Genetic analyses of ketosis and a newly developed risk indicator in Fleckvieh, Braunvieh and German Holstein H. Hamann, A. Werner, L. Dale, P.
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1 Genetic analyses of ketosis and a newly developed risk indicator in Fleckvieh, Braunvieh and German Holstein H. Hamann, A. Werner, L. Dale, P. Herold Speaker: Pera Herold
2 Genetic analyses of ketosis and a newly developed risk indicator in Fleckvieh, Braunvieh and German Holstein H. Hamann 1, A. Werner 2, L. Dale 2, P. Herold 1 1 State Office for Geoinformation and Rural Development Baden-Württemberg, Germany 2 Association for Performance and Quality Testing Baden-Württemberg, Germany Slide 2, June, 15, 2017
3 Outline 1. Goal and derivation of the KetoMIR index 2. Genetic analyses 3. Results 4. Conclusion Slide 3, June, 15, 2017
4 Goal and derivation of the KetoMIR index: Modelling of ketosis risk via KetoMIR index Ketosis reference: Ketosis diagnoses registered in LKV-Baden- Württemberg health monitoring project GMON Variables: > 1000 dairy farms primarily herd management tool Standardized MIR spectra available from January 2012 (Bentley & Foss, from November 2012 Bentley only) from regular milk analysis Indirect usage by via MIR based components (standard milk recording components, fatty acids, minerals, aceton, BHB, citrat) Environmental factors (Days in milk, breed, calving number) Grelet et al. Slide 4, June, 15, 2017
5 Goal and derivation of the KetoMIR index: KetoMIR index: based on logistic regression numeric range between 0 and 1 partition in three classes healthy : low risk : high risk : Calibration set Validation set (n= ) (n=2.966) Sensitivity: Specificity Slide 5, June, 15, 2017
6 cum. prob. function prob. function Probability functions of the KetoMIR index and derivaton of KetoMIR classes healthy low risk high risk high risk low risk healthy Slide 6, June, 15, 2017
7 Distribution of KetoMIR classes for breeds and weeks in milk Fleckvieh (Dual purpose Simmental) Braunvieh (German Brown) Deutsch Holstein (German Holstein) high risk low risk healthy Weeks in milk Slide 7, June, 15, 2017
8 Genetic analyses: Can the KetoMIR index be used as auxiliary trait in breeding programmes? - Is the KetoMIR index (classes) heritable? - How is the KetoMIR index genetically related to ketosis? - (How is the KetoMIR index genetically related to other traits of interest?) Slide 8, June, 15, 2017
9 Genetic analyses: Data: Fleckvieh: Braunvieh: Deutsch Holstein: lactations with information for the first three test day records (analysed separately or as average) Repeatability model (within breed): HYS, lactation number, days in milk, permanent environmental effect, animal effect KetoMIR index KetoMIR classes (categorical) healthy low risk high risk C3 KetoMIR classes (binary) healthy vs low risk + high risk B050 healthy + low risk vs high risk B075 Slide 9, June, 15, 2017
10 Genetic analyses: Is the KetoMIR index (classes) heritable? Heritabilities for the KetoMIR index, catecorical and binary classes Fleckvieh (Dual purpose Simmental) Braunvieh (German Brown) Deutsch Holstein (German Holstein) TD Index C3 B050 B075 TD Index C3 B050 B075 TD Index C3 B050 B Ø Ø Ø Slide 10, June, 15, 2017
11 Genetic analyses: How is the KetoMIR index genetically related to ketosis? Genetic correlations between ketosis (clinical) and the KetoMIR index and categorical classes Fleckvieh Braunvieh Deutsch Holstein TD Index C3 Index C3 Index C Ø Slide 11, June, 15, 2017
12 Genetic analyses: How is the KetoMIR index genetically related to other traits of interest? Genetic correlations between KetoMIR index and traits for milk components Fat content Protein content Fat-protein-ratio TD Fleckvieh Braunvieh Deutsch Holstein Ø Ø Ø Slide 12, June, 15, 2017
13 Genetic analyses: Can the KetoMIR index be used as auxiliary trait in breeding programmes? - Is the KetoMIR index (classes) heritable? - How is the KetoMIR index genetically related to ketosis? - How is the KetoMIR index genetically related to other traits of interest? Slide 13, June, 15, 2017
14 Conclusion: Data collecting as a matter of the routine milk analyses Requirements for breeding value estimation are given Establishment of a breeding value evaluation for the KetoMIR index - based on a single test day record - based on the average of several test day records Calculation of economic weights Cross validation based on breeding values Slide 14, June, 15, 2017
15 Thank you for your attention! Slide 15, June, 15, 2017
16 Breeding strategies: Selection against ketosis liability: - based on a single (first) test day record (strategy I) breaking the peaks in the KetoMIR curve - based on the average of several test day records (strategy II) lowering the general level of the KetoMIR curve Slide 16, June, 15, 2017
17 KetoMIR index 1.00 Breeding strategies Initial curve (hypothetical) 0.75 Strategy I 0.50 Strategy II Days in milk Slide 17, June, 15, 2017
18 Genetic analyses: How is the KetoMIR index genetically related to other traits of interest? Genetic correlations between KetoMIR index and traits for milk components Milk yield SCS TD Fleckvieh Braunvieh Deutsch Holstein Ø Ø Slide 18, June, 15, 2017
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