INNOVATIONS IN BRAIN TUMOR MANAGEMENT

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APRIL 5-6, 2019 NEW YORK Memorial Sloan Kettering Cancer Center presents INNOVATIONS IN BRAIN TUMOR MANAGEMENT Rockefeller Research Laboratories 430 East 67th Street New York, New York

INNOVATIONS IN BRAIN TUMOR MANAGEMENT DAY 1 The overall objective of this course is to provide an up-to-date review of brain cancer. Day 1 will focus on the Innovations in Brain Tumor Management for practitioners. Day 2 will focus on Living with a Brain Tumor, a multidisciplinary review of care and services available at MSK. MSK Program Planning Committee Director, Neuro-Oncology Fellowship Program FRIDAY, APRIL 5 DAY 1 OVERVIEW Day 1, Innovations in Brain Tumor Management, will provide an up-to-date review of neuro-oncology including a review of the most common primary brain tumors. An emphasis will be placed on cutting edge innovations in the management of brain tumors essential for practitioners managing neuro-oncology patients, including novel treatment approaches and upcoming biomarker evaluations such as CSF cell free DNA. The target audience for day 1 includes physicians, trainees, and allied health professionals caring for patients with brain tumors. Associate Director, Neuro-Oncology Fellowship Program Learning Objectives Update participants on specific types of brain tumors encountered in clinical practice including low-grade gliomas, glioblastoma, primary CNS lymphoma, and meningioma Provide a review of the most cutting edge new and emerging treatment strategies for brain tumors, including targeted therapies, immunotherapies, and CAR T-cell therapies Review new and updated strategies for neurosurgical and radiation treatments for gliomas and brain metastases Acting Co-Chair, Co-Director, Neuro Advanced Care Unit Acting Co-Chair, 1 Day 1, Innovations in Brain Tumor Management, is directed towards healthcare providers. We invite patients and caregivers to attend day 2, Living with a Brain Tumor. #MSKneuro-oncologyCME 2

INNOVATIONS IN BRAIN TUMOR MANAGEMENT DAY 1 FRIDAY, APRIL 5 MSK Course Director (Day 1) Invited Course Faculty Director, Neuro-Oncology Fellowship Program Martin J. van den Bent, MD, PhD Director, Department of Neuro-Oncology The Brain Tumor Center at Erasmus MC Cancer Institute Christine Brown, PhD Associate Director, T Cell Therapeutics Research Laboratory; Departments of Hematology & Hematopoietic Cell Transplantation and Immuno-Oncology City of Hope MSK Course Faculty Acting Co-Chair, Co-Director, Neuro Advanced Care Unit Kathryn Beal, MD Associate Attending Department of Radiation Oncology Cameron W. Brennan, MD Director, Intraoperative MRI Department of Neurosurgery Lisa M. DeAngelis, MD Acting Physician-in-Chief, Memorial Hospital Lillian Rojtman Berkman Chair in Honor of Jerome B. Posner Eli L. Diamond, MD Assistant Attending Christian Grommes, MD Assistant Attending Acting Co-Chair, Robert J. Young, MD Director, 3T Neuroradiology Imaging Department of Radiology Jedd D. Wolchok, MD, PhD Chief, Melanoma & Immunotherapeutics Service Director, Parker Institute for Cancer Immunotherapy at MSK Timothy F. Cloughesy, MD Director, Neuro-Oncology Program; UCLA Health Minesh Mehta, MD Chief, Radiation Oncology; Department of Radiation Oncology Miami Cancer Institute at Baptist Health South Florida SCHEDULE 8:00 am Registration & Breakfast 8:30 am Welcome & Introduction 8:40 am Advances in Neuroimaging Robert J. Young, MD 9:00 am Lower Grade Glioma: at the end of the first stage? Martin J. van den Bent, MD, PhD 9:30 am Seizure Management in Glioma 9:50 am Q&A 10:00 am Break 10:10 am Innovations in Glioma Surgery Cameron W. Brennan, MD 10:30 am Radiation Therapy for Glioma Kathryn Beal, MD 10:50 am CAR T cell Therapy for Glioma Christine Brown, PhD 11:20 am Evaluation of Novel Agents in Glioblastoma Timothy F. Cloughesy, MD 11:50 am Q&A 12:00 pm Lunch 1:00 pm Advances in Immune Checkpoint Inhibition Jedd D. Wolchok, MD, PhD 1:30 pm Brain Metastases Minesh Mehta, MD 2:00 pm Meningioma 2:20 pm Q&A 2:30 pm Break 2:40 pm Precision Medicine Approaches in Neuro-Oncology 3:00 pm CNS Lymphoma Christian Grommes, MD 3:20 pm Histiocytosis and Erdheim-Chester Disease Eli L. Diamond, MD 3:40 pm Q&A 3:50 pm Closing Remarks and Perspectives Lisa M. DeAngelis, MD 4:10 pm Adjourn Networking Reception Attendees are invited to join the course faculty for a networking reception from 4:10-5:30 pm at Zuckerman Research Center. 3 4

LIVING WITH A BRAIN TUMOR DAY 2 SATURDAY, APRIL 6 DAY 2 OVERVIEW Day 2, Living with a Brain Tumor, will provide attendees education and up-to-date information on medical, behavioral, and social implications of a brain tumor diagnosis. It will introduce the multidisciplinary care clinic (MDCC) and services available at MSK for patients and caregivers to address coping skills and improve quality of life after brain tumor diagnosis. In addition to lectures, the conference will include opportunities for interactive conversation between participants and faculty. Learning Objectives The target audience for day 2 includes patients with primary brain tumors, caregivers of patients with brain tumors, nurses, residents, fellows, neurologists, neuro-oncologists, social workers, rehabilitation medicine physicians, case managers, and physical therapists. MSK is pleased to invite patients and caregivers to attend Saturday, April 6, on a complimentary basis. If you are a patient or caregiver interested in attending, please email cme@mskcc.org to register. Update participants on principle and rationale of clinical trials Learn about patient and caregiver services offered at MSK Introduce the multidisciplinary care clinic model-consisting of nurses, physical therapist, rehabilitation medicine doctor, nutritionist, case manager, social worker, and spiritual adviser. MSK Course Director (Day 2) Associate Director, Neuro-Oncology Fellowship Program SCHEDULE 8:30 am Breakfast 9:00 am Welcome & Introduction 9:05 am General Overview of Brain Tumor Therapies 9:30 am Patient and Practictioners Views on Clinical Trials Thomas Kaley, MD Dana Bossert, RN, BSN, OCN 9:55 am Q&A MSK Course Faculty Yesne Alici, MD, FACLP, FAPM Clinical Director, Psychiatry Service Department of Psychiatry Allison J. Applebaum, PhD Psychologist MSK Counseling Center Dana Bossert, RN, BSN, OCN Nursing Coordinator, ECD Registry Alan Carver, MD Attending Neurologist Director, Neuro-Oncology Fellowship Program Acting Co-Chair, Lisa Ruppert, MD Assistant Physiatrist, Assistant Director, Cancer Rehabilitation Medicine Fellowship Maryann Sibilla, BSN, RN Registered Nurse Outpatient Services 10:00 am Break 10:10 am Maintaining and Improving Mobility Lisa Ruppert, MD 10:30 am Coping with Brain Tumor Diagnosis Yesne Alici, MD, FACLP, FAPM 10:50 am Caregiver Burden: What To Do About It and How to Prevent It! Allison J. Applebaum, PhD 11:10 am Q&A 11:20 am Treating the Whole Patient from a Nursing Perspective Maryann Sibilla, BSN, RN 11:30 am Multidisciplinary Care Clinic Multidisciplinary Care Clinic Panel 11:55 am Q&A 12:00 pm Lunch 12:30 pm Closing Remarks Alan Carver, MD Dominique Jean-Charles, Anastasia Zankowsky, LMSW 12:45 pm Adjourn MSN, MPH, RN, CCM Clinical Social Worker 5 Nurse Case Manager - Case Management Department 6

COURSE REGISTRATION Registration Fees (Fri-Sat, April 5-6) Early General Physicians (MDs, PhDs and DOs) $300 $350 Residents, Fellows, Advanced Practice Providers, Nurses, and Other Healthcare Providers $100 $150 Industry Professionals** $575 $625 Registration Fees (Sat, April 6 Only) All Providers -- $75 *Early registration expires March 1, 2019 **Industry professionals may attend MSK CME activities for their own education. Marketing, sales, and promotion of products and services is strictly prohibited at MSK CME activities. ROCKEFELLER RESEARCH LABORATORIES Register Online: mskcc.org/neuro-oncology Course registration includes continental breakfast, lunch, and refreshment breaks. Please contact cme@mskcc.org at least one week prior to the course if you have any special dietary requests or require any specific accommodations. MSK is pleased to invite patients and caregivers to attend day 2 on a complimentary basis. If you are a patient or caregiver interested in attending, please email cme@mskcc.org to register (registration is required in order to attend). MSK CME offers a 30% discounted rate for MSK Alumni, MSK Cancer Alliance and Cancer Care Partners. If you are a member of one of these groups, please contact cme@mskcc.org for more information. MSK employee registration is complimentary. However, you must complete course registration in order to attend this course. Symposium Location Memorial Sloan Kettering Cancer Center Rockefeller Research Laboratories 430 East 67th Street New York, NY Accommodations For information on hotels in the vicinity of MSK with discounted rates, please visit: mskcc.org/cme. Contact Memorial Sloan Kettering Cancer Center Office of Continuing Medical Education mskcc.org/cme cme@mskcc.org Accreditation Memorial Sloan Kettering Cancer Center is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. AMA Credit Designation Statement Memorial Sloan Kettering Cancer Center designates this live activity for a maximum of 9.25 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Faculty Disclosure It is the policy of MSK to make every effort to insure balance, independence, objectivity, and scientific rigor in all continuing medical education activities which it provides as an ACCME accredited provider. In accordance with ACCME guidelines and standards, all faculty participating in an activity provided by MSK are expected to disclose any significant financial interest or other relationship with the manufacturer(s) of any commercial product(s) and/or provider(s) of commercial services which are discussed by the faculty members in an educational presentation. As required by the ACCME, when an unlabeled use of a commercial product or an investigational use not yet approved for any purpose is discussed during an educational activity, MSK requires the speaker to disclose that the product is not labeled for the use under discussion or that the product is still investigational. 7 8