UvA-DARE (Digital Academic Repository) Novel regulators of megakaryopoiesis: The road less traveled by Zeddies, S. Link to publication Citation for published version (APA): Zeddies, S. (2015). Novel regulators of megakaryopoiesis: The road less traveled by General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (http://dare.uva.nl) Download date: 22 Feb 2019
Novel regulators of megakaryopoiesis Novel regulators of megakaryopoiesis - The road less traveled - Sabrina Zeddies Sabrina Zeddies
Novel regulators of megakaryopoiesis - The road less traveled by Sabrina Zeddies
ISBN: 978-94-6182-562-9 Printing: Off Page, www.offpage.nl Cover and layout: Sabrina Zeddies The research in this thesis was performed at the Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, Amsterdam, The Netherlands. Printing of this thesis was financially supported by: Sanquin Blood Supply Horst and Rosemarie Zeddies Copyright 2015 by Sabrina Zeddies. All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without prior permission of the author.
Novel regulators of megakaryopoiesis - The road less traveled by - Academisch proefschrift ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. D. C. van den Boom ten overstaan van een door het college voor promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel op dinsdag 26/05/2015, te 10:00 uur door Sabrina Zeddies geboren te Hamelen, Duitsland
Promotiecommissie Promotor: prof. dr. C. E. van der Schoot Universiteit van Amsterdam Copromotor: dr. D. C. Thijssen-Timmer Sanquin Bloedvoorziening Amsterdam Overige leden: prof. dr. M.H.J. van Oers Universiteit van Amsterdam prof. dr. P.L. Hordijk Universiteit van Amsterdam prof. dr. W.H. Ouwehand University of Cambridge prof. dr. J.J. Zwaginga Universiteit Leiden dr. K. Freson Universiteit Leuven prof. dr. G. Auburger Goethe-Universität Frankfurt Faculteit der Geneeskunde
Two roads diverged in a yellow wood, And sorry I could not travel both And be one traveler, long I stood And looked down one as far as I could To where it bent in the undergrowth; [ ] Two roads diverged in a wood, and I, I took the one less traveled by, And that has made all the difference. Robert Frost
Contents Chapter 1 General introduction and scope of this thesis 9 Chapter 2 The transcription factor MEIS1 regulates early 47 erythroid and megakaryocytic cell fate Haematologica October 2014 99:1555-1564; Graphical abstract selected for cover illustration Chapter 3 ATAXIN2 is crucial for megakaryocyte protein 79 homeostasis and proper platelet functionality Submitted Chapter 4 The actin-binding protein TROPOMYOSIN 1 115 (TPM1) is a critical regulator of F-actin distribution and polymerization during megakaryopoiesis Manuscript in preparation Chapter 5 Pathogen reduction treatment using riboflavin 137 and ultraviolet light impairs platelet reactivity towards specific agonists in vitro Transfusion. 2014 Sep;54(9):2292-300 Chapter 6 General discussion 157 Chapter 7 English summary 185 Nederlandse samenvatting List of publications Curriculum vitae Dankwoord PhD portfolio