Anne Schuchat, MD Director, National Center for Immunization and Respiratory Diseases, CDC
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1 Surveillance for Vaccine-preventable Disease and Immunization Coverage Anne Schuchat, MD Director, National Center for Immunization and Respiratory Diseases, CDC IOM Committee National Vaccine Plan Chicago, IL July 24, 2008
2 New, complex outcomes Old clinical presentations now unfamiliar Newly preventable pathogens
3 Challenging Surveillance Climate, Increasingly Complex Needs Health care sector: fragmented delivery, financing strains Health IT: EMRs, PHRs, privacy, interoperability, IIS uptake Complex needs for surveillance systems Justify return on public investments Monitor national, state, local programs Track vax performance over time and pops. Forecast resurgent disease, pockets of need Initiate timely public health responses
4 Role for Surveillance for Vaccine-Preventable Disease Vital link between immunization policy & health outcomes Early warning system for changes in population susceptibility and force of infection Informs program monitoring
5 What Reportable, Nationally Notifiable systems Enhanced systems Laboratorybased systems Vaccination coverage (e.g. NIS) Where All states Selected locations Selected laboratories All states, selected cities Why Support elimination Prompt public health response Monitor national trends Identify nat l dis. trends Monitor new vaccine performance Assess policy Inform vaccine formulation (flu, Pnc) Assess vaccine performance Monitor state and national program Identify disparities
6 Laboratory-based systems
7 Cases per 100, Invasive Pneumococcal Disease rates in children aged <5 years, 1998 through 2006 Overall PCV7 type Serotype 19A PCV7 introduction Year CDC, ABCs/Emerging Infections Program Network
8
9 Total Acute Gastroenteritis (AGE) and Rotavirus AGE cases, Jan-April, Total AGE Rotavirus Number of cases New Vaccine Surveillance Network
10 Address More Complex Outcomes
11 Monitoring Complex Outcomes of New Vaccines and Recommendations HPV Vaccine Cervical ca, other ca HPV prevalence CIN, Genital warts Influenza, PCV13 P&I, ILI - nonspecific Pneumonia hosp s Rotavirus vaccines Diarrhea hospitalizations
12 Aggregating disparate information
13 Clinical and demographic data (age, outcome, complications) Immunization history Case definition Laboratory data, +/- clinical specimen Reasons unimmunized (Eg PBEs) Epidemiologic context Travel hx Outbreak associated School or Day-care information
14 Future Needs in Aggregating Data and Addressing More Complex Outcomes: Better Use of Technology IT can address some, not all needs Large-linked databases useful when vax effects large, outcomes specific But Special lab testing needed for some key outcomes and interview needed for PH response Role for human touch in VPD tracking will evolve, but can t be eliminated Improved dx tests still needed for some VPDs
15 Duration of Protection
16 Reported Pertussis Cases U.S., , , ,000 25,000 20,000 15,000 > 18 yrs yrs Number of cases 200, , ,000 DTP 10,000 5, < 11 yrs 50, Year National Notifiable Disease Surveillance System (NNDSS)
17 Duration of Protection: Future challenges Low levels of many VPDs Less circulation less natural boosting Assessing of long-term protection requires reliable correlate Surv. for breakthrough cases can inform booster dose policy Long-term monitoring of new outcomes needed (e.g., HPV, Tdap)
18 Indirect Effects
19 Incidence / 100, Herd (Indirect) Effect: Invasive pneumococcal disease in adults >18 years, 1998/ , PCV7 serotypes PCV7 licensed >80 yo: -90% yo: -88% yo: -84% yo: -88% ABCs/Emerging Infections Program Network (CDC unpublished) Year
20 Indirect Effects: Future Issues Influenza vaccine recently recommended for all children 6 mo 18 years Demonstrating important indirect or herd effects of influenza vaccination would support sustainability of school-aged programs overcome impact of stalled rates of influenza vaccination in elderly and high risk reduce need to find more effective formulations for elderly and immunocompromised Other needs: Assess indirect benefits of Tdap, rotavirus, meningococcal vaccination
21 Assess immunization coverage
22 Sustained High Levels of Protection in Preschool-Aged Children Percent Target MMR(1+) DTP / DTaP(3+) Polio (3+) Hep B (3+) PCV 7 (3+) 20 Hib (3+) Varicella (1+) National immunization survey
23 Immunization Registry Sentinel Sites: Dose 1 coverage in <3 mo olds of rotavirus vs. DTaP, PCV % Vaccinated RV DTaP PCV7 0 Arizona DC Michigan Minnesota Montana Oregon Data as of May 15, 2007 Sentinel Site
24 Immunization Coverage: The Way Forward Implement recent Strategic Assessment* Annual Teen NIS state-specific, national Vax acceptance and SES modules Develop methods for sustainability: Less landline use census pilot (sample frame) Use Immunization Information Systems when uptake sufficient (pvt use << public currently) Address small-area variation, exemptors Develop targeted approaches for hot spots Registry efforts; stdzing school entry surveys *Summary of internal/external strategic review to be distributed
25 Permit rapid public health response
26 Chaves Co, NM N=1, Unknown Mar 17 Grant County, WA Outbreak N=19 Source= Japan Apr 12 - May 30 San Francisco, CA N=2, Sources: India (1), Italy (1) Apr 18, Jun 22 Measles Cases Reported to CDC/NCIRD January 1 to July 11, 2008 (N= 132) Vernon County, WI N=1 Source=Germany Apr 25 Milwaukee County, WI Outbreak, N=6 Source=China-H1 Mar 19-Apr 25 Missaukee County, MI Outbreak, N=4 Source=Unknown, D5 Feb 29-Apr 8 Pittsburgh, PA N=1 Source=Unknown Apr 12 Chicago, IL N=1 Source=Switzerland Apr 17 Nassau County, NY N=1, Source=Israel Apr 4 Los Angeles, CA N=2 Source=Unknown Mar 23-Apr 16 San Diego, CA Outbreak N=12 (CA =11, HI =1) Source=Switzerland, D5 Jan 25-Feb 16 Honolulu, HI N=4 Sources: Italy (2) China (1) Philippines (1) Feb 5-May 22 Cass Co, MO N=1 Source Unknown Apr 7 Pima County, AZ Outbreak N=18 Source=Switzerland, D5 Feb 13-May 2 Scott County, AR N=2 Source= Unknown Feb 12-Feb 22 Baton Rouge, LA N=1, Russia May 14 Du Page Co, I L Outbreak N=27 Source=Italy, D4 May 15-Jun 25 New York City, NY N=27 Sources: Israel (1) Belgium (2) D4 Italy (1) Other Importassociated (10) Source Unknown (13) Fairfax, VA Jan 18-Jun 10 N=1 Source=India Feb 25 D.C. N=1 Source Unknown Apr 20 Fulton Co, GA N=1 Pakistan May 14
27 Measles, US, 2008 As of July 11, N=132* # Cases Age Group 20 (16%) < 12 mos 32 (25%) 12 mos -4 years 41 (33%) 5-19 years 28 (22%) years 5 (4%) > 50 years old 38/41(93%) of the school-aged children were PBEs * Information on age was available for 126 cases
28 Need for VPD & IZ Monitoring: Greater than ever but getting more difficult? Complacency about disease risk Clinicians, parents lack familiarity with sx Lab assay challenges in vaccinated people Global interdependence VPD risk around the world impacts risk here Local level coverage data most useful for program improvements but least available Resource-intensive unless comprehensive IIS or comparable system available
29 How will we know we re there? Evaluation plans Measure progress toward disease elimination/reduction targets Measure progress toward achievement of coverage goals Report VPD burden and immunization coverage on annual basis Availability of data (coverage, incidence) at the program level where it is needed
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