Healthberry 865 Anthocyanins with proven health benefits
About Evonik Evonik is the creative industrial group from Germany and one of the world s leading specialty chemicals companies. Around 80 percent of Evonik s sales come from marketleading positions, which we are systematically expanding. In 2016, our more than 35,000 Evonik employees produced sales of 12.7 billion and an operating result (EBITDA) of 2.165 billion. Our business activities are aligned with three global megatrends: besides resource efficiency and globalization, our focus is also on the key growth sector of health and nutrition. Our Health Care Business Line is firmly embedded within the Evonik Group, enabling us to promise our customers stability and staying power essential components for building long-term partnerships. Performance through partnership Our capabilities and processes have been honed over decades of development, manufacturing and logistics, by collaborating with our customers to deliver the right product at the right price, in the right place at the right time. We have also built a global presence that ensures local proximity. That makes us even more effective in understanding where our customers are coming from and helping them to get where they want to go. Evonik means stability and reliability in securing your launchpad towards long-term growth. Meeting the evolving demands of a global, growing, diverse and increasingly discerning consumer base is especially tough in the food industry. The pressure is on to keep delivering unique food experiences, and the rise of nutraceuticals is just one indication of the challenges ahead. Evonik is now uniquely positioned to transform these challenges into opportunities as your enabler in realizing a whole new potential for creating more innovative, better and healthier nutraceuticals. 2 L+L 17-01-041 vnd Br Healthberry 865, DIN A4, us.indd 13. Jul 2017; 16:44 Uhr
Introducing Healthberry 865 The main obstacle to adding antioxidants like anthocyanins in effective doses to the human diet has always been the sheer amount of fruits or vegetables that would have to be ingested to achieve a significant effect. Until now. Healthberry 865 is an innovative, ready-to-use natural compound with a high anthocyanin content 30 percent derived from bilberries and blackcurrants. It is combined with maltodextrin and citric acid as excipients. The complex, patented production process ensures a constant, stable composition. Our product builds on the antioxidant properties of anthocyanins that is, their ability to scavenge the free radicals and chelate the metal ions that are viewed as causes for diseases and aging in humans. The positive effects of anthocyanins on human health range from preventing heart disease, diabetes and certain forms of cancer to strengthening the nervous system and visual acuity. These health benefits are scientifically proven. Though standardized mainly for anthocyanins cyanidin-3-glucoside (C 3G) and delphinidin- 3-glucoside (D3G), our formulation also contains other anthocyanins such as cyanidin-3-rutinoside (C3R) and cyanidin-3-galactoside (C3Gal). Healthberry 865 packs the health promoting power of anthocyanins into a convenient solution for nutraceutical and food supplement design. 3
The case for Healthberry 865 The amount of actual bilberries and blackcurrants needed to achieve the same antioxidative effect as Healthberry 865 would be impossible to incorporate into single daily servings. Scientifically proven health benefits The active ingredients of Healthberry 865 have been subjected to independent clinical cell line, animal and human randomized double-blind placebo-controlled trials at universities, university hospitals and pharmacological companies in Europe, Canada, the US and China. The findings all concur on the value of the anthocyanins contained in Healthberry 865 in health promotion and disease prevention. 4 L+L 17-01-041 vnd Br Healthberry 865, DIN A4, us.indd 13. Jul 2017; 16:44 Uhr
100 % natural product origin Derived from natural bilberries and blackcurrants, Healthberry 865 contains consistently high-quality ingredients of Norwegian and New Zealand origin. Constant product composition The patented production process prevents the seasonal fluctuations of active ingredients occurring in the raw material, thus ensuring a constant, stable composition. Easy handling and processing Healthberry 865 is supplied in powder form for easy admixture into nutraceutical formulations. Supply security Evonik s capabilities as a global manufacturer with world-class logistics ensure that Healthberry 865 customers can count on an unparalleled degree of product availability. 5
Designing new, healthier nutraceuticals Applications The main application area is dietary supplements, where the typical scenario would be to integrate Healthberry 865 into a customer s formulation. Application success is already proven in commercial products. This route offers the advantage of ready usability. Healthberry 865 could also be a value-add factor in functional food design, such as energy and sports foods and beverages. Beyond the product, support More than an excellent product with a proven performance, Healthberry 865 comes with over six decades of know-how in optimal formulation and delivery systems as part of the package. So our team can mesh with yours, providing the technical application, analytics and formulation support to translate your idea into a nutraceutical reality. 6 L+L 17-01-041 vnd Br Healthberry 865, DIN A4, us.indd 13. Jul 2017; 16:44 Uhr
Healthberry 865: Opening a world of possibilities for enhancing existing food lines and creating new, targeted nutraceutical solutions for specific markets. Anthocyanins: a natural source of health benefits Anthocyanins are water-soluble pigments that belong to the class of flavonoids. Depending on the ph, they are responsible for the red, blue and purple colors of several fruits and vegetables, with red indicating higher acidity and dark blue being associated with strong alkalinity. Sources rich in anthocyanins are berries, cherries, red grapes, red wine, red cabbage and the black variants of soybean and rice. Anthocyanins are trusted colorants in the food industry. The antioxidative properties of anthocyanins are potent as well, and they are increasingly documented in scientific studies. The effectiveness of anthocyanins in supporting heart health, diabetes, obesity, cancer prevention and eye health is no longer questioned. The following anthocyanins are present in high concentrations in Healthberry 865: Malvidin Pelargonidin Cyanidin Common anthocyanins Petunidin Delphinidin Peonidin Cyanidin-3-glucoside (C 3G) Delphinidin-3-glucoside (D3G) Cyanidin-3-rutinoside (C 3R) Six main anthocyanins occurring in nature Cyanidin-3-galactoside (C 3Gal) They are derived from blackcurrants and bilberries grown in Norway and New Zealand and known for their high purity. 7
The benefits of Healthberry 865 are backed by scientific studies Normal coronary artery Cardiovascular disease (CVD) prevention There are several components to CVD pathology, and several risk factors, such as atherosclerosis, hypertension, hyperlipidemia, inflammation and oxidative stress, accelerate the disease. Human intervention studies performed with Atherosclerosis Healthberry 865 showed positive effects on several of these parameters in promoting heart health. The studies (in vivo) show increased HDL-cholesterol and decreased LDLcholesterol levels, which underscores a heart health promoting effect, in people at risk of developing CVD. Healthberry 865 has also been given recommended usage status by the Norwegian Heart and Lung Association. Artery Atherosclerotic Plaque (LDL accumulation) Bad (LDL) stores cholesterol in the blood stream Good (HDL) regulates LDL storage and promotes excretion Scientific studies Cardiovascular Dyslipidemic people HDL levels cholesterol efflux to serum Pre-hypertensive men HDL levels LDL levels Patients with hypercholesterolemia HDL levels flow mediated dilation LDL levels pro-inflammatory cytokines Qin Y et al., (2009) Am J Clin Nutr, 90 (3):485-92 Hassellund SS et al., (2013) J Hum Hypertens, 27 (2):100-6 Zhu Y et al., (2011) Clin Chem, 57 (11):1524-1533 Zhu Y et al., (2013) Nutr Metab Cardiovasc Dis, 23 (9):843-9 In addition, the C 3G and D3G anthocyanins in Healthberry 865 not only reduce pro-inflammatory cytokines the proteins impacting the interactions between cells separately, but they also show beneficial synergies, further underscoring the product's efficacy in heart disease prevention. Take away Important outcome C 3G and D3G show synergies: C 3G pro-inflammatory cytokines D3G pro-inflammatory cytokines C3G + D3G in combination pro-inflammatory cytokine 1+1=3 The material used in the studies is MEDOX. As the active ingredients are exactly the same, the studies can be used for Healthberry 865 as well. Increase 8 L+L 17-01-041 vnd Br Healthberry 865, DIN A4, us.indd 13. Jul 2017; 16:44 Uhr Decrease
Positive impact on diabetes, obesity, cancer and eye health Adipocyte dysfunction is a common symptom in the development of obesity, as well as insulin resistance in diabetes. Studies (in vitro) show that supplementation of the C3G in Healthberry 865 significantly reduces fat accumulation in visceral areas and liver tissue. Specifically, the beneficial effects include reduced levels of the type of protein that builds up in obese individuals. The anthocyanins in Healthberry 865 also have a positive impact in cancer prevention. Tested on two leukemia cell lines, the effect of C3G exposure showed conclusively that C3G induces programmed cell death for malignant cells and reduces cell proliferation. This inhibitory effect is even more evident in malignant cells exposed to D3G. Eye health is another area in which the anthocyanins contained in Healthberry 865 are beneficial. Specifically, the C3G and C3R anthocyanins present in the product have a proven effect of stimulating and accelerating the regeneration of rhodopsin, a protein that is key to enabling vision in low-light conditions, for instance. Obesity Cancer Vision In rats, C3G regulates adipocytokine secretion, which is associated with obesity-linked disorders Tsuda T et al., (2004) Biochem Biophys 316:149-57 Tsuda T et al., (2005) Arch Biochem Biophys 1733(2-3):137-47 Proliferation of leukemia cells after C3G exposure Apoptosis of leukemia cells after C3G exposure Fimognari C et al., (2004) Biochem Pharm 67 (11):2047-56 Regeneration of rhodopsin (involved in light perception) after C3G and C3R exposure Plasma cholesteryl ester transfer protein (CETP) after C3 G exposure. Increased CETP found in obese individuals Cell invasion and migration of glioblastoma cells after D3G exposure Cell migration of glioblastoma cells after C3G exposure Qin Y et al., (2009) Am J Clin Nutr 90:485-92 Lamy S et al., (2007) J Cell Biochem 100 (1):100-11 Matsumoto H et al., (2003) J Agric Food Chem 51(12):3560-3 Take away Important outcome D3G and C3G both show positive effects in the prevention of obesity and cancer and the stimulation of eye health. Increase Decrease 9
Safe. Safer. Safest. Product safety is as essential to us as to our customers. We ve built our reputation on staying true to that simple and straightforward principle. At Evonik, maintaining the toughest standards, be they based on legislation or self-imposed, comes from selecting only the highest-quality raw materials and ensuring excellence in product manufacturing and supply, together with efficient and reliable order processing. And from never cutting corners. Our customers are always welcome to our facilities to assess and verify our capabilities and our commitment to quality and product safety. Healthberry 865 measures up to the toughest standards and more ISO 22000 certification pending Food safety assured: pesticides, heavy metals and biological contaminants are strictly controlled, and are all under detectable limits HACCP implementation pending GMO-free Free of European listed allergens, gluten-containing grains, crustaceans, eggs, fish, peanuts, soy, milk (including lactose), nuts, celery, mustard, sesame seed, sulfur dioxide, lupine and mollusks Statements on allergens, residual solvents and BSE/TSE are available upon request. 10 L+L 17-01-041 vnd Br Healthberry 865, DIN A4, us.indd 13. Jul 2017; 16:44 Uhr
Quality ingredients, quality products With a comprehensive range of quality systems, certification processes and analytics services, Evonik offers a solid basis for building trust in the quality of our products. Add this to a well-honed manufacturing and logistics platform, and what you get is not only the best guarantee for a product up to your high standards, but also the assurance of ready availability. That is because we know that when it comes to foods, consistency at all levels is key. And we understand that our products must deliver on your promise. Only with Healthberry 865 Evonik s proprietary HPLC tool for analyzing anthocyanins uniquely combines qualitative and quantitative parameters to deliver the precision and thoroughness that are essential to product performance: Excellent separation of single components Determination of reference sample content Quantitative analysis of all single anthocyanin glycosides in complex mixtures 11
This information and all further technical advice are based on our present knowledge and experience. However, it implies no liability or other legal responsibility on our part, including with regard to existing third party intellectual property rights, especially patent rights. In particular, no warranty, whether express or implied, or guarantee of product properties in the legal sense is intended or implied. We reserve the right to make any changes according to technological progress or further developments. The customer is not released from the obligation to conduct careful inspection and testing of incoming goods. Performance of the product described herein should be verified by testing, which should be carried out only by qualified experts in the sole responsibility of a customer. Reference to trade names used by other companies is neither a recommendation, nor does it imply that similar products could not be used. Healthberry reg. trademark of Evonik Industries AG and its subsidiaries. EVONIK NUTRITION & CARE GmbH Health Care Business Line Pharma & Food Ingredients healthberry@evonik.com www.evonik.com/healthberry