Vitatene (DSM Nutritional Products León) Perfiles Profesionales en la Industria Alimentaria

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1 Vitatene (DSM Nutritional Products León) Perfiles Profesionales en la Industria Alimentaria

2 1. DSM Vitatene: Quiénes somos? 2. Nuestra Cultura: One DSM 3. Qué perfil profesional necesitamos?

3 1. DSM Vitatene: Quiénes somos?

4 Vitatene Leon SPAIN Page 3

5 Page 4

6 Page 5

7 Our Monuments&landscapes León (Spain) Page 6

8 VITATENE HISTORY

9 1997: R&D Activities starting up in Antobioticos SA June, 1999: Constitution of the Society May, 2004: Starting up of the Plant Nov., 2009: Separation from Antibioticos SA July, 2011: Ownership transfer from P&R to Royal DSM Page 8

10 DSM OVERVIEW

11 DSM Structure - Clusters and Business Groups DSM Managing Board Nutrition Pharma Performance Materials Polymer Intermediates DSM Nutritional Products Human Nutrition & Health Animal Nutrition & Health Personal Care DSM Pharmaceutical Products DSM Anti-Infectives DSM Engineering Plastics DSM Dyneema DSM Fibre Intermediates DSM Food Specialties DSM Resins Page 10

12 DSM is everywhere Page 11

13 Page 12

14 WHAT WE DO? NATURAL CAROTENOIDS

15 Industrial manufacture of carotenoids Most of carotenoids in the market are produced by chemical synthesis: 500 Tn Just a few produced from Natural sources Vitatene manufactures natural carotenoids Page 14

16 More than 700 naturally occurring carotenoids Annual carotenoids production in nature: 100 million tons Nature is a powerful CAROTENOIDS IN NATURE source of carotenoids Page 15

17 CAROTENOID PRODUCTION IN NATURE The biosynthetic path of carotenoids is universal in bacteria, fungi and vegetables (G. Sandmann, 2001) Page 16

18 Page Carotenoids Natural products Tetraterpenes Carotenes b-carotene Lycopene Xantophylls Lutein Astaxanthin ' 14' 13' 12' 11' 10' 9' 8' 7' 6' 5' 4' 3' 2' 1' 19' 20' ' 17' 16' ' 14' 13' 12' 11' 10' 9' 8' 7' 6' 5' 4' 3' 2' 1' 19' 20' ' 17' 16' ' 14' 13' 12' 11' 10' 9' 8' 7' 6' 5' 4' 3' 2' 1' 19' 20' ' 17' 16' OH HO ' 14' 13' 12' 11' 10' 9' 8' 7' 6' 5' 4' 3' 2' 1' 19' 20' ' 17' 16' O OH O HO

19 Lycopene or Beta-carotene crystals are accumulated INSIDE Blakeslea trispora fungus cells Page 18

20 b-carotene & Lycopene: Identical Biosynthetic Route OPP Isopentenyl-PP Geranyl-PP OPP + OPP Fitoene Fitofluoene Carotene Neurospore ne Lycopene Carotene b Carotene Page 19

21 Production Process RECOVERY FORMULATION Blakeslea trispora fermentation Beta-carotene crystal Final formulations Page 20

22 Strain (+) Blakeslea trispora Vegetatives Strain (-) Broth purification Fermentation Betanat & Lyconat Production Process: Under N 2 atmosfere Biomass centrifugation Crystal filtration Page 21 Crystal drying Crystallisation Extraction Biomass drying

23 CWD Formulation Powder Formulation Process Carotenoid solution Antioxidant VITATENE Emulsion Homogenisation Evaporation Agglomeration Packaging Starch suspension Page 22

24 Microencapsulation of carotenoids: Formulation technology to make carotenboid water dispersible Page 23

25 What we obtain? Liquid emulsion: Oily Formulations Powder Formulations Page 24

26 DSM León FORMULATIONS Just a few of lypophilic applications Oily formulations Page 25

27 DSM León FORMULATIONS But in nature and most of applications carotenoids are mainly in aqueous environments Page 26

28 Carotenoid formulation dispersible in water Page 27

29 Tablets Page 28

30 Colour portfolio for different applications and market necesities Eye health ACE Breakfast Energy Immunity Page 29

31 Applications Food colorant Supplement Food fortification Page

32 CWD Formulation Reg Approvals of BC from B trispora USES: EUROPEAN COMMISSION FDA JECFA Colour Additive Reg1333/2008 food addit 21 C.F.R Legal Opinion 04/01/2004 Nutrient Dir 1925/ /12/2006 (1) Self Determined GRAS Status Expert Opinion, 7/1/04 57 th JECFA meeting, 05/06/2001: approved Food Suppl. Dir 2002/46/EC 10/6/2002 (1) Expert Scientific Opinion, 08/10/2002 Page 31

33 CWD Formulation Reg Appr of Lycopene from B trispora USES EUROPEAN COMMISSION FDA JECFA Colour Additive Reg1333/2008 on food additives Nutrient Food Suppl Commission Decission 2009/365/EC authorizing the use of Lycopene from B. trispora FDA GRAS notice No. GRN June 20, 2005 FDA: No questions December, 2005 Expert Scientific Op OS, Nov 02 CWD, May 04 Legal Op., Jan 04 JECFA 67th meeting, Rome, June 2006: approved Page 32

34 Page 33

35 2. Nuestra Cultura: ONE DSM

36 One DSM Culture Page 35

37 One DSM Culture Rapidly adapt and anticipate to changing customer and industry requirements Be fully in tune with the challenges of the external world Track, learn and compete with best practices for all functions Broaden our networks and engage with stakeholders Page 36

38 One DSM Culture Page 37

39 One DSM Culture Set ambitious targets and take ownership to deliver Take responsibility for own actions and performance of teams Deliver on your promises Recognize and celebrate successes and view mistakes as learning opportunities Page 38

40 One DSM Culture Embrace differences and create a more diverse workforce to drive high performance Foster inclusion to mirror our internationalization and drive innovation & sustainability Balance leadership profiles (a.o. gender and nationality) to improve decision making processes Ensure and apply bridging skills and commit to our joint values Page 39

41 Page 40

42 One DSM Culture Actively share, build and co-create on internal and external ideas, knowledge and expertise Harvest the power of growing global workforce in a leveraged organizational model Speed up decision making and execution Trust each other's skills as we are ONE DSM Page 41

43 3. Qué Perfil Profesional Necesitamos?

44 Page 43

45 Page 44

46 1º Secreto del Mercado Laboral: Hasta en los mejores tiempos siempre hay millones de personas que NO consiguen empleo Page 45

47 2º Secreto del Mercado Laboral: Hasta en los peores tiempos siempre hay millones de personas que SI consiguen empleo Page 46

48 Perfil Profesional INGLES FLUÍDO FORMACIÓN TECNICA, INFORMATICA HIGIENE Y SEGURIDAD ALIMENTARIA, CALIDAD, SHE COLABORACION, NEGOCIACIÓN, INTEGRACIÓN, COMUNICACIÓN COMPROMISO, RESPONSABILIDAD, DISPONIBILIDAD, ENFOQUE POSITIVO Page 47

49 GRACIAS POR VUESTRA ATENCIÓN!

The Chemical Synthesis Route (Continued) FIGURE 2 SYNTHESIS OF CAROTENOIDS: FLOW CHART FOR PREPARATION OF BETA-IONONE FIGURE 3 SYNTHESIS

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