V.A.C. VeraFlo Therapy can help.

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1 WOUND CARE IS COMPLEX & COSTLY Therapy can help. PROBLEM Complex wounds pose challenges to clinicians and patients in terms of achieving desired outcomes while managing healthcare costs. 1-5 OUTCOMES & BENEFITS Independent studies have demonstrated that Negative Pressure Wound Therapy can be more effective than V.A.C. Negative Pressure Wound Therapy alone. Retrospective study with Prontosan Wound Irrigation Solution showed: 6 Reduced OR Visits Reduced Time to Final Surgical Procedure Reduced Length of Stay Prospective study with Saline showed: 2 Enhanced Granulation Tissue SOLUTION Therapy, the only NPWT system with an instillation feature which allows solution to dwell in the wound for thorough contact with the wound bed, has demonstrated better outcomes when compared to V.A.C. Therapy alone. 6,2 vaculta.com

2 The evolution of V.A.C. Therapy: V.A.C.Ulta NPWT Therapy System with Therapy Automated Therapy With two pumps, one for automated, controlled instillation and the other for removal of topical wound solutions, for example, saline or Prontosan Wound Irrigation Solution Product Enhancements Intuitive Touch Screen Interface with simple menus Fill Assist helps to determine correct instillation volume Dressing Soak instills topical wound solutions into the wound for easier dressing removal and increased patient comfort Dressings with higher tensile strength and less hydrophobicity C Drape with improved adhesive properties D Therapy combines the proven benefits of V.A.C. Therapy with an instillation option featuring dwell time

3 National statistics show that managing complex wounds can be costly. There are over 6.5 MIL. patients afflicted with chronic wounds and over $25 BIL. is spent annually to treat them. 1-2 It takes an average of 25.4 DAYS to treat complex wounds using moist wound dressings. 3 Each year trauma accounts for 2.3 MIL. hospitalizations associated with inpatient costs of $33.7 BIL. 7 The cost of treating a single full-thickness pressure ulcer is as high as $70,000 and total annual costs for treatment of pressure ulcers in the U.S. is estimated at $11 BIL. 4 What is your approach to closure? Cleansing Regularly wash and cleanse the wound bed, thereby: Removing infectious materials Reducing risk of compromised wound healing due to contamination or bioburden Diluting and solubizing devitalized tissue and slough Granulation Promote granulation tissue formation Cover exposed structures Increase wound fill Decrease wound volume Addressing malodorous wounds Decreasing viscosity and volume of exudate Reducing pain and discomfort at dressing changes Closure

4 Reported Clinical Outcomes & Benefits Cleansing approach with Prontosan Wound Irrigation Solution Physicians at MedStar Georgetown University Hospital, Center for Wound Healing examined the impact of Therapy with Prontosan Wound Irrigation Solution (using either a 6 or 20 min. soak time and negative pressure of 3.5 hours or 2hours at -125mmHg) versus V.A.C. Therapy in 142 patients with infected wounds that required hospitalization and serial surgical debridement. 5 STUDY RESULTS Trips to OR Reduced OR Visits NPWT: n=74 NPWTi: n=34 20 min dwell time Reduction of ~1/2 Trip p=0.003 V.A.C. Therapy Therapy Reduced Length of Stay 14.9 In this study Therapy with Prontosan instillation was more cost effective than V.A.C. Therapy. An economic model based on MedStar Georgetown University study results and cost modeling assumptions indicates potential savings as high as: $8,613 savings per patient in the 6 min. dwell time group A $9,117 savings per patient in the 20 min. dwell time group B Days Days V.A.C. Therapy Reduced Time to Final Surgical Procedure Therapy 7.5 Reduction of ~4 days p=0.034 Reduction of ~2 days p=0.002 Actual savings will vary based on individual facility costs, protocol and patients. V.A.C. Therapy Therapy

5 Therapy with Prontosan Wound Irrigation Solution provides ease of use through: Automated volumetric therapy with customizable dwell time Compatible bottle with spikable cap adapter Streamlined solution ordering and facility supply room storage What is Prontosan Wound Irrigation Solution? Prontosan is a clear and virtually odorless wound cleanser containing PHMB (polyhexamethylene biguanide) and betaine (surfactant). These two ingredients are combined to maximize wound cleansing: PHMB (Polyhexanide) functions as a preservative (also found in contact lens solution) that inhibits the growth of microorganisms in the bottle. Betaine (Surfactant) is a surface-active cleanser that provides immediate debridement. Cleansing and granulation approach with saline In a prospective, multi-center case series of 131 patients with complex wounds treated with Therapy using saline with a 10 minute soak time and negative pressure ranging between 4 and 12 hours at -125mmHg, the authors found that: 2 35% of patients had received conventional V.A.C. Therapy prior to Therapy 35% 65% Complex wounds closed with Therapy 98% Therapy Previously on V.A.C. Therapy The main observed clinical effect noted by the authors was that Therapy using saline showed enhanced granulation tissue production compared to conventional V.A.C. Therapy, in terms of filling the dead space more rapidly and completely.

6 Wound healing is a process. Let Therapy help remove the complexity. When using V.A.C.Ulta Therapy Unit for V.A.C. Therapy only, it is compatible with V.A.C. Dressings featuring SensaT.R.A.C. Technology. V.A.C.ULTA SYSTEM ORDERING INFORMATION FOR V.A.C. VERAFLO THERAPY Part Number Description ULTDEV01/US V.A.C.Ulta Therapy Unit, United States ULTVFL05SM Dressing, 5-pack, Small ULTVFL05MD Dressing, 5-pack, Medium ULTVCL05MD V.A.C. VeraFlo Cleanse Dressing, 5-pack, Medium ULTVFL05LG Dressing, 5-pack, Large ULTLNK0500 V.A.C. VeraLink Cassette, 5-pack ULTDUO0500 V.A.C. VeraT.R.A.C. Duo Tube Set, 5-pack Prontosan Wound Irrigation with Adapter, case of 10 M /5 500mL InfoV.A.C. Canister with Gel M /5 1000mL InfoV.A.C. Large Canister with Gel *V.A.C.Ulta Therapy Unit is compatible with all InfoV.A.C. Canisters For more information, visit or call References: 1. Human Skin Wounds: A Major and Snowballing Threat to Public Health and the Economy. Sen CK, Gordillo GM, Roy S, et ad. Wound Repair Regen., Nov-Dec, 2009; (17)6: ) 23 Sept 2013]. 2. Brinkert D, Ali M, Naud M, Maire N, Trial C, Teot L, Negative Pressure Wound Therapy with Saline Instillation: 131 Patient Case Series. Int Wound J, 2013 Dec; 10(s1): Gabriel A, Shores J, Heinrich C, Bagai W, et al. Negative pressure wound therapy with instillation: a pilot study describing a new method for treating infected wounds. Int Wound J. 2008;5(3): Gibbons W, Shanks HT, Kleinhelter P, Jones P. Eliminating facility-acquired pressure ulcers at Ascension Health. Joint Commission Journal on Quality and Patient Safety. 2006; 32: Kim PJ, Attinger CE, Steinberg JS, et al. The Impact of Negative-Pressure Wound Therapy with Instillation Compared with Standard Negative-Pressure Wound Therapy:A Retrospective, Historical, Cohort, Controlled Study. Plast. Reconstr. Surg.2014; 133: Finkelstein, E.A., Corso, P.S., & Miller, T.R. The Incidence and Economic Burden of Injuries in the United States. USA: Oxford University Press Centers for Disease Control and Prevention. (2012). Trauma. Retrieved from Footnotes: A. V.A.C. VeraFlo Therapy System daily cost approximately 7 V.A.C. VeraFlo Therapy cycles per day. $ (based on customer daily rental and disposable rates; assumes 5.8 rental days, 1 canister daily for five days, three medium dressings, one cassette, 700 ml Prontosan, 1 Ltr saline plus spike). $94.93 (assumes 7.2 rental days, three medium V.A.C. GranuFoam Silver Dressings, two canisters). Total therapy days equals Time to Final Surgical Procedure Days 2 days; NPWT and NPWTi typically applied 1-3 days after admission. B. V.A.C. VeraFlo Therapy System daily cost approximately 10 V.A.C. VeraFlo Therapy cycles per day. $ is based on customer daily rental and disposable rates; assumes 5.5 rental days, 1.5 canisters daily for five days, three medium dressings, one cassette, 700 ml Prontosan, 1 Ltr saline plus spike. $94.93 (assumes 7.2 rental days, three medium V.A.C. GranuFoam Silver Dressings, two canisters). Total therapy days equals Time to Final Surgical Procedure Days 2 days; NPWT and NPWTi typically applied 1-3 days after admission. C. Compared to V.A.C. GranuFoam Dressing D. Compared to V.A.C. Drape NOTE: Specific indications, contraindications, warnings, precautions and safety information exist for KCI Products and therapies. Please consult a physician and product instructions for use prior to application. Rx only KCI Licensing, Inc. All rights reserved. Prontosan is a trademark of B. Braun Medical Inc. All other trademarks designated herein are proprietary to KCI Licensing, Inc., its affiliates and/or licensors. DSL# US (REV. 9/14) LIT#29-A-243

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