The first year of operation of PSI s new SC cyclotron and beam lines for proton therapy.

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The first year of operation of PSI s new SC cyclotron and beam lines for proton therapy. Marco Schippers, Jürgen Duppich, Gudrun Goitein, Eugen Hug, Martin Jermann, Anton Mezger,Eros Pedroni, for the PROSCAN team (>50 persons) Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 1

PROSCAN: Stand-alone facility at PSI January-June 2007 Cyclotron Experiment OPTIS-2 Degrader Med. Pavillon Gantry-2 Energy selection Gantry-1 10 m Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 2

Contents Acceptance tests of cyclotron Commissioning of beam lines Operation experience Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 3

Acceptance tests and commissioning of cyclotron Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 4

250 MeV SC-cyclotron basic design: NSCL (Henry Blosser) Delivered by ACCEL/Varian an intensive collaboration Sign contract: April 2001 Extracted beam: April 2005 Beam on Gantry-1: June 2006 First patient: Febr 2007 Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 5

Levels of Quality Assurance of cyclotron Measurements for information & reference, not specified e.g.: field maps Acceptance of subsystems (factory acceptance by ACCEL) e.g.: coil-winding vacuum Acceptance tests (37) defined by PSI acceptance measurements e.g.: beam quality nr. of beam interruptions access to components / exchange time acceptance checks e.g.: documentation Dec 05 - Febr 06 33 done & OK Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 6

Energy measurement Ion chamber in water tank to measure proton range Range in water => E=250.4(1) MeV Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 7

Reliability: beam interruptions 16 unscheduled interrupts, automatic restart, 10 hour test nr of interrupts 14 12 10 8 6 4 Result: No beam during 3.0 minutes (spec: <6 min=1%), nr longer than 10 sec = 2 (spec: < 5) 2 0 1 6 11 16 21 26 31 36 41 46 51 56 interrupt length (sec) Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 8

Beam on/off and stability Vertical deflector in cycl. Center -beam on/off Necessary for fast dynamic scanning (Gantry-2) Acceptance tests: repetition rate 1 khz beam off < 50 μsec intensity stability σ<5% (for Gantry-1 and München: ) Beam intensity On/off by means of Vertical deflector in center 0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 time (ms) 40 μs 0.6 0.7 0.8 ms Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 9

Scan modes of new Gantry-2 Spot scanning: step & shoot Cont. scanning TV mode khz-intensity modulation intensity 0 time (ms) 10 7 s for a 1 liter volume. Target repainting: 17 scans / 2 min. Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 10

Fast intensity control with Vertical Deflector Intensity + beam scanning: Dose 15 cm / 30 ms David Meer, Christian Hilbes, (Dec. 2006) Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 11

Intensity control - Max intensity set by: Ion source + phase slits Roles of deflector plate: - decrease drift of intensity - set requested intensity within 5% Febr. 2007: start program to reach spec=> best:σ =3 % (see poster) Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 12

Extraction efficiency Rextr R=30cm 140 probe signal (%) 120 100 80 60 40 20 Simulations of probe efficiency Measurement of current on probe: Extr eff= 80.6% 0 30 40 50 60 70 80 90 Radius in cyclotron (cm) Electrostatic extraction elements R=30 cm: 100% Routinely: 80-83% Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 13

>80% extraction efficiency: Low dose to service staff inside cyclotron Mid plane, open cap 24 h after beam off, June 2007 (extracted beam integral 72 μa.h) : on pole, closed cap: mid plane, open pole cap: 400 μsv/h (40 mrem/h) 250 μsv/h (25 mrem/h) Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 14

Commissioning of beam lines Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 15

Beam-energy adjustment Degrader unit Q Q Q Steerer Kicker dispersive focus; position E-error Carbon wedge degrader 238-70 MeV 5 mm ΔRange in 50 ms Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 16

Energy scanning, Estep ~5 mm range in water. Current in Dipole Degrader +0.5 MeV Beam energy error -0.5 MeV 50 ms Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 17

Energy: Degrader error sensitivity Slit aperture: dp/p ± 0.5% E degrader MLFC If degrader-error ±5 MeV: E-shift (MeV). 200 MeV: ± 1.5 90 MeV: ± 0.2 - highest sensitivity at high energy - if degrader error <1 MeV: mainly transmission loss. Measured Range (cm) Range Variations: σ = 0.4 mm σ = 0.4 mm σ = 0.3 mm =>σe < 0.05% Cycl+beamline Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 18

Transmission Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 19

Dual scattering system for OPTIS-2 Transmission = 0.5% at 70 MeV, dp/p=+/- 1% => Optimize scattering system Beam 5 cm 1 st foil widens beam 2 nd foil flattens beam W Al Dual Ring: eff. = 36% Multiple Ring: eff. = 57% The Multiple Ring solution follows the ideas presented by Yoshihisa Takada (poster PTCOG43) Test foil made by laser ablation (Fachhochschule Windisch) Design model tested and confirmed at HMI Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 20

Operation experience Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 21

Operation during patient treatment Febr-May 2007: 18 patients treated at Gantry-1 Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 22

Operation statistics first 15 weeks of patient treatment HF power, extracted beam, arc current of ion source. Machine Up when: HF on AND Ion source high 961 hours Up Time 18 patients Gantry-1 Availability = 95% Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 23

Analysis of Unsched. Down Time UDT per week: occurs as single events MTBF (UDT>0.5 h) 1.5-2 weeks (typically at start up) Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 24

Conclusions and Outlook: We are happy with performances of cyclotron and beam lines Last problems are being solved Patient treatment has started at Gantry-1 and runs successfully Currently in progress: (see poster). acquire experience and optimize operation commissioning OPTIS-2 installation Gantry-2 Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 25

The End Marco Schippers, Cyclotron conf., Catania Oct. 1-5, 2007 26