UvA-DARE (Digital Academic Repository) Cancer and thrombosis van Es, N. Link to publication Citation for published version (APA): van Es, N. (2017). Cancer and thrombosis: Improvements in strategies for prediction, diagnosis, and treatment General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (http://dare.uva.nl) Download date: 25 Dec 2018
CANCERANDTHROMBOSIS CANCERANDTHROMBOSIS improvementsinstrategiesfor prediction,diagnosis,andtreatment NickvanEs NickvanEs
CANCER AND THROMBOSIS: IMPROVEMENTS IN STRATEGIES FOR PREDICTION, DIAGNOSIS, AND TREATMENT Nick van Es
Copyright 2017, N. van Es, Amsterdam, The Netherlands No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means, without prior written permission of the author. ISBN 978 94 6299 749 3 Author: Layout: Cover: Printed by: Nick van Es Nick van Es Photo by Stepan Popov Ridderprint Financial support for printing this thesis was kindly provided by Itreas, Stichting ter Bevordering van de Klinische Epidemiologie, Stichting tot Steun Promovendi Vasculaire Geneeskunde, Bayer, Boehringer Ingelheim, Chipsoft, Daiichi Sankyo, Federatie Nederlandse Trombosediensten, LEO Pharma, Medcon International, Pfizer, Sanofi Aventis, Servier Nederland Farma, Stichting AMSTOL, University of Amsterdam, and Wim Bos Transport. Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.
CANCER AND THROMBOSIS: IMPROVEMENTS IN STRATEGIES FOR PREDICTION, DIAGNOSIS, AND TREATMENT ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. ir. K.I.J. Maex ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel op vrijdag 17 november 2017, te 14.00 uur door Nick van Es geboren te Naarden
PROMOTIECOMMISSIE Promotores prof. dr. S. Middeldorp AMC UvA prof. dr. P.M.M. Bossuyt AMC UvA Copromotores prof. dr. H.R. Büller dr. M. Di Nisio AMC UvA Università degli studi Gabriele d'annunzio di Chieti Overige leden: prof. dr. D.P.M. Brandjes prof. dr. S.C. Cannegieter prof. dr. F.W.G. Leebeek dr. J.M.M.B. Otten prof. dr. R.J.G. Peters prof. dr. H.C.P.M. van Weert AMC UvA LUMC Erasmus MC Rotterdam Slotervaartziekenhuis, Amsterdam AMC UvA AMC UvA Faculteit der geneeskunde
CONTENTS CHAPTER 1 General introduction and outline 10 CHAPTER 2 Deep vein thrombosis and pulmonary embolism 18 PART I CHAPTER 3 CHAPTER 4 CHAPTER 5 CHAPTER 6 CHAPTER 7 Improvements in strategies for prediction Comparison of risk prediction scores for venous thromboembolism in cancer patients: a prospective cohort study The Khorana score for the prediction of venous thromboembolism in patients with pancreatic cancer: a retrospective cohort study The Khorana score for the prediction of venous thromboembolism in patients with solid cancer: an individual patient data meta analysis Extracellular vesicles exposing tissue factor for the prediction of venous thromboembolism in patients with cancer: a prospective cohort study Risk prediction for venous thromboembolism in patients with solid cancer: derivation and validation of a clinical prediction model 52 74 90 108 126 PART II Improvements in strategies for diagnosis CHAPTER 8 CHAPTER 9 CHAPTER 10 Wells rule and D dimer testing to rule out pulmonary embolism: a systematic review and individual patient data meta analysis The original and simplified Wells rules and age adjusted D dimer testing to rule out pulmonary embolism: an individual patient data meta analysis Screening for occult cancer screening in patients with unprovoked venous thromboembolism: a systematic review and individual patient data meta analysis 146 168 184
Part III Improvements in strategies for treatment CHAPTER 11 CHAPTER 12 CHAPTER 13 Direct oral anticoagulants compared with vitamin K antagonists for acute symptomatic venous thromboembolism: clinical evidence from phase 3 trials Edoxaban for venous thromboembolism in patients with cancer: results from a non inferiority subgroup analysis of the Hokusai VTE randomised, double blind, double dummy trial Edoxaban for treatment of venous thromboembolism in patients with cancer: rationale and design of the Hokusai VTE cancer study 210 230 250 CHAPTER 14 Summary and perspectives 262 APPENDICES Nederlandse samenvatting 276 List of peer reviewed publications 280 Authors and affiliations 283 Portfolio 290 Dankwoord 294 About the author 297