Conference Theme. Pre-Conference Events

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Conference Theme Pediatric cancers are the leading cause of disease-related death in children however, childhood cancers possess a distinct etiology defined as a rare disease when contrasted with the adult cancer landscape. Due to being classified as a rare disease, pediatric cancer discovery efforts have unique challenges due to more limited basic and translational informatics infrastructure. At the same time, the rare nature of pediatric cancers creates an impetus for innovation in informatics to accelerate discovery and improve outcomes. Harnessing this potential through distributed and federated efforts in data generation, sharing, and analysis requires new approaches and tools to provide an opportunity for pediatric and adult cancers to partner in creating a collaborative data driven healthcare ecosystem. The 2017 Fall Conference will be focused on the roles of pediatric oncology in the context of a data driven and cancer data ecosystem. The main agenda is designed to understand and discuss both challenges and solutions in pediatric cancer. In the spirit of innovation and novel collaborative solutions, the initial workshop day is designed around machine learning and artificial intelligence, including techniques that cut across the domain of Cancer informatics. As a whole, the goal is to engage the CI4CC and pediatric communities to develop new ideas, create new partnerships, and build solutions that will ensure all cancer patients are best served by the cancer data ecosystem. Pre-Conference Events Cycling4CI Cycling Fundraiser, Sunday October 22, 8:00 am

Monday, October 23rd (Day Zero) Machine Learning / Artificial Intelligence Workshop Conference Welcome 8:00 am - 8:15 am Fall 2017 Conference Welcome Sorena Nadaf, MS, MMI (City of Hope Comprehensive Cancer Center) 8:15 am - 8:45 am Fall 2017 Conference Symposium Chairs Kickoff Adam Resnick, PhD (Children s Hospital of Philadelphia) Allison Heath, PhD (Children s Hospital of Philadelphia) 8:45 am - 9:30 am Special Keynote: Can AI Cure Cancer Marty Tenenbaum, PhD (Cancer Commons) 9:30 am - 10:00 am Booth Time / Networking Break Artificial Intelligence / Deep Learning Platforms 10:00 am - 10:30 am AI in Cancer: From Cells to Sentences Ravi Pandya (Microsoft) 10:30 am - 11:00 am Machine Learning in the Cloud Angel Pizzaro MSE (Amazon Web Services) 11:00 am - 11:30 am Artificial Intelligence: Opportunities & Obstacles in Cancer Genomics Casey Greene, PhD (UPenn) 11:30 am - 1:00 pm Networking Lunch & Special Corporate Introduction by Inspirata Inc. Cancer Information Data Trust Dr. Trevor Heritage 1:00 pm - 2:00 pm The Future of AI in Healthcare: an Interactive Session/Panel Panel Chair: Adam Resnick, PhD (CHOP) - Ravi Pandya (Microsoft) - Samuel Volchenboum, MD, PhD (University of Chicago) - Marty Tenenbaum, PhD (Cancer Commons) - Casey Greene, PhD (UPenn) Pediatric Commons and Platforms 2:00 pm - 2:30 pm St. Jude Pediatric Cancer Genome Project Brady Davis (DNAnexus) 2:30 pm - 3:00 pm Supporting the Pediatric Data Landscape Michael Hultner PhD (Seven Bridges) 3:00 pm - 3:15 pm Booth Time / Networking Break

3:15 pm - 3:45 pm Data Sharing, Visualization and Analysis with PedcBioPortal Pichai Raman, PhD (Children s Hospital of Philadelphia) 3:45 pm - 4:30 pm Building a Pediatric Research Data Commons Samuel Volchenboum, MD, PhD (University of Chicago) Cancer Center Director Keynote and Reception 4:30 pm - 5:15 pm Cancer Center Director s Keynote Stephen B. Gruber, M.D., Ph.D., M.P.H. (USC) 5:45 pm Cancer Center Director s Reception and Society Dinner Tuesday, October 24th (Day One) Patients and Foundations as Partners in Cancer Informatics 8:00 am - 8:05am Welcome Day 1 Adam Resnick, PhD (Children s Hospital of Philadelphia) Allison Heath, PhD (Children s Hospital of Philadelphia) 8:05 am - 9:05 am Cancer Center Leaders Panel Panel Chair: Steven T. Rosen, M.D. (COH Comprehensive Cancer Center) - Stephen B. Gruber, M.D., Ph.D., M.P.H. (USC) - Peter Yu M.D., FACP, FASCO (MSKCC/Hartford) - Larry W. Kwak, M.D., Ph.D (City of Hope Comprehensive Cancer Center) - Mike Prados M.D. (University of California, San Francisco) - Ching Lau M.D., Ph.D. (Connecticut Children s/jax) 9:05 am - 9:30 am Dragon Master Foundation and Open Data Amanda Haddock (President) 9:30 am - 9:55 am Putting the Levers in the Hands of Parents: Participants as Drivers Katherine Lambertson (Genetic Alliance) 9:55 am - 10:25 am Booth Time / Networking Break 10:25 am - 10:50 am Sage and Children s Tumor Foundation: Partners in Collaborative Rare Disease Research Robert Allaway, PhD (Sage Bionetworks) 10:50 am - 11:15 am Using chatbots and social networking to collect family health history Brandon Welch MS, PhD (Medical University of South Carolina) 11:15 am - 12:00 pm Corporate Keynote Oracle Health Sciences Machine Learning and Artificial Intelligence in Cancer Informatics Summerpal Kahlon, MD

12:00 pm - 1:00 pm Networking Lunch National Pediatric Cancer Initiatives 1:00 pm - 1:25 pm NCI TARGET Jaime Guidry Auvil, PhD (National Cancer Institute) 1:25 pm - 1:50 pm An Introduction to the Childhood Cancer Data Lab Casey Greene, PhD (University of Pennsylvania) 1:50 pm - 2:15 pm SU2C and Immunotherapy Platforms for Pediatric Cancers Kristopher Bosse, MD (Children s Hospital of Philadelphia) 2:15 pm - 2:40 pm The Gabriella Miller Kids First Data Resource Center (DRC) Allison Heath, Ph.D. (Children s Hospital of Philadelphia) Cancer Diagnostics, Precision Medicine and Clinical Trials in Pediatrics 2:40 pm - 3:05 pm Pediatric and Young Adult Early Case Capture Eric Durbin, DrPH (University of Kentucky) 3:05 pm - 3:30 pm Pediatric cancer clinical trial and research consortia landscape: From COG to consortia-based initiative Angela Waanders, MPH MD (Children s Hospital of Philadelphia) 3:30 pm - 3:55 pm Clinical Utility of Integrated Genomic Profiling in Pediatric Cancers Marilyn Li, MD (Children s Hospital of Philadelphia) 3:55 pm - 4:20 pm N of 1 Trials: TGEN and the Pacific Pediatric Neuro-Oncology Consortium (PNOC) Mike Prados MD (University of California, San Francisco) 4:20 pm - 4:45 pm Genomic Analysis Methods for Identification of Cancer Driver Pathways in Childhood Brain Tumors Lauren Sanders (University of California, Santa Cruz) 4:45 pm - 5:05 pm Precision Oncology in Pediatric Oncology Ching Lau M.D., Ph.D. (Connecticut Children s/jax) 5:05 pm - 5:30 pm Cancer Genomics and Cognitive Computing: Bending the Analysis Curve Aditya Pai, (IBM) Evening Program 6:00 pm Reception 8:00 pm Social Event (Casual)

Wednesday, October 25th (Day Two) Cancer Data Commons, Data Sharing and Initiative Updates 8:00 am - 8:05 am Welcome Day 2 Sorena Nadaf, MS, MMI (City of Hope Comprehensive Cancer Center) 8:05 am - 8:30am The Changing Data-Driven Discovery Landscape of Cancer: A Retrospective 8:30 am - 9:00 am Cancer Research Data Commons Allen Dearry, PhD (National Cancer Institute) 9:00 am - 9:45 am Corporate Keynote: Forte CTmatch4CC: Federated Trial Matching for Cancer Cures Laura Hilty, Regina Schwind, Paul Eggerling-Boeck 9:45 am - 10:15 am Proteomics and Imaging Data Commons Izumi Hinkson, PhD 10:15 am - 10:45 am Bloodpac Ryan Dittamore, PhD Cancer Center Informatics Shared Resource & Core Updates 10:45 am - 11:15 am Cancer Center Shared Resources 10min updates Moderator: Scott Sobecki (Vanderbilt University) CI4CC Initiatives Updates, Recognitions, Raffle, and Meeting Conclusion 11:15 am - 11:45am CI4CC Society Updates Sorena Nadaf MS, MMI, Warren Kibbe PhD - Cancer Center CCSG IT Initiative Kickoff, Other Initiative updates - Fall 2018 Wrap Up and Recognitions - Spring 2018 Symposium Announcement