ARIC V5 / NCS Code Book III, S.5. Section 5: Derived Variable File

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1 Chapter III. Derived Files Derived Variable Dataset (DERIVE_NCS51) ARIC V5 / NCS Code Book III, S.5 Page 1 of 16 Derived Variable Dataset: FORM CODE=DERIVE_NCS51 VERSION=1.0 Instructions: Derived variables for NCS Stages 2/3. ADSIGREGVOL51 Total Ad Signature Region Volume (Mm3) 1968 Range ( median= mean= std= ) 1212 Missing CENTER Field Center 666 F 863 J 706 M 945 W CMHFREQ51 Frequency Of Definite Microhemorrhage 1958 Range ( median=0 mean=1.0 std=6.6 ) CMHPRES51 Microhemorrhage Presence DEEPCMHFREQ51 Frequency Of Deep Cerebral Microhemorrhage Missing

2 Page 2 of 16 DEEPCMHPRES51 Deep Cerebral Microhemorrhage Present (0=no, 1=yes) DEMDXL1_51 Dementia Diagnosis Level Missing DEMETIO51 Ncs Mci Dementia Etiology Determined By Review 2168 Range 1-11 ( median=4 mean=5.7 std=4.2 ) DEMRVTYPE51 Ncs Mci Dementia Review Type 497 A 1302 D 369 S DEMSEAD51 Ncs Mci Dementia Secondary Etiology - Alzheimer's Disease 108 A 116 DR 1944 NA DEMSEALCI51 Ncs Mci Dementia Secondary Etiology Alcohol-Related Cognitive Impairment 3 DR 2165 NA

3 Page 3 of 16 DEMSECVD51 Ncs Mci Dementia Secondary Etiology - Cerebrovascular Disease 96 A 305 DR 1766 NA 1 SR DEMSEDCI51 Ncs Mci Dementia Secondary Etiology Depression-Related Cognitive Impairment 46 A 126 DR 1994 NA 2 SR DEMSEHTRCI51 Ncs Mci Dementia Secondary Etiology Head Trauma-Related Cognitive Impairment 3 A 31 DR 2134 NA DEMSELBD51 Ncs Mci Dementia Secondary Etiology Lewy Body Disease 63 A 180 DR 1925 NA DEMSEMRCI51 Ncs Mci Dementia Secondary Etiology Medication-Related Cognitive Impairment 3 A 29 DR 2135 NA 1 SR

4 Page 4 of 16 DEMSEOMPDCI51 Ncs Mci Dementia Secondary Etiology - Other Major Psychiatric Disorder-Related Cognitive Impairment 2 A 3 DR 2163 NA DEMSEOND51 Ncs Mci Dementia Secondary Etiology Other Neurodegenerative Disorder 2 A 18 DR 2148 NA DEMSESDRCI51 Ncs Mci Dementia Secondary Etiology Systemic Disease-Related Cognitive Impairment 1 A 25 DR 2142 NA DGWFSCVOL51 Freesurfer Deep Grey Cortical Volume (Mm3) 1968 Range ( median=42373 mean= std= ) 1212 Missing ETIV51 Estimated Total Intracranial Volume (Mm3) 1977 Range ( median= mean= std= ) 1203 Missing FRFSCVOL51 Freesurfer Total Frontal Cortical Volume (Mm3) 1968 Range ( median= mean= std= ) 1212 Missing

5 Page 5 of 16 GENDER Sex (From Ftra22) 1839 F 1341 M ID Aric Id 3180 Present Text suppressed INFRATCMHFREQ51 Frequency Of Infratentorial Microhemorrhage 1945 Range 0-17 ( median=0 mean=0.1 std=0.8 ) 1235 Missing INFRATCMHPRES51 Infratentorial Microhemorrhage Present (0=no, 1=yes) LAC15FREQ51 Frequency Of Lacunes (Modified Definition (15mm)) LAC15PRES51 Lacunar Infarct Present (Modified Definition (15mm))

6 Page 6 of 16 LAC20FREQ51 Frequency Of Lacunes (Standard Definition (20mm)) LAC20PRES51 Lacunar Infarct Present (Standard Definition (20mm)) LARGECORTFREQ51 Frequency Of Large Cortical Infarction LARGECORTINFPRES51 Large Cortical Infarction Presence

7 Page 7 of 16 LOBARCMHFREQ51 Frequency Of Lobar Microhemorrhage 1942 Range ( median=0 mean=0.4 std=4.9 ) 1238 Missing LOBARCMHPRES51 Lobar Microhemorrhage Present (0=no, 1=yes) 13 E MRFDROP51 Ppt Dropped From Infarction Dataset (Mrf) Missing MRIINELIGIBLE51 Ineligible For Mri Missing MRIREFUSAL51 Refused Mri Missing MRIWASTE51 Waste (Etiv-Totbvol) 1970 Range ( median= mean= std= ) 1210 Missing

8 Page 8 of 16 MRMDROP51 Ppt Dropped From Microhemorrhage Dataset (Mrm) Missing MRSDROP51 Ppt Dropped From Freesurfer Dataset (Mrs) Missing MRWDROP51 Ppt Dropped From Wmh Dataset (Mrw) Missing NOFINDINF51 1=no Infarction 0=infarction Found NOFINDMRM51 1=no Mch/Ss 0=mch/Ss Found OCFSCVOL51 Freesurfer Occipital Cortical Volume (Mm3) 1968 Range ( median=40008 mean= std= ) 1212 Missing PAFSCVOL51 Freesurfer Parietal Cortical Volume (Mm3) 1968 Range ( median= mean= std= ) 1212 Missing

9 Page 9 of 16 RACEGRP Race (From Ftra23) 5 A 919 B 3 I 2253 W REVIEWERPRIM51 Primary Etiologic Dx Missing REVIEWERSYND51 Reviewer Syndromic Dx 326 D 1158 M 670 N 14 U S2BASEWT51 Ncs Stage 2 Sampling Base Weight 3000 Range ( median=1 mean=1.6 std=1.1 ) 180 Missing

10 Page 10 of 16 S2REFADJ51 Ncs Stage 2 Sampling Weight Adjustment For Refusal 3000 Range ( median= mean= std= ) 180 Missing S2SAMWT51 Ncs Stage 2 Sampling Weight 3000 Range ( median= mean= std= ) 180 Missing S3BASEWT51 Ncs Stage 3 Sampling Base Weight 1978 Range ( median=1 mean=1.7 std=1.2 ) 1202 Missing S3REFADJ51 Ncs Stage 3 Sampling Weight Adjustment For Refusal 1978 Range ( median= mean= std= ) 1202 Missing S3SAMWT51 Ncs Stage 3 Sampling Weight (Normalized To Clinic Visits) 1978 Range ( median= mean= std= ) 1202 Missing

11 Page 11 of 16 SECETIODX151 First Secondary Etiologic Dx Missing SECETIODX251 Second Secondary Etiologic Dx Missing SECETIODX351 Third Secondary Etiologic Dx Missing

12 Page 12 of 16 SECETIODX451 Fourth Secondary Etiologic Dx Missing SECETIOREV1 Ncs Mci Dementia Secondary Etiology Selected By Reviewer Missing SECETIOREV2 Ncs Mci Dementia Secondary Etiology Selected By Reviewer Missing

13 Page 13 of 16 SECETIOREVA Ncs Mci Dementia Secondary Etiology Selected By Adjudicator 81 AD 2 ADCV 16 ADDE 6 ADLB 1 ADME 1 ADOD 1 ADPD 74 CV 6 CVDE 13 CVLB 1 CVME 16 DE 2 HT 35 LB 8 LBDE 1 LBPD 1 ME 1 ODHT 1 SD 2913 Missing SMALLCORTFREQ51 Frequency Of Small Cortical Infarction SMALLCORTINFPRES51 Small Cortical Infarction Presence

14 Page 14 of 16 STAGE_2_COMPLETE Stage 2 Complete (1=yes, 0=no) STAGE_3_COMPLETE Stage 3 Complete-Mri Data Present SUBCORTFREQ51 Frequency Of Subcortical Infarction SUBCORTICALCMHFREQ 51 Frequency Of Subcortical Microhemorrhage 1942 Range 0-38 ( median=0 mean=0.5 std=2.1 ) 1238 Missing SUBCORTICALCMHPRES 51 Subcortical Microhemorrhage Present (0=no, 1=yes) 13 E

15 Page 15 of 16 SUBCORTINFPRES51 Subcortical Infarction Presence SUBJECTID Subject Id 3180 Present Text suppressed SUPERSIDFREQ51 Frequency Of Superficial Siderosis SUPERSIDPRES51 Superficial Siderosis Presence TEFSCVOL51 Freesurfer Temporal Cortical Volume (Mm3) 1968 Range ( median= mean= std= ) 1212 Missing TOTBRAINVOL51 Total Brain Volume (Mm3) 1971 Range ( median= mean= std= ) 1209 Missing

16 Page 16 of 16 V5AGE51 Visit 5 Age 3180 Range ( median=77 mean=77.0 std=5.5 ) VENTVOL51 Ventvol Lobe Volume (Mm3) 1968 Range ( median=34664 mean= std= ) 1212 Missing WMATR51 White Matter At Risk 1971 Range ( median= mean= std= ) 1209 Missing WMHPCT51 Percentage Of White Matter Hyperintensities 1971 Range ( median=2.83 mean=3.981 std=3.556 ) 1209 Missing WMHPRES51 White Matter Hyperintensity Presence Missing WMHVOL51 Volume Of White Matter Hyperintensities 1971 Range ( median= mean= std= ) 1209 Missing

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