Anti-aging / Soothing BEAUTY OF THE FUTURE
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1 BEAUTY OF THE FUTURE Anti-aging / Soothing
2 Anti-aging / Soothing
3 NATURAL INGREDIENT NATIVE TO THE INDIAN SUBCONTINENT USED FOR ITS SOOTHING AND ANTI-AGING PROPERTIES. FOCUS ON THE PRODUCT SOOTHING ACTIVITY protects the skin from the inflammation induced by UV. is an extract of Phaseolus Radiatus seed, a mung bean rich in tannin, sterol and flavonoid. From old time, the fermented beans extract has been used for dermatitis and wound healing. Phaseolus radiatus is used in cosmetic field for its nourishing properties. TNF-α Gene expression (%) No UV UV OIL,1% OIL,5% OIL,1% OIL,5% Bisabolol,5% We are able to produce by a cold fermentation process a low molecular product that shows strong soothing and antiaging properties. is proposed in 2 forms: oil and water soluble. Human Keratinocytes were submitted to UV to promote inflammation. Cells were treated with several concentrations of Oil or Bisabolol as positive controle. The expression of TNF-α gene was measured by qpcr.
4 BIOLOGICAL ACTIVITY promotes skin soothing effect by inhibiting the major inflammatory mediators : TNFα, COX2, IL1α. KERATINOCYTES IL1α TNF α COX 2 FIBROBLASTS IL1α TNF α COX 2 Gene expression (%) OIL,5 % Human Keratinocytes and fibroblasts were incubated with to promote inflammation. Cells were treated with several concentrations of OIL. The expression of TNFα, COX2 and IL1α genes were measured by qpcr. Gene expression (%) OIL 2ppm reduces the expression of TNFα, COX2, IL1α, at gene and protein levels. Protein synthesis (%) Untreated D-panthenol 5ppm WATER SOLUBLE ppm TNF-α COX-2 IL1- α WATER SOLUBLE 5ppm TNF - α COX - 2 IL1- α GAPDH D-panthenol WATER SOLUBLE Control 5 ppm ppm 5 ppm Human Keratinocytes were treated with several concentrations of WATER SOLUBLE or D-panthenol as positive control. The expression of TNFα, COX2 and IL1α proteins were measured by Western Blot analysis.
5 STRENGTHENING OF THE EPIDERMIS BARRIER Skin explants were treated 1 days with OIL. Thickening of the Stratum corneum after OIl treatment (Red arrow) The compartiments of the skin were observed by Immunohistochemistry. Untreated Day Untreated Day 1 OIL at 3% Day 1 Protects the skin and maintains the water balance. Collagen 1 gene expression (%) Untreated UV OIL,5% Human Fibroblasts were submitted to UV to affect the Collagen I expression. Cells were treated with several concentrations of OIL. The expression of the Collagen I gene was measured by qpcr. IMPROVEMENT OF THE DERMIS In aged skin the dermal papillae tend to flatten. Skin explants were treated 1 days with OIL. UNTREATED Day UNTREATED Day 1 OIL 3% Day 1 The Collagen 1 was labeled by immunofluorescence (green). The dermal papillae are indicated by white arrows. OIL restores the dermis papillary and increases the Collagen I synthesis.
6 TECHNICAL INFORMATION INCI NAMES > OIL Caprylic/Capric Triglyceride, Phaseolus radiatus seed extract, Phenoxyethanol, Ethylhexylglycerin WATER SOLUBLE Phaseolus radiatus seed extract, Butylene Glycol, Phenoxyethanol, Ethylhexylglycerin APPLICATIONS Skin care Sun care APPLICATIONS DOSE OF USE > 1-5% 1-5% Oil > Water soluble > ASPECT > Oil > Yellowish green Water soluble > Amber FOR COSMETIC USE ONLY. SOLUBILITY > Oil soluble > Water soluble > ODOR > Characteristic odor
7 Head office CS BERGERAC Cedex France Factory address 82, Route du Guel 2413 PRIGONRIEUX France Tél. +33 () Fax : +33 () E.mail : info@sollicebiotech.com DESIGN YELLOW AGENCY () REV 214 SEPTEMBER
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