NEW INSIGHTS IN RESEARCH, DIAGNOSIS, AND CLINICAL CARE

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Department of Epidemiology and Biostatistics University of California, School of Medicine University of California 11 TH ANNUAL OSTEOPOROSIS NEW INSIGHTS IN RESEARCH, DIAGNOSIS, AND CLINICAL CARE HOTE L KABUKI S A N FRA NCIS CO, CA LIFORNIA THURSDAY - FRIDAY Dennis M. Black, PhD Professor of Epidemiology and Biostatistics University of California, Ann V. Schwartz, PhD Associate Professor of Epidemiology and Biostatistics University of California,

11 TH ANNUAL OSTEOPOROSIS NEW INSIGHTS IN RESEARCH, DIAGNOSIS, AND CLINICAL CARE Hotel Kabuki, California Presented by the Department of Epidemiology and Biostatistics of the University of California, School of Medicine, this 2-day course features an expert faculty that will discuss the epidemiology, pathophysiology, diagnosis, and treatment of osteoporosis. Specific topics will include the cell biology of osteoporosis, bone biomechanics, endocrine and nutrition aspects of osteoporosis, and advances in skeletal imaging, such as CT and MRI scanning. The course will also critically review current treatment options and preview new treatments under study. There will be an emphasis on recent developments and current controversies in the etiology, diagnosis, and management of osteoporosis. TARGET AUDIENCE The course is designed for physicians and other professionals in health research or clinical care who would find additional scientific background in the disease helpful, including those specifically involved in osteoporosis such as clinical trial managers, statisticians, physical therapists, and radiologic technologists. No prior clinical or scientific training in osteoporosis is required. EDUCATIONAL OBJECTIVES An attendee completing this course should be able to improve clinical competence to: Use the combination of both bone mineral density and the WHO/FRAX calculator to diagnose osteoporosis and predict fracture risk; Include both non-pharmacological and pharmacological counseling and therapy to patients for osteoporosis prevention and management; Include new pharmacological therapies in treatment of osteoporosis; Evaluate the benefits and risks of continuing long-term osteoporosis therapy; Recognize and treat osteoporosis. ACCREDITATION The University of California, School of Medicine (UCSF) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. UCSF designates this live activity for a maximum of 12.25 AMA PRA Category 1 Credit/s TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity. This CME activity meets the requirements under California Assembly Bill 1195, continuing education and cultural and linguistic competency. Nurses: For the purpose of recertification, the American Nurses Credentialing Center accepts AMA PRA Category 1 Credit issued by organizations accredited by the ACCME. Pharmacy: The California Board of Pharmacy accepts as continuing professional education those courses that meet the standard of relevance to pharmacy practice and have been approved for AMA PRA Category 1 Credit. AAFP: Application for CME credit has been filed with the American Academy of Family Physicians. Determination of credit is pending. Geriatric: The approved credits shown above include 12.25 credits toward meeting the requirement under California Assembly Bill 1820, Geriatric Medicine.

11 TH ANNUAL OSTEOPOROSIS NEW INSIGHTS IN RESEARCH, DIAGNOSIS, AND CLINICAL CARE THURSDAY, JULY 24, 2014 8:00 am Registration and Continental Breakfast Bone Strength and Fracture Epidemiology 8:30 Bone Structure and Function and the Dolores Shoback, MD Bone Remodeling Cycle 9:10 Q&A 9:20 Beyond BMD: Bone Quality and Bone Strength Mary Bouxsein, PhD 10:00 Q&A 10:05 Break 10:25 Risk Factors for Fracture Dennis Black, PhD 10:50 Q&A Tools of Risk Assessment and Diagnosis 10:55 Osteoporosis Diagnosis: BMD, FRAX and Steven Harris, MD, FACP Assessment of Secondary Osteoporosis 11:30 Q&A 11:40 Lunch (on your own) Special Topics in Osteoporosis 1:10 pm Bad to the Bones: Corticosteroids and Prevention Nancy Lane, MD of Corticosteroid-induced Osteoporosis 1:40 Q&A 1:45 Bad to the Bones: Cancer Treatments and Other Jonathan Graf, MD Medications 2:15 Q&A 2:20 Ask for a Consult. Panel on Treatment of Jonathan Graf, MD Osteoporosis Secondary to Medications. Steven Harris, MD Nancy Lane, MD 2:50 Break 3:10 Kyphosis: Causes, Consequences, Treatment Wendy Katzman, PhD 3:45 Q&A 3:50 Osteoporosis in Chronic Kidney Disease TBD 4:20 Q&A Treatment and Prevention: Non-Pharmacologic Interventions 4:25 The Other Half of the Fracture Equation: Edgar Pierluissi, MD Fall Prevention and Management 4:55 Q&A 5:00 pm Adjourn GENERAL INFORMATION Advanced registration closes one (1) business day prior to start of course. REGISTRATION INFORMATION Tuition: $425 Physicians $325 Nurses/Pharmacists/ Allied Health Professionals/ Residents/Fellows Payment may be made by Visa, MasterCard, AmEx or check. REGISTER VIA: Online: www.cme.ucsf.edu Mail: Complete course registration form and send with payment to: UCSF Office of CME P.O. Box 45368, CA 94145-0368 Fax: Fax completed registration form to: (415) 502-1795 (be sure to include your credit card number) Phone: To register by phone or to inquire about registration status, please call UCSF s CME Registration Office at (415) 476-5808. On-Site Registration: Generally we are able to accommodate on-site registration at our courses however pre-registration is preferred to ensure that we have adequate course materials. Please check our website for up-to-date information on the course: www.cme.ucsf.edu REFUND POLICY Cancellations received in writing before the first day of the course will be refunded, less a $75 administrative fee. No refunds will be made on cancellations received after that date.

FRIDAY, JULY 25, 2014 8:00 am Continental Breakfast Hotel Kabuki, California Treatment and Prevention: Non-Pharmacologic Interventions continued 8:30 Vertobroplasty and Kyphoplasty Doug Bauer, MD 8:55 Q&A 9:00 Controversies in the Use of Vitamin D and Calcium Deborah Sellmeyer, MD 9:30 Q&A 9:40 Break 10:00 Case Studies of Interpretation of BMD Scans Deborah Sellmeyer, MD 10:35 Q&A Treatment and Prevention: Pharmacologic Interventions 10:40 Bisphosphonates: Efficacy Dennis Black, PhD 11:05 Q&A 11:10 SERMS and Estrogen Clifford Rosen MD 11:25 Q&A 11:30 Lunch (on your own) Treatment and Prevention: Pharmacologic Interventions continued 1:00 pm Denosumab Clifford Rosen, MD 1:15 Q&A 1:20 Teriparatide Alone and in Combination with Anne Schafer, MD Anti-Resorptives 1:40 Q&A 1:45 Controversies in Long Term Treatment Dennis Black, PhD 2:10 Q&A 2:15 Bone Turnover Markers to Monitor Treatment Doug Bauer, MD 2:35 Q&A 2:40 Break Clinical Issues, Choices, and Dilemmas in Osteoporosis Therapy 3:00 An Overview of Treatment: Who and When to Treat Dolores Shoback, MD 3:30 Q&A New Treatments 3:35 Odanacatib and Anti-sclerostin Antibody: Mary Bouxsein, PhD New Treatments on the Horizon 3:55 Q&A 4:00 Ask for a Consult. A Roundtable on Steven Harris MD Osteoporosis Cases. Deborah Sellmeyer MD Cliff Rosen MD 4:40 Adjourn/Evaluations CONFERENCE LOCATION HOTEL KABUKI A block of guestrooms has been reserved at the special UCSF conference rate of $209/night. You are urged to make your reservations early. The cut-off date is June 23, 2014, or until the group room block is filled. After this date, rooms will be provided on a space-available basis only. To make hotel reservations on-line, go to www.cme.ucsf.edu and click on the hotel link in the Travel & Lodging section of the course webpage. If you prefer to telephone in your reservation, call 1-800-533-4567 and identify yourself as a member of this UCSF conference to receive the special rate. By staying at the host hotel, you help UCSF meet its contractual obligations and keep registration fees reasonable. RENTAL CAR Hertz is offering special rates for participants of this conference; simply call 800-654-2240 and refer to convention number 03BW0133, or call your travel agent. You may also make reservations at www.hertz.com. Advance reservations are recommended. AIR TRANSPORTATION UCSF has negotiated special fares with American and United Airlines for our course attendees. You may use the following tour codes to book on your own: American www.aa.com code: 1574DV United www.united.com code: ZS2J871241

0569 University of California, Office of Continuing Medical Education UCSF Box 0742, CA 94143-0742 E Printed on Recycled Paper For more information or to register online visit our website at www.cme.ucsf.edu. You may also reach us by calling the Office of CME at (415) 476-4251 or emailing info@ocme.ucsf.edu. COURSE DIRECTORS Dennis M. Black, PhD Professor of Epidemiology and Biostatistics University of California, Ann V. Schwartz, PhD Associate Professor of Epidemiology and Biostatistics University of California, GUEST FACULTY Mary L. Bouxsein, PhD Associate Professor, Department of Orthopedic Surgery Harvard Medical School, Boston, MA Nancy Lane, MD Endowed Professor of Medicine and Rheumatology University of California at Davis Davis, CA Clifford J. Rosen, MD Professor of Medicine Tufts University School of Medicine Maine Medical Center Research Institute Scarborough, ME Deborah E. Sellmeyer, MD Associate Professor of Medicine, Director, Johns Hopkins Metabolic Bone Center Baltimore, MD UCSF COURSE FACULTY (University of California, ) Douglas C. Bauer, MD Professor of Medicine and of Epidemiology and Biostatistics Jonathan Graf, MD Associate Professor of Medicine; Division of Rheumatology, General Hospital Steven T. Harris, MD, FACP Professor of Medicine Wendy Katzman, PT, DPTSc Assistant Professor of Physical Therapy & Rehabilitation Science Edgar Pierluissi, MD Associate Professor of Medicine Medical Director of the Acute Care for Elders Unit at the General Hospital Anne Schafer, MD Assistant Professor of Medicine, Division of Endocrinology VA Medical Center Dolores M. Shoback, MD Professor of Medicine, UCSF Endocrine Research Unit VA Medical Center

St St Course Registration Form www.cme.ucsf.edu 11 TH ANNUAL OSTEOPOROSIS: NEW INSIGHTS IN RESEARCH, DIAGNOSIS, AND CLINICAL CARE Hotel Kabuki, California Mail to : UCSF Office of CME P.O. Box 45368, CA 94145-0368 æ Dr. æ Mr. æ Mrs. æ Ms. Last Name First M.I. Degree Specialty Address City State Zip Daytime Phone Fax Email Address Label Code Letter (see address label: example, A, B, C, D, etc.) Would you like to be on our priority email list? Yes No Date of birth to be used as OCME registrant number: / / X X Month Day Please indicate if you have any special needs: Registration Fees: $425 Physicians $325 Nurses/Allied Health Professionals/Residents/Fellows Make checks payable to UC Regents Please charge my credit card: Visa MasterCard AmEx for $ / Card # Expiration date Name on Card (Please Print) Authorized Signature Refund Policy: Cancellations received in writing before the first day of the course will be refunded, less a $75 administrative fee. No refunds will be made on cancellations received after that date. Please check our website for up to date information on the course: www.cme.ucsf.edu. Hotel Kabuki 1625 Post Street, CA 94115 www.jdvhotels.com 415-922-3200 Webster St way c St kson St Vallejo St shington St ay St Sacramento St California St Pine St Bush St Sutter St Post St Laguna St Buchanan St Buchanan St Landmarks Neighborhoods Points of Interest Parks Cable Car Lines PACIFIC HEIGHTS JAPAN TOWN JAPANESE Octavia St Gough St LAFAYETTE PARK Hotel Kabuki ST. MARY'S anklin St Peter Yorke wy Starr K n Ness Av Vallejo St Broadway 101 Pacific St Jackson St Washington St Clay St Sacramento St California St Pine St Bush St Sutter St Post St Geary St rth St Cable Car Line Hyde St NOB HILL Leavenworth St Jones St MEP15001 Online registration: www.cme.ucsf.edu Registration Information: (415) 476-5808 Course Information: (415) 476-4251 Fax: (415) 502-1795 GRACE CATHEDRAL MASONIC AUDITORIUM SAN FRANCISCO O Farrell St O Farrell St Ellis St Taylor St Mason St Powell St t Stockton St CHINATOWN UNION SQUARE POR S AME