The following chart summarizes details regarding the enzymes found in the Similase line of products. USP (ph 7.5) PC; FCC (ph 7.0) HUT; FCC (ph 4.

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Reginald Douglas
5 years ago
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1 The Essential Role of Digestive Enzymes Adequate digestive enzyme activity is critical for normal gastrointestinal function and overall health. The three main types of enzymes involved in the digestion of macronutrients are amylase, protease, and lipase.* Intestinal mucosal enzymes, including sucrase, lactase, maltase, as well as other enzymes, such as protease with dipeptidyl peptidase IV (DPP IV) activity, are also important for complete digestion and assimilation of nutrients.* Research indicates that digestive enzyme activity in the body slowly declines with age and in certain clinical conditions. 1,2,9,10 When there is insufficient digestive enzyme activity in the body, byproducts of partially digested and undigested food can cause symptoms of gas, bloating, belching, and nausea. Deficiencies in digestive enzymes and imbalances in gastrointestinal ph can also impair digestion and contribute to a variety of other clinical disorders. 2,3,5,11-14 Supplementation with digestive enzymes can compensate for inadequate enzyme activity in many situations.* 1-5,15 The following chart summarizes details regarding the enzymes found in the Similase line of products. Enzymes Sources Activity Units & Food Types Digested Protease I, II, III, IV, V Aspergillus oryzae, A. melleus, (ph 7.5) PC; HUT; Proteins and polypeptides from animals & plants (meat, fish, eggs, dairy, wheat, legumes, vegetables, etc.), proline dipeptides from gluten, casein A. oryzae ; Starches, complex carbohydrates, polysaccharides I, II Rhizopus oryzae, ; FCC (ph 6.5) Fats, oils, triglycerides from animals and plants I, II ; Dietary fiber, cellulose, hemicellulose A. oryzae A; Lactose Sucrase Saccharomyces sp. Sumner; Sucrose Maltase Malt barley (Hordeum vulgare) DP ; Maltose, starch, polysaccharides U; FCC (ph 6.0) Dietary phytate, phytic acid, pectin, cellulose Alpha-Galactosidase GaIU; FCC (ph 5.5) Indigestible oligosaccharides and sugars, in beans, legumes, vegetables, grains, e.g. stachyose, raffinose

2 The Importance of Acid-Stable Enzymes with Broad ph Activity Digestive enzymes require specific ph conditions for optimal activity. Pepsin activity in the stomach requires normal gastric acidity. Pancreatic enzymes are optimally active only in neutral to alkaline intestinal conditions. Research has shown that production of bicarbonate, needed to alkalinize the upper small intestine, and gastric acid, needed to activate pepsin in the stomach, can decline with age and in certain clinical conditions. 3,16,17 Supplementation with pancreatic enzymes or pepsin may be ineffective in individuals with ph imbalances since these conditions can result in impaired enzyme activity. At Integrative Therapeutics, we formulate our pancreatic enzymes to address some of these common issues, as seen in the products on the back of this brochure. The Pure Plant Enzymes in the Similase line of supplements are naturally acid-stable and provide activity in both acid and alkaline conditions. Derived from fungal sources and plants, they begin working in the stomach and continue in the intestines. Because of their ability to be active throughout a broad ph range, the Similase line of enzyme supplements support digestion regardless of age, digestive function, and ph balance.* 3,18 They are ideal for individuals who cannot benefit optimally from pancreatic enzymes or pepsin supplements, or who prefer a vegetarian alternative to these animal-derived enzymes.* The following chart summarizes the broad ph range of enzyme activity for Similase digestive enzymes.* ph Range of Enzyme Activity ACID ALKALINE Protease I Protease II Protease III Protease IV I II Sucrase Maltase Alpha- Galactosidase

3 The Similase Line of Digestive Enzymes At Integrative Therapeutics, we are proud to be one of the most trusted and recognized leaders in enzyme supplementation. The Similase family of digestive enzymes has been used in clinical practice for over 20 years, and in that time, hundreds of millions of doses of Similase digestive enzymes have been prescribed. Similase Comprehensive, high-potency digestive enzymes This physician-developed formula provides a higher potency and broader range of digestive enzymes than other products.* Similase provides superior support of carbohydrate, protein, fat, fiber, and phytate digestion under virtually all gastrointestinal ph conditions.* Similase helps relieve occasional indigestion, gas, and bloating and provides comprehensive support for digestion and assimilation of nutrients from the diet.* Similase serves as the foundation for the more targeted formulas in the Similase line described below. #74239, 90 Veg Capsules; #74230, 180 Veg Capsules 790 mg 32,000 23,800 Protease I, II, III, IV (ph 7.5) 30,000 48,750 PC 82,000 HUT I, II 2,100 FIP 970 FCC III (ph 4.5) 1,600 A 1.7 U I, II SU Maltase (Malt Diastase) 32,100 DPº Daily Value not established. Other ingredients: cellulose, vegetable capsule (modified cellulose), and calcium laurate. your healthcare professional. Not recommended for use if peptic ulcer, gastritis, or heartburn is present. Similase Lipo High lipase digestive enzymes Similase Lipo is a high potency formula with a full range of digestive enzymes plus additional lipase activity to aid in the digestion and assimilation of fats and fat-soluble nutrients.* Similase Lipo promotes an optimal intestinal response to dietary fats.* Studies have shown that acid-stable enzymes like those found in Similase Lipo can be used safely and effectively for pancreatic enzyme replacement support and may be more effective than supplementation with pancreatic enzymes in certain individuals.* 1-4 #106005, 90 Veg Capsules 640 mg 32,000 23,800 Protease I, II, III, IV (ph 7.5) 30,000 48,750 PC 82,000 HUT I, II 6,150 FIP 2,530 FCC III (ph 4.5) 1,600 A 1.7 PU I, II INVU Maltase (Malt Diastase) 32,100 DPº Daily Value not established. Other ingredients: vegetable capsule (modified cellulose), your healthcare professional. Not recommended for use if peptic ulcer, gastritis, or heartburn is present. Similase BV Bean and vegetable digestive enzymes A comprehensive, Pure Plant Enzyme supplement that aids in the digestion of all food groups, while also providing added enzyme activity for the digestion of beans, legumes, and cruciferous vegetables (e.g. broccoli, cabbage, and brussel sprouts) that produce gas in sensitive individuals.* Similase BV features alpha-galactosidase to support the breakdown of difficult to digest sugars and oligosaccharides in offending foods.* #106001, 90 Veg Capsules; #106002, 180 Veg Capsules 626 mg 21,320 15,860 Protease I, II, III, IV (ph 7.5) 30,000 48,750 PC 82,000 HUT Alpha-Galactosidase FCC (ph 5.5) 900 GalU I, II 280 I, II 2,100 FIP PU FCC III (ph 4.5) 1,130 A 270 INVU Maltase (Malt Diastase) 32,100 DPº Daily Value not established. your healthcare professional. Not recommended for use if peptic ulcer, gastritis, or heartburn is present.

integrativepro.com/similase 800.931.1709 Gluten and casein digestive enzymes Digestion of gluten and casein can be particularly difficult for some individuals.

4 integrativepro.com/similase Gluten and casein digestive enzymes Digestion of gluten and casein can be particularly difficult for some individuals. Similase GFCF provides enzymes to support comprehensive digestive health, while also featuring superior dipeptidyl peptidase IV (DPP IV) activity for the digestion of proline-containing dipeptides from hidden gluten and casein.* Similase GFCF supports a gluten-free, casein-free lifestyle and helps relieve #73952, 120 Veg Capsules Servings per container 60 %DV <1 g <1% 536 mg* DPP IV Protease Blend (Protease I, II, III, IV, V) (ph 7.5) I, II FCC (ph 6.5) I, II 134,660 22,660 12,557 9,530 12, A comprehensive plant-based enzyme supplement in easy-to-swallow capsules designed specifically for children. Similase Jr. also contains DPP IV and supports the digestion of proteins, carbohydrates, fats, fiber, and phytates under virtually all gastrointestinal ph conditions.* It helps to relieve #106009, 90 Veg Capsules Protease (Provides Dipeptidylpeptidase IV (ph 7.5) (DPP IV), Exopeptidase, Endopeptidase, and Peptide Peptidohydrolase activity) (ph 7.0) FCC III (ph 4.5) Maltase (Malt Diastase) working in the stomach and continues in the intestines. Concentrate-HP helps to support comfortable dietary fat digestion, gastric emptying time, and normal stool fat content.*4,8 %DV 315 mg 6,700 6,000 High-quality gamma-oryzanol and deglycyrrhizinated licorice (DGL) extract are also included for the support of healthy gastrointestinal mucosa.* Helps relieve occasional indigestion, gas, and bloating while providing targeted support for the GI mucosa.* Protease is omitted due to its potential for irritation in sensitive patients. #136006, 90 Veg Capsules; #136007, 180 Veg Capsules of age, digestive function, and ph balance.* They have been used in a multitude of clinical applications including:1-8 Support for digestion of dietary carbohydrate, protein, fat, and fiber* Relief of occasional indigestion, gas, and bloating* Panplex 2-Phase Pancreatic enzyme replacement support* Panplex 2-Phase provides support for both the gastric and intestinal phases of digestion.* Formulated from Support of normal gastric emptying time* research findings and case studies, Panplex 2-Phase is a safe and effective means of supporting healthy gastric Promoting lactose digestion* acid levels and enhancing digestion throughout the gastrointestinal tract.* This formula features a 2-phase delivery system and high-potency 6X pancreatic enzyme concentrate. Phase I provides hydrochloric acid (HCI) and Bio-Zyme This clinically studied formula contains a high-potency pancreatic enzyme complex to optimize digestion and support the body s natural cytokine response.* Bio-Zyme provides full-strength, undiluted pancreatic extract with 10X potency for optimum health benefits.* Taken with meals, Bio-Zyme supports digestion of fats, carbohydrates, and proteins.* When taken in between meals, Bio-Zyme has been clinically shown to reduce occasional pain associated with exercise and overuse.*19,20 Similase Sensitive Stomach herbs, marshmallow, and slippery elm, to provide gentle support for digestion.* wide range of gastrointestinal ph conditions, supporting optimal digestion regardless release matrix designed to protect against deactivation of enzymes by stomach acid.* Daily Value (DV) not established. Similase Sensitive Stomach features Pure Plant Enzymes and the demulcent Impaired digestive function is a common problem that can result in a wide variety of clinical pepsin for release in the stomach. Phase II provides pancreatin and bile salts in a unique, chemical-free delayed- 14,500 20,200 PC 34,300 HUT 2,000 CFAU 2,400 LacU INVU 0.64 PU 10,800 DPº your healthcare professional. Not recommended for use if peptic ulcer, gastritis, or heartburn is present. Digestive enzymes plus GI mucosal support* DIGESTIVE ENZYMES support to patients for decades. The found in Similase are effective under a is ph-stable and active under virtually all gastrointestinal ph conditions. It provides digestive activity that begins feature unique delivery methods to maintain effectiveness through each phase of digestion. This high-potency enzyme supplement provides targeted support for the digestion of fats.* Concentrate-HP include high potency pancreatic enzymes and combination supplements for effective, soothing relief.* They Concentrate-HP Other ingredients: cellulose, vegetable capsule (modified cellulose), inulin (from chicory root), calcium laurate, and silicon dioxide. Recommendations: Take 2 capsules with each meal or as recommended by your healthcare professional. Children s digestive enzymes Integrative Therapeutics enzyme products extend beyond the Similase line of supplements. Additional offerings conditions. The physician-formulated line of enzymes has been providing unparalleled digestive HUT PC FIP U A SU Percent Daily Values (DV) are based on a 2,000 calorie diet. *Daily Value not established. Similase Jr. Additional Enzyme Considerations %DV* <1 g <1%* Slippery Elm (Ulmus rubra) Bark 240 mg 220 mg 200 mg 170 mg 80 mg Deglycyrrhizinated Licorice (DGL) (Glycyrrhiza glabra) Root Extract Gamma-Oryzanol (from rice bran) Marshmallow (Althaea officinalis) Root Extract 21,170 15, *Percent Daily Values (DV) are based on a 2,000 calorie diet. Daily Value not established. Recommendations: Take 1 or 2 capsules three times daily at the beginning of meals, or as recommended by your healthcare professional. References Nakamura T, et al. Pancreas. 1998;16(3): Roberts I. Pancreas. 1989;4(4): Schneider MU, Knoll-Ruzicka ML, Domschke S, Heptner G, Domschke W. Hepatogastroenterology. 1985;32(2): Zorn J. Fortschr Med. 1978;96(38): Medow MS, Thek KD, Newman LJ, et al. Am J Dis Child. 1990;(11): Di Stefano, Miceli E, Missanelli A, et al. Dig Dis Sci. 2007;52(1): Sandberg AS, Hulthen LR, Turk M. J Nutr. 1996;126(2): Nakae Y, Onouchi H, Kagaya M, Kondo T. J Gastroenterol. 1999;34(4): Vellas B, Balas D, Moreau J, Bouisson M, Senegas-Balas F, Guidet M, Ribet A. Int J Pancreatol. 1988;3(6): Saltzman JR, Russell RM. Gastroenterol Clin North Am. 1998;27(2): Hvatum M, Kanerud L, Hallgren R, Brandtzaeg P. Gut. 2006;55(9): Husby S, Jensenius JC, Svehag SE. Scand J Immunol. 1986;24(4): Mack DR, Flick JA, Durie PR, et al. J Pediatr. 1992;120(5): Mancilla A, Madrid S, Hurtado H, et al. Rev Med Chil. 2008;136(8): Borowitz D, Goss CH, Limauro S, et al. J Pediatr. 2006;149(5): Laugier R, Bernard JP, Berthezene P, Dupuy P. Digestion. 1991;50(3-4): Guslandi M, Pellegrini A, Sorghi M. Gerontology. 1999;45(4): Ishibashi T, Matsumoto S, Harada H, Ochi K, et al. Nippon Ronen Igakkai Zasshi. 1991;28(5): Miller PC, Bailey SP, Barnes ME, Derr SJ, Hall E E. J Sports Sci Apr;22(4); Miller PC, Bailey SP, Cormier S, Khlebopros A, Hall EE. Med Sci Sports Exerc. 2002;34(5):S ITLLC-0456 #66834 C U LT I VAT E H E A LT H Y PRACT I CE S Similase GFCF

5 integrativepro.com/similase Gluten and casein digestive enzymes Digestion of gluten and casein can be particularly difficult for some individuals. Similase GFCF provides enzymes to support comprehensive digestive health, while also featuring superior dipeptidyl peptidase IV (DPP IV) activity for the digestion of proline-containing dipeptides from hidden gluten and casein.* Similase GFCF supports a gluten-free, casein-free lifestyle and helps relieve #73952, 120 Veg Capsules Servings per container 60 %DV <1 g <1% 536 mg* DPP IV Protease Blend (Protease I, II, III, IV, V) (ph 7.5) I, II FCC (ph 6.5) I, II 134,660 22,660 12,557 9,530 12, A comprehensive plant-based enzyme supplement in easy-to-swallow capsules designed specifically for children. Similase Jr. also contains DPP IV and supports the digestion of proteins, carbohydrates, fats, fiber, and phytates under virtually all gastrointestinal ph conditions.* It helps to relieve #106009, 90 Veg Capsules Protease (Provides Dipeptidylpeptidase IV (ph 7.5) (DPP IV), Exopeptidase, Endopeptidase, and Peptide Peptidohydrolase activity) (ph 7.0) FCC III (ph 4.5) Maltase (Malt Diastase) working in the stomach and continues in the intestines. Concentrate-HP helps to support comfortable dietary fat digestion, gastric emptying time, and normal stool fat content.*4,8 %DV 315 mg 6,700 6,000 High-quality gamma-oryzanol and deglycyrrhizinated licorice (DGL) extract are also included for the support of healthy gastrointestinal mucosa.* Helps relieve occasional indigestion, gas, and bloating while providing targeted support for the GI mucosa.* Protease is omitted due to its potential for irritation in sensitive patients. #136006, 90 Veg Capsules; #136007, 180 Veg Capsules of age, digestive function, and ph balance.* They have been used in a multitude of clinical applications including:1-8 Support for digestion of dietary carbohydrate, protein, fat, and fiber* Relief of occasional indigestion, gas, and bloating* Panplex 2-Phase Pancreatic enzyme replacement support* Panplex 2-Phase provides support for both the gastric and intestinal phases of digestion.* Formulated from Support of normal gastric emptying time* research findings and case studies, Panplex 2-Phase is a safe and effective means of supporting healthy gastric Promoting lactose digestion* acid levels and enhancing digestion throughout the gastrointestinal tract.* This formula features a 2-phase delivery system and high-potency 6X pancreatic enzyme concentrate. Phase I provides hydrochloric acid (HCI) and Bio-Zyme This clinically studied formula contains a high-potency pancreatic enzyme complex to optimize digestion and support the body s natural cytokine response.* Bio-Zyme provides full-strength, undiluted pancreatic extract with 10X potency for optimum health benefits.* Taken with meals, Bio-Zyme supports digestion of fats, carbohydrates, and proteins.* When taken in between meals, Bio-Zyme has been clinically shown to reduce occasional pain associated with exercise and overuse.*19,20 Similase Sensitive Stomach herbs, marshmallow, and slippery elm, to provide gentle support for digestion.* wide range of gastrointestinal ph conditions, supporting optimal digestion regardless release matrix designed to protect against deactivation of enzymes by stomach acid.* Daily Value (DV) not established. Similase Sensitive Stomach features Pure Plant Enzymes and the demulcent Impaired digestive function is a common problem that can result in a wide variety of clinical pepsin for release in the stomach. Phase II provides pancreatin and bile salts in a unique, chemical-free delayed- 14,500 20,200 PC 34,300 HUT 2,000 CFAU 2,400 LacU INVU 0.64 PU 10,800 DPº your healthcare professional. Not recommended for use if peptic ulcer, gastritis, or heartburn is present. Digestive enzymes plus GI mucosal support* DIGESTIVE ENZYMES support to patients for decades. The found in Similase are effective under a is ph-stable and active under virtually all gastrointestinal ph conditions. It provides digestive activity that begins feature unique delivery methods to maintain effectiveness through each phase of digestion. This high-potency enzyme supplement provides targeted support for the digestion of fats.* Concentrate-HP include high potency pancreatic enzymes and combination supplements for effective, soothing relief.* They Concentrate-HP Other ingredients: cellulose, vegetable capsule (modified cellulose), inulin (from chicory root), calcium laurate, and silicon dioxide. Recommendations: Take 2 capsules with each meal or as recommended by your healthcare professional. Children s digestive enzymes Integrative Therapeutics enzyme products extend beyond the Similase line of supplements. Additional offerings conditions. The physician-formulated line of enzymes has been providing unparalleled digestive HUT PC FIP U A SU Percent Daily Values (DV) are based on a 2,000 calorie diet. *Daily Value not established. Similase Jr. Additional Enzyme Considerations %DV* <1 g <1%* Slippery Elm (Ulmus rubra) Bark 240 mg 220 mg 200 mg 170 mg 80 mg Deglycyrrhizinated Licorice (DGL) (Glycyrrhiza glabra) Root Extract Gamma-Oryzanol (from rice bran) Marshmallow (Althaea officinalis) Root Extract 21,170 15, *Percent Daily Values (DV) are based on a 2,000 calorie diet. Daily Value not established. Recommendations: Take 1 or 2 capsules three times daily at the beginning of meals, or as recommended by your healthcare professional. References Nakamura T, et al. Pancreas. 1998;16(3): Roberts I. Pancreas. 1989;4(4): Schneider MU, Knoll-Ruzicka ML, Domschke S, Heptner G, Domschke W. Hepatogastroenterology. 1985;32(2): Zorn J. Fortschr Med. 1978;96(38): Medow MS, Thek KD, Newman LJ, et al. Am J Dis Child. 1990;(11): Di Stefano, Miceli E, Missanelli A, et al. Dig Dis Sci. 2007;52(1): Sandberg AS, Hulthen LR, Turk M. J Nutr. 1996;126(2): Nakae Y, Onouchi H, Kagaya M, Kondo T. J Gastroenterol. 1999;34(4): Vellas B, Balas D, Moreau J, Bouisson M, Senegas-Balas F, Guidet M, Ribet A. Int J Pancreatol. 1988;3(6): Saltzman JR, Russell RM. Gastroenterol Clin North Am. 1998;27(2): Hvatum M, Kanerud L, Hallgren R, Brandtzaeg P. Gut. 2006;55(9): Husby S, Jensenius JC, Svehag SE. Scand J Immunol. 1986;24(4): Mack DR, Flick JA, Durie PR, et al. J Pediatr. 1992;120(5): Mancilla A, Madrid S, Hurtado H, et al. Rev Med Chil. 2008;136(8): Borowitz D, Goss CH, Limauro S, et al. J Pediatr. 2006;149(5): Laugier R, Bernard JP, Berthezene P, Dupuy P. Digestion. 1991;50(3-4): Guslandi M, Pellegrini A, Sorghi M. Gerontology. 1999;45(4): Ishibashi T, Matsumoto S, Harada H, Ochi K, et al. Nippon Ronen Igakkai Zasshi. 1991;28(5): Miller PC, Bailey SP, Barnes ME, Derr SJ, Hall E E. J Sports Sci Apr;22(4); Miller PC, Bailey SP, Cormier S, Khlebopros A, Hall EE. Med Sci Sports Exerc. 2002;34(5):S ITLLC-0456 #66834 C U LT I VAT E H E A LT H Y PRACT I CE S Similase GFCF

conditions. The physician-formulated line of enzymes has been providing unparalleled

conditions. The physician-formulated line of enzymes has been providing unparalleled INTEGRATIVE GASTROINTESTINAL" integtativepro.com/similase 800.931.1709 SIMILASE DIGESTIVE ENZYMES Impaired digestive function is a common problem that can result in a wide variety of clinical conditions.