TECHNOLOGY & INNOVATION Zelko Relic VP RESEARCH & DEVELOPMENT 1 2014 Align Technology, Inc. 1
FORWARD LOOKING STATEMENT During this presentation and corresponding commentary we may make forwardlooking statements, including statements regarding Align s strategy for future growth, the anticipated impact of product innovation, consumer demand generation, geographic expansion and sales force productivity on, among other things, customer adoption, as well as statements related to Align s business outlook. Any such forward-looking statements contained in this presentation and corresponding commentary are based upon information available to Align as of the date hereof. These forward-looking statements are only predictions and are subject to risks, uncertainties and assumptions that are difficult to predict. As a result, actual results may differ materially and adversely from those expressed in any forward-looking statement. Factors that may cause such a difference include, but are not limited to, the factors that are discussed in more detail in Align Technology s Forms 10-K and 10-Q, as well as in other reports and documents filed from time to time with the Securities and Exchange Commission. Align undertakes no obligation to revise or update publicly any forward-looking statements for any reason. 2 2014 Align Technology, Inc. 2
EARLY DAYS OF INVISALIGN Wires and brackets - GOLD STANDARD Invisalign clear aligners - Aesthetic alternative, selective applicability - Less predictable outcomes, lower clinical confidence - Difficulty with multiple tooth movements Extrusions, rotations, root control - Treatment planning and manufacturing processes that were not easily scalable CLINCHECK SET-UP ALIGNER TRACKING 3 2014 Align Technology, Inc. 3
EVOLUTION OF INVISALIGN Significant increase in applicability Tremendous predictability improvements From a toolbox to solutions Single Tooth Movements Multi-Tooth Movements Broader Malocclusion Solutions Building Clinically Viable Product 4 2014 Align Technology, Inc. 4
MORE COMPREHENSIVE SOLUTIONS INVISALIGN G5 FOR DEEP BITES Horizontal rectangular attachments Optimized attachments for retention and extrusion No features for intrusion Pressure areas for intrusion No bite ramps 5 2014 Align Technology, Inc. 5
MORE COMPREHENSIVE SOLUTIONS INVISALIGN G5 FOR DEEP BITES 6 2014 Align Technology, Inc. 6
MORE COMPREHENSIVE SOLUTIONS INVISALIGN G5 FOR DEEP BITES Horizontal rectangular attachments Optimized attachments for retention and extrusion No features for intrusion Pressure areas for intrusion No bite ramps 7 2014 Align Technology, Inc. Precision bite ramps customized per patient, per stage 7
MORE COMPREHENSIVE SOLUTIONS INVISALIGN G5 FOR DEEP BITES 8 2014 Align Technology, Inc. 8
CLINCHECK PRO EASE OF USE WITH GREATER CONTROL Simple user interface for precise control of the treatment goal for each patient Adjustments for moving single tooth to whole dentition in real-time 9 2014 Align Technology, Inc. 9
CLINCHECK PRO WITH 3D CONTROLS 10 2014 Align Technology, Inc. 10
INVISALIGN TODAY Highly predictable, consistent results Complex Invisalign treatments Dr. Yau Dr. Toki 11 2014 Align Technology, Inc. 11
EVOLUTION OF INVISALIGN INNOVATION 2000-08 2009 2010 2011 2013 2014 Process optimization 1.5 Release Invisalign G3 Invisalign G4 SmartTrack Invisalign G5 Optimal treatment protocols Improvement of device accuracy and design Manufacturing process automation 3D printing process development TOOL BOX SmartForce features provide extrusion and rotation force systems to achieve predictable tooth movements SOLUTIONS Improved Power Ridge feature for control of lingual root torque Precision Cuts designed for use with elastics to help treat Class II and Class III Next generation of SmartForce features for greater root tip control and improved predictability Multi-tooth extrusion for anterior open bite Invisalign G4 for improved root control Next generation aligner material improves control of tooth movements with Invisalign ClinCheck Pro Comprehensive SmartForce features for greater tooth control and predictability of Deep Bite treatment 3D controls provide more precise control over the final tooth position 12 2014 Align Technology, Inc. 12
INNOVATION ACCELERATES ADOPTION AND UTILIZATION GROWTH Smart Track 170,000 Case Shipments G4 17,000 150,000 130,000 110,000 Submitting Orthodontists Avg # Cases / Orthothodists 1.5 G3 21.9 24.2 26.4 15,000 13,000 11,000 90,000 18.0 9,000 70,000 50,000 9.8 12.0 12.6 11.9 12.5 14.4 13.7 13.8 7,000 5,000 30,000 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 3,000 Note: Utilization for North American Orthodontists 13 2014 Align Technology, Inc. 13
MORE COMPLETE SOLUTIONS APPLIED ACROSS MALOCCLUSION SEGMENTS Deep Bite Extraction Class II Cross Bite Class III 14 2014 Align Technology, Inc. 14
INCREASING INVISALIGN APPLICABILITY WITH BROADER SOLUTIONS FOR ALL TYPES OF MALOCCLUSIONS Crowding Class II Deep Bite Cross Bite Class III 70% 60% 50% 40% Invisalign Treated Treated Another Way 30% 20% 10% 0% Crowding Class II Class I Deep bite Midline Asymmetry Spacing Posterior Crossbite Diastema Open Bite Class III Anterior Crossbite Source: Align product efficacy study, Dec 2012 North America Customers 15 2014 Align Technology, Inc. 15
THE ALIGN INNOVATION ADVANTAGE BIOMECHANICS AUTOMATED TREATMENT PLANNING & MANUFACTURING EXCEPTIONAL R&D CAPABILITIES MATERIALS INTRAORAL SCANNING 3D DESIGN & MODELING 16 2014 Align Technology, Inc. DATA MINING MACHINE LEARNING 16
EXTENDING OUR LEAD THROUGH INNOVATION Experienced global team of innovators Extensive knowledge and expertise in orthodontics and digital dentistry Unmatched product pipeline of expanded solutions Customer-centric focus and collaboration 17 2014 Align Technology, Inc. 17
Driving clear aligner therapy towards standard of care for orthodontics while helping to transform our customers dental practices