Specifications, etc.) Quality management in EU funded projects Quality management in national and international research projects Webinars, counseling International biobanking standards General quality management systems Integrated management systems Interface management systems Inhouse training, Workshops Summerschools, Master courses BBMRI-ERIC Self-Assessment Survey for biobanks / researchers BBMRI-ERIC Audit May 24, 2018 MC&AoM meeting, Bologna 8

9 BBMRI-ERIC / QM Network Norway PARTICIPANTS Finland 11 Sweden 4 Estonia 2 United Kingdom 7 Latvia 2 Germany 13 Poland 4 Netherlands 1 Czech Republic 2 Belgium 11 France 6 Austria 15 Switzerland 2 Greece IARC 1 Turkey 5 Italy 9 Cyprus Malta 6 May 24, 2018 MC&AoM meeting, Bologna 9

10 BBMRI.fi Collaboration of Biobanks Goal to function as a one-stop shop Joint projects beween biobanks Participation to BBMRI-ERIC BBMRI.fi is on the Finnish Infrastructure Roadmap BBMRI.fi National Node: Coordinating Institute : THL National Coordinator: Anu Jalanko Coordination funding from the Academy of Finland 10

11 11 BBMRI.fi - BBMRI-ERIC 2018 BBMRI-ERIC Assembly of Members Members: Riina Vuorento, Olli Carpen Experts: Veli-Matti Kosma, Markus Perola, Sandra Liede Steering Group Ministry of Education and Culture Ministry of Social Affairs and Health Background organizations of biobanks (THL, Universities, Hospital districts, FINBB, FRCBS) Academy of Finland BBMRI-ERIC Finance Committee Member: Sirpa Nuotio BBMRI-ERIC ELSI Common Service BBMRI-ERIC IT Common Service Management Group Chair: National Coordinator Members: Biobank Directors BBMRI-ERIC Management Committee Member: Anu Jalanko (Vice chair) Auria Biobank THL Biobank Helsinki Biobank FHRB Biobank Biobank of Eastern Finland Borealis Biobank Biobank of Central Finland Tampere Clinical Biobank FRC Blood Service Biobank

12 The Finnish Biobank Act of Biobanks Registration of biobanks, wide consent and protection of participants Transfer of existing sample and data collections to biobanks Possibility to recontact Possibility to collect samples and data from the health care Collaboration with industry Terveystalo Biobank Finland 12

13 Finnish Biobanks registered biobanks Biobanks have samples and data of 2,6 million study participants Veripalvelun Biopankki Collaboration of biobanks: Since 2011 BBMRI.fi coordinates collaboration of biobanks as a part of BBMRI-ERIC 9 biobanks as members, 1 observer FINBB Biobank Cooperative (legal entity) established in hospital biobanks as partners 13

14 Collaboration of Finnish Biobanks IT collaboration Sitra Isaacus pilot all biobanks tests integration of data Digital pathology Academy of Finland infrastructure project- 3 biobanks and CSC SA-COHORT Academy of Finland project - 2 biobanks and University of Oulu Public relations Regular meetings, www- and social media activities Formatting biobank consent and documents for children Development Group of National Biobanks practical solutions Preparation, launch and implementation of FinnGen project FINBB preparation of fresh tissue collection 14

15 Research Services of Finnish Biobanks Processing and logistics of human samples: FFPE, frozen tissues, blood, serum, plasma, urine, DNA, RNA, cells Sample collection and storage Production of tissue microarrays (TMA), whole slide imaging and digital pathology services Immunohistochemical staining Sample associated biological data, including genomic and metabolomics data Genomic data services and consultation of research use Real life data anlysis services of clinical data in EHR Evidence-based feasibility studies for clinical trials Consultation and training services

16 Finnish biobanking activities are expanding New biobank consents Biobank access projects Studies with biobanked samples and data resulted in 90 publications in 2017!

17 Industry driven studies are expanding Most current biobank projects are by the two first biobanks established in 2014 Auria Biobank : 46 % Industry driven biobank studies 54 % Academic Research THL Biobank 17 % Industry driven biobank studies 83 % Academic Research Biobank access projects

18 FinnGen Biobanks: Coordinating partners: Funding: Funding partners:

19 FinnGen project has boosted collecting new blood samples for biobanks Cumulative number of new biobank samples Oct 2017 Nov 2017 Dec 2017 Jan 2018 Feb 2018 Mar 2018 Picture from: Anu Loukola, Helsinki Biobank

20 BBMRI.fi - Goals Coordination: Integration of BBMRI and FINBB activities Yearly training day Increase in biobank key performance indicators Quality: Participation to implementation of ISO-276 standard BBMRI-ERIC quality visits BBMRI-ERIC quality requirements fulfilled ICT infrastructure: National availability service in production use by FINBB, intergrated with BBMRI-ERIC CS-IT Tools for clinical text mining in use Ethical and Legal Issues (ELSI): Annual national seminar Consultation service for biobanks Implementation of GDPR requirements

21 Needs and Challenges 31/05/2018 Efficient use of hospital data in research Harmonization and cleaning of clinical data Data lakes to all university hospitals? Genome data management Currently THL Biobanks large genome data resources are managed in collaboration with UH/FIMM Biobanks will produce huge amounts of genome data in the near future Role of Genome Center? Management of other Big data Imaging data Metabolomics, Proteomics, Transcriptomics etc.

22 2019: BBMRI.fi activities will be integrated with FINBB Biobank Cooperative All 10 Finnish biobanks collaborate under BBMRI.fi 6 biobanks have established a Cooperative FINBB (legal entity) BBMRI services will be integrated with the FINBB services FINBB will be the BBMRI.fi coordinating institute from 2019 Terveystalo Biobank Finland 31/05/2018

23 Contact Biobanks! finbb.fi