Evidence-based on advanced therapy
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1 Evidence-based on advanced therapy A presentation to: ASCoN Workshop and Conference 7-10 th December 2017 Chiang Mai Thailand Assoc. Prof Dr Julia Patrick Engkasan Rehabilitation Physician University of Malaya Kuala Lumpur Malaysia Trusted evidence. Informed decisions. Better health.
2 Contents 01 Introduction to Cochrane Rehabilitation Field 02 Cycle of Evidence based Medicine 03 Locomotor therapy 04 Summary of evidence 05 What s next?
3 12 Cochrane Fields and Networks 1. Cochrane Child Health 2. Cochrane Complementary Medicine 3. Cochrane Consumer Network 4. Cochrane Global Ageing 5. Cochrane Global Mental Health 6. Cochrane Insurance Medicine 7. Cochrane Neurosciences 8. Cochrane Nursing Care 9. Cochrane Nutrition 10. Cochrane Pre-hospital and Emergency Care 11. Cochrane Primary Care 12. Cochrane Rehabilitation
4 Vision All rehabilitation professionals can apply Evidence Based Clinical Practice Decision makers will be able to take decisions according to the best and most appropriate evidence
5 Mission Allow all rehabilitation professionals to combine the best available evidence as gathered by high quality Cochrane systematic reviews, with their own clinical expertise and the values of patients Improve the methods for evidence synthesis, to make them coherent with the needs of disabled people and daily clinical practice in rehabilitation.
6 Goals 1. To connect stakeholders and individuals involved in production, dissemination, and implementation of evidence based clinical practice in rehabilitation, creating a global network 2. To undertake knowledge translation for Cochrane on reviews relevant to rehabilitation, with dissemination to stakeholders, in line with Cochrane s knowledge translation strategy 3. To develop a register of Cochrane and non Cochrane systematic reviews relevant to rehabilitation
7 Goals 4. To promote Evidence Based Clinical Practice and provide education and training on it and on systematic review methods to stakeholders 5. To review and strengthen methodology relevant to Evidence Based Clinical Practice to inform both rehabilitation and other Cochrane work related to rehabilitation and stimulating methodological developments in other Cochrane groups 6. To promote and advocate for Evidence Based Clinical Practice in rehabilitation to other Cochrane groups and wider rehabilitation stakeholders
8 Cochrane Rehabilitation Internal organization Trusted evidence. Informed decisions. Better health.
9 Website
10 EBM Cycle
11 Evidence-based on advanced therapy There is a decision to make
12
13 Locomotor training Step training Train them how to step well Coordinated step, adequate speed Provide sensory input specific to waking Overground training Patient stands and walks on level surfaces Community training
14 Locomotor training Role of spinal cord in the control of walking Intense repetitive training can lead to coordinated stepping response Provide sensory experience of walking the right way of walking (compared to gait training) Activity-based therapy Aim is independent community walking without aids or compensatory movements
15 Physiological basis of locomotor training Focuses on retraining the motor function via plastic change Enhances the afferent input to the spinal cord and activates the central pattern generators (CPGs) embedded within the lumbosacral spinal cord Plastic changes in the spinal cord and sensory motor cortex Only in incomplete injury Hubli & Dietz, The Physiological basis of neurorehabilitation locomotor training after SCI 2013
16 Other forms of therapy
17 Advantages & disadvantages of robotics locomotor training Early initiation in severely dependent persons Able to increase the intensity and duration of training while maintaining a physiological gait pattern Biofeedback system Reduces personnel cost Expensive to buy Expensive to maintain (software licensing / updates) Trained personnel Space Access
18 Finding the evidence
19 P - Persons with SCI I Robotics Gait Training C Other forms of physiotherapy O Impairment (strength), Activity (walking Speed, distance, safety)
20 Methods Developed search strategy Search terms & databases (Locomotor, gait, walking, ambulat*, Robotics paraplegia, SCI, paralysis) Published systematic reviews of locomotor therapy in person with SCI
21 Study ID/ year Mehrholz et al 2017 Population Intervention Comparison Outcome(s) Any age,gender type of traumatic SCI, time post injury, level of initial walking ability BWSTT and robotic gait training Overground gait training and any other forms of physiotherapy Walking speed and walking distance Nam et al 2017 Acute & chronic, Traumatic & nontraumatic, non progressive, Incomplete spinal cord injury (AIS B,C,D), Variable walking ability RAGT (Lokomat) Other exercise / physiotherapy (BWS gait training or no treatment) Gait distance (2 and 6min) Gait velocity (m/s), LEMS FIM-L, WISCI, spasticity & TUG Tefertiller et al Adults with stroke, SCI, TBI, MS and PD Robotic locomotor training (Lokomat, Lokohelp Gait trainer) Overground training, FES Walking speed (10MWT, 5MWT, 25FWT) Walking endurance (capacity to cover a distance in a defined time) 6MWT, 2MWT Time measures of functional mobility TUG (Timed Up and Go) Level of independence SCIM WISCI WISCI II
22 Study ID N studies N participants Mehrholz studies RCTs (3 studies) 344 (141) Treatment protocol Robotics intervention varies Varies Varies Treatment duration Nam et al studies RCTs mins; 3-5X per week Lokomat varies Tefertiller et al studies 2 RCTs and 11 non-rcts (3 CR, 4 CS, 2PP, 1CC & 1 cohort) mins, 5x week Lokomat 12 weeks
23 Tefertiller et al. 2011
24 NAM et al Gait velocity with time since injury
25 NAM et al Gait velocity with different interventions
26 NAM et al Gait distance
27 Mehrholz et al RAGT 5 RCTs and 344 participants Walking speed: 3 trials with 141 participants Walking distance: 3 trials with 141 participants
28 Mehrholz et al. 2017
29 Robotics Mehrholz et al Walking speed
30 Mehrholz et al Walking distance Robotics Overground
31 Improvement in the walking speed 0.07m/s (Nam et al) Improvement in distance covered 45m (Nam et al) (Acute SCI)
32 Possible improvements Robotics Possible improvement Possible increase in walking speed (0.13m/s) with Robotics compared to OGT
33
34
35
36
37 Your clinical judgement Local context
38 Patient preferences and values The differences in the outcome What does 0.13 m/s improvement mean? What does USD3,000 means to them?
39
40 Julia Patrick Engkasan Rehabilitation Physician University Malaya Kuala Lumpur Malaysia
Cochrane Rehabilitation Report sullo stato attuale di Cochrane Rehabilitation field e prospettive future nell ottica di ISPRM
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