Hélène D. Moreau Postdoctoral fellow Spatio-temporal regulation of antigen presentation Unit, INSERM U932 Institut Curie, 12 rue Lhomond, 75005 Paris, France. +33 (0) 1.56.24.68.06 - helene.moreau@curie.fr Education and training PhD in Immunology 2010-2013 Institut Pasteur / Paris Diderot University / B3MI, Paris, France Undergraduate and graduate studies 2006-2010 Ecole Normale Supérieure / Paris Diderot University, Paris, France Qualifications PhD in Immunology (Summa Cum Laude, Honoris Causa) 2013 Paris Diderot University, Paris, France ENS Diploma - Biology 2010 Ecole Normale Supérieure (ENS), rue d'ulm, Paris, France Master's degree - Advanced Immunology (Summa Cum Laude) 2010 ENS / Institut Pasteur / Paris Diderot University "Agrégation" of Biochemistry - Bioengineering 2009 Highest teaching diploma in France Bachelor s degree - Biology (Magna Cum Laude) 2007 ENS / Paris Diderot University, Paris, France Research and teaching experience Postdoctoral fellow Spatiotemporal regulation of antigen presentation, INSERM U932, Institut Curie, Paris, France Principal Investigator: Dr AM Lennon Duménil Project title: Impact of biochemical and physical extracellular cues on dendritic cell function and migration 2014 - present Postdoctoral fellow 2013-2014 Principal Investigator: Dr P Bousso Project title: Molecular mechanisms regulating T cell dynamics during antigen recognition Teaching assistant in Immunology 2010-2013 Paris Diderot University, Paris, France PhD Thesis 2010-2013 Principal Investigator: Dr P Bousso Project title: Regulation and Signaling properties of T-cell immunological synapses and kinapses in vivo Master's degree intership (2 nd year) 2009 Principal Investigator: Dr P. Bousso Project title: T cell sensing of antigen affinity
Master's degree intership (1 st year) 2008 Mount Sinai School of Medicine, New York, NY, USA Principal Investigator: Prof. G. J. Randolph Project title: Impact of dyslipidemia on dendritic cell migration Bachelor's degree intership (3 rd year) 2007 Université de Montréal, INSERM U549, Montreal, Canada Principal Investigator: Dr P. Ancuta Project title: Differential susceptibility of T cell subsets to HIV infection Publications Scientific articles and reviews Moreau HD, Boggle G and Bousso P. Predicting the outcome of T cell activation by dendritic cells using a virtual lymph node model. In prep. Moreau HD, Lemaître F, Garrod KR, Lennon-Duménil AM and Bousso P. Signal strength regulates antigenmediated T cell deceleration by distinct mechanisms to promote exploration or arrest. Submitted. Moreau HD and Bousso P. Visualizing how T cells collect activation signals in vivo. Curr Opin Immunol 2014 Feb;26:56-62. Lemaître F, Moreau HD, Vadele L and Bousso P. Phenotypic CD8+ T cell diversification occurs before, during and after the first T cell division. J Immunol 2013 Aug 15;191(4):1578-85. Garrod KR, Moreau HD, Garcia Z, Lemaître F, Bouvier I, Albert ML and Bousso P. Dissecting T cell contraction in vivo using a genetically encoded reporter for apoptosis. Cell Reports. 2012 Nov 29;2(5):1438-47. Bousso P and Moreau HD. Functional Immunoimaging: the revolution continues. Nature Reviews Immunology. 2012 Dec;12(12):858-64. Moreau HD and Bousso P. DISC: a guide to in vivo cytometry. IntraVital. 2012 Jul/Aug/Sept;1(1):27-31. Cytometry uncovers TCR signaling during synapses and kinapses in vivo. Immunity. 2012 Aug 24;37(2):351-63. Beuneu H, Lemaître F, Deguine J, Moreau HD, Bouvier I, Garcia Z, Albert ML and Bousso P. Visualizing the functional diversification of CD8+ T cell responses in lymph nodes. Immunity. 2010 Sep 24;33(3):412-23. Book chapters Moreau HD. Respiration of Animals and interaction with the environment, Integrated functions of blood circulation, A phylogenetic approach of biodiversity. In: Denoeud J, Ferroir T, Guipponi O, Moreau H, Paulhiac-Pison M, Pons ML and Tejedor F. Biologie et Geologie, Performances Concours, 2 ème année, Lavoisier Ed. (Textbook for students in 2 nd year of Prep School, in French) Moreau HD. Functionnal organization of biomolecules, Chemistry of the living matter and biosynthesis, 2
Developmental biology of Vertebrates. In: Denoeud J, Godinot C, Guipponi O, Moreau H, Paulhiac-Pison M and Tejedor F. Biologie et Geologie, Performances Concours, 1 ère année, Lavoisier Ed. (Textbook for students in 1 st year of Prep School, in French) Moreau HD. Diversity and classification of living organisms, Respiration of Animals. In: MoreauHD, Denoeud J, Ferroir T, Guipponi O, Paulhiac-Pison M, Pons ML and Tejedor F. Biologie et Geologie, Méthodes et Annales, 2 ème année, Lavoisier Ed. (Textbook for students in 2 nd year of Prep School, in French) Moreau HD. Basic Biochemistry, Principles of cell metabolism and enzymology, Molecular and cell biology techniques. In: MoreauHD, Godinot C, Paulhiac-Pison M and Tejedor F. Biologie et Geologie, Méthodes et Annales, 1 ère année, Lavoisier Ed. (Textbook for students in 1 st year of Prep School, in French) Scientific communications Moreau HD, Lemaître F, Lennon-Dumenil AM and Bousso P. Regulation and signaling properties of T cell immunological synapses and kinapses in vivo. Short presentation, Annual meeting of the French Society for Immunology, Paris, France. 2013 November 6 th. Lemaître F, Moreau HD, Vedelle L and Bousso P. Phenotypic CD8 + T cell diversification occurs before, during, and after the first T cell division. Selected presentation for the «Young cytometrist award»", 17 th Annual Conference of the French Association for Cytometry, Strasbourg, France. 2013 October 16 th. Moreau HD and Bousso P. Dynamic In Situ Cytometry. Invited speaker, 17 th Annual Conference of the French Association for Cytometry, Strasbourg, France. 2013 October 16 th. Cytometry uncovers TCR signaling during synapses and kinapses in vivo. Short presentation, Immunology department retreat, Institut Pasteur, France. 2012 Oct 15-16. Moreau HD, Lemaître F, Terriac E, Azar G, Piel M, Lennon-Dumenil AM, and Bousso P. To stop or not to stop: the T cell dilemna. Short presentation, EMBO YIP PhD course, Heidelberg, Germany. 2012 Sept 10-15. Moreau HD, Lemaître F, and Bousso P. Dynamic In Situ Cytometry. Poster presentation, EMBO YIP PhD course, Heidelberg, Germany. 2012 Sept 10-15. Cytometry uncovers TCR signaling during synapses and kinapses in vivo. Poster presentation, Immunobiology and immunochemistry, Gordon conference, Les Diablerets, Switzerland. 2012 June 10-15. Moreau HD, Lemaître F, Terriac E, Azar G, Piel M, Lennon-Dumenil AM, and Bousso P. Vizualizing T cell sensing of TCR-pMHC affinity in vivo. Poster presentation, Immunology department retreat, Institut Pasteur, France. 2011 June 20-22. Moreau HD, Lemaître F, Terriac E, Azar G, Piel M, Lennon-Dumenil AM, and Bousso P. Vizualizing T cell sensing of TCR-pMHC affinity in vivo. Short presentation, Homeostasis and perturbations of Immunity, EMBO conference, Capo Caccia, Italy. 2011 3
May 15-22. Moreau HD, Lemaître F, Azar G, Celli S, and Bousso P. How T cells sense the affinity of TCR ligands in vivo? Short presentation, Immunology department retreat, Institut Pasteur, France. 2010 May 4-6. Fellowships and awards Post-doctoral fellowship 2014 Fondation ARC pour la recherche sur le cancer Post-doctoral fellowship 2013 Fondation pour la Recherche Médicale Thesis award 2013 Biological sciences national academy of pharmacy Thesis award 2013 French Society for Immunology Best oral presentation award 2012 Immunology department retreat, Institut Pasteur Best oral presentation award 2011 Homeostasis and perturbations of immunity, EMBO conference, Capo Caccia, Italy PhD felowship 2010 Ecole Normale Supérieure - Ministère de l'enseignement Supérieur et de la Recherche Best oral presentation award 2010 Immunology department retreat, Institut Pasteur 4
Skills Languages French (mother tongue), English (Oxford Placement Test: C2), Spanish (conversational) IT FlowJo, ImageJ, Imaris, Prism Graphpad, Illustrator, Office, EndNote Lab techniques Cell culture, Retroviral infection Animal experimentation (mouse, rat) Flow cytometry Epifluorescence imaging, Two-photon intravital and explanted imaging Statistical analyses (INSERM training) 5