SUBSIDIARIES EXHIBIT 21 Johnson & Johnson, a corporation, had the U.S. and international subsidiaries shown below as of December 31, 2017. Certain U.S. subsidiaries and international subsidiaries are not named because they were not significant in the aggregate. Johnson & Johnson is not a subsidiary of any other entity. Name of Subsidiary U.S. Subsidiaries: Abbott Medical Optics, Inc. Acclarent, Inc. Actelion Pharmaceuticals US, Inc. Actelion US Holding Company Advanced Sterilization Products Services Inc. Alios BioPharma, Inc. ALZA Corporation AMO Development, LLC AMO Holdings, Inc. AMO Manufacturing USA, LLC AMO Sales and Service, Inc. AMO USA, LLC AMO USA Sales Holdings, Inc. AMO US Holdings, Inc. Aragon Pharmaceuticals, Inc. BioMedical Enterprises, Inc. Biosense Webster, Inc. Centocor Research & Development, Inc. Codman & Shurtleff, Inc. Coherex Medical, Inc. Cordis LLC CoTherix Inc. DePuy Mitek, LLC DePuy Products, Inc. DePuy Spine, LLC DePuy Synthes Products, Inc. DePuy Synthes Sales, Inc. DePuy Synthes, Inc. Diabetes Diagnostics, Inc. Ethicon Endo-Surgery, Inc. Ethicon Endo-Surgery, LLC Ethicon LLC Ethicon US, LLC Ethicon, Inc. Heartport, Inc. Janssen Biotech, Inc. Janssen Global Services, LLC Janssen Oncology, Inc. Janssen Ortho LLC Texas California Massachusetts Indiana Ohio Massachusetts Ohio Texas
Janssen Pharmaceuticals, Inc. Janssen Products, LP Janssen Research & Development, LLC Janssen Scientific Affairs, LLC Janssen Supply Group, LLC Janssen-Cilag Manufacturing, LLC Johnson & Johnson (Middle East) Inc. Johnson & Johnson Consumer Inc. Johnson & Johnson Finance Corporation Johnson & Johnson Health and Wellness Solutions, Inc. Johnson & Johnson Health Care Systems Inc. Johnson & Johnson Innovation - JJDC, Inc. Johnson & Johnson International Johnson & Johnson Japan Inc. Johnson & Johnson Services, Inc. Johnson & Johnson Urban Renewal Associates Johnson & Johnson Vision Care, Inc. JOM Pharmaceutical Services, Inc. LifeScan, Inc. LifeScan LLC LifeScan Products LLC McNeil Consumer Pharmaceuticals Co. McNeil Healthcare LLC Medical Device Business Services, Inc. MegaDyne Medical Products, Inc. Mentor Texas L.P. Mentor Worldwide LLC Micrus Endovascular LLC NeoStrata Company, Inc. NeuWave Medical, Inc. Novira Therapeutics, Inc. Ortho Biologics LLC Ortho Biotech Holding LLC Patriot Pharmaceuticals, LLC Pulsar Vascular, Inc. Rutan Realty LLC SterilMed, Inc. Synthes USA Products, LLC Synthes USA, LLC Synthes, Inc. TearScience, Inc. The Anspach Effort, LLC Torax Medical, Inc. Vogue International LLC Michigan Florida California Indiana Utah Minnesota Florida
International Subsidiaries: Actelion Ltd Apsis Apsis GmbH Beijing Dabao Cosmetics Co., Ltd. Berna Rhein B.V. Biosense Webster (Israel) Ltd. Cilag AG Cilag GmbH International Cilag Holding AG Cilag Holding Finance Unlimited Company CNA Development GmbH Cordis de, S.A. de C.V. Covagen AG Crucell N.V. DePuy DePuy International Limited DePuy Unlimited Company DePuy Synthes Eos Limited DePuy Synthes Gorgan Limited DePuy Synthes Jason Limited DePuy Synthes Leto S.A.R.L. EES, S.A. de C.V. Ethicon Unlimited Company Ethicon PR Holdings Unlimited Company Ethnor del Istmo, S.A. Global Investment Participation B.V. GMED Healthcare BVBA J.C. General Services CVBA Janssen Biologics () Janssen Biologics B.V. Janssen Cilag Farmaceutica S.A. Janssen Egypt Janssen Holding GmbH Janssen Inc. Janssen Irish Finance Company UC Janssen Korea Ltd. Janssen Pharmaceutica NV Janssen Pharmaceutica (Proprietary) Limited Janssen Pharmaceutical Janssen Pharmaceutical K.K. Janssen Pharmaceutical Sciences Unlimited Company Janssen R&D Janssen Sciences UC Israel Luxembourg Panama Argentina Egypt Canada Korea, Republic of South Africa Japan
Janssen Vaccines & Prevention B.V. Janssen Vaccines AG Janssen Vaccines Corp. Janssen-Cilag Janssen-Cilag A/S Janssen-Cilag AB Janssen-Cilag AG Janssen-Cilag B.V. Janssen-Cilag de S. de R.L. de C.V. Janssen-Cilag Farmaceutica Ltda. Janssen-Cilag Farmaceutica, Lda. Janssen-Cilag GmbH Janssen-Cilag Kft. Janssen-Cilag Limited Janssen-Cilag Limited Janssen-Cilag NV Janssen-Cilag OY Janssen-Cilag Pharma GmbH Janssen-Cilag Pty Ltd Janssen-Cilag S.A. Janssen-Cilag S.p.A. Janssen-Cilag, C.A. Janssen-Cilag, S.A. Janssen-Cilag, S.A. de C.V. JJC Acquisition Company B.V. Johnson & Johnson () Investment Ltd. Johnson & Johnson () Limited Johnson & Johnson (New Zealand) Limited Johnson & Johnson (Philippines), Inc. Johnson & Johnson (Proprietary) Limited Johnson & Johnson (Thailand) Ltd. Johnson & Johnson AB Johnson & Johnson AG Johnson & Johnson Finance Company Johnson & Johnson Consumer Holdings Johnson & Johnson Consumer NV Johnson & Johnson Consumer Services EAME Ltd. Johnson & Johnson de Argentina S.A.C. e. I. Johnson & Johnson de Chile S.A. Johnson & Johnson de Colombia S.A. Johnson & Johnson de Venezuela, S.A. Johnson & Johnson del Ecuador S.A. Johnson & Johnson del Peru S.A. Johnson & Johnson do Brasil Industria E Comercio de Produtos Para Saude Ltda. Korea Denmark Brazil Portugal Hungary Thailand Finland Austria Colombia Italy Venezuela Spain New Zealand Philippines South Africa Thailand Argentina Chile Colombia Venezuela Ecuador Peru Brazil
Johnson & Johnson European Treasury Company Johnson & Johnson Finance Limited Johnson & Johnson Financial Services GmbH Johnson & Johnson for Export & Import LLC Johnson & Johnson Gesellschaft m.b.h. Johnson & Johnson GmbH Johnson & Johnson Group Holdings GmbH Johnson & Johnson Hellas Commercial and Industrial S.A. Johnson & Johnson Hellas Consumer Products Commercial Societe Anonyme Johnson & Johnson Holding GmbH Johnson & Johnson Holdings K.K. Johnson & Johnson Inc. Johnson & Johnson Industrial Ltda. Johnson & Johnson Innovation Limited Johnson & Johnson International Financial Services Company Johnson & Johnson K.K. Johnson & Johnson Korea Selling & Distribution Limited Liability Company Johnson & Johnson Limitada Johnson & Johnson Limited Johnson & Johnson LLC Johnson & Johnson Luxembourg Finance Company Sarl Johnson & Johnson Management Limited Johnson & Johnson Medical Johnson & Johnson Medical (Shanghai) Ltd. Johnson & Johnson Medical B.V. Johnson & Johnson Medical GmbH Johnson & Johnson Medical Korea Limited Johnson & Johnson Medical Limited Johnson & Johnson Medical, S.A. de C.V. Johnson & Johnson Medical NV Johnson and Johnson Medical (Pty) Ltd Johnson & Johnson Medical Pty Ltd Johnson & Johnson Medical S.A. Johnson & Johnson Medical S.p.A. Johnson & Johnson Medical Taiwan Ltd. Johnson & Johnson Medical, S.C.S. Johnson & Johnson Medikal Sanayi ve Ticaret Limited Sirketi Johnson & Johnson Middle East FZ-LLC Johnson & Johnson Nordic AB Johnson & Johnson Pacific Pty. Limited Johnson & Johnson Poland Sp. z o.o. Johnson & Johnson Private Limited Johnson & Johnson Pte. Ltd. Johnson & Johnson Pty. Limited Johnson & Johnson Romania S.R.L. Egypt Austria Austria Greece Greece Japan Canada Brazil Japan Korea, Republic of Portugal Russian Federation Luxembourg Korea, Republic of South Africa Argentina Italy Taiwan Venezuela Turkey United Arab Emirates Poland India Singapore Romania
Johnson & Johnson S.p.A. Johnson & Johnson Sante Beaute Johnson & Johnson Sihhi Malzeme Sanayi Ve Ticaret Limited Sirketi Johnson & Johnson Swiss Finance Company Limited Johnson & Johnson Taiwan Ltd. Johnson & Johnson UK Treasury Company Limited Johnson & Johnson Vision Care () Johnson & Johnson, S.A. Johnson & Johnson, S.A. de C.V. Johnson & Johnson, s.r.o. Johnson & Johnson, s.r.o. Latam International Investment Company Unlimited Company Latam Properties Holdings Unlimited Company Lifescan LifeScan Scotland Limited McNeil AB McNeil Denmark APS McNeil Healthcare (UK) Limited McNeil AB Medos International Sarl Medos Sarl Mentor B.V. Mentor Holding PP Mentor Medical Systems B.V. OBTECH Medical Sarl OMJ Unlimited Company OMJ PR Holdings Limited Omrix Biopharmaceuticals Ltd. OptiMedica Corporation Shanghai Johnson & Johnson Limited Shanghai Johnson & Johnson Pharmaceuticals, Ltd. Synthes GmbH Synthes Holding AG SYNTHES Medical Immobilien GmbH Synthes Produktions GmbH Turnbuckle Investment Unlimited Company Xian-Janssen Pharmaceutical Ltd. Italy Turkey Taiwan Spain Czech Republic Slovakia Denmark Israel