Association of a nicotine receptor polymorphism with reduced ability to quit smoking in pregnancy
|
|
- Maximilian Morton
- 5 years ago
- Views:
Transcription
1 Research Symposium, MRC CAiTE & Department of Social Medicine, University of Bristol, 3 rd March Association of a nicotine receptor polymorphism with reduced ability to quit smoking in pregnancy Rachel Freathy (rachel.freathy@pms.ac.uk)
2 Cnattingius (2004) Nicotine Tob Res; Bolling et al. (2007) The Information Centre Despite a strong public health message, many women continue to smoke in pregnancy Year 2000 prevalence: 12% (USA), 13% (Sweden), 20% (UK)
3 Genes may be important in determining which women quit Between 20% and 40% of female smokers quit during pregnancy Probability of quitting may be influenced by: Age SEP Partner smoking Parity Genes Cnattingius (2004) Nicotine Tob Res Up to 70% of the variance in nicotine dependence is due to genetic factors High concordance between the smoking behaviour of adoptees and their biological full siblings Lerman & Berrettini (2003) Am J Med Genet B Neuropsychiatr Genet; Osler et al. (2001) Genet Epidemiol
4 A genome-wide association study identified a common variant that predisposes smokers to smoke more N = Icelandic smokers SNP in nicotinic acetylcholine receptor gene, CHRNA3. Nearby genes: CHRNA5, CHRNB4 Thorgeirsson et al Nature
5 Thorgeirsson et al Nature A genome-wide association study identified a common variant that predisposes smokers to smoke more Frequency of the CHRNA3 risk allele P=5x10-7 P=5x10-16 P = 4x10-6 P = 2x10-8 P = 7x10-6 P = 0.04 TT AT % AA Never smoked 1-10 cigs per day cigs per day cigs per day cigs per day
6 Thorgeirsson et al Nature The genetic variant is not associated with smoking initiation Frequency of the CHRNA3 risk allele % P=0.60 P = 4x10-6 P = 2x10-8 P = 7x10-6 P = 0.04 TT AT AA Never smoked All smokers
7 Hypothesis: Some people will find it harder to give up smoking than others because of their genetics Genetic variant Heavier smoking Harder to quit Pregnancy is a time of high pressure to quit We aimed to test the hypothesis that: CHRNA3 risk allele less likely to quit smoking in pregnancy
8 Methods: study subjects were pregnant mothers from the South-West ALSPAC: N= women EFSOCH: N= women smoked regularly just before pregnancy First trimester 28% had stopped smoking 72% still smoked regularly Third trimester 43% had stopped smoking 57% still smoked regularly
9 Results: The risk allele was associated with higher odds of continued smoking in pregnancy Percentage of women who continued to smoke in the first trimester 80 P = % R = risk allele N = non-risk allele 50 NN NR RR Freathy et al. submitted
10 Results: The risk allele was associated with higher odds of continued smoking in pregnancy Percentage of women who continued to smoke in the third trimester 80 P = % R = risk allele N = non-risk allele 50 NN NR RR Freathy et al. submitted
11 Results: The risk allele was associated with heavier smoking before pregnancy and in the first trimester Frequency of the risk allele P = 1x10-5 P = P = % Cigs per day: Pre-pregnancy First trimester N=2379 N=1741 No difference between smokers and non-smokers: OR = 1.02 [95%CI: ]; P=0.57 Third trimester N=1361 Freathy et al. submitted
12 Results: Adjustment for pre-pregnancy smoking weakened, but did not remove the association Odds ratio for continued smoking vs quitting Unadjusted OR (95%CI) P value 1.27 (1.11, 1.45) (1.12, 1.44) Freathy et al. submitted
13 Results: Adjustment for pre-pregnancy smoking weakened, but did not remove the association Odds ratio for continued smoking vs quitting Unadjusted Adjusted for pre-pregnancy smoking quantity OR (95%CI) P value OR (95%CI) P value 1.27 (1.11, 1.45) (1.03, 1.39) (1.12, 1.44) (1.05, 1.39) Smoking quantity Genetic variant Smoking cessation Freathy et al. submitted
14 Results: The risk allele was not associated with environmental factors that may influence smoking cessation in pregnancy Potential confounder Association with continuing to smoke Odds ratio (95%CI) P value Age 0.98 (0.96, 1.00) Occupation 1.38 (1.08, 1.76) Education level 0.73 (0.68, 0.79) Age started smoking 0.66 (0.59, 0.75) Partner smoking 1.80 (1.49, 2.18) Freathy et al. submitted
15 Results: The risk allele was not associated with environmental factors that may influence smoking cessation in pregnancy Potential confounder Association with continuing to smoke Odds ratio (95%CI) P value P value for association with genetic variant Age 0.98 (0.96, 1.00) Occupation 1.38 (1.08, 1.76) Education level 0.73 (0.68, 0.79) Age started smoking 0.66 (0.59, 0.75) Partner smoking 1.80 (1.49, 2.18) Freathy et al. submitted
16 Birth weight adjusted for sex and gestation We hypothesized that the risk allele would be associated with reduced birth weight in smoking mums 48g lower birth weight per 10 extra cigarettes/day in 1 st trimester Smoking quantity Birth weight CHRNA3 allele = 0.8 cigs/day CHRNA3 variant? Expected effect of CHRNA3 variant on birth weight = 4g (95%CI: 1-6g) lower per allele
17 Birth weight adjusted for sex and gestation Results: There was a trend to reduced birth weight for smoking mums with the risk allele, as expected 48g lower birth weight per 10 extra cigarettes/day in 1 st trimester Smoking quantity Birth weight CHRNA3 allele = 0.8 cigs/day CHRNA3 variant? Observed effect of CHRNA3 variant on birth weight = 28g (95%CI: 2-59g) lower per allele N=1829 mums; P=0.07 P = 0.86 in non-smoking mums
18 Results: Larger numbers of mothers and babies will be needed to confirm association with birth weight Instrumental variables analysis: F=9.46 Ordinary regression: 48g lower BW per 10 extra cigarettes smoked in 1 st trimester Using CHRNA3 as IV: 318g lower BW (95%CI: -118 to 753g) per 10 cigs in 1 st trimester
19 Summary Each copy of the CHRNA3 risk allele is associated with higher odds of continued smoking in pregnancy OR = 1.27 (95%CI: ) We replicated the association with smoking quantity pre-pregnancy and in the first trimester Adjustment for pre-pregnancy smoking weakened, but did not remove the association with quitting Birth weight association consistent with expected, but bigger numbers required for secondary outcomes
20 Could genotype inform intervention strategy? Application to other situations: after diagnosis of CHD, Crohn s etc
21 Acknowledgements Exeter Team: Bev Shields Bea Knight Michael Weedon Tim Frayling Andrew Hattersley Bristol Team: Sue Ring Bruna Galobardes George Davey Smith Avon Longitudinal Study of Parents and Children (ALSPAC) Exeter Family Study of Childhood Health (EFSOCH) All study subjects and healthcare professionals who contributed to the studies
22
23 ALSPAC mums: smoking SNP-BMI association by ever-smoking status (N=6161) 23.5 BMI NN NR Genotype N=non-risk allele R=risk allele L-R test P value for deviation from additive model = RR S2 S1 Ever-smoker Numbers in each group NN NR RR Yes No
THE FIRST NINE MONTHS AND CHILDHOOD OBESITY. Deborah A Lawlor MRC Integrative Epidemiology Unit
THE FIRST NINE MONTHS AND CHILDHOOD OBESITY Deborah A Lawlor MRC Integrative Epidemiology Unit d.a.lawlor@bristol.ac.uk Sample size (N of children)
More informationMATERNAL INFLUENCES ON OFFSPRING S EPIGENETIC AND LATER BODY COMPOSITION
Institute of Medicine & National Research Council Food and Nutrition Board & Board on Children, Youth & Families Examining a Developmental Approach to Childhood Obesity: The Fetal & Early Childhood Years
More informationDoes prenatal alcohol exposure affect neurodevelopment? Attempts to give causal answers
Does prenatal alcohol exposure affect neurodevelopment? Attempts to give causal answers Luisa Zuccolo l.zuccolo@bristol.ac.uk MRC IEU, School of Social and Community Medicine Background Prenatal alcohol
More informationQuestion 1: Has your doctor or health care professional told you that you had type 1 or type 2 diabetes?
DIABETES - Questions list Question 1: Has your doctor or health care professional told you that you had type 1 or type 2 diabetes? Type 1 diabetes Type 2 diabetes Neither Routing rule: ( Type 1 Diabetes->2
More informationFetal exposure to alcohol and cognitive development: results from a Mendelian randomization study. Sarah Lewis
Fetal exposure to alcohol and cognitive development: results from a Mendelian randomization study Sarah Lewis Is moderate drinking during pregnancy really harmful? Alcohol and pregnancy - conflict and
More informationEarly cigarette use behaviors and alcohol
Washington University School of Medicine Digital Commons@Becker Posters 2003: Drinking and the High School Student 2003 Early cigarette use behaviors and alcohol Pamela A. Madden Washington University
More informationMRC Integrative Epidemiology Unit (IEU) at the University of Bristol. George Davey Smith
MRC Integrative Epidemiology Unit (IEU) at the University of Bristol George Davey Smith The making of a University Unit MRC Centre for Causal Analyses in Translational Epidemiology 2007 to 2013 Interdisciplinary
More informationMitochondrial DNA Haplogroups and Breast Cancer Risk Factors in the Avon Longitudinal Study of Parents and Children (ALSPAC)
Article Mitochondrial DNA Haplogroups and Breast Cancer Risk Factors in the Avon Longitudinal Study of Parents and Children (ALSPAC) Vivienne Riley 1, A Mesut Erzurumluoglu 2,3, Santiago Rodriguez 3 and
More informationThe effect of FADS genotypes, fatty acids, and fish intake on mental development in children
The effect of FADS genotypes, fatty acids, and fish intake on mental development in children Results from the ALSPAC study Eva Lattka Colin D Steer, Pauline M Emmett, Norman Klopp, Thomas Illig and Berthold
More informationReduced birth weight is associated with late-onset
ORIGINAL ARTICLE Type 2 Diabetes Risk Alleles Are Associated With Reduced Size at Birth Rachel M. Freathy, 1,2 Amanda J. Bennett, 3 Susan M. Ring, 4 Beverley Shields, 2 Christopher J. Groves, 3 Nicholas
More informationThe Nottingham eprints service makes this work by researchers of the University of Nottingham available open access under the following conditions.
Naughton, Felix and Foster, Katharine and Emery, Jo and Cooper, Sue and Sutton, Stephen and Leonardi- Bee, Jo and Jones, Matthew and Ussher, Michael and Whitemore, Rachel and Leighton, Matthew and Montgomery,
More informationSMOKING RELAPSE ONE YEAR AFTER DELIVERY AMONG WOMEN WHO QUIT SMOKING DURING PREGNANCY
International Journal of Occupational Medicine and Environmental Health, 2005;8(2):59 65 SMOKING RELAPSE ONE YEAR AFTER DELIVERY AMONG WOMEN WHO QUIT SMOKING DURING PREGNANCY KINGA POLAŃSKA, WOJCIECH HANKE,
More informationDAILY SMOKERS - AVERAGE NUMBER OF CIGARETTES SMOKED DAILY KEY MESSAGES
DAILY SMOKERS - AVERAGE KEY MESSAGES On average, daily smokers in Peel smoke 12 cigarettes per day (2011/2012) and this has remained stable over time. Daily smokers in Ontario smoke slightly more per day
More informationTrends in electronic cigarette use in England
Trends in electronic cigarette use in England Robert West Jamie Brown Emma Beard University College London Updated 14 th April 215 Background Electronic cigarette use has become prevalent in many countries
More informationDr Caitlin Notley. Preventing Return to Smoking Postpartum: PReS Study
Dr Caitlin Notley Preventing Return to Smoking Postpartum: PReS Study DEVELOPMENT OF AN EVIDENCE BASED COMPLEX INTERVENTION FOR MAINTAINING POSITIVE BEHAVIOUR CHANGE c.notley@uea.ac.uk @AddictionUEA https://www.uea.ac.uk/medicine/research/addiction
More informationHow do we know that smoking causes lung cancer?
How do we know that smoking causes lung cancer? Seif Shaheen Professor of Respiratory Epidemiology Centre for Primary Care and Public Health Blizard Institute Barts and The London School of Medicine and
More informationSmoking in offspring of alcoholic twins
Washington University School of Medicine Digital Commons@Becker Posters 2006: Alcohol and Tobacco Dependence: from Bench to Bedside 2006 Smoking in offspring of alcoholic twins Jeffrey F. Scherrer Washington
More informationSCHS Studies North Carolina Public Health
SCHS Studies North Carolina Public Health A Special Report Series by the 1908 Mail Service Center, Raleigh, N.C. 27699-1908 www.schs.state.nc.us/schs/ No. 138 October 2003 Tobacco Use Among Pregnant Women
More informationUniversity of Bristol - Explore Bristol Research. Peer reviewed version. Link to published version (if available): /peds.
Gustavson, K., Ystrom, E., Stoltenberg, C., Susser, E., Suren, P., Magnus, P.,... Reichborn-Kjennerud, T. (2017). Smoking in pregnancy and child ADHD. Pediatrics, 139(2), [e20162509]. DOI: 10.1542/peds.2016-2509
More informationDeveloping Genetic Education for Smoking Cessation. Julia F. Houfek, PhD, APRN-CNS, BC Associate Professor UNMC College of Nursing
Developing Genetic Education for Smoking Cessation Julia F. Houfek, PhD, APRN-CNS, BC Associate Professor UNMC College of Nursing Research Team Members Lynne Buchanan, PhD, APRN-NP Pamela Jones, PhD, RN,
More informationAssociation of plasma uric acid with ischemic heart disease and blood pressure:
Association of plasma uric acid with ischemic heart disease and blood pressure: Mendelian randomization analysis of two large cohorts. Tom M Palmer, Børge G Nordestgaard, DSc; Marianne Benn, Anne Tybjærg-Hansen,
More informationParental exposure to environmental toxicants, GSTM1 and GSTT1 polymorphisms and the risk of congenital heart disease
Parental exposure to environmental toxicants, GSTM1 and GSTT1 polymorphisms and the risk of congenital heart disease Monica Cresci, Ilenia Foffa, Maria Giovanna Neri, Lamia Ait-Ali, Nicoletta Botto and
More information2007: Alcohol Use Across the Lifespan
Washington University School of Medicine Digital Commons@Becker Posters 2007: Alcohol Use Across the Lifespan 2007 DSM-IV nicotine withdrawal and alcohol dependence: Association findings with the Nicotinic
More informationPREGNANCY SMOKING AND CHILD OUTCOMES FROM BIRTH TO 15 MONTHS: FINDINGS FROM NORTHEAST TENNESSEE. Beth Bailey, PhD
PREGNANCY SMOKING AND CHILD OUTCOMES FROM BIRTH TO 15 MONTHS: FINDINGS FROM NORTHEAST TENNESSEE Beth Bailey, PhD Associate Professor of Family Medicine, East Tennessee State University Associate Director
More informationCannabis use and adverse outcomes in young people: Summary Report
Cannabis use and adverse outcomes in young people: Summary Report CAYT Impact Study: Report No. 7 Sally Bridges, Julia Hall and Chris Lord with Hashim Ahmed and Linda Maynard 1 The Centre for Analysis
More informationSMOKING STAGES OF CHANGE KEY MESSAGES
KEY MESSAGES In Peel among current daily or occasional smokers: o 19% are not thinking are not thinking about quitting (pre-contemplation stage) in the next six months; o 21% are thinking about quitting
More informationImpact of infant feeding on growth trajectory patterns in childhood and body composition in young adulthood
Impact of infant feeding on growth trajectory patterns in childhood and body composition in young adulthood WP10 working group of the Early Nutrition Project Peter Rzehak*, Wendy H. Oddy,* Maria Luisa
More informationRunning head: CHRON'S DISEASE GENE-ENVIRONMENTAL INTERACTION 1
Running head: CHRON'S DISEASE GENE-ENVIRONMENTAL INTERACTION 1 A review of Crohn's Disease Gene-Environmental Interaction A study of gene-environment interaction between genetic susceptibility variants
More informationUniversity of Bristol - Explore Bristol Research. Peer reviewed version. Link to published version (if available): 10.
Richmond, R. C., Sharp, G. C., Ward, M. E., Fraser, A., Lyttleton, O., McArdle, W. L.,... Relton, C. L. (2016). DNA methylation and body mass index: investigating identified methylation sites at HIF3A
More informationFTO gene variants are strongly associated with type 2 diabetes in South Asian Indians
Diabetologia (2009) 52:247 252 DOI 10.1007/s00125-008-1186-6 SHORT COMMUNICATION FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians C. S. Yajnik & C. S. Janipalli & S.
More informationNicotine dependence treatment: A translational research approach
Washington University School of Medicine Digital Commons@Becker Presentations 2009: Translating Basic Science Findings to Guide Prevention Efforts 2009 Nicotine dependence treatment: A translational research
More informationGenetic predisposition to obesity leads to increased risk of type 2 diabetes
Diabetologia (2011) 54:776 782 DOI 10.1007/s00125-011-2044-5 ARTICLE Genetic predisposition to obesity leads to increased risk of type 2 diabetes S. Li & J. H. Zhao & J. Luan & C. Langenberg & R. N. Luben
More informationAlcohol and nicotine use and dependence: Common genetic and other risk factors
Washington University School of Medicine Digital Commons@Becker Presentations 2006: Alcohol and Tobacco Dependence: from Bench to Bedside 2006 Alcohol and nicotine use and dependence: Common genetic and
More informationExploring the Developmental Overnutrition Hypothesis Using Parental Offspring Associations and FTO as an Instrumental Variable
Exploring the Developmental Overnutrition Hypothesis Using Parental Offspring Associations and FTO as an Instrumental Variable Debbie A. Lawlor 1,2*, Nicholas J. Timpson 1,3, Roger M. Harbord 2, Sam Leary
More informationSmoking and Smoking Cessation in England 2011: Findings from the Smoking Toolkit Study
Smoking and Smoking Cessation in England 211: Findings from the Smoking Toolkit Study Robert West and Jamie Brown Cancer Research UK Health Behaviour Research Centre University College London robert.west@ucl.ac.uk
More informationSmoking among shift workers: more than a confounding factor
Smoking among shift workers: more an a confounding factor Ludovic van Amelsvoort Nicole Jansen IJmert Kant Occupational Heal Epidemiology Maastricht University The Neerlands. Background Shift work: Associated
More informationPrevalence and Risk Factors for Hyperacusis in Children: a Birth Cohort Study
Prevalence and Risk Factors for Hyperacusis in Children: a Birth Cohort Study Rachel Humphriss MSc PhD CS Clinical Scientist (Audiology) University Hospitals Bristol NHS Foundation Trust Rachel.humphriss@uhbristol.nhs.uk
More informationMaternal smoking, alcohol drinking, and febrile convulsion
Seizure (2008) 17, 320 326 www.elsevier.com/locate/yseiz Maternal smoking, alcohol drinking, and febrile Farnaz Vahidnia a, *, Brenda Eskenazi b, Nicholas Jewell c a School of Public Health, University
More informationRelationships between adiposity and left ventricular function in adolescents: mediation by blood pressure and other cardiovascular measures
Relationships between adiposity and left ventricular function in adolescents: mediation by blood pressure and other cardiovascular measures H Taylor 1, C M Park 1, L Howe 2, A Fraser 2 D Lawlor 2, G Davey
More informationGenetics and Underwriting in Health Insurance
Genetics and Underwriting in Health Insurance Angus Macdonald Heriot-Watt University, Edinburgh Outline Genetic epidemiology Example 1 Alzheimer s disease Example 2 Coronary heart disease Single-Gene Disorders
More informationDr Johan Morreau. Paediatrician Rotorua
Dr Johan Morreau Paediatrician Rotorua Smoking in pregnancy Implications for the baby (and mother) Johan Morreau 2013 Major Issue Lifelong implications More important than the BP a Paediatrician s perspective
More informationImpacts of Early Exposure to Work on Smoking Initiation Among Adolescents and Older Adults: the ADD Health Survey. David J.
Impacts of Early Exposure to Work on Smoking Initiation Among Adolescents and Older Adults: the ADD Health Survey David J. Lee, PhD University of Miami Miller School of Medicine Department of Public Health
More informationCOMPLICATIONS OF PRE-GESTATIONAL AND GESTATIONAL DIABETES IN SAUDI WOMEN: ANALYSIS FROM RIYADH MOTHER AND BABY COHORT STUDY (RAHMA)
COMPLICATIONS OF PRE-GESTATIONAL AND GESTATIONAL DIABETES IN SAUDI WOMEN: ANALYSIS FROM RIYADH MOTHER AND BABY COHORT STUDY (RAHMA) Prof. Hayfaa Wahabi, King Saud University, Riyadh Saudi Arabia Hayfaa
More informationTobacco Control: Big Fast Benefits. Stanton A. Glantz, PhD Professor of Medicine University of California San Francisco
Tobacco Control: Big Fast Benefits Stanton A. Glantz, PhD Professor of Medicine University of California San Francisco Australia (December 2012) Australian Government, Department of Health 2015 The California
More informationIntroduction. Kristine Marceau 1,2 Rohan H. C. Palmer. Taylor F. Smith 5 John E. McGeary
Passive rge or Developmental Gene-Environment Cascade? An Investigation of the Role of Xenobiotic Metabolism Genes in the Association Between Smoke Exposure During Pregnancy and Child Birth Weight Kristine
More informationReducing smoking in pregnancy: learning from the babyclear approach
Reducing smoking in pregnancy: learning from the babyclear approach Ruth Bell Institute of Health & Society, Newcastle University Smoking in pregnancy Maternal smoking is major cause of avoidable mortality
More informationInvestigating causality in the association between 25(OH)D and schizophrenia
Investigating causality in the association between 25(OH)D and schizophrenia Amy E. Taylor PhD 1,2,3, Stephen Burgess PhD 1,4, Jennifer J. Ware PhD 1,2,5, Suzanne H. Gage PhD 1,2,3, SUNLIGHT consortium,
More informationSmoking Among Pregnant Women in the Baffin Region of Nunavut. Chantal Nelson PhD Candidate, Population Health University of Ottawa
Smoking Among Pregnant Women in the Baffin Region of Nunavut Chantal Nelson PhD Candidate, Population Health University of Ottawa Background 80% of pregnant women in Nunavut smoke compared to the national
More informationPhysical activity as an aid for smoking cessation
Physical activity as an aid for smoking cessation - study David Faeh, MD Christiane Ruffieux, PhD Jacques Cornuz, MD, MPH Background Prevalence of smoking in Switzerland: 33% Most smokers cumulate both
More informationGenetics of Nicotine Dependence & Impact of Smoking on Bladder Cancer Risk and Prognosis
Genetics of Nicotine Dependence & Impact of Smoking on Bladder Cancer Risk and Prognosis BCAN August 2014 Helena Furberg Barnes Assistant Attending Epidemiologist www.mskcc.org Current smoking in the US
More informationSMOKING CESSATION. Why bother?
SMOKING CESSATION Why bother? Supporting policies COPD A disease characterised by airflow obstruction. It is usually progressive, not fully reversible and does not change markedly over several months.
More informationThe Science and Practice of Perinatal Tobacco Use Cessation
1 The Science and Practice of Perinatal Tobacco Use Cessation Erin McClain, MA, MPH Catherine Rohweder, DrPH Cathy Melvin, PhD, MPH erin_mcclain@unc.edu Prevention of Tobacco Use and Secondhand Smoke Exposure
More informationEpidemiology and Prevention
Epidemiology and Prevention Associations of Pregnancy Complications With Calculated Cardiovascular Disease Risk and Cardiovascular Risk Factors in Middle Age The Avon Longitudinal Study of Parents and
More informationIMPLICATIONS OF GENE- ENVIRONMENT INTERPLAY FOR APPROACHES TO SUBSTANCE ABUSE AND COMORBIDITY
Ppt. Oslo 3 th Nov 9 IMPLICATIONS OF GENE- ENVIRONMENT INTERPLAY FOR APPROACHES TO SUBSTANCE ABUSE AND COMORBIDITY By Michael Rutter PERCENTAGE OF GENETIC INFLUENCE REPORTED IN BEHAVIORAL GENETIC STUDIES
More informationFATHER ABSENCE AND DEPRESSIVE SYMPTOMS IN ADOLESCENT GIRLS FROM A UK COHORT
FATHER ABSENCE AND DEPRESSIVE SYMPTOMS IN ADOLESCENT GIRLS FROM A UK COHORT Iryna Culpin, Roberto Melotti, Ricardo Araya, Carol Joinson School of Social and Community Medicine Avon Longitudinal Study of
More informationSelf-Reported Exposure to Second-Hand Smoke and Positive Urinary Cotinine in Pregnant Nonsmokers
Original Article DOI 10.3349/ymj.2009.50.3.345 pissn: 0513-5796, eissn: 1976-2437 Yonsei Med J 50(3): 345-351, 2009 Self-Reported Exposure to Second-Hand Smoke and Positive Urinary Cotinine in Pregnant
More informationParental antibiotics and childhood asthma : a population-based study. Örtqvist, A.K.; Lundholma, C.; Fang, F.; Fall, T.; Almqvist, C.
This is an author produced version of a paper accepted by Journal of Allergy and Clinical Immunology. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal
More informationWhat is a case control study? Tarani Chandola Social Statistics University of Manchester
What is a case control study? Tarani Chandola Social Statistics University of Manchester Imagine. It is 1950 You suspect an association b/w smoking and lung cancer How would you show this? Cases Find cases
More informationMendelian Randomisation and Causal Inference in Observational Epidemiology. Nuala Sheehan
Mendelian Randomisation and Causal Inference in Observational Epidemiology Nuala Sheehan Department of Health Sciences UNIVERSITY of LEICESTER MRC Collaborative Project Grant G0601625 Vanessa Didelez,
More informationDevelopment and Prediction of Hyperactive Behaviour from 2 to 7 Years in a National Population Sample
Development and Prediction of Hyperactive Behaviour from 2 to 7 Years in a National Population Sample Elisa Romano, Ph.D. University of Ottawa Richard E. Tremblay, Ph.D. Abdeljelil Farhat, Ph.D. Sylvana
More informationUNIVERSITY OF CALIFORNIA, LOS ANGELES
UNIVERSITY OF CALIFORNIA, LOS ANGELES BERKELEY DAVIS IRVINE LOS ANGELES MERCED RIVERSIDE SAN DIEGO SAN FRANCISCO UCLA SANTA BARBARA SANTA CRUZ DEPARTMENT OF EPIDEMIOLOGY SCHOOL OF PUBLIC HEALTH CAMPUS
More informationThe Breast Cancer Family Registry: Description of Resource and some Applications
The Breast Cancer Family Registry: Description of Resource and some Applications Mary Beth Terry, PhD Associate Professor Department of Epidemiology Mailman School of Public Health Overview of Talk Description
More informationAssociation of Genetic Risk for Schizophrenia With Nonparticipation Over Time in a Population-Based Cohort Study
American Journal of Epidemiology The Author 2016. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. This is an Open Access article distributed under
More informationUnderstanding Statistics for Research Staff!
Statistics for Dummies? Understanding Statistics for Research Staff! Those of us who DO the research, but not the statistics. Rachel Enriquez, RN PhD Epidemiologist Why do we do Clinical Research? Epidemiology
More informationNorthern Tobacco Use Monitoring Survey Northwest Territories Report. Health and Social Services
Northern Tobacco Use Monitoring Survey 2004 Northwest Territories Report Health and Social Services 1.0 Introduction The Canadian Tobacco Use Monitoring Survey (CTUMS) was initiated in 1999 to provide
More informationCross-sectional association between smoking depictions in films and adolescent tobacco use nested in a British cohort study
See Editorial, p 844 1 School of Oral and Dental Sciences, University of Bristol, Bristol, UK 2 Department of Pediatrics, Dartmouth Medical School, Hanover, New Hampshire, USA Correspondence to Dr Andrea
More informationHuman Genetics and Gene Mapping of Complex Traits
Human Genetics and Gene Mapping of Comple Traits Advanced Genetics, Spring 205 Human Genetics Series Tuesday 4/07/5 Nancy L. Saccone, nlims@genetics.wustl.edu What is different aout Human Genetics (recall
More informationSMOKING CESSATION WORKSHOP. Dr Mark Palayew December
SMOKING CESSATION WORKSHOP Dr Mark Palayew December 5 2016 Conflicts of Interest None Case 1 Mr. T is a 55 year old smoker 2 packs/day He has been smoking continuously since age 16 When he wakes up at
More informationBiostatistics and Epidemiology Step 1 Sample Questions Set 1
Biostatistics and Epidemiology Step 1 Sample Questions Set 1 1. A study wishes to assess birth characteristics in a population. Which of the following variables describes the appropriate measurement scale
More informationComparing the Cochrane review of electronic cigarettes to other meta-analyses
Comparing the Cochrane review of electronic cigarettes to other meta-analyses Jamie Hartmann-Boyce Cochrane Tobacco Addiction Group, Nuffield Department of Primary Care Health Sciences, University of Oxford.
More informationDependence Treatment: From Mouse to Man to Medicine. Caryn Lerman, Ph.D. Transdisciplinary Tobacco Use Research Center
Nicotine Dependence Treatment: From Mouse to Man to Medicine Caryn Lerman, Ph.D. Transdisciplinary Tobacco Use Research Center UPENN About this presentation Dr. Lerman presented this on December 1, 2009,
More informationShould I breastfeed or keep smoking? Linked decisions by low-income Shelby County women
Should I breastfeed or keep smoking? Linked decisions by low-income Shelby County women Kenneth D. Ward, PhD Professor and Director, Division of Social and Behavioral Sciences School of Public Health The
More informationNational Wear Red Day
National Wear Red Day FRIDAY, FEBRUARY 6, 2015 Heart disease it s not just a man s disease. ach year, 1 in women die of heart disease and stroke. But we can change that because 80 percent of cardiac events
More informationSCENARIO 1: ICD-10-CM
ICD-10 Tobacco Billing Guide Scenarios SCENARIO 1: 16-year-old male Sports physical examination and annual check-up Shortness of breath upon exertion Smokes 5-6 cigarettes a day Began smoking 8 months
More informationThe effect of parental alcohol use on alcohol use in young adults: the mediating role of parental monitoring and peer deviance
The effect of parental alcohol use on alcohol use in young adults: the mediating role of parental monitoring and peer deviance Liam Mahedy liam.mahedy@bristol.ac.uk South West Public Health Scientific
More informationThe Latest on Vaping Among U.S. Teens
The Latest on Vaping Among U.S. Teens Jon Macy, PhD, MPH Indiana University School of Public Health Bloomington Presentation Outline Overview of Electronic Nicotine Delivery Systems (ENDS) New Prevalence
More informationManaging drug misuse in pregnancy and beyond
Managing drug misuse in pregnancy and beyond Dr Emily Finch Clinical Director Addictions CAG, South London and Maudsley Foundation NHS Trust Rachel Evans, Adfam 1 / Aims of the session Update on management
More informationGSK Medicine: Study Number: Title: Rationale: Study Period: Objectives: Indication: Study Investigators/Centers: Data Source:
The study listed may include approved and non-approved uses, formulations or treatment regimens. The results reported in any single study may not reflect the overall results obtained on studies of a product.
More informationMaternal smoking during pregnancy and daughters risk of gestational diabetes and obesity
DOI 10.1007/s00125-013-2936-7 ARTICLE Maternal smoking during pregnancy and daughters risk of gestational diabetes and obesity K. Mattsson & K. Källén & M. P. Longnecker & A. Rignell-Hydbom & L. Rylander
More informationGenetics of COPD Prof. Ian P Hall
Genetics of COPD 1 Prof. Ian P. Hall Dean, Faculty of Medicine and Health Sciences The University of Nottingham Medical School Ian.Hall@nottingham.ac.uk Chronic obstructive pulmonary disease (COPD) 900,000
More informationSupplementary Online Content
Supplementary Online Content Baker TB, Piper ME, Stein JH, et al. Effects of nicotine patch vs varenicline vs combination nicotine replacement therapy on smoking cessation at 26 weeks: a randomized clinical
More informationDiabetes and pregnancy. diabetes. and. pregnancy
Diabetes and pregnancy i diabetes and pregnancy www.glucomen.co.uk Diabetes and Pregnancy Diabetes is a medical condition where there is too much sugar (glucose) in the bloodstream. Glucose is the main
More informationARTICLE. Neonate Characteristics After Maternal Use of Antidepressants in Late Pregnancy. 1-8 HAVE BEEN PUBlished
Neonate Characteristics After Maternal Use of Antidepressants in Late Pregnancy Bengt Källén, MD, PhD ARTICLE Background: Exposure to antidepressants during the third trimester of pregnancy has been associated
More informationSleep Problems and Smoking Cessation in Women
Sleep Problems and Smoking Cessation in Women Michele D. Levine, Michele L. Okun, Patricia R. Houck, Melissa A. Kalarchian & Marsha D. Marcus University of Pittsburgh Medical Center Sleep and Smoking Cigarette
More informationPharmacogenetics of Tobacco Smoking and Lung Cancer
Pharmacogenetics of Tobacco Smoking and Lung Cancer Christopher Amos, Ph.D. Laura Bierut, M.D. Caryn Lerman, Ph.D. Rachel Tyndale, Ph.D. Center for Genomic Medicine Geisel College of Medicine at Dartmouth
More informationSmoking Cessation in Pregnancy. Jessica Reader, MD, MPH Family Medicine Obstetrics Fellow June 1st, 2018
Smoking Cessation in Pregnancy Jessica Reader, MD, MPH Family Medicine Obstetrics Fellow June 1st, 2018 Tobacco Cessation in Pregnancy: Objective 1. Overview of the negative effects of tobacco abuse in
More informationThe Society for Social Medicine John Pemberton Lecture Developmental overnutrition an old hypothesis with new importance?*
Published by Oxford University Press on behalf of the International Epidemiological Association ß The Author 2013; all rights reserved. International Journal of Epidemiology 2013;42:7 29 doi:10.1093/ije/dys209
More informationFigure S1. Flowchart of sample included in the analysis.
Figure S1. Flowchart of sample included in the analysis. 3098 mother/infant pairs with EMR records of well-child and specialty visits 418 cases with any ADHD diagnosis 94 cases with any ASD diagnosis while
More informationDNBC application form
ref. 2011-27 Project title: Applicant: Other partners taking part in the project Names and work addresses: The association of early growth with wheezing and asthma Name: Agnes Sonnenschein-van der Voort,
More informationDoes cigarette reduction while using nicotine replacement predict quitting? Observational evidence from the Rapid Reduction Trial
10 th UKSBM ASM; Nottingham 2014 Does cigarette reduction while using nicotine replacement predict quitting? Observational evidence from the Rapid Reduction Trial Lindson-Hawley N; West R; Michie S; Aveyard
More informationBlood Types and Genetics
Blood Types and Genetics Human blood type is determined by codominant alleles. An allele is one of several different forms of genetic information that is present in our DNA at a specific location on a
More informationA spotlight on becoming Smokefree NHS and local implementation
A spotlight on becoming Smokefree NHS and local implementation James Mapstone Deputy Regional Director, South of England Public Health England Jennie Leleux Health & Wellbeing Programme Manager, Public
More informationFor more information about how to cite these materials visit
Author(s): Kerby Shedden, Ph.D., 2010 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike 3.0 License: http://creativecommons.org/licenses/by-sa/3.0/
More informationProject TEACH Addressing Tobacco Treatment for Pregnant Women Jan Blalock, Ph.D.
Project TEACH Addressing Tobacco Treatment for Pregnant Women Jan Blalock, Ph.D. Prevalence of Smoking and Cessation During Pregnancy In 2014, 14% in women with Medicaid coverage versus 3.6% of women with
More informationNote: for non-commercial purposes only
Impact of maternal body mass index before pregnancy on growth trajectory patterns in childhood and body composition in young adulthood WP10 working group of the Early Nutrition Project Wendy H. Oddy,*
More informationCochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library)
A systematic review of smoking cessation and relapse prevention interventions in parents of babies admitted to a neonatal unit (after delivery) Divya Nelson, Sarah Gentry, Caitlin Notley, Henry White,
More informationRandomized controlled trial of physical activity counseling as an aid to smoking cessation: 12 month follow-up
Addictive Behaviors 32 (2007) 3060 3064 Short communication Randomized controlled trial of physical activity counseling as an aid to smoking cessation: 12 month follow-up Michael Ussher a,, Robert West
More informationNIH Public Access Author Manuscript Obesity (Silver Spring). Author manuscript; available in PMC 2013 December 01.
NIH Public Access Author Manuscript Published in final edited form as: Obesity (Silver Spring). 2013 June ; 21(6): 1256 1260. doi:10.1002/oby.20319. Obesity-susceptibility loci and the tails of the pediatric
More informationContingency Tables Summer 2017 Summer Institutes 187
Contingency Tables 87 Overview ) Types of Variables ) Comparing () Categorical Variables Contingency (two-way) tables Tests 3) x Tables Sampling designs Testing for association Estimation of effects Paired
More informationPROFILE OF CURRENT SMOKERS KEY MESSAGES
PROFILE OF CURRENT SMOKERS KEY MESSAGES In Peel in 2011/2012, 14% of the population or 162,500 people were current smokers. In 2011/2012, the proportion of current smokers was significantly lower in Peel
More information