Detoxification: A Comprehensive Approach Made Simple*

Transcription

1 Detoxification: A Comprehensive Approach Made Simple* Kelly C. Heim Ph.D. *These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

2 Speaker disclosure Kelly C. Heim Ph.D. I am a paid advisor to Pure Encapsulations. I have no other conflicts of interest to disclose. The Company assumes no liability for presenter s information, whether conveyed verbally or in these materials. All presentations represent the opinions of the presenter and do not represent the position or the opinion of the Company. Reference by the presenter to any specific product, process or service by trade name, trademark, or manufacturer does not constitute or imply endorsement or recommendation by the Company. Seminars, teleconferences and webinars such as this are for educational purposes only and are intended for licensed health care practitioners. These therapies are not substitutions for standard medical care. Practitioners are solely responsible for the care and treatment provided to their own patients.

3 "Poison is in everything, and no thing is without poison. The dosage makes it either a poison or a remedy."

4 Sustaining Life

5 Diversity = Defense Combinations and/or libraries of phytochemicals are the most effective plant defenses Diversity can negotiate uncertainty Diversity can counter threats that are unprecedented

6 Exogenous Toxins (Xenobiotics) Xenobiotics are chemicals that are not made by the body and are therefore foreign. Plant metabolites (e.g. psoralens and pthalides) Heavy metals Environmental contaminants Industrial toxins Drugs Benzene

7 Endogenous toxins Insidious biochemicals generated by the body: Hormones Reactive metabolites Estradiol

8 Biotransformation Metabolism of toxins occurs primarily in the intestinal wall and liver Phase I creates a site for the subsequent addition of a polar molecule Phase II adds the polar molecule, rendering the toxin less active and more soluble, enabling excretion Phase III is the excretion

9 Phase I: Site Creation TOXIN Cytochrome p450 TOXIN Usually more soluble Often very reactive B-complex vitamins Phytochemical inducers Antioxidants

10 Phase II: Conjugation TOXIN Phase II Enzymes TOXIN C Nutritional cofactors Amino acids Glutathione

11 Glutathione Sulfotransferases (GST) TOXIN Phase II enzyme Conjugates estrogens and environmental toxins GST GSH TOXIN Less reactive Easily excreted

12 Phase II is highly responsive to nutritional support Reaction Enzyme Nutritional support* Glutathione conjugation GSTs Glutathione, glutamine, NAC, ALA, glycine, folate* Amino acid conjugation Aminotransferases Cysteine, glycine* Methylation COMT Methionine, folate, methylcobalamin * Sulfation Glucuronidation SULTs UGTs Isothiocyanates, flavonoids, curcuminoids, triterpenoids, diallyl disulfide* *These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

13 Phase III: Efflux TOXIN TOXIN Elimination Efflux Pump Cell

14 INTESTINAL LUMEN INTESTINAL CELL MEMBRANE CELL INTERIOR Phase III

15 Overview TOXIN Phase III Phase I TOXIN Phase II TOXIN C Phase III Elimination

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17 Which is easier?

18 Phytonutrients have generalized, positive effects* Cruciferous vegetables (glucosinolates)* Tea (catechins)* Berries (flavonoids)* Vegetables and spices* o o o Polyphenols curcuminoids, flavonoids* Sulfur-containing compounds diallyl disulfide* Glucuronidase modulators piperine, curcuminoids* *These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

19 Which bioactive is best? Glucosinolates Indole 3-carbinol (I3C) Sulforaphane (SFN) 3,3 -Diindolylmethane (DIM)

20 Nrf2: A multi-organ detoxifier Acts in the nucleus of cells of nearly every organ to serve a general detoxifying role G.I. tract Kidneys Spleen Brain Lungs Skin

21 Nrf2 A genomic switch that activates >1000 protective genes Protective against: Toxins Reactive metabolites ROS Environmental xenobiotics GSH Nrf2 GPx 2 SOD2 GST VDR UGT NQO1

22 Nrf2: Master inducer of antioxidant and detoxification genes UltraGSH Detox* *These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

23 Nutritional support for glutathione synthesis* NAC* SLC7A11 Cystine TXNRD1 Cysteine L-Glutamine GCL Glutamylcysteine SLC6A9 Glycine GSH GSSG GSR Liver G.I. Detox* NADPH *These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

24 Estrogen Detoxification Methylated estrogens

25 Genetic variations that impact detoxifying potential Single nucleotide polymorphisms (SNPs) affect the structure and function of detoxification enzymes. Phase I: p450 SNPs Phase II: Glutathione transferases (GSTs) UDP glucuronosyltransferases (UGTs) Sulfotransferases Antioxidant defenses (SOD2, GPx)

26 Accommodate unknown genetic variations Target as many pathways as possible through these 4 approaches*: 1. Develop a comprehensive diet, supplement and lifestyle program* 2. Diversify and vary dietary fruits, vegetables and spices over the longterm* 3. Select combinations and formulas over stand-alone ingredients for detox protocols* 4. Focus on umbrella targets such as Nrf2, which ramify to many different phase II reactions and antioxidant systems *These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

27 Circadian influences Preliminary evidence that glucuronidation increases with fasting Some detoxifying phytochemicals are more bioavailable in the morning* More research is needed to clarify clinical significance Best approach is to periodically rotate the time of day of supplement administration *These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

28 Detoxification: Key objectives 1. A detoxifying diet 2. Gut microbial balance 3. Gut integrity and motility 4. Heavy metals 5. Optimal biotransformation a. Xenobiotics b. Hormones

29 A detoxifying diet Hypoallergenic Organically grown, natural and whole foods Rich in fruits, vegetables, fiber 8 12 oz ( ml) of water, ideally 8 times per day

30 Digestive health: Structure and function Structure = Epithelial integrity Maintain the mucosal barrier architecture to limit passage of toxins and allergens into the bloodstream Intestinal epithelium

31 Digestive health: Structure and function Function = Motility

32 Gut microbial balance Gut microbiota Participate in many aspects of xenobiotic detoxification Express enzymes that the human genome does not encode o These enzymes can transform toxins into less insidious metabolites

33 Heavy metals Lead, mercury, cadmium and arsenic are present in agricultural, industrial, and residential settings May enter the human body through food, water, air, or absorption through the skin Are toxic when they are not metabolized by the body and accumulate in tissues

34 Detox Pure Pack UltraNutrient (3 capsules) EPA/DHA essentials (1 softgel) Liver-G.I. Detox (2 capsules) Alpha lipoic acid, curcumin, broccoli, silymarin, amino acids NAC 600 mg (1 capsule) Taurine 1,000 mg (1 capsule)

35 PureClear Hypo-allergenic rice protein enhanced with free-form amino acids, vitamins and minerals to support detoxification* 15 grams protein B complex for phase I detoxification* Amino acids such as taurine, methionine, glutamine and glycine for phase II detoxification* Antioxidant support* Vitamins and minerals for comprehensive support* *These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

36 Probiotic 5 Blend of key probiotic bacteria to support gastrointestinal and immune health* Provides 10 billion CFU Lactobacillus acidophilus Lactobacillus rhamnosus Bifidobacterium longum Bifidobacterium lactis Bifidobacterium bifidum *These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

37 PureBi Ome Detox 12.5 billion CFU of a 4-strain clinically researched probiotic blend with n-acetyl-lcysteine, milk thistle and broccoli sprout concentrate Microbial flora can bind and transform toxins within the body to promote detoxification* Moderates the absorption of toxins across the intestinal barrier into the body* Binds and enhances the excretion of heavy metals* Supports phase II detoxification with sulforaphane from broccoli* Probiotic supplementation promotes healthy glutathione reductase activity to support optimal glutathione synthesis* NAC and silymarin support glutathione synthesis* *These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

38 G.I. Fortify Supports the function, microflora balance, integrity, tone, and detoxification of the G.I. tract* Psyllium husk and flax seed powder for gut integrity and motility* l-glutamine for glutathione synthesis and gut epithelial health* Deglycyrrhizinated licorice (DGL), marshmallow root, aloe (inner fillet) and slippery elm for advanced mucosal protection* Triphala to support colon detoxification* *These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

39 G.I. Fortify Powder (1 heaping scoop): Capsules (3): Psyllium husk 4 g L-glutamine 1 g Aloe (inner fillet) 100 mg Flax seed powder 2.25 g DGL 600 mg Marshmallow root 400 mg Slippery Elm 200 mg Triphala 90 mg Psyllium husk 1100 mg L-glutamine 500 mg Aloe (inner fillet) 100 mg Flax seed powder 400 mg Chlorella 100 mg

40 HM Complex Supports detoxification and defenses against mild exposure to common heavy metals* Modified citrus pectin, cilantro and chlorella bind metals and promote their excretion* NAC and selenium promote urinary excretion of mercury and enhance glutathione levels* Alpha lipoic acid promotes the biliary excretion of inorganic mercury and supports antioxidant protection* l-methionine supports phase II detoxification* *These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

41 Liver-G.I. Detox Supports multiple detox pathways in the gut and liver* Alpha lipoic acid, curcumin and broccoli for Nrf2 support* NAC, methionine, glutamine, glycine, taurine provide substrates for phase II and glutathione synthesis* Silymarin: promotes phase I and phase II detox and supports glutathione* Artichoke supports biliary flow* *These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

42 DIM Detox Promotes healthy estrogen metabolism* Supports hormonal detoxification with BioResponse DIM * Supports healthy hormone phase II glucuronidation and sulfation* Sulforaphane, calcium-dglucarate, taurine, glycine and NAC* Promotes antioxidant defenses to protect liver cell health* *These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

43 Zero Compromises. Pure Results.