Lectures 4 Early fetal assessment, screening, ultrasound and treatment modalities during pregnancy. II. Asphyxia and Resuscitation (3 lectures)...

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Outline of a 2 year Neonatology educational course (80 lectures) PLUS 2 graduate level courses (GENETICS and BIOSTATISTICS & EPIDEMIOLOGY Approximate Percent in Examination I. Maternal-Fetal Medicine (6 lectures)... 6% Physiology and maternal adaptation to pregnancy A. Maternal medical disorders affecting the fetus B. Effect of medications and environmental agents on fetus Lectures 3 Obstetric conditions and complications affecting the fetus Lectures 4 Early fetal assessment, screening, ultrasound and treatment modalities during pregnancy Lectures 5 Fetal monitoring including FHR and Doppler Lectures 6 Labor and Delivery II. Asphyxia and Resuscitation (3 lectures)... 4% Lectures 1 Perinatal Asphyxia/ Hypoxic Ischemic Encephalopathy Neonatal resuscitation Simulation and case studies III. Cardiovascular (8 lectures)... 9% Embryology, Development and physiology Cyanotic congenital heart disease Acyanotic congenital heart disease Cardiopulmonary distress in the absence of congenital heart disease 1

Ultrasonography define the anatomy with case studies Electrocardiography, electrophysiology, and dysrhythmias Lecture 7 Pharmacologic therapy of heart disease IV. Respiratory (12 lectures)... 12% Embryology and lung development Pulmonary physiology Surfactant metabolism Respiratory distress syndrome (RDS)/Transient tachypnea Pneumonias, meconium aspiration syndrome (MAS), and PPHN Lecture 7 Other causes of respiratory distress including CDH, CPAM, chylothorax and air-leak syndromes Lecture 8 Apnea of prematurity and neonatal respiratory control Lecture 9 Non-invasive Respiratory support (CPAP and NIMV). 0 Mechanical Respiratory Therapy (PPV, HFOV, HFJV) 1 Inhaled ino and ECMO, ino 2 Chronic lung disease, bronchopulmonary dysplasia V. Genetics, Dysmorphism and IEM (20 lectures)... 7% Graduate level course done once every 3 years by the division of Medical Genetics 2

VI. Nutrition (6 lectures)... 8% Nutrition and growth (fetal and neonatal) including changes in body composition Large- and small-for-gestational age (LGA - SGA) infants Minerals, vitamins, and trace elements Enteral nutrition Parenteral nutrition Energy requirements with case studies VII.Water/Salt/Renal (3 lectures)... 5% Water and electrolyte metabolism Normal and abnormal renal function and development in the fetus and neonate Acquired renal disease VIII.Endocrine/Metabolic/Thermal (6 lectures)... 5% Sexual differentiation and adrenal disorders Thyroid disorders Pituitary and Adrenal disorders Glucose metabolism Calcium, phosphorous, and magnesium metabolism Thermal regulation 3

IX. Immunology (3 lectures)... 3% Lectures 1 Development and biology of the immune system Specific components of the immune system: B-lymphocytes (Ig), T- lymphocytes and PMNs Complement system, circulating factors and inflammation X. Infectious Diseases (6 lectures)... 6% Lectures 1 & 2 Infections of organ systems Lectures 3 & 4 Etiologic agents: Bacteria Lectures 4 & 6 Etiologic agents: Viruses, Fungi and Protozoa Preventive measures XI. Gastroenterology (6 lectures)... 4% Development of the GI tract including digestion and absorption Developmental anomalies and GI obstruction Pancreas, CF and malabsorption syndromes Abdominal wall defects Acquired disorders of the GI tract including NEC Liver disease of the newborn infant/abdominal masses XII. Bilirubin (2 lectures)... 2% Bilirubin: Biochemistry, Metabolism & Toxicity 4

Bilirubin: Physiologic, Pathologic and Breast Milk Jaundice XIII. Skin Disorders (2 lectures)... 2% XIV. Hematology/Oncology (4 lectures)... 5% Erythrocytes disorders Platelets and coagulation Leukocytes and Transfusions Neonatal Oncology XV.Neurology (6 lectures)... 7% Neurologic evaluation and neuro-diagnostic laboratory tests (LP) Development of the nervous system including CBF and neurotransmitters NTD and hydrocephalus Intracranial hemorrhage, vascular injury and Neurological trauma Seizures and Neurodiagnostic evaluations Other Neurologic Disorders including vascular malformations and neurocutaneous disorders XVI. Developmental outcome (3 lectures)... 3% Neurodevelopmental examination and diagnosis of ND impairment Cerebral palsy and Mental retardation 5

Effects of the environment and Neonatal abstinence/withdrawal syndromes XVII. Eyes, Ears, Nose, Mouth, Throat, and Neck (3 lecture)... 3% Normal development and abnormalities of EENT Normal development and abnormalities of mouth, throat and neck Retinopathy of prematurity XVIII. Basic Principles of Pharmacology (2 lectures)... 2% XIX.Health Services Delivery, Ethics & Family counseling (2 lectures)... 2% Organization and Health Services Delivery Ethical issues, limits of viability and end of life care XX. Core Knowledge in SA (12 lectures)...... 5% Principles of Teaching and Learning -4 Evidence Based Neonatology workshop/excercises GL course done once every 3 years by MD/MPH Obstetrician in conjunction with MFM fellows 8 lectures 6