Citation for published version (APA): Owusu, E. D. A. (2018). Malaria, HIV and sickle cell disease in Ghana: Towards tailor-made interventions

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UvA-DARE (Digital Academic Repository) Malaria, HIV and sickle cell disease in Ghana Owusu, E.D.A. Link to publication Citation for published version (APA): Owusu, E. D. A. (2018). Malaria, HIV and sickle cell disease in Ghana: Towards tailor-made interventions General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (http://dare.uva.nl) Download date: 29 Jan 2019

Malaria, HIV and sickle cell disease in Ghana: towards tailor-made interventions Malaria, HIV and sickle cell disease in Ghana: tailor-made Malaria, HIVtowards and sickle cell disease interventions in Ghana: towards tailor-made interventions Ewurama Dedea Ampadu Owusu Ewurama Dedea Ampadu Owusu AMC, University of Amsterdam Ewurama Dedea Ampadu Owusu AMC, University of Amsterdam 515651-sub01-os-Owusu.indd 1,6 17-04-18 10:33 Malaria, HIV and sickle cell disease 515651-L-sub01-os-Owusu Processed on: 17-4-2018

Malaria, HIV and sickle cell disease in Ghana: towards tailor-made interventions Ewurama Dedea Ampadu Owusu

Malaria, HIV and sickle cell disease in Ghana: towards tailor-made interventions PhD thesis, University of Amsterdam, the Netherlands ISBN: 978-94-028-1027-1 Layout and cover: Paranymphs: Printed by: Back page illustration: Ewurama Owusu Benjamin Jelle Visser & Esmée Ruizendaal Ipskamp printing, the Netherlands Adapted from https://www.pinterest.ch/pin/474637248209102528/ Copyright 2018 Ewurama DA Owusu, Amsterdam, the Netherlands Chapter 7 may not be reproduced, stored or transmitted in any form or by any means without the prior permission of the publisher of the included book chapter.

MALARIA, HIV AND SICKLE CELL DISEASE IN GHANA; TOWARDS TAILOR-MADE INTERVENTIONS. ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. ir. K.I.J. Maex ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel op woensdag 30 mei 2018, te 16:00 uur door Ewurama Dedea Ampadu Owusu geboren te Accra, Ghana

Promotiecommissie: Promotor(es): prof. dr. M.P. Grobusch AMC-UvA Copromotor(es): dr. C.A. Brown dr. P. F. Mens University of Ghana AMC- UvA Overige leden: prof. dr. M. Boele van Hensbroek AMC-UvA dr. R.P.M. Gerrets prof. dr. A. Verbon prof. dr. W.J. Wiersinga dr. J.T. Bousema prof. dr. F.G.J. Cobelens Universiteit van Amsterdam Erasmus Universiteit Rotterdam AMC-UvA Radboud Universiteit Nijmegen AMC-UvA Faculteit der Geneeskunde

Contents Page Chapter 1 General introduction and outline of thesis 7 PART 1 Chapter 2 The Interaction Between Sickle Cell Disease and HIV Infection: 39 A Systematic Review Clinical Infectious Diseases 2014; 60 (4):612-626 PART 2 Chapter 3 Characteristics of asymptomatic Plasmodium spp. parasitaemia in 63 Kwahu-Mpraeso, a malaria endemic mountainous district in Ghana, West Africa Malaria Journal 2016;15:38 Chapter 4 Prevalence of Plasmodium falciparum and non-p. falciparum infections 87 in a highland district in Ghana, and the influence of HIV and sickle cell disease Malaria Journal 2017;16(1):167 PART 3 Chapter 5 Malaria and sickle cell disease in HIV patients on co-trimoxazole 111 prophylaxis: an observational study. International Journal of Infectious Diseases 2018;69:29-34 Chapter 6 P. falciparum diagnostic tools in under- 5- year- old HIV patients in 147 two ART clinics in Ghana; are there missed infections? Malaria Journal 2018;17(1):92 Chapter 7 Knowledge, attitudes and practices regarding malaria in people living 187 with HIV in rural and urban Ghana. Acta tropica 2018;181:16-20 Chapter 8 General discussion of study findings 221

Addendum Samenvatting 250 Curriculum Vitae 254 Contributing authors 255 List of Publications 258 PhD Portfolio 259 Word of thanks 265