Dr. Hem C Jha EDUCATION Ph. D., Birla Institute of Technology, Pilani, 2010. M.Sc., Devi Ahilya Vishwavidyalaya, Indore, 2003. B.Sc., University of Rajasthan, Jaipur, 2001. WORK EXPERIANCE Ramanujan Fellow: Indian Institute of Technology Indore, India (2016 - ). Research Associate: University of Pennsylvania, Philadelphia, USA (2015-16). Postdoctoral Fellow: University of Pennsylvania, Philadelphia, USA (2010-15). AWARDS AND FELLOWSHIP Ramanujan fellowship award from Department of Science and Technology (DST), India (2016). Ramalingaswami fellowship award from Department of Biotechnology (DBT), India (2015). Not availed. Outstanding post doctoral fellow by India Biosciences for Young Investigator Meeting (YIM) at Srinagar, India (2015). Outstanding Young Investigator at Young Investigator Meeting (YIM-Boston), USA (2014). Judge in platform presentation and poster presentation in 13 th Annual Biomedical Postdoctoral research symposium, at University of Pennsylvania, Philadelphia, USA (2014). Distinguished postdoctoral fellow at 5 th National Post Doc association organized at Rutgers University, New Jersey USA, (2013). Senior research fellowship from Indian Council of Medical Research, India (2008). Second prize in poster presentation "Biosparks"07, 5 th Annual Research Festival, SLS, JNU, New Delhi, India (2007). First prize in poster presentation at International symposium on recent advances in cardiovascular sciences (RACS). Global conference on heart disease. DIPSAR, New Delhi, India (2007).
Senior research fellowship from University Grant Commission, India (2005). Junior research fellowship from UGC-CSIR, India (2003) Research: Host-pathogen interaction- Epstein-Barr virus and Helicobacter pylori associated coinfection in cancer progression. Epigenetic regulation- Pathogens derived pathogenesis in cancer. Pathogens burden during viral infection of Gastric Cancer, Head and Neck Cancer and Multiple Sclerosis. Drug discovery in cancer and infectious agents derived diseases. Genetic Engineering PUBLICATION Jha HC, Pei Y and Robertson ES. Epstein Barr Virus: Diseases Linked to Infection and Transformation. Front. Microbiol. 2016, 7:1602. doi: 10.3389/fmicb.2016.01602. Pei Y, Banerjee S, Sun Z, Jha HC, Robertson ES. E2F6 regulation through EBNA3C in EBV associated B cell malignancy. Plos Pathogens. 2016; 12(8), e1005844. Jha HC, Sun Z, Upadhayay SK, El-Naccache D, Robertson ES. KSHV-mediated regulation of Par3 and SNAIL contributes to cell transformation. Plos Pathogens. 2016, 12 (7): e1005801. doi:10.1371/journal.ppat.1005801. Sun Z, Jha HC, Pei Y, Robertson ES. Involvement of RIG family proteins in KSHV induced malignancy. Journal of Virology. 2016, doi: JVI.01079-16. Shukla SK ±, Jha HC ±, El-Naccache D, Robertson ES. Role of amino acid 130-159 amino terminus domain of EBNA3C during early EBV infection. Oncotarget, 2016, DOI: 10.18632/oncotarget.7502. ± Equal contribution. Jha HC ±, Banerjee S ±, Robertson ES. Role of Gammaherpesviruses in Cancer Pathogenesis. Pathogens. 2016, 5(1), 18; ± Equal contribution. Jha HC ±, Mehta D ±, Lu J, El-Naccache D, Shukla S, Kovacsics C, Kolson D, Robertson ES. Gammaherpesvirus infection in neuronal cells. mbio 6(6):e01844-15. doi:10.1128/mbio. 01844-15, ± Equal contribution Research highlight appeared in EurekAlert, ScienceDaily, Medscape, Penn Medicine highlighted news.
Saha A ±, Jha HC ±, Upadhayay S, Robertson ES. Epigenetic silencing of tumor suppressor genes during in vitro Epstein-Barr virus infection. PNAS 2015 Sep 15;112(37):E5199-207, ± Equal contribution. Jha HC ±, Shukla SK ±, Lu J, Aj MP, Banerjee S, Robertson ES. Dissecting the roles of EBNA3C domains important for EBV-induced B-cell growth and proliferation. Oncotarget. 2015 Oct 6;6(30):30115-29, JIF:6.6. ± Equal contribution. Sun Z, Jha HC, Robertson ES. LANA mediated Bub1 recruits PCNA during KSHV latent replication and DNA translasion synthesis. Journal of Virology. 2015 Oct 15;89(20):10206-18. Jha HC, Yang K, El-Naccache D, Sun Z, Robertson ES. EBNA3C regulates p53 through induction of Aurora Kinase B. Oncotarget 2015 Oncotarget, 6(8), 5788-5803. Uppal T, Jha HC, Verma SC, Robertson ES. Chromatinization of the KSHV genome during KSHV life cycle. Cancers (Review) 2015, 7(1), 112-142. Banerjee S ±, Jha HC ±, Robertson ES. Regulation of the metastasis suppressor Nm23-H1 by tumor viruses. Naunyn-Schmiedeberg's Arch Pharmacol (review) (2015) 388:207 224, ± Equal contribution. Jha HC ±, Lu J ±, Verma SC, Banergee S, Mehta D, Robertson ES. KSHV genome programming during the early stages of primary blood mononuclear cell infection. mbio. 2014, 5(6):e02261-14, ± Equal contribution. Dzeng RK ±, Jha HC ±, Lu J, Saha A, Banergee S, Robertson ES. Small Molecule Growth Inhibitors of Human Oncogenic Gammaherpesvirus Infected B-Cells. Molecular Oncology. 2015; 9: 365-376, ± Equal contribution. Banerjee S, Lu J, Cai Q, Sun Z, Jha HC, Robertson ES. EBNA3C augments Pim-1mediated phosphorylation 1 and degradation of p21 to promote B-cell proliferation. PLoS Pathogens. 2014;10(8): e1004304. Sun Z, Xiao B, Jha HC, Lu J, Banerjee S, Robertson ES. KSHV encoded LANA can induce chromosomal instability through targeted degradation of the mitotic checkpoint kinase Bub1. J Virology. 2014; 88(13):7367-78. Jha HC ±, Prasad M ±, Saha A, Banerjee S, Lu J, Robertson ES. EBV essential antigen EBNA3C attenuates H2AX expression. J Virology. 2014; 88(7): 3776-88. ± Equal contribution. Jha HC, Lu J, Saha A, Cai Q, Banerjee S, Prasad M, Robertson ES. EBNA3C-Mediated Regulation of Aurora Kinase B Contributes to Epstein-Barr Virus-Induced B-Cell Proliferation through Modulation of the Activities of the Retinoblastoma Protein and Apoptotic Caspases. J Virology. 2013; 87(22):12121-38.
Banerjee S, Lu J, Cai Q, Saha A, Jha HC, Dzeng RK, Robertson ES. The EBV latent antigen 3C inhibits apoptosis through targeted regulation of interferon regulatory factors 4 and 8. Plos Pathogens. 2013; 9(5), e1003314. Jha HC ±, Upadhyay SK ±, Prasad M, Lu J, Cai Q, Saha A, Robertson ES. H2AX phosphorylation is important for LANA mediated KSHV episome persistence. J Virology. 2013; 87(9):5255-69. ± Equal contribution. Banerjee S, Jha HC, Cai Q, Robertson ES. Burkitt's Lymphoma. 2013. Springer New York (Book Chapter). ISBN 978-1-4614-4312-4. Gao J, Cai Q, Lu J, Jha HC, Robertson ES. Upregulation of Cellular Bcl-2 by the KSHV Encoded RTA Promotes Virion Production. PLoS ONE. 2011; 6 (8): e23892. Srivastava P, Bhengraj AR, Jha HC, Vardhan H, Jha R, Singh LC, Salhan S, Mittal A. Differing Effects of Azithromycin and Doxycycline on Cytokines in Cells from Chlamydia trachomatis-infected Women. DNA Cell Biol. 2012; 31(3): 392-401. Jha HC, Srivastava P, Vardhan H, Singh LC, Bhengraj AR, Prasad J, Mittal A. Chlamydia pneumoniae heat shock protein 60 is associated with apoptotic signaling pathway in human atheromatous plaques of coronary artery disease patients. J Cardiology. 2011; 58(3):216-25. Jha HC, Srivastava P, Prasad J, Mittal A. Chlamydia pneumoniae heat shock protein 60 enhances expression of ERK, TLR-4 and IL-8 in atheromatous plaques of coronary artery disease patients. Immunological Investigation. 2011; 40(2), 206-222. Upadhayay SK, Jha HC, Saha A, Robertson ES. Cancer associated Viruses (Book Chapter). 2011. Springer, ISBN 978-1-4614-0016-5. Vardhan H, Bhengraj AR, Jha R, Srivastava P, Jha HC, Mittal A. Higher expression of ferritin protects Chlamydia trachomatis infected HeLa 229 cells from reactive oxygen species mediated cell death. Biochem Cell Biol. 2010; 88:1 8. Jha HC, Divya A, Prasad J, Mittal A. Circulatory plasma inflammatory marker in male and female coronary artery disease patients. Heart & Lung: The Journal of Acute and Critical Care. 2010; 39(4), 296-303. Jha HC, Mittal A. Sequencing of Chlamydia pneumoniae in coronary artery disease patients attending tertiary hospital in India. American Journal of Infection Control. (Letters to Editor) 2010; Vol. 38 No. 6. Jha HC, Mittal A. Why first degree relatives of coronary artery disease patient's have Chlamydia pneumoniae infection. International Journal of Cardiology. (Letters to Editor) 2010, 144(3):e46-7.
Jha HC, Srivastava P, Divya A, Prasad J, Mittal A. Presence of Chlamydia pneumoniae is higher in aorta and coronary artery compared to carotid artery in coronary artery disease patients. APMIS. 2009; 117: 905 911. Srivastava P, Jha HC, Salhan S, Mittal A. Azithromycin treatment modulates cytokine production in Chlamydia trachomatis infected women. Basic & Clinical Pharmacology & Toxicology. 2009;104, 478 482. Jha HC, Srivastava P, Sarkar R, Prasad J, Mittal A. Higher serum level of IL-8 and IL-4 in Chlamydia pneumoniae infected coronary artery disease patients may indicate disease pathogenesis. Mediators of Inflammation. 2009; 2009:561532. Vardhan H, Dutta R, Vats V, Gupta R, Jha R, Jha HC, Srivastava P, Bhengraj AR, MittalA. Elevated IL-8 promotes cellular sustenance not the proliferation of Chlamydia trachomatis infected HeLa 229 cells. Mediators of Inflammation. 2009; 2009: 417658. Jha HC, Mittal A. Coronary Artery Disease patient's first degree relatives may be at higher risk for atherosclerosis. International Journal of Cardiology (Letters to Editors) 2009 Jul 10; 135 (3):408-9. Jha HC, Srivastava P, Sarkar R, Prasad J, Mittal A. Chlamydia pneumoniae IgA and elevated level of IL-6 may synergize to accelerate coronary artery disease outcome. Journal of Cardiology. 2008; 52: 140-145. Srivastava P, Gupta R, Jha HC, Jha R, Bhengraj AR, Salhan S, Mittal A. Serovar specific immune responses to peptides of variable regions of Chlamydia trachomatis Major Outer Membrane Protein in serovar D infected women. Clinical and Experimental Medicine. 2008; 8(4):207-15. Jha HC, Prasad J, Mittal A. High IgA seropositivity for combined Chlamydia pneumoniae, Helicobacter pylori infection and high sensitive C-reactive protein in Coronary Artery Disease patients in India can serve as atherosclerotic marker. Heart Vessels. 2008; 23: 390-396. Jha HC, Vardhan H, Gupta R, Verma R, Prasad J, Mittal A. Higher incidence of persistent chronic infection of Chlamydia pneumoniae among CAD patients in India is a cause of concern. BMC Infectious Diseases. 2007; 7:48. Research highlight appeared in Nature India (first article in first volume) news. RESEARCH OPPORTUNITIES
Students interested in pursuing Ph.D. in the field of Virology, Cancer, Multiple sclerosis, Drug discovery, Genetic engineering are most welcome to apply through the Indian Institute of Technology (IIT) Indore Ph.D. programme or can e-mail detailed curriculum vitae to hemcjha@iiti.ac.in Students with CSIR/UGC, DBT, ICMR, Inspire JRF or GATE qualifications are encouraged to apply Positions for 2 Ph.D. students are currently available Student: 1. JRF: Mr. Shyam Singh