The Heart of the Matter

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Cleveland Clinic Genomic Medicine Institute Cardiovascular Genetics & Genomics: The Heart of the Matter Thursday, September 13, 2018 InterContinental Hotel and Bank of America Conference Center Cleveland, OH 44106 Register Online: www.ccfcme.org/genetics

An Invitation from Dr. Charis Eng Dear Colleagues, I am pleased to invite you to attend the Genomic Medicine Institute s 6th annual genetics education symposium, entitled Cardiovascular Genetics and Genomics: The Heart of the Matter. We are planning an engaging day with an emphasis on advances in the diagnosis, management, and treatment of genetic conditions related to cardiovascular health. The chairman of Cleveland Clinic s Heart and Vascular Institute, Lars Svensson, MD, PhD, will deliver the morning keynote address. Other topics include the limitations of genetic testing and variations of uncertain significance, the practice of telegenetics, professional social media use and pharmacogenomics. Please refer to the enclosed agenda for more details about this year s speakers and topics. I am sure you will enjoy this day of education and discussion centered on our common interests in genetic and genomic medicine. We will close the day with my presentation, Your Genes, Your Wine, Your Health, followed by a wine reception where you ll have the opportunity to join together with your colleagues. Sincerely, Charis Eng, MD, PhD Hardis Chair, Genomic Medicine Institute Director, Cleveland Clinic Planning Committee Courtney Becker-Howell, MHSA Emma Keel Jenn Lonzer, MA Lauren Palange, MS, LGC Brittany Psensky, MS, LGC Ron Rerko, MS Christina Rigelsky, MS, LGC Amy Shealy, MS, LGC Diane Stanely Clements, MS, LGC Julie Wood, MS

Activity Director Charis Eng, MD, PhD Hardis Chair, Genomic Medicine Institute Director, Cleveland Clinic Cleveland Clinic Faculty Adnan Alsadah, MD Peter Aziz, MD Pediatric Cardiology Angelika Erwin, MD, PhD David Flannery, MD Neil Friedman, MD Director of the Center for Pediatric Neurosciences Mazen Hanna, MD Cardiovascular Medicine Jennifer Hockings, PharmD, PhD Rebekah Moore, MS, LGC Rocio Moran, MD Lauren Palange, MS, LGC Dermot Phelan, MD, PhD Director of the Sports Cardiology Center Brittany Psensky, MS, LGC Lars Svensson, MD, PhD Chair of the Heart and Vascular Institute Kenneth Zahka, MD Children s Hospital and Pediatric Institute Course Overview This program, presented by Cleveland Clinic s Genomic Medicine Institute, will provide the opportunity to review the latest advances in genetics and genomics and offer state-of-the-art information to healthcare providers treating patients with genetic conditions. Expert Cleveland Clinic faculty will share case-based presentations highlighting the advances of genetics and genomics in cardiovascular disorders. Who Should Attend We invite practitioners and healthcare professionals seeking to learn the latest developments in medical genetics, especially providers in Cardiology, Family Practice, Internal Medicine and Specialties, Pediatrics, and other health care professionals. Trainees and students with an interest in expanding their knowledge of genomic medicine and related topics are also encouraged to attend. By Attending, You Will Be Able To: Assess novel genetic service delivery models in cardiovascular healthcare Describe present and emerging genetic technologies and their applications in cardiovascular healthcare Discuss current management practices of patients with a diagnosis of, or at high-risk for, hereditary cardiovascular disorders Review the social and ethical implications of genetic screening and testing in the cardiovascular healthcare setting Explore current reimbursement trends and cost savings strategies for genetic services Describe the importance and process of family history taking in cardiovascular disease

Agenda Thursday, September 13, 2018 A five minute Q&A is included in each speaker s allotted time. 7:00 AM Registration, Continental Breakfast 7:45 AM Opening Remarks Charis Eng MD, PhD 8:00 AM Genetics Primer Adnan Alsadah, MD 8:30 AM Keynote: Aorta/Connective Tissue Lars Svensson, MD, PhD 9:00 AM ACTA2 Spectrum/CNS Vasculopathy Neil Friedman, MD 9:30 AM Fabry Disease Angelika Erwin, MD, PhD 10:00 AM Break 10:15 AM Social Media and Your Professional Life Rebekah Moore, MS, LGC 10:45 AM Pharmacogenomics Jennifer Hockings, PharmD, PhD 11:15 AM Variants of Uncertain Significance, Limitations of Genetic Testing, Interpretation of Panels Lauren Palange, MS, LGC 11:45 AM Lunch 12:45 PM Congenital Heart Disease Rocio Moran, MD 1:15 PM Hypertrophic Cardiomyopathy Kenneth Zahka, MD 1:45 PM Care of Athletes with Inherited Cardiac Disease Dermot Phelan, MD, PhD 2:15 PM New Treatments for Cardiac Amyloidosis Mazen Hanna, MD 2:45 PM Inherited Cardiomyopathies / Role of Genetics in Autopsies for Sudden Death Peter Aziz, MD 3:15 PM Break 3:30 PM Family History Taking in Cardiovascular Disease Brittany Psensky, MS, LGC 4:00 PM Telegenetics Update David Flannery, MD 4:30 PM Your Genes, Your Wine, Your Health Charis Eng, MD, PhD 5:00 PM Adjourn/Reception (agenda is subject to change)

Venue & Accommodations InterContinental Hotel and Bank of America Conference Center 9801 Carnegie Ave., Cleveland OH 44106 Please call 216.707.4100 or 855.364.5195 or visit www.ichotelsgroup.com to reserve your room. Parking Valet parking is available at the hotel for an additional charge. Parking is available in the 100th Street visitor s parking garage (Parking Lot 2) for a charge of $10 per day. Americans with Disabilities Act Continuing Education fully intends to comply with the legal requirements of the Americans with Disabilities Act. If you need assistance, please notify the Genomic Medicine Institute via email at gmieducation@ccf.org at least two weeks prior to the activity. General Information For additional information about this activity, contact the Genomic Medicine Institute at gmieducation@ccf.org. Accreditation Continuing Education is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Continuing Education designates this live activity for a maximum of 7.75 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association for Category 2 credit. The Ohio Board of Nursing will accept at face value the number of contact hours awarded for an educational activity that has been approved for CE by a nationally accredited system of CE approval. Faculty Disclosure Continuing Education has implemented a policy to comply with the current Accreditation Council for Continuing Medical Education Standards for Commercial Support requiring resolution of all faculty conflicts of interest. Faculty declaring a relevant commercial interest will be identified in the activity syllabus. Genomic Medicine Institute Launched in 2005, the Genomic Medicine Institute (GMI) is housed in the Lerner Research Institute s Center for Genomics Research Building. GMI is specifically designed to enhance translational genomic medicine. The open design laboratory space is next to GMI s clinical unit, the Center for Personalized Genetic Healthcare (CPGH), the Genomic Medicine Biorepository (GMB) and the Genomics Core Facility. Vision To bring genetic and genomic expertise to all of Cleveland Clinic s clinical care subspecialties. Mission To translate genetic research discoveries into better patient care by engaging in clinical practice, research and education; to provide a work culture that enables us to bring genetics and genomics, through our research and clinics, into all subspecialties of the Cleveland Clinic s healthcare system; and to foster innovation toward realizing the benefits of personalized genomic-based healthcare. Clinical Expertise (CPGH) is the Cleveland Clinic s first comprehensive clinical genetics program, providing family history-based disease risk assessment and management for prenatal to adult onset disorders. CPGH s genetic experts (5 Geneticists and 14 Genetic Counselors) work closely with Cleveland Clinic s healthcare professionals to provide genetic counseling services and, if appropriate, genetic testing. Clinical genetics care is integrated throughout the Cleveland Clinic system in over 24 locations. CPGH provides genetic counseling and testing services in the areas of: Cancer genetics Cardiovascular genetics General genetics Preconception & Prenatal genetics Neurogenetics and Neurometabolism Appointments: 216.636.1768 EPIC Order: Consult to Genetic Counseling Website: www.ccf.org/cpgh Deadline for Registration and Cancellation Preregistrations are accepted online until 9:00 AM ET September 12, 2018. To register after this date, please do so onsite. In case of cancellation, a full refund will be made if canceled by September 6, 2018. After September 6, a $25 cancellation fee will be deducted from your refund. Written notification of your cancellation is required in order to process your refund. NO REFUNDS WILL BE ISSUED AFTER September 12, 2018. Registration Register online at: www.ccfcme.org/genetics Physicians - $100 Non-physicians- $25 Resident*/Fellows* - $25 Cleveland Clinic Alumnus - $25 Registration fee includes: symposium session, continental breakfast, refreshment breaks, lunch, reception, and syllabus. For questions concerning registration, email cmeregistration@ccf.org or call 216.448.8710. *Letter from program director is required to receive the discounted fee. If letter is not received two weeks prior to the activity, the full physician fee will be charged.