LIVER CANCER: NOVEL ADVANCEMENTS IN 2018

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MOUNT SINAI LIVER CANCER PROGRAM 13 TH ANNIVERSARY NOVEL ADVANCEMENTS IN 2018 FRIDAY, DECEMBER 14, 2018 Hatch Auditorium 1468 Madison Avenue, 2 nd floor New York, NY Program Director JOSEP M. LLOVET, MD, PhD Professor of Medicine Co-Director, Mount Sinai Liver Cancer Program Sponsored by Mount Sinai Liver Cancer Program 1st NCI recognized Liver Cancer Program in the U.S.

MOUNT SINAI LIVER CANCER PROGRAM NOVEL ADVANCEMENTS IN 2018 FRIDAY, DECEMBER 14, 2018 PROGRAM 8:30 9:00am Registration 9:00 9:10am Welcome and Opening Ramon Parsons, MD, PhD Director, Tisch Cancer Institute 9:10 9:40am Achievements of Mount Sinai Liver Cancer Program 2005-18 Josep M. Llovet, MD, PhD 9:40 10:20am Hans Popper Lecture: Introduction: Josep M. Llovet, MD, PhD HCC Incidence in the Era of DAA Drugs for HCV Infection Hashem B. El-Serag, MD, PhD Baylor College of Medicine 10:20 10:30am Coffee Break 10:30 10:50am NASH Epidemics and Liver Cancer Amon Asgharpour, MD Division of Liver Diseases, Department of Medicine 10:50 11:10am Epidemiology and Surveillance of HCC Paolo Boffetta, MD Hematology and Medical Oncology, Oncological Sciences, Preventive Medicine, Tisch Cancer Institute 11:10 11:30am The Promise of Liquid Biopsy in the Management of Liver Cancer Augusto Villanueva, MD, PhD 11:30 11:50am Classical vs Molecular Pathology in Liver Cancer M. Isabel Fiel, MD Mount Sinai Liver Cancer Program, Department of Pathology 11:50 12:30pm Lunch 13 TH ANNIVERSARY 10:30 11:50am PATHOGENESIS, EPIDEMIOLOGY AND DIAGNOSIS OF LIVER CANCER Chairman: Augusto Villanueva, MD, PhD, Mount Sinai Liver Cancer Program, Division of Liver Diseases 12:30 1:50pm MANAGEMENT OF LIVER CANCER (EARLY-INTERMEDIATE STAGE): Chairman: Myron Schwartz, MD, Mount Sinai Liver Cancer Program, Department of Surgery 12:30 12:50pm Recent Advances in the Surgical Treatment of Liver Cancer Myron Schwartz, MD Mount Sinai Liver Cancer Program, Department of Surgery

12:50 1:10pm Role of SBRT in the Treatment of HCC Kenneth Rosenzweig, MD Chair, Department of Radiation Oncology 1:10 1:30pm Chemoembolization and Radioembolization in HCC Management Edward Kim, MD Mount Sinai Liver Cancer Program, Department of Radiology, Department of Surgery 1:30 1:50pm Assessment of Radiological Response in Liver Cancer Sara Lewis, MD Department of Radiology 1:50 2:10pm Coffee Break 2:10 3:30pm MANAGEMENT OF LIVER CANCER (ADVANCED STAGE) Chairman: Josep M. Llovet, MD, PhD, Mount Sinai Liver Cancer Program, Division of Liver Diseases 2:10 2:50pm Molecular Targeted Therapies in Advanced HCC Josep M. Llovet, MD, PhD 2:50 3:10pm Emerging Immune Therapies in Liver Cancer Max Sung, MD Mount Sinai Liver Cancer Program 3:10 3:30pm Molecular Tumor Board in ISMMS Jane Houldsworth, PhD Division of Molecular Pathology 3:30 3:50pm Coffee Break 3:50 5:10pm NOVEL TARGETS AND BIOMARKERS FOR LIVER CANCER TREATMENT Chairman: Samuel Waxman, MD, Mount Sinai Liver Cancer Program Department of Hematology and Medical Oncology, Department of Oncological Sciences 3:50 4:10pm Biomarkers of Response to Immune Checkpoint Inhibitors in HCC Daniela Sia, PhD 4:10 4:30pm Experimental Models for Driver Identification in Liver Cancer Amaia Lujambio, PhD Mount Sinai Liver Cancer Program, Department of Oncological Sciences 4:30 4:50pm Anti-fibrotic Agents as a Chemopreventive Approach in Liver Cancer Youngmin Lee, MD, PhD 4:50 5:10pm Exploring Epigenetic Drugs in Liver Cancer Ernesto Guccione, PhD Department of Oncological Sciences, Department of Pharmacological Sciences 5:10pm Closing Remarks

MOUNT SINAI LIVER CANCER PROGRAM 13 TH ANNIVERSARY NOVEL ADVANCEMENTS IN 2018 FRIDAY, DECEMBER 14, 2018 Hatch Auditorium 1468 Madison Avenue, 2nd floor New York, NY Complimentary Online Registration International Attendees $100 Cancellation Policy: All refund and cancellation requests must be emailed to the CME office at cme@mssm.edu by December 7, 2018. Cancellations after this date are not eligible for a refund. An administrative fee of $50 will be deducted from your refund. No refunds will be issued for registration fees that are equal to or less than $50. Conference Information Office of CME at 212-731-7950 e-mail: cme@mssm.edu

Location Hatch Auditorium, Guggenheim Pavillion, 2nd floor. 1468 Madison Ave, New York, NY Directions and Parking: www.icahn.mssm.edu/about/visiting ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI Program Director JOSEP M. LLOVET, MD, PhD, Professor of Medicine Co-Director, Mount Sinai Liver Cancer Program Program Chairs MYRON SCHWARTZ, MD, Professor of Surgery, Director of Liver Surgery SAMUEL WAXMAN, MD, Professor of Medicine, Department of Hematology and Medical Oncology, Department of Oncological Sciences AUGUSTO VILLANUEVA, MD, PhD, Target Audience Hepatologists and Gastroenterologist, Oncologists, Surgeons, Radiologist, Pathologists and Basic Scientists interested in liver cancer from the New York Area and beyond. Activity Description This conference will assemble multidisciplinary experts on chronic liver diseases, hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) from the Mount Sinai Liver Cancer Program and one outstanding invited lecturer. The meeting is intended to provide a summary of the state-of the-art knowledge of the novel advancements reported in 2018 on the pathogenesis and clinical management of liver cancer, including the research conducted in Mount Sinai. Activity Learning Objectives Recognize the new trends in the epidemiology of liver cancer and the impact of new anti-viral therapies. Review the current surgical and loco-regional treatments for liver cancer. Evaluate new molecular targeted therapies approved and in clinical development for HCC and cholangiocarcinoma. Describe novel targets and biomarkers for a precision medicine approach of liver cancer. Registration Fee International Attendees $100 All Others Complimentary Register Online at: Credit Designation The designates this live activity for a maximum of 7.0 AMA PRA Category 1 Credit(s). Physicians should claim only the credit commensurate with the extent of their participation in the activity. Accreditation The is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Verification of Attendance Verification of attendance will be provided to all professionals. Special Needs The is in full compliance with provisions of the Americans with Disabilities Act (ADA) and is accessible for individuals with special needs. If you require special accommodations please contact the Page and William Black Post-Graduate School of Medicine at 212-731-7950. Acknowledgment This activity is made possible in part by educational grants from: Bayer HealthCare, Celsion Corporation, Bristol-Myers Squibb, BTG International, Eisai, Glycotest

The Page and William Black Post Graduate School One Gustave L. Levy Place, Box 1193 New York, NY 10029-6574 MOUNT SINAI LIVER CANCER PROGRAM 13 TH ANNIVERSARY NOVEL ADVANCEMENTS IN 2018 DECEMBER 14, 2018 Hatch Auditorium, 1468 Madison Avenue, 2nd floor Complimentary Online Registration