UvA-DARE (Digital Academic Repository) Bronchial Thermoplasty in severe asthma d'hooghe, J.N.S. Link to publication Citation for published version (APA): d'hooghe, J. N. S. (2018). Bronchial Thermoplasty in severe asthma General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (http://dare.uva.nl) Download date: 14 Jan 2019
BRONCHIAL THERMOPLASTY IN SEVERE ASTHMA Julia Nella Sofia d Hooghe
BRONCHIAL THERMOPLASTY IN SEVERE ASTHMA Thesis, Universiteit van Amsterdam, 2018 Julia Nella Sofia d Hooghe, The Netherlands, 2018 Lay-out: Loes Kema Cover design: Vincent Versluis Printed by: GVO drukkers & vormgevers, Ede, NL. ISBN: 978-94-6332-357-4 This thesis concerns research on Bronchial Thermoplasty (BT) and Optical Coherence Tomography (OCT) in severe asthma patients and is part of the Unravelling Targets of Therapy in Bronchial Thermoplasty in Severe Asthma (TASMA) trial (ClinicalTrials.gov No.NCT02225392). The TASMA study is an investigator initiated, multicentre, international randomized controlled trial funded by the Dutch Lung Foundation (grant nr 5.2.13.064JO), the Netherlands Organization for Health Research and Development (ZonMw) (grant nr 90713477), the Academic Medical Centre, University of Amsterdam and Boston Scientific. Material support was provided by: Boston scientific, Olympus and St. Jude Medical. Financial support for the publication of this thesis is provided by: Dutch Lung Foundation, Stichting Astma Bestrijding, Boston Scientific, Abbott Chipsoft B.V.
BRONCHIAL THERMOPLASTY IN SEVERE ASTHMA ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. ir. K.I.J. Maex ten overstaan van en door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel op dinsdag 5 juni 2018, te 14:00 uur door Julia Nella Sofia d Hooghe geboren te Ravenstein
PROMOTIECOMMISSIE: Promotor: Prof. dr. J.T. Annema Co-promotores: Dr. P.I. Bonta Dr. D.M. de Bruin Overige leden: Prof. dr. E.H.D. Bel Prof. dr. A.G.J.M. van Leeuwen Prof. dr. B. Preckel Prof. dr. P.L. Shah Dr. N.H.T. ten Hacken Dr. G.J. Braunstahl Imperial College London UMCG Franciscus Gasthuis & Vlietland Faculteit der Geneeskunde
TABLE OF CONTENTS PART I Introduction 7 Chapter 1 General introduction and aims of the thesis 9 PART II Bronchial Thermoplasty 25 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Emerging understanding of the mechanism of action of Bronchial Thermoplasty in asthma Journal of Pharmacology and Therapeutics 2018, 181: 101-107 Propofol and Remifentanil Sedation for Bronchial Thermoplasty: a Prospective Cohort Trial Respiration 2017, 93 (1): 58-64 Reduction of airway smooth muscle mass after Bronchial Thermoplasty: are we there yet? Am J Respir Crit Care Med 2015, 191 (10): 1207-1208 Clinical response of severe asthma patients following Bronchial Thermoplasty European Respiratory Journal 2017, PA3029, abstract Airway smooth muscle reduction after Bronchial Thermoplasty correlates with FEV 1 Submitted for publication, under review 22 51 67 71 77 PART III Imaging of the airway wall 85 Chapter 7 Chapter 8 Chapter 9 Optical Coherence Tomography and confocal laser endomicroscopy in pulmonary diseases Curr Opin Pulm Med 2017, 23 (3): 275-283 Identification and quantification of airway wall layers with Optical Coherence Tomography: a histology based validation study PloS One 2017, 12 (10): https://doi.org/10.1371/journal. pone.018414 Acute radiological abnormalities after Bronchial Thermoplasty Respiration 2017, 94 (3): 258-262 87 107 131
Chapter 10 Radiological abnormalities following Bronchial Thermoplasty: pathophysiology understood? Eur Respir J 2017, 50 (6): https://doi org/10.1183/13993003.01537-2017 139 PART IV Discussion 143 Chapter 11 Chapter 12 APPENDICES Appendix A Appendix B Appendix C Appendix D General discussion and summary Nederlandse samenvatting Ned Tijdschr Allergie en Asthma 2017, 17: 29-35 Acknowledgements (Dankwoord) List of Publications PhD Portfolio Curriculum Vitae 145 159 165 167 169 171 173