19 3 2007 6 Chinese Bulletin of Life Sciences Vol. 19, No. 3 Jun., 2007 1004-0374(2007)03-0321-05 ( 510405) Wnt Notch BMP R735.35; R730.21 A From crypt stem cell to colorectal cancer WEN Bin*, CHEN Weiwen (Guangzhou University of Chinese Medicine, Guangzhou 510405, China) Abstract: The intestinal epithelium follows the paradigms of stem cell biology established for other self-renewing tissues. With a unique topology, it constitutes a two-dimensional structure folded into valleys and hills: the proliferative crypts and the differentiated villi. Its unprecedented self-renewal rate appears reflected in a high susceptibility to renewal and those that underlie colorectal cancer are remarkably symmetrical. Wnt BMP and Notch signaling cascades play a critical roles in epithelial self-renewal and cancer. The malignant transformation of the intestinal epithelial cells does not rely on mutational changes in generic oncogenes or tumor suppressors, rather, the transformation process appears to specifically subvert the physiological regulators of the epithelium, the mutation of colon stem cell maybe an initial story of oncogenesis, colorectal cancer is the results of depressed of colon stem cell differention. Key words: colorectal cancer; crypt stem cell; tumour stem cell; signaling transduction 10 10 [1-2] [3] 2006-12-29 2007-01-23 (30400602 30672687) (1971 ) * E-mail wen_bin04@yahoo.com.cn
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