Patterns of Heredity Genetics
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1 Patterns of Heredity Genetics
2 DO NOW Hand in outlines (my desk) Pick up tests from back table and review them. We will be going over the zipgrade and the short answer together. Save your questions for the end.
3 Genetics = the study of heredity by which traits are passed from parents to offspring
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5 A unit of heredity that occupies a specific location on a chromosome and codes for a particular product. It consists of DNA and is a part of the chromosome.
6 Thanks Mom and Dad! We inherit genes from our parents Those genes code for the traits we express Most traits are coded by more than 1 gene! Ex: eye color, hair color, etc.
7 A pair of chromosomes are called homologs (homo meaning same) Homologous chromosomes have the same size, structure, and genetic information.
8 Alternative forms of a gene that occupy corresponding positions on homologous chromosomes.
9 We have 23 pairs of chromosomes 1 pair are known as the sex chromosomes, which determines the sex of the offspring (and has other important genetic information too!) Males = XY Females = XX
10 The history of Gregor Mendel Austrian Monk Czech Bred different varieties of garden pea. First to develop rules that accurately predict patterns of heredity. Determined specific units of inheritance = genes and alleles
11 1) self pollination occurs within the same flower or same plant 2) cross pollination occurs between different plants
12 1. Several traits exist in two clear different forms. Ex: Flower color was either purple OR white 2. The male and female reproductive parts are enclosed within the same flower. It is easy to control mating by allowing a flower to fertilize itself (self fertilization), or you can transfer pollen to another flower (cross pollination). 3. The garden pea is small, grows easily, matures quickly, and produces many offspring. Results can be obtained quickly with many offspring.
13 Steps in Mendel s research 1. Allowed each garden pea to self-pollinate for several generations to ensure true-breeding for that particular trait. P Generation = parental generation 2. Mendel then cross-pollinated two P generation plants that had different forms of the trait (purple and white flower). The offspring from that were called the F1 generation. F 1 generation = Filial generation (of son or daughter) 3. Allowed the F1 generation to self-pollinate and those offspring are called the F2 generation. F2 Generation = Filial generation 2
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15 Mendel s Crosses with Pea Plants P1 parental generation Pure tall plants X Cross F first filial generation Pure short plants Pollination All Tall plants Self Pollination 1 F 2 second filial generation 787 tall plants, 277 short plants 3 to 1 ratio
16 Ratio of Mendel s Research P Generation had a true-breeding purple and white flower The F1 generation consisted of ALL purple flowers The F2 generation had 705 purple flowers and 224 white flowers. That is a ratio of about 3:1 or 3/1 He found that ratio for all of the traits
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18 Color and texture
19 DO NOW: Pick up outlines and tests from the back Take out notebooks
20 Mendel s 3 Principles of Inheritance 1) The Law of Segregation: Each inherited trait is defined by a gene pair. Parental genes are randomly separated to the sex cells so that sex cells contain only one gene of the pair. Offspring therefore inherit one genetic allele from each parent when sex cells unite in fertilization. 2) The Law of Independent Assortment: Genes for different traits are sorted separately from one another so that the inheritance of one trait is not dependent on the inheritance of another.
21 3) The Law of Dominance: An organism with alternate forms of a gene will express the form that is dominant. The genetic experiments Mendel did with pea plants took him eight years ( ) and he published his results in During this time, Mendel grew over 10,000 pea plants, keeping track of progeny number and type. Mendel's work and his Laws of Inheritance were not appreciated in his time. It wasn't until 1900, after the rediscovery of his Laws, that his experimental results were understood.
22 Mendel s Laws Dd
23 Mendel s Laws Law of segregation the two alleles for a trait segregate when gametes are formed.
24 Law of independent assortment alleles of different genes separate independently of one another during gamete formation. Pea plant color independent from wrinkles
25 DO NOW 1. Take out baby labs, we are going to present our babies! 2. Then onto Monohybrids and dihybrids
26 Phenotype vs. Genotype Genotype: The set of alleles that an individual has (not always obvious) phenotype: the physical appearance of a trait
27 Different alleles present Ex: Bb Two of the same alleles Ex: BB or bb Can be homozygous recessive or homozygous dominant
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29 Recessive vs. Dominant Recessive: The trait not expressed when the dominant form of the trait is present Dominant: The expressed form of the trait when present (even if it is just 1 allele)
30 In dogs, black fur is dominant over white fur color. B = black fur b = white fur BB or Bb bb
31 DO NOW Take out your labs and have them out on your desk. Each group will come up to introduce their baby!
32 DO NOW If Joseph Gordon-Levitt is heterozygous for brown hair (H=Black, h=blonde) 1. What is JGL s genotype? 2. What is JGL s phenotype? Beyonce is homozygous dominant for brown hair. 1. What is her genotype? 2. What is her phenotype? WHAT ARE THE CHANGES THE OFFSPRING WILL HAVE BROWN HAIR???
33 Punnett Square A diagram that predicts the outcome of a genetic cross by considering all possible combinations of gametes in the cross. Crossing only 1 trait is called a monohybrid cross. Crossing 2 traits is called a dihybrid cross.
34 1. Phenotypic Ratio and %: 2. Genotypic Ratio :
35 1. Phenotypic Ratio and %: 2. Genotypic Ratio :
36 1. Phenotypic Ratio and %: 2. Genotypic Ratio :
37 DO NOW: What is the probability of: - flipping a coin and getting tails? - tossing a dice and getting a 4? (ratio and percentage)
38 Probability calculations can predict the results of genetic crosses. It is the likelihood that a specific event will occur. = number of one kind of possible outcome Total number of all possible outcomes Example: If you flip a coin, you will have 1 outcome, but two possible outcomes. Your answer would be ½.
39 How do you write a ratio? When flipping a coin and it lands on tails ½ or 1:2 Genotypic ratio: What is genetically written. Phenotypic ratio: what physical traits you would see Pg. 113
40 Relate probability to a Punnett Square 1. What is the phenotypic ratio? 2. What is phenotypic %?
41 Crosses that involve 2 traits
42 Example of %
43 Test Cross In a test cross, an individual whose phenotype is dominant, but whose genotype is not known, is crossed with a homozygous individual. Ex: Brown eyes are brown, but can be BB or Bb. To find out if the person with brown eyes is homozygous or heterozygous, you cross it with a recessive person's genotype and the outcome will tell you depending on the ratio
44 Spongebob squarepants doesn t know whether or not he is Homozygous Dominant or Heterozygous for his yellow color. The recessive trait is a white sponge. Let s say that we perform a test cross on spongebob (spongebob + a white female sponge) and all of the baby sponges are yellow. What would spongebob s genotype be?
45 Inheritance of Traits Pedigree a family history that shows how a trait is inherited over several generations.
46 You can see how a genetic disorder runs in a family. Carriers are individuals who are heterozygous for an inherited disorder but do not show symptoms. Carriers can pass the allele for the disorder to their offspring
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48
49 DO NOW Fill in genotypes!
50 Pleiotropy The single gene controlling or influencing multiple, possibly unrelated, phenotypic traits. Ex: albinism
51 Occurrence of one or more extra sets of all chromosomes in an organism. Ex. A triploid organism (3n) - means that it has three complete sets of chromosomes.
52 Autosomal vs. Sex-Linked
53 Examples of Sex-Linked Traits Red-green colorblindness Male Pattern Baldness Hemophilia Duchenne Muscular Dystrophy Compare: Male : XhY X HY Female: XHXH X HX h X hx h
54 What do you see?
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57 Linked genes usually do not segregate independently because they are so close together on a chromosome.
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59 Incomplete dominance a trait that is intermediate between two parents
60 Polygenic Traits several genes influence a trait A wide range of variability! Genes can be located on different chromosomes
61 Multiple alleles genes with 3 or more alleles
62 Codominance two dominant alleles are expressed at the same time.
63 Determine Blood Type Determine the possible offspring of the following crosses below 1. AB and O 2. AA and BO 3. AB and AB
64 Neither trait is dominant instead, both traits are shown (No Blending) Ex) Roan Cows Red + White = RED AND WHITE
65 Traits can be influenced by the environment! Hydrangea Flowers: When in acidic soil, they bloom blue flowers When in basic soil, they will bloom pink flowers Arctic Fox Enzymes will make pigments during a certain time of the year.
66 DO NOW: List any genetic disorders you know about. Share with the class
67 Genetic Disorders Sickle Cell Anemia Cystic Fibrosis (CF) Hemophilia Tay- Sachs Disease Huntington s Disease (HD) Hypercholesterolemia In Groups, you will research a specific disease and present it to the class.
68 Treating Genetic Disorders Most genetic disorders cannot be cured, although progress is being made. Families who have a history of genetic disorders are recommended to undergo counseling before having a child. They can find out how it could affect their offspring. Some genetic disorders can be treated if diagnosed early enough, such as PKU (lacking a certain enzyme). If known, that child can be put on a certain diet and medicine routine.
69 Gene Therapy May soon allow scientists to correct certain recessive genetic disorders by replacing defective genes with copies of a healthy one. First step of gene therapy is to isolate a copy of the gene. Scientists are trying to input that gene into the cell by attaching it to a cold virus. Attempts in humans have not been successful. However, the outlook is promising.
70 What is genetic mapping? Genetic mapping - also called linkage mapping - can offer firm evidence that a disease transmitted from parent to child is linked to one or more genes. It also provides clues about which chromosome contains the gene and precisely where it lies on that chromosome. Genetic maps have been used successfully to find the single gene responsible for relatively rare inherited disorders, like cystic fibrosis and muscular dystrophy. Maps have also become useful in guiding scientists to the many genes that are believed to interact to bring about more common disorders, such as asthma, heart disease, diabetes, cancer and psychiatric conditions.
71 TWINS
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