Trends in STDs: US Perspective. Michael Towns, M.D. WW Vice President, Medical Affairs BD Diagnostic Systems
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1 Trends in STDs: US Perspective Michael Towns, M.D. WW Vice President, Medical Affairs BD Diagnostic Systems
2 Outline Overview of STD Epidemiology and Current Situation in US Overview of Chlamydia infections Screening Guidelines & Recommendations Efficacy of Screening Reimbursement for testing Conclusions
3 Overview of STD Epidemiology The Top 3 reportable STDs in the US (rank) 1. Chlamydia (estimated ~ 3 million new cases/yr) 2. Gonorrhea 3. Syphilis Co-infections also common (up to 30%)
4 Estimated Annual Burden and Cost of STD in the U.S. Estimated Annual Cases Estimated Annual Direct Cost (millions) Chlamydia 2.8 million $624 Gonorrhea 718,000 $173 Syphilis 70,000 $22 Hepatitis B * 82,000 $42 Genital Herpes 1.6 million $985 Trichomoniasis 7.4 million $179 HPV 6.2 million $5,200 HIV * 40,000 $8, million $15.3 billion * Costs of sexually-acquired cases only.
5 The Hidden Epidemic: An Urgent Reality Still With Us STDs are hidden epidemics of tremendous health and economic consequences in the U.S. They are hidden from public view because many Americans are reluctant to address sexual health issues in an open way and because of the biological ands social factors associated with these diseases. In addition, the scope, impact, and consequences of STDs are under-recognized by the public and health care professionals.
6 Chlamydia trachomatis Affects both men and women In men, predominately causes urethritis In women, predominately causes both urethritis and cervicitis (50%) with 25% urethritis or cervicitis alone The majority of those infected are asymptomatic (up to 75% of women!!) Disease can be easily diagnosed and cured If not detected, can lead to pelvic inflammatory disease (PID), infertility, and tubal pregnancies in women PID occurs in up to 40% of women who have untreated chlamydial infection Increases risk of HIV infection in both women and men
7 Chlamydia (cont) Is transmitted via sexual intercourse, as well as oral and anal sex Transmission is facilitated since majority are asymptomatic and don t know that they are infected Sexually active women younger than 25 yr old are at greatest risk of disease AND are at the greatest risk for complications as a result of undetected and untreated chlamydial infection yo women account for ~50% of reported cases in US yo women account for an additional 33% of cases CDC reports that 1 in 10 teenage girls in US are infected
8 Chlamydia Rates Among Females, Cases per 100,000 population Oct Age Group
9 Present Situation in US Chlamydia cases are increasing (apparently) Increase in Screening activities Use of more sensitive diagnostic tests Increased emphasis on reporting Improvements in use of information systems Possible true increases in prevalence, (but recent data suggests a decline)
10 Chlamydia Rates: Total and by sex: United States, Rate (per 100,000 population) Men Women Total Note: As of January 2000, all 50 states and the District of Columbia had regulations requiring the reporting of chlamydia cases.
11 Chlamydia Rates by state: United States and outlying areas, 2006 Guam VT 191 NH 152 MA 241 RI 292 CT 312 NJ 232 DE 429 MD 390 DC 612 Rate per 100,000 population <= >300 (n= 1) (n= 21) (n= 32) Puerto Rico 130 Virgin Is. 187 Note: The total rate of chlamydia for the United States and outlying areas (Guam, Puerto Rico and Virgin Islands) was per 100,000 population.
12 Chlamydia Cases by reporting source and sex: United States, Cases (in thousands) non-std Clinic Male non-std Clinic Female STD Clinic Male STD Clinic Female
13 Chlamydia Median state-specific positivity among 15- to 24-year-old women tested in family planning clinics: United States, Median state-specific positivity rate Note: As of 1997, all 10 Health and Human Services (HHS) regions, representing all 50 states, the District of Columbia, and outlying areas, reported chlamydia positivity data. SOURCE: Regional Infertility Prevention Projects; Office of Population Affairs; Local and State STD Control Programs; Centers for Disease Control and Prevention
14 Chlamydia Positivity among 15- to 24-year-old women tested in family planning clinics by state: United States and outlying areas, Positivity (%) VT 3.9 NH 4.1 MA 4.7 RI 6.7 CT 5.7 NJ 7.5 DE 7.7 MD 5.7 DC 7.2 < >=10.0 (n= 8) (n= 38) (n= 7) Puerto Rico 6.4 Virgin Is Note: Includes states and outlying areas that reported chlamydia positivity data on at least 500 women aged years screened during SOURCE: Regional Infertility Prevention Projects; Office of Population Affairs; Local and State STD Control Programs; Centers for Disease Control and Prevention
15 Chlamydia trachomatis infections continue to increase? or decrease? The correct answer is: DECREASE By how much? At this point in 2007 there were 816,774 cases As of October 14, ,658 cases
16 Gonorrhea Rates: United States, and the Healthy People 2010 target Rate (per 100,000 population) Gonorrhea 2010 Target Note: The Healthy People 2010 target for gonorrhea is 19.0 cases per 100,000 population.
17 Gonorrhea Rates: Total and by sex: United States, and the Healthy People 2010 target Rate (per 100,000 population) Male Female Total 2010 Target Note: The Healthy People 2010 target for gonorrhea is 19.0 cases per 100,000 population.
18 Gonorrhea Rates by state: United States and outlying areas, 2006 Guam VT 11.6 NH 13.7 MA 38.0 RI 47.2 CT 74.4 NJ 63.0 DE MD DC Rate per 100,000 population <= >100 (n= 5) (n= 27) (n= 22) Puerto Rico 7.7 Virgin Is Note: The total rate of gonorrhea for the United States and outlying areas (Guam, Puerto Rico and Virgin Islands) was per 100,000 population. The Healthy People 2010 target is 19.0 cases per 100,000 population.
19 Untreated Chlamydia Infection 3-5 fold Increased Risk of HIV Up to 40% Pelvic Inflammatory Disease (PID) Neonatal Pneumonia & Conjunctivitis 17% Chronic Pelvic Pain 9% Ectopic Pregnancy 17% Infertility
20 CT and GC Control: A Tale of Two Infections Chlamydia Rates: Total and by sex: U.S., * Gonorrhea Rates by race/ethnicity: U.S., * Rate (per 100,000 population) 600 Men Women 480 Total Rate (per 100,000 population) American Indian/AK Native Asian/Pacific Islander Black Hispanic White Chlamydia Trends in positivity among 15- to 24- year-old women tested in family planning clinics by HHS region, Pelvic inflammatory disease Hospitalizations of women 15 to 44 years of age: U.S., Hospitalizations (in thousands) 75 Region X Region V Region I Region IX X IX VIII VII VI V IV III II I Region II Acute, Unspec. Chronic Region VIII Region III Region VII Region VI Region IV *Preliminary 2007 data
21 Chlamydia Age- and sex-specific rates: United States, 2006 Men Rate (per 100,000 population) Women Age Total 517.0
22 Gonorrhea Age- and sex-specific rates: United States, 2006 Men Rate (per 100,000 population) Women Age Total 124.6
23 Screening Guidelines in US
24 US Preventive Services Task Force (USPSTF) Group that systematically reviews the evidence of effectiveness of a wide range of clinical preventive services Currently in the US, it is recommended that ALL sexually active women <25 yo should be screened routinely, as well as those 25 yo who have multiple sex partners Routine screening will reduce the risk of PID, as well as improve the health of those pregnant
25 Chlamydia Screening Recommendations Sexually active women 24 yo All sexually active women with new or multiple sexual partners Or Whose partners have had multiple partners within the past year, regardless of age Have a history of STD within the last year, regardless of age All pregnant women at least once, regardless of age Consider re-screening any infected woman, especially adolescents, 3-4 months after treatment, due to high incidence of re-infection
26 How effective is screening? According to the CDC, states that have chlamydia screening programs have infection rates that have been reduced by 67%! Results from a randomized clinical study (NEJM 1996) showed a reduction in cases of PID in those screened for chlamydia compared to no screening CDC estimates that for every $1 spent on screening, that $12 is saved in treatment costs
27 CT Screening Prevents PID: Clinical Trial, Seattle HMO, Randomized controlled trial high-risk women, ages yo 1009 assigned to intervention (invitation to get tested) 1598 assigned to usual care Among intervention group, 64% were tested, with 7% positive and treated Outcome of PID within 1 yr: 9 cases in screening group 33 cases in usual care group (RR=0.44) PID Rate (per 1000) Usual Care Screened Scholes, et. al., NEJM 334:1362-6, 1996
28 Pelvic inflammatory disease Initial visits to physicians offices by women 15 to 44 years of age: United States, Visits (in thousands) Note: The relative standard error for these estimates ranges from 19% to 30%. SOURCE: National Disease and Therapeutic Index (IMS Health)
29 CT screening coverage, (HEDIS): slowly but surely Chlamydia Screening: Ages % Commercial Medicaid Commercial Medicaid
30 Estimated Chlamydia Screening Coverage (HEDIS), Females 16-26, U.S.A. and California, Percent Screened Natl MCO Natl Medicaid MediCal MC NCal HMO FPACT Source: California Chlamydia Action Coalition Report, 2005
31 Will health insurance pay for screening? STD testing is covered by most U.S. health insurance plans. Surveys of major health insurers indicate that preventive care services (including vaccination and testing) are increasingly covered for persons at risk, under plans with a preventive care component. - Health insurers report that specific risk factor data is not required for reimbursement; an assessment by a clinician that the preventive care service is medically indicated is usually sufficient. - Office billing staff may need training in appropriate codes that allow for reimbursement.
32 Partnerships to Expand CT Screening Highest ranking clinical preventive services with lowest utilization rates (% population coverage) (Masciosek MV. Am J Prev Med 2006) Tobacco-use interventions (35%) Colorectal cancer screening > 50 (35%) Pneumococcal immunization > 65 (56%) Screening sexually active women < 25 for CT annually (40%) Next steps with Partnership for Prevention CT Screening Implementation Guide National Coalition for CT Screening Steering Committee of 8 organizations Discussions with additional organizations ongoing Committees to focus on Public Awareness, Provider Education, Health Services Research, Advocacy Planning meeting in May
33 Getting the Word out: STD Prevention is Everyone s Business Given the high incidence of STD and nature of our prevention approaches, STD prevention is relevant for ALL segments of society, not just those traditionally considered at high-risk. ALL youth: need for better awareness of STD and prevention options ALL pre-teen and adolescent females: need for HPV vaccine ALL persons yo: at least 1 HIV test ALL sexually active F < 26: CT screening ALL sexually active MSM: annual STD/HIV testing In short, now more than ever, STD prevention is EVERYONE s business. Comprehensive approach to STD prevention is a shared concern among a variety of stakeholders interested in the health of our young people public health (national, state, local), health care providers, parents, educators public Normalizing conversations and policies around STD prevention so that we deal with this topic as openly and normatively as we would concerns about obesity or pandemic influenza is CRITICAL if we are going to effectively engage this broad network of stakeholders.
34 Priorities for Infertility Prevention: CT & GC Control Chlamydia Expand screening of sexually active women < 26 public sector screening into potentially higher prevalence populations (e.g., schools, detention) private sector screening (enhanced promotion of guidelines, partnerships with health plans and professional organizations) Reduce re-infection (improved partner management, re-screening) Male screening (selected high-prevalence venues) Gonorrhea Maintain effective therapy Monitoring GC resistance Access to effective antibiotics a growing problem
35 Conclusions STDs are still a major problem in the US Chlamydia is the most frequently reported STD in the US The problem with Chlamydia is that the majority of infections are asymptomatic Therefore, screening programs are needed to detect these infections Screening offers the opportunity for detection of disease and subsequent treatment Screening leads to a decrease in PID and associated costs of treating the complications of undiagnosed chlamydial infections
36
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