Information Source List Type High (H) Moderate (M) Low (L) GHS Category 1A (Known) or 1B (Presumed) for any route of exposure

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1 Carcinogenicity (C) Mutagenicity/Genotoxicity (M) List High (H) Moderate (M) Low (L) GHS Category 1A (Known) or 1B (Presumed) for any route of exposure GHS Category 2 (Suspected) for any route of exposure or limited or marginal evidence of carcinogenicity in animals (See Guidance) Adequate data available, and negative studies, no structural alerts, and GHS not classified. EPA-C (1986) Group A, B1 or B2 Group C Group E EPA-C (1996, 1999, 2005) Known or Likely Not Likely E CMR (1) Category 1 or 2 Category 3 E CMR (2) Carc 1A or 1B Carc 2 E H-statements H350 or H350i H351 E R-phrases R45 or R49 R40 E SVHC Reason for inclusion: Carcinogenic Category 1A or 1B Category 2 Not IARC Group 1 or 2A Group 2B Group 4 Carcinogenic Group 1 or 2 Carcinogenic Group 3, 4, or 5 NIOSH-C Occupational Cancer NTP-RoC Known or Reasonably Anticipated Prop 65 Known to the state to cause cancer EPA-C(1986) Group D EPA-C (1999) Suggestive Evidence, but not sufficient to assess human carcinogenic potential EPA-C (2005) Suggestive evidence of carcinogenic potential IARC Group 3 List High (H) Moderate (M) Low (L) GHS Category 1A (Known) or 1B (Presumed) for any route of exposure GHS Category 2 (Suspected) for any route of exposure or limited or marginal evidence of mutagenicity in animals (See Guidance) Adequate data available, and negative studies for both chromosomal aberrations and gene mutations, no structural alerts, and GHS not classified. E CMR (1) Category 1 or 2 Category 3 E CMR (2) Muta 1A or 1B Muta 2 E H-statements H340 H341 E R-phrases R46 R68 E SVHC Reason for inclusion: Mutagenic Category 1A or 1B Category 2 Not Germ Cell Mutagen 1, 2, or 3a Germ Cell Mutagen 3b or 5 Page 1/6

2 Reproductive Toxicity (R) List High (H) Moderate (M) Low (L) Note: GHS Reproductive Toxicity includes both reproductive and developmental effects, while the Green Screen separates them into two distinct hazard endpoints. This classification must be based on reproductive effects alone. GHS Category 1A (Known) or 1B (Presumed) for any route of exposure GHS Category 2 (Suspected) for any route of exposure or limited or marginal evidence of reproductive toxicity in animals (See Guidance) E H-statements H360F, H360FD, H360Fd H360Df, H361f, H361fd E R-phrases R60 R62 NTP-OHAaT Prop 65 Category 1A (Known); Category 1B (Presumed) Clear Evidence of Adverse Effects - Reproductive Known to the state to cause reproductive effects-male or Female Category 2 (Suspected) Adequate data available, and negative, no structural alerts, and GHS not classified. Not (i.e. positively determined to be negative) Clear Evidence of No Adverse Effects - Reproductive Limited Evidence of Adverse Effects - Reproductive or Some Evidence of Adverse Effects - Reproductive NTP-OHAaT Limited Evidence of No Adverse Effects - Reproductive or Some Evidence of No Adverse Effects - Reproductive Insufficient Evidence for a Conclusion - Reproductive Toxicity List High (H) Moderate (M) Low (L) Developmental Toxicity (D) Endocrine Activity (E) Note: GHS Reproductive Toxicity includes both reproductive and developmental effects, while the Green Screen separates them into two distinct hazard endpoints. This classification must be based on developmental effects alone. GHS Category 1A (Known) or 1B (Presumed) for any route of exposure GHS Category 2 (Suspected) for any route of exposure or limited or marginal evidence of developmental toxicity in animals (See Guidance) Adequate data available, and negative, no structural alerts, and GHS not classified. E H-statements H360FD, H360D, H360Df, or H362 H360Fd, H361d, H361fd E R-phrases R61 or R64 R63 Category 1A or 1B Category 2 Not NTP-OHAaT Clear Evidence of Adverse Effects - Clear Evidence of No Adverse Effects - Developmental Developmental Prop 65 Known to the state to cause developmental effects G&L Developmental Neurotoxicant Boyes-N Developmental Neurotoxicity Effects Pregnancy Risk Group A or B Pregnancy Risk Group C Pregnancy Risk Group D Limited Evidence of Adverse Effects - Developmental or Some Evidence of Adverse Effects - Developmental NTP-OHAaT Limited Evidence of No Adverse Effects - Reproductive or Some Evidence of No Adverse Effects - Developmental Insufficient Evidence for a Conclusion - Developmental Toxicity List High (H) Moderate (M) Low (L) All Available Evidence of endocrine activity and Evidence of endocrine activity. related human health effect. studies, and no structural alerts. E ED Category 3a E SVHC Reason for Inclusion: Endocrine Activity E ED OSPAR SIN TEDX Category 1 or 2 Category 3b Endocrine Disruptor Reason for Inclusion: Endocrine Disruptor Listed on the TEDX List of Potential Endocrine Disruptors Page 2/6

3 Acute Mammalian Toxicity (AT) Systemic Toxicity/Organ Effects (ST) Single Exposure Repeated* Exposure Guidance Values for Animal (see GHS for further information) List Very High (vh) High (H) Moderate (M) Low (L) GHS Category 1 or 2 for any route of exposure GHS Category 3 for any route of exposure GHS Category 4 for any route of exposure GHS Category 5 or adequate data available, and negative studies, no structural alerts, and GHS not classified. Oral LD 50 (mg/kg) 50 > > >2000 Dermal LD 50 (mg/kg) 200 > > >2000 Inhalation-Gas or Vapor LC 50 (mg/l) 2 >2-10 >10-20 >20 Inhalation-Dust/Mist/Fumes LC 50 (mg/l) 0.5 > >1-5 >5 Class 2.3 Group A, or Class 6.1 Group 1 or Group 2 Class 6.1 Group 3 E H-statements H300, H310, or H330 H301, H311, or H331 H302, H312, or H332 E R-phrases R26, R27 or R28 Category 1 and 2 Category 3 Category 4 Category 5 and "Not " Class 2.3 Group B Class 2.3 Group C Class 2.3 Group D EPA-AMT Extremely Hazardous Substance E R-phrases R20, R21, or R22 R23, R24, or R25 WHMIS D1A Toxic D1B Toxic List Very High (vh) High (H) Moderate (M) Low (L) GHS Category 1 Single Exposure for any route of exposure GHS Category 2 Single Exposure for any route of exposure GHS Category 3 Single Exposure for any route of exposure GHS Guidance Oral (mg/kg-bw) 300 > Values for Animal Dermal (mg/kg-bw) 1000 > (see GHS for Inhalation-Gas or Vapor (mg/l/4h) 10 >10-20 further information) Inhalation-Dust/Mist/Fumes (mg/l/4h) 1.0 > E H-statements H370 H371 H335 E R-phrases R39, R39/23, R39/24, or R39/25, R39/26, R39/27, R39/28 R68/20, R68/21, or R68/22, R37 not classified Category 1 Category 2 Category 3 "Not " GHS Category 1 Repeated Exposure for any route of exposure GHS Category 2 Repeated Exposure for any route of exposure not classified Oral (mg/kg-bw/day) 10 > >100 GHS Guidance Dermal (mg/kg-bw/day) 20 > >200 Values for Animal Inhalation-Gas or Vapor (mg/l/6h/day) 0.2 > >1.0 (see GHS for further information) Inhalation-Dust/Mist/Fumes (mg/l/6h/day) 0.02 > >0.2 E H-statements H372 H373 E R-phrases R48/23, R48/24, R48/25 R48/20, R48/21, R48/22 Category 1 Category 2 "Not " E R-phrases R48 "Danger of serious damage to health by prolonged exposure" Page 3/6

4 Neurotoxicity (N) Single Exposure Repeated* Eye Irritation Skin Irritation Respiratory Skin (IrE) (IrS) Sensitization (SnR*) Sensitization Both List Very High (vh) High (H) Moderate (M) Low (L) A-Lists GHS Criteria Systemic Toxicity/Organ Effects using SEPA Risk Assessment Guidance to define applicable neurotoxic effects. GHS Criteria Systemic Toxicity/Organ Effects using SEPA Risk Assessment Guidance to define applicable neurotoxic effects. E H-statements E R-phrases Boyes-N G&L GHS Category 1 GHS Category 2 Single Exposure for any Single Exposure for route of exposure any route of exposure GHS Category 3 Single Exposure for any route of exposure not classified Category 1 Category 2 Category 3 "Not " GHS Category 1 Repeated Exposure for any route of exposure GHS Category 2 Repeated Exposure for any route of exposure not classified Category 1 Category 2 "Not " GHS Category 1A (high frequency of occurrence) GHS Category 1B (low to moderate frequency of occurrence) not classified. Category 1A Category 1B "Not " Sensitizing Substances Sh (Skin) or Sah (Respiratory and Skin) E H-statements H317 E R-phrases R43 High (H) Moderate (M) Low (L) GHS Category 1A (high frequency of occurrence) GHS Category 1B (low to moderate frequency of occurrence) not classified. Category 1A Category 1B "Not " Sensitizing Substances Sa (Respiratory) or Sah (Respiratory and Skin) Asthmagen (G) AOEC Asthmagen (Rr) and/ or (Rs) and/or (Rrs) E H-statements H334 E R-phrases R42 Very High (vh) High (H) Moderate (M) Low (L) GHS Category 1 (Corrosive) GHS Category 2 (Irritant) GHS Category 3 (Mild irritant) not classified. Class 8 E H-statements H314 H315 E R-phrases R34 or R35 R38 Category 1 Category 2 Category 3 "Not " Very High (vh) High (H) Moderate (M) Low (L) GHS Category 1 (Irreversible) GHS Category 2A (Irritating) GHS Category 2B (Mildly irritating) not classified. E H-statements H318 H319 H320 E R-phrases R41 Category 1 Category 2A Category 2B "Not " E R-phrases Listed for Neurotoxic Effects Neurotoxicant R36 H336 R67 Page 4/6

5 Acute Aquatic Toxicity (AA) Chronic Aquatic Toxicity (CA) Persistence (P) Bioaccumulation Potential (B) Measurement Very High (vh) High (H) Moderate (M) Low (L) GHS Category 1 GHS Category 2 GHS Category 3 Guidance Values (see GHS for further information) LC 50 or EC 50 (mg/l) Sufficient data available and not classified 1 >1 to 10 > 10 to 100 >100 it non-human Note: Could be based on acute or chronic aquatic toxicity. Only DSL assess here if the classification is based on acute aquatic toxicity. E H-statements H400 E R-phrases R50 R51/53 R52/53 Category 1 Category 2 Category 3 "Not " E R-phrases R51 or R52 Measurement Very High (vh) High (H) Moderate (M) Low (L) GHS Category 4 Guidance Value (mg/l) 0.1 >0.1 to 1.0 > 1.0 to 10 >10 it non-human Note: Could be based on acute or chronic aquatic toxicity. Only DSL assess here if the classification is based on chronic aquatic toxicity. E H-statements H413 E R-phrases R53 Category 4 it non-human Note: Could be based on acute or chronic aquatic toxicity. Only DSL assess here if the classification is based on chronic aquatic toxicity. Media & Measurement List Very High (vh) High (H) Moderate (M) Low (L) Very Low (vl) Soil or Sediment (1/2 life in days OR Result) Water (1/2 life in days OR Result) Air (1/2 life in days OR Result) Long-Range Environmental Transport >180 or recalcitrant >60 to 180 Evidence Suggestive Evidence DSL Persistent (P) Measurement Very High (vh) High (H) Moderate (M) Low (L) Very Low (vl) BAF (Bioaccumulation Factor) BCF (Bioconcentration Factor) > 5000 > 5000 > 1000 to 5000 > 1000 to 5000 > 500 to 1000 > 500 to 1000 > 100 to 500 > 100 to Log Kow (Log octanol-water partition > 5.0 > 4.5 to 5.0 > 4.0 to coefficient ) Monitoring (Presence in humans or wildlife) Evidence Suggestive Evidence DSL Bioaccumulative (B) 16 to 60 > 60 or recalcitrant > 40 to to 40 < 16 OR GHS Rapid degradability < 16 OR GHS Rapid degradability > 5 or recalcitrant >2 to 5 < 2 Meets 10-day window in Ready Biodegradation Test Meets 10-day window in Ready Biodegradation Test Page 5/6

6 Reactivity (Rx) Flammability (F) - GHS Criteria & Guidance - GHS Criteria & Guidance Measurement List Very High (vh) High (H) Moderate (M) Low (L) Explosives GHS nstable GHS Division 1.1, 1.2, or 1.3 GHS Division 1.4 or 1.5 Self-reactive Substances GHS A or B GHS C or D GHS E or F Substances which on contact with water emit flammable gases GHS Category 1 GHS Category 2 GHS Category 3 Oxidizing Gases GHS Category 1 Oxidizing Liquids and Solids GHS Category 1 GHS Category 2 GHS Category 3 Organic Peroxides GHS A or B GHS C or D GHS E or F Self-heating Substances GHS Category 1 GHS Category 2 Substances Corrosive to Metal GHS Category 1 E H-statements H200, H240, H241, H260, H271 E R-phrases R09 E H-statements E R-phrases WHMIS Division 1.6 or Adequate data available and GHS not G or Adequate data available and GHS not G or Adequate data available and GHS not Class 1 Group 1.1, 1.2, or 1.3 Class 1 Group 1.4, 1.5, or 1.6 Class 4.2 Group 2 Class 4.2 Group 3 Class 4.3 Group 1 Class 4.3 Group 2 Class 4.3 Group 3 Class 5.1 Group 1 Class 5.1 Group 2 Class 5.1 Group 3 Class 5.2 B Class 5.2 C or D Class 5.2 E or F Class 5.2 G H201, H202, H203, H251, H270 H204, H205, H252, H290 Measurement Very High (vh) High (H) Moderate (M) Low (L) Flammable Liquid GHS Category 1 GHS Category 2 GHS Category 3 or 4 Flammable Gases (including chemically unstable gases) GHS Category 1 GHS Category 2 or GHS Category A Flammable Solids GHS Category 1 GHS Category 2 Aerosols GHS Category 1 GHS Category 2 Pyrophoric Liquids GHS Category 1 Pyrophoric Solids GHS Category 1 Class 3 Group 1 Class 3 Group 2 or Class 4.2 Group 1 E H-statements H224 H220, H222, H225, H250 Class 4.1, Class 5.2 A H261, H272 H242 R01, R06, R07, R15 R02, R04, R05, R08, R14, R16, R19, R44 B6, C, or F Class 3 Group 3 H221, H223, H226, H227, H230 E R-phrases R17 WHMIS B1 B3 Class 2.1 E H-statements H228 E R-phrases R10 (Gas or Solid), R11 (Solid) R10 (Liquid only) R11 (Liquid only) R12 (Gas only) WHMIS B4 or B5 B2 GHS Category B or Adequate data available and GHS not GHS Category 3 or Adequate data available and GHS not Page 6/6

7 Carcinogens, Mutagens, Reproductive Toxins (CMR) List Category List High (H) Moderate (M) Low (L) SIN CMR E R-phrases List Category List High (H) Moderate (M) Low (L) R60/61 May impair fertility and May cause harm to the unborn child (H for R and D) Hazard Endpoints Addressed One or more of the following: Carcinogenicity, Mutagenicity, Reproductive Toxicity, Developmental Toxicity. Hazard Endpoints Addressed 1 Reproductive and Developmental Toxicity Reproductive and/or Developmental Toxicity E CMR (1) E CMR (2) E H-statement E SVHC Reproduction Category 1: known to impair fertility in humans or cause developmental toxicity in humans (H for R and/or D) Reproduction Category 2: should be regarded as if they impair fertility to humans or cause developmental toxicity to humans (H for R and/or D) Reproduction Category 3: possible (M for R and/or D) Repr 1A (H for R and/or D) 1 Repr 1B (H for R and/or D) 1 Repr 2 (M for R and/or D) H360 (with any combo of letters or no letters) "May damage fertility or the unborn child <state specific effect if known > <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard" H361 (with any combo of letters or no letters) "Suspected of damaging fertility or the unborn child <state specific effect if known> <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>." Reason for inclusion: Toxic for reproduction (H for R and/or D) Reproductive and/or Developmental Toxicity Page 7/6

8 Various Combinations of Group I, II and II* Endpoints PBTs, vpvbs and other combinations of Persistence, Bioaccumulation and Toxicity List Category List High (H) Moderate (M) Low (L) DSL it human WHMIS DSL D2 Toxic - With other effects Sensitizing Substances Sah (H for SnS and SnR) Sensitizing Substances SP (H for SnS and/or SnR) Hazard Endpoints Addressed One or more of the following Human Health Effects: Carcinogenicity, Mutagenicity/Genotoxicity, Reproductive Toxicity, Developmental Toxicity, Acute Mammalian Toxicity, System Toxicity/Organ Effects. Respiratory and Skin Sensitization Skin and/or Respiratory Sensitization One or more of the following Chronic Human Health Effects: Carcinogenicity, Mutagenicity/Genotoxicity, Reproductive Toxicity, Developmental Toxicity, Skin Sensitization, Respiratory Sensitization, Systemic Toxicity/Organ Effects, Eye Irritation, Skin Irritation. E Corrosive Reactivity and/or Eye Irritation/Corrosivity and/or Skin Irritation/Corrosivity List Category List High (H) Moderate (M) Low (L) PBiT human PPBiT non-human Hazard Endpoints Addressed PBT [Persistence, Bioaccumulation and Human Toxicity (Human Health Effects)] PBT [Persistence, Bioaccumulation, and any of the following: Acute Aquatic Toxicity, Chronic Aquatic Toxicity, Carcinogenicity, Mutagenicity, Reproductive Toxicity, Developmental Toxicity, Systemic Toxicity/Organ Effects-Repeated Exposure. EPA PBT PBT 1 PBT [Persistence, Bioaccumulation and any of the following: Ecotoxicity, Carcinogenicity, Mutagenicity, Reproductive Toxicity, Developmental Toxicity, Neurotoxicity, Other chronic effects, or effects from site releases] vpvb 1 vpvb [Persistence, Bioaccumulation] PBT [Persistence, Bioaccumulation and any of the following: Ecotoxicity PBT 1 and/or Human Toxicity (Human Health Effects)] E PBT POP 1 Persistent Organic Pollutant [Persistence, Bioaccumulation and any of the following: Ecotoxicity and/or Human Toxicity (Human Health Effects)] PBT [Persistence, Bioaccumulation, and any of the following: Acute E SVHC PBT 1 Aquatic Toxicity, Chronic Aquatic Toxicity, Carcinogenicity, Mutagenicity, Reproductive Toxicity, Developmental Toxicity] vpvb 1 vpvb [Persistence, Bioaccumulation] NWMP - Priority PBT 1 PBT [Persistence, Bioaccumulation and any of the following: Ecotox and/or Human Toxicity (Human Health Effects)] OR P3 Persistent PBT [Persistence, Bioaccumulation and any of the following: Ecotox and/or Pollutants Human Toxicity (Human Health Effects)] OSPAR PBT 1 PBT [Persistence, Bioaccumulation, and any of the following: Acute Aquatic Toxicity, Chronic Aquatic Toxicity, Carcinogenicity, Mutagenicity, Reproductive Toxicity, Developmental Toxicity, Systemic Toxicity/Organ Effects repeated exposure)] vpvb Persistence and Bioaccumulation SIN Persistence, Bioaccumulation and any of the following: Ecotoxicity and/or PBT Human Toxicity (Human Health Effects) Stockholm POP 1 PBT [Persistence, Bioaccumulation and any of the following: Ecotoxicity and/or Human Toxicity (Human Health Effects)] TRI PBT PBT 1 PBT [Persistence, Bioaccumulation, and Acute Aquatic Toxicity] WA PBT PBT PBT [Persistence, Bioaccumulation and any of the following: Ecotoxicity and/or Human Toxicity (Human Health Effects)] Page 8/6

9 PBTs, vpvbs and other combinations of Persistence, Bioaccumulation and Toxicity Reactivity and/or Flammability List Category List High (H) Moderate (M) Low (L) CEPA CEPA Toxic E H-statement E R-phrases VwVwS H410 "Very toxic to aquatic life with long lasting effects." H411 "Toxic to aquatic life with long lasting effects." H412 "Harmful to aquatic life with long lasting effects." R50/53 "Very Toxic to Aquatic Organisms, May cause long-term adverse effects in the aquatic environment" R51/53 "Toxic to Aquatic Organisms, May cause long-term adverse effects in the aquatic environment" R52/53 "Harmful to Aquatic Organisms, May cause long-term adverse effects in the aquatic environment" Class 1-"low hazard to waters" Class 2-"hazard to waters" Class 3-"severe hazard to waters" List Category List High (H) Moderate (M) Low (L) Hazard Endpoints Addressed One or more of the following: Human Health Effects, Ecotoxicity, and/or Fate endpoints. T & P and/or B [(Chronic Aquatic Toxicity and sometimes Persistence) or (Acute Aquatic Toxicity and Persistence and/or Bioaccumulation)] Any combination of the following: Acute Mammalian Toxicity, Systemic Toxicity/Organ Effects, Carcinogenicity, Reproductive Toxicity, Developmental Toxicity, Acute Aquatic Toxicity, Chronic Aquatic Toxicity, Persistence, Bioaccumulation. Hazard Endpoints Addressed R12 Liquid: Reactivity and/or Flammability R03 "Extreme risk of explosion by shock, friction, fire or other sources of ignition.": Reactivity and/or Flammability E R-phrases R18 "In use, may form flammable/explosive Reactivity and/or Flammability vapour-air mixture.": Reactivity and/or Flammability R30 "Can become highly flammable in use.": Reactivity and/or Flammability Page 9/6

Last Updated: March 8, 2016

1 GreenScreen Version 1.3 Specified s Last Updated: March 8, 2016 Abbreviation CPA Type Name 1 AOEC Authoritative B Association of Asthmagens Occupational and Environmental Clinics (AOEC) Exposure Code