Clinical Validation of the NeuroGuide QEEG Normative Database. Phase Reset Duration Means. abs(out-phase) Cross Spectral Power. Burst Amplitude Means

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1 Clinical Validation of the NeuroGuide QEEG Normative Database Multiple R Correlation Coefficient PLATE 2.6 Phase Difference Coherence Phase Reset per Second Phase Reset Locking Interval Means Amplitude Asymmetry Phase Reset Duration Means Burst Amplitude Means abs(out-phase) Cross Spectral Power Patient ID: NX la_0 Z-Values of EEG Features Referenced to Norms abs(in-phase) Absolute Power Phase Reset Amplitude Means Peak Frequency Absolute Power: Delta Theta Alpha Beta Z-values 3.0 Relative Power: Delta Theta Alpha Beta Power Asymmetry: Delta Theta Alpha Beta Coherence: Delta Theta Alpha Beta PLATE 3.2 Plates.indd 1 8/19/2008 6:52:31 PM

2 PLATE 3.3 Delta Theta Delta Theta Absolute Power Absolute Power Significant Deviation from normal (Baseline) (After 25 sessions of neurotherapy) Functioning in the normal range Overall Response Control Overal Attention Visual Response Control Visual Attention Auditory Response Control Auditory Attention /18/ sessions 11 am 09/20/ sessions 3:30 pm 05/01/2007 Baseline 10:30 am Social Attention Sep-07 Rule Breaking Feb-08 Aggressive This is 10-year-old ADHD male who after having neuropsychological testing that validated his impaired attention and underlying brain dysfunction underwent neurofeedback therapy. The changes in brain function, performance, and behavior are noted here PLATE 3.4 Plates.indd 2 8/19/2008 6:52:32 PM

3 Left hemisphere lateral view BETAs DELTA ALPHA1 PLATE 4.2 Left hemisphere medial view THETA ALPHA2 DELTA PLATE 4.3 PLATE 4.5 Plates.indd 3 8/19/2008 6:52:32 PM

4 PLATE 4.6 PLATE 4.7 PLATE 4.8 PLATE 4.9 Plates.indd 4 8/19/2008 6:52:33 PM

5 PLATE 4.10 PLATE 4.11 PLATE 4.12 Plates.indd 5 8/19/2008 6:52:35 PM

6 PLATE 4.13 Click View > Dynamic JTFA > Color Maps to view instantaneous power, coherence, phase, amplitude asymmetry, derivatives and phase reset PLATE 5.2 Plates.indd 6 8/19/2008 6:52:36 PM

7 Montage: LinkEars Z Scored FFT Summary Information EEG ID: JSME01 Delta Theta Alpha Absolute Power Beta High Beta Relative Power Amplitude Asymmetry Coherence Phase Lag PLATE 5.6 Z-Score 1.96 Z-Score 2.58 Z-Score Plates.indd 7 8/19/2008 6:52:37 PM

8 Montage: LinkEars EEG ID: 2JSE0250 Z Scored FFT Summary Information Delta Theta Alpha Absolute Power Beta High Beta Relative Power Amplitude Asymmetry Coherence Phase Lag Z-Score 1.96 Z-Score 2.58 Z-Score PLATE 5.7 Plates.indd 8 8/19/2008 6:52:37 PM

9 Montage: LinkEars EEG ID: 3JSME012 Z Scored FFT Summary Information Delta Theta Alpha Absolute Power Beta High Beta Relative Power Amplitude Asymmetry Coherence Phase Lag Z-Score 1.96 Z-Score 2.58 Z-Score PLATE 5.8 Plates.indd 9 8/19/2008 6:52:38 PM

10 Montage: LinkEars EEG ID: JODEE082 Z Scored FFT Summary Information Delta Theta Alpha Absolute Power Beta High Beta Relative Power Amplitude Asymmetry Coherence Phase Lag Z-Score 1.96 Z-Score 2.58 Z-Score PLATE 5.9 Plates.indd 10 8/19/2008 6:52:38 PM

11 Montage: LinkEars EEG ID: DELAJE01 Z Scored FFT Summary Information Delta Theta Alpha Absolute Power Beta High Beta Relative Power Amplitude Asymmetry Coherence Phase Lag Z-Score 1.96 Z-Score 2.58 Z-Score PLATE 5.10 Plates.indd 11 8/19/2008 6:52:39 PM

12 PLATE 5.11 PLATE 5.12 PLATE 5.13 Plates.indd 12 8/19/2008 6:52:39 PM

13 PLATE 5.14a PLATE 5.14b Montage: Deymed EEG ID: Montage: Deymed EEG ID: Z Scored FFT Summary Information Z Scored FFT Summary Information Delta Theta Alpha Beta High Beta Delta Theta Alpha Beta High Beta Absolute Power Absolute Power Relative Power Relative Power Amplitude Asymmetry Amplitude Asymmetry Coherence Coherence Phase Lag Phase Lag Z-Score 1.96 Z-Score 2.58 Z-Score 3.09 PLATE 5.15a Z-Score 1.96 Z-Score 2.58 Z-Score 3.09 PLATE 5.15b Plates.indd 13 8/19/2008 6:52:42 PM

14 PLATE 5.16a PLATE 5.16b Plates.indd 14 8/19/2008 6:52:44 PM

15 PLATE 5.17a PLATE 5.17b PLATE 5.18a PLATE 5.18b PLATE 5.19a Plates.indd 15 8/19/2008 6:52:45 PM

16 PLATE 5.19b Montage: Deymed EEG ID: Montage: Deymed EEG ID: Z Scored FFT Summary Information Z Scored FFT Summary Information Delta Theta Alpha Absolute Power Beta High Beta Delta Theta Alpha Absolute Power Beta High Beta Relative Power Relative Power Amplitude Asymmetry Amplitude Asymmetry Coherence Coherence Phase Lag Phase Lag Z-Score 1.96 Z-Score 2.58 Z-Score 3.09 PLATE 5.20a Z-Score 1.96 Z-Score 2.58 Z-Score 3.09 PLATE 5.20b Plates.indd 16 8/19/2008 6:52:48 PM

17 PLATE 5.21a PLATE 5.21b PLATE 5.22a PLATE 5.22b Plates.indd 17 8/19/2008 6:52:49 PM

18 PLATE 5.23a PLATE 5.23b 30 LITERATURE CITATION FREQUENCY: CEREBRAL HYPOPERFUSED AREAS in several brain disorders Frontal Temporal Cingulate Parietal Limbic Occipital Basal Ganglia Schizophrenia Autism ADD/ADHD PLATE 7.3 PLATE 7.7 Plates.indd 18 8/19/2008 6:52:51 PM

19 COMPUTER INSERTS CALIBRATION PLATE 7.9 COMPUTER INSERTS FALSE COLOR PLATE 7.10 PLATE 7.11 Plates.indd 19 8/19/2008 6:52:53 PM

20 PLATE 7.12 Examples of QEEG analyses BESA BioSemi BrainMaster Cadwell CapScan DeyMed Lexicor MindSet Mitsar NeuroNav NeuroPrax NeuroScan Nicolet NuAmps ProComp XLTEK etc. FFT Z Score Pre- vs post- treatment statistics and Z-score EEG biofeedback PLATE 11.1 Plates.indd 20 8/19/2008 6:52:55 PM

21 T2 Gray Matter and EEG Beta Amplitude EEG BETA C3 (Log 10 uv) R 0.82 P EEG BETA F3 (Log 10 uv) R 0.74 P (a) T2 Relaxation Time (Msec) (b) T2 Relaxation Time (Msec) EEG BETA C4 (Log 10 uv) R 0.77 P EEG BETA T4 (Log 10 uv) R 0.70 P (c) T2 Relaxation Time (Msec) PLATE 11.4 (d) T2 Relaxation Time (Msec) PLATE 15.2 Plates.indd 21 8/19/2008 6:52:58 PM

22 PLATE 15.4 PLATE Hz 22 Hz 23 Hz 24 Hz 25 Hz Hz 27 Hz 28 Hz 29 Hz 30 Hz PLATE 15.7 Plates.indd 22 8/19/2008 6:52:58 PM

23 6 Hz 7 Hz 8 Hz 9 Hz 10 Hz PLATE 15.8 Before Training: Coherence Delta 1 4Hz Theta 4 8Hz Alpha 8 12Hz Beta 12 25Hz High Beta 25 30Hz PLATE Coherence Delta Theta Alpha Beta High Beta PLATE Plates.indd 23 8/19/2008 6:52:59 PM

24 QEEG / Topographic Brain Maps Generalized Anxiety Disorder Subtypes Delta Theta Alpha Beta Normal % Delta Theta Alpha Beta High Beta Subtype: Anxiety, Insomnia, Alcohol / Drug Abuse 0.0 Standard Deviations 55% 3.0 Delta Theta Alpha Beta High Alpha Subtype: Anxiety, Depression, ADD 21% Delta Theta Alpha Beta Low Alpha Subtype: Anxiety, Insomnia, Alcohol / Drug Abuse 71% Delta Theta Alpha Beta Cingulate Dysfunction: Anxiety, Rumination, Obsessive Compulsive Disorder 44% 32% 22 hz 23 hz 24 hz 25 hz High Mean Frequency Beta: Anxiety, Alcoholism, Insomnia SINGLE-BAND MAGNITUDE TOPOGRAPHIES MICROVOLTS 9 hz 10 hz 11 hz 12 hz High Mean Frequency Alpha: Anxiety, Insomnia PLATE 17.1 Plates.indd 24 8/19/2008 6:53:00 PM

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