Dataset Coding Guide - Raine Study (Pregnancy Cohort Study) - Raine Year 1 Examination

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1 Page 1 Y1_A1 Exam Weight (Numeric:8:) number corresponds (kg) Y1_A10 Exam Abdominal skinfold (Numeric:8:) number corresponds (mm) Y1_A2 Exam Length crown-heel (Numeric:8:) number corresponds (cm) Y1_A3 Exam Length crown-rump (Numeric:8:) number corresponds (cm) Y1_A4 Exam Head circumference (Numeric:8:) number corresponds (cm) Y1_A5 Exam Chest circumference (Numeric:8:) number corresponds (cm) Y1_A6 Exam Mid arm circumference (Numeric:8:) number corresponds (cm) Y1_A7 Exam Triceps skinfold (Numeric:8:) number corresponds (mm) Y1_A8 Exam Subscapular skinfold (Numeric:8:) number corresponds (mm) Y1_A9 Exam Suprailiac skinfold (Numeric:8:) number corresponds (mm) Y1_CBP1 Exam Systolic blood pressure (Numeric:3:) number corresponds Y1_CBP2 Exam Diastolic blood pressure (Numeric:3:) number corresponds Y1_CBP3 Exam Blood pressure state (Character:1:) 0 Sleeping 1 Awake, quiet 2 Awake, active/excited 3 Crying Y1_CBP4 Exam Blood pressure instrument (Character:1:)

2 Page 2 A Mercury sphygmomanometer B Aneroid sphygmomanometer D Dinamap blood pressure recorder E Other electronic device (eg infrasonde) X Other (eg manual palpation) Y1_DE1 Develop/Denver Gross motor (Character:1:) A Adequate F Fail N Normal Y1_DE2 Develop/Denver Fine motor (Character:1:) A Adequate F Fail N Normal Y1_DE3 Develop/Denver Personal/social (Character:1:) A Adequate F Fail N Normal Y1_DE4 Develop/Denver Language (Character:1:) A Adequate F Fail N Normal Y1_DM10_C Exam Dysmorphology screen-hair (Character:5:5) 8 NA - no anomalies detected

3 Page 3 A Sparse hair B Alopecia C Coarse/wiry hair D Low posterior hair line E Widows peak F Double crown G Hypopigmented/albinism H Hirsute facies L Infestation or infection (eg lice, tinea, capitus) M O Z White forelock Electric hair Other Y1_DM11_C Exam Dysmorphology screen-hands (Character:5:5) 8 NA - no anomalies detected A Small hands B Brachydactyly (short fingers) C Arachnodactyly (long fingers) D Broad fingers E Clinodactyly F Other finger anomalies G Broad thumbs H Digitalised thumbs I Hypoplastic thumb(s) J Other thumb anomalies K Syndactyly L Polydactyly M Hypoplastic/dysplastic nails

4 N Single crease 5th (little) finger O Single palmar (simian) crease P Short metacarpals Q Clubbing R Leukonychia S Paronychia or whitlow Z Other Page 4 Y1_DM12_C Exam Dysmorphology screen-joint (Character:5:5) 8 NA - no anomalies detected A Hypermobility B Restricted movements/contractures - Small joints of hand C Restricted movements/contractures - Wrists D E F G H Restricted movements/contractures - Elbows Restricted movements/contractures - Shoulders Restricted movements/contractures - Hips Restricted movements/contractures - Knees Restricted movements/contractures - Ankles I Restricted movements/contractures - Neck/spine J Swelling/inflammation - Interphalangeal K L M Swelling/inflammation - Metacarpo-phalangeal Swelling/inflammation - Wrists Swelling/inflammation - Elbows

5 Page 5 N O P Q R S T U Swelling/inflammation - Shoulders Swelling/inflammation - Hips Swelling/inflammation - Knees Swelling/inflammation - Ankles Swelling/inflammation - Neck/spine Absent patellae Dislocated hip(s) Other joint dislocation(s) Y1_DM13_C Exam Dysmorphology screen-abdo (Character:5:5) 8 NA - no anomalies detected A Enlarged/distended B Ascites C Hepatomegaly D Splenomegaly E Enlarged left kidney F Enlarged right kidney G Enlarged bladder H Faecal masses I Other masses J Umbilical hernia K Inguinal hernia L Abnormal anus M Abdominal bruit N Diastasis of recti P Enlarged lymph nodes Y1_DM14_C Exam Dysmorphology screen-mouth (Character:5:5) 8 NA - no anomalies detected A Microstomia

6 B C D E F G H I J K L M N O P Q R S T U V W X Y Z Page 6 Macrostomia Prominent lips Downturning corners of mouth Lip pits Cleft lip Cleft lip and palate Cleft palate without cleft lip Submucous cleft Bifid uvula High-arched palate Ridged palate Macroglossia Irregular or amputated tongue "Tongue-tie" Hypodontia Enamel hypoplasia Dental caries Mesiodens Other anomalies of teeth Hypertrophied alveolar margin Epulis or dental cysts Mouth ulcers/stomatitis Pharyngitis/tonsillitis Crowding of posterior oropharynx/tonsillar hypertrophy Chipped/damaged/stained/wide gapped teeth Y1_DM15_C Exam Dysmorphology screen-face (Character:5:5) 8 NA - no anomalies detected

7 Page 7 A B C D Fat, puffy midface Flat midface Malar hypoplasia Maxillary hypoplasia Y1_DM16_C Exam Dysmorphology screen-neck (Character:5:5) 8 NA - no anomalies detected A Short neck B Webbed neck/redundant skin C Sternomastiod "tumour" D Cysts E Sinuses F Lymphadenopathy G Goitre H Tracheostomy P Enlarged lymphnodes Y1_DM17_C Exam Dysmorphology screen-chest (Character:5:5) 8 NA - no anomalies detected A Small chest B Hyperexpanded (barrel) chest C Pectus excavatum (sunken chest) D Pectus carinatum (pidgeon chest) E Harrisons sulcus F Intercostal/suprasternal recession G Tachypnoea at rest H Deviated trachea I Unequal air entry J Wheezing (rhonchi, rhales) K Crackles (crepitations)

8 Page 8 L M N O P Q Z Other adventitiae Widely spaced nipples Other nipple anomalies Abnormal clavicles Stridor/Croup Gynaecomastia/breast enlargement Other Y1_DM18_C Exam Dys screen-male genitals (Character:5:5) 8 NA - no anomalies detected A Undescended left testis B Undescended right testis C Testicular hypoplasia/atrophy D Hydrocoele(s) E Short/small penis F Hypospadias G Chordee H Abnormal foreskin I Shawl scrotum J Bifid scrotum K Ambiguous genitalia L Circumcised M Pubic hair Z Other Y1_DM19_C Exam Dysmorphology screen-neuro (Character:6:5) 8 NA - no anomalies detected A Spasticity - quadriplegia B Spasticity - diplegia C Spasticity - hemiplegia

9 D E F G H I J K L M N Page 9 Hypotonia Weakness - generalised Weakness - localised Muscle wasting - generalised Muscle wasting - localised Muscle hypertrophy Abnormal sensation Segmental denervation - arms Segmental denervation - legs Spinal cord lesion Involuntary movements (chorea, athetosis) O P Q R S T U V W X Y Dystonia Muscle fasciculation (incl tongue) Ataxia - truncal Ataxia - appendicular (incl dysdiadochokinesis, past - pointing) Facial nerve palsy Bulbar/pseudobulbar palsy Extraocular nerve palsy Unclear speech (incl dysarthria, oral dyspraxia) Clumsy (incl motor dyspraxia) Seizures (observed) Tremor Y1_DM1_C Exam Dysmorphology screen-eyes (Character:5:5) 8 NA - no anomalies detected A Convergent strabismus - manifest B Convergent strabismus - latent (cover test only)

10 C D E F G H I J K L M N O P Page 10 Divergent strabismus - manifest Divergent strabismus - latent Unequal pupils Non-reactive pupil(s) Other pupillary abnormalities Corneal opacity Cataract(s) or other lens opacity Lens dislocation Retinal pigmentation Abnomal irides Other colobomata Microphthalmos Short palpebral fissures Upslanting paplebral fissures (Monoloid slant) Q R S T U V W X Y Z Downslanting paplebral fissures (anti-monoloid slant) Hypertelorism Hypotelorism Epicanthic folds Ptosis Abnormal eyebrows Conjuntivitis Tearing Conjuntival haemorrhage Other Y1_DM20_C Exam Dysmorphology screen-feet (Character:5:5) 8 NA - no anomalies detected A Small feet

11 Page 11 B C D E F G H I J K L M N Z Short hallux Broad hallux Hammer/claw toe deformity Syndactyly Polydactyly Other toe anomalies Pes cavus Pes planus Short metatarsals Prominent heels Talipes equinovarus Talipes (other) Metatarsus varus (adductus) Positional talipes Y1_DM21_C Exam Dysmorphology screen-limb (Character:5:5) 8 NA - no anomalies detected A Short limbs B Limb deformity C Hemihypertrophy or hemiatrophy D Radial hypoplasia E Bow legs F Internal tibial torsion Y1_DM2_C Exam Dysmorphology screen-ears (Character:5:5) 8 NA - no anomalies detected A Lowset ears B Rotated ears C Pre-auricular tags/pits D Malformed auricles

12 Page 12 E Small ears F Upward "take off" of lobe G Retraction of tympanic membrane(s) H Middle ear effusion I Inflammation of tympanic membrane(s) J Scarring of tympanic membrane(s) K Prominent/"bat" ears L Grommets (tympanostomy tubes) in situ M O Z Creased lobes Abnormal helix Other Y1_DM3_C Exam Dysmorphology screen-skull (Character:5:5) 8 NA - no anomalies detected A Abormal shape - scaphocephaly B Brachycephaly/flat occiput C Prominent occiput D Plagiocephaly E Wide sutures F Raised sutures G Frontal bossing H Wide fontanelle J Cranial bruit K Macrocephaly (>98th percentile) L Microcephaly (<2nd percentile) Z Other Y1_DM4_C Exam Dysmorphology screen-skin (Character:5:5) 8 NA - no anomalies detected A Pallor

13 Page 13 B Plethora C Cyanosis (central) D Cyanosis (peripheral) E Jaundice F Thickened skill/ichthyosis G Hyperpigmentation (generalised) H Cafe au lait spots I Naevi J Albinism K Depigmented patches L Pityraisis versicolor M Haemangiomata N Telangiectases O Other cysts/tumours/hamartomata P Bruising/petechiae Q Hypohidrosis R Eczema (atopic dermatitis) S Sebborrhoeic dermatitis (incl cradle cap) T U V W X Y Z Miliaria Psoriasis Napkin dermatitis Other erythematous rash Acne/pustules/contagious infection Hirsutism Other anomalies (eg skin tags, dimples, scars, burns) Y1_DM5_C Exam Dysmorphology screen-spine (Character:5:5) 8 NA - no anomalies detected

14 Page 14 A Scoliosis B Kyphosis C Lordosis D Abnormal swelling E Spina bifida F Sacral dimple/naevus/haemangioma/hairy tuft G H Z Pilonidal sinus Mongolian spot Other anomolies of spine Y1_DM6_C Exam Dysmorphology screen-heart (Character:5:5) 8 NA - no anomalies detected A Hyperdynamic pulses B Absent brachial pulse(s) C Weak/absent femoral pulse(s) D Cardiomegaly/displaced apex E Abnormal heart sounds F Thrill G Murmur - innocent H Murmur - other Y1_DM7_C Exam Dys screen-female genitals (Character:5:5) 8 NA - no anomalies detected A Hypoplastic labia majora B Clitoral hypertrophy C Short recto-vaginal distance D Labial adhesions E Abnormal hymen F Labial/pubic hair

15 Page 15 G Vaginal tags Y1_DM8_C Exam Dysmorphology screen-nose (Character:5:5) 8 NA - no anomalies detected A Rhinorrhoea (not crying) B Nasal obstruction C Low nasal bridge D Broad nasal bridge E Small or short nose F Bulbous, large or prominent nose G Anteverted nares H Hypoplastic nares I Scarred nares J Long philtrum K Short pliltrum L Prominent/deep philtrum Y1_DM9_C Exam Dysmorphology screen-jaw (Character:5:5) 8 NA - no anomalies detected A Micrognathia B Prognathism C Fine/pointed jaw Y1_ECO1 Examiners comments (Character:30:) Y1_ECO2 Examiners comments (Character:30:) Y1_ECO3 Exam Comments (Character:30:) Y1_ELM1 Early Lang Milestone-expressive (Character:2:) 8 9 Y1_ELM2 Early Lang Milestone-receptive (Character:2:) 8

16 Page 16 9 Y1_ELM3 Early Lang Milestone-visual (Character:2:) 00 Visually impaired 8 9 Y1_LLA Teeth Lower L) central incisor (Character:1:) Y1_LLB Teeth Lower L) lateral incisor (Character:1:) Y1_LLC Teeth Lower L) canine (Character:1:) Y1_LLD Teeth Lower L) first molar (Character:1:)

17 Page 17 Y Present Y1_LLE Teeth Lower L) second molar (Character:1:) Y1_LRA Teeth Lower R) central incisor (Character:1:) Y1_LRB Teeth Lower R) lateral incisor (Character:1:) Y1_LRC Teeth Lower R) canine (Character:1:) Y1_LRD Teeth Lower R) first molar (Character:1:)

18 Page 18 A C N Y Absent Carious Not yet erupted Present Y1_LRE Teeth Lower R) second molar (Character:1:) Y1_N1 Neurology Tone R) arm (Character:1:) 0 Marked hypotonia 1 Mild hypotonia 2 Normal tone 3 Mild hypertonia 4 Marked hypertonia Y1_N10 Neurology Plantars left (Character:1:) 0 None 1 Downward 2 Uncertain 3 Upward (Babinski) Y1_N11 Neurology Sensation R) arm (Character:1:) 0 None 1 Reduced 2 Normal 3 Hyperaesthesia

19 Page 19 Y1_N12 Neurology Sensation R) leg (Character:1:) 0 None 1 Reduced 2 Normal 3 Hyperaesthesia Y1_N13 Neurology Sensation L) arm (Character:1:) 0 None 1 Reduced 2 Normal 3 Hyperaesthesia Y1_N14 Neurology Sensation L) leg (Character:1:) 0 None 1 Reduced 2 Normal 3 Hyperaesthesia Y1_N2 Neurology Tone R) leg (Character:1:) 0 Marked hypotonia 1 Mild hypotonia 2 Normal tone 3 Mild hypertonia 4 Marked hypertonia

20 Page 20 Y1_N3 Neurology Tone L) arm (Character:1:) 0 Marked hypotonia 1 Mild hypotonia 2 Normal tone 3 Mild hypertonia 4 Marked hypertonia Y1_N4 Neurology Tone L) leg (Character:1:) 0 Marked hypotonia 1 Mild hypotonia 2 Normal tone 3 Mild hypertonia 4 Marked hypertonia Y1_N5 Neurology Reflexes R) arm (Character:1:) 0 None 1 Depressed 2 Normal 3 Hyper-reflexia 4 Hyper reflexia with clonus and/or crossed response Y1_N6 Neurology Reflexes R) leg (Character:1:) 0 None 1 Depressed 2 Normal 3 Hyper-reflexia 4 Hyper-reflexia with clonus and/or crossed response

21 Page 21 Y1_N7 Neurology Reflexes L) arm (Character:1:) 0 None 1 Depressed 2 Normal 3 Hyper-reflexia 4 Hyper-reflexia with clonus and/or crossed response Y1_N8 Neurology Reflexes L) leg (Character:1:) 0 None 1 Depressed 2 Normal 3 Hyper-reflexia 4 Hyper-reflexia with clonus and/or crossed response Y1_N9 Neurology Plantars right (Character:1:) 0 None 1 Downward 2 Uncertain 3 Upward (Babinski) Y1_STY1 Stycar Near vision (Character:1:) A Abnormal N Normal U Uncertain

22 Page 22 Y1_STY2 Stycar Visual fields (Character:1:) H Homonymous hemianopia N Normal T Bitemporal hemianopia U Uncertain Y1_STY3 Stycar Distance vision (Character:1:) A Abnormal N Normal U Uncertain Y1_STY4 Stycar Hearing (Character:1:) A Abnormal D Delayed response N Normal U Uncertain Y1_TYPE Type of developmental assessment (Character:1:) Y1_ULA Teeth Upper L) central incisor (Character:1:) Y1_ULB Teeth Upper L) lateral incisor (Character:1:)

23 Page 23 C N Y Carious Not yet erupted Present Y1_ULC Teeth Upper L) canine (Character:1:) Y1_ULD Teeth Upper L) first molar (Character:1:) Y1_ULE Teeth Upper L) second molar (Character:1:) Y1_URA Teeth Upper R) central incisor (Character:1:)

24 Page 24 Y1_URB Teeth Upper R) lateral incisor (Character:1:) Y1_URC Teeth Upper R) canine (Character:1:) Y1_URD Teeth Upper R) first molar (Character:1:) Y1_URE Teeth Upper R) second molar (Character:1:) Y1_XDAT Examination date (Numeric:8:)

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