UvA-DARE (Digital Academic Repository) Mucorales between food and infection Dolat Abadi, S. Link to publication

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UvA-DARE (Digital Academic Repository) Mucorales between food and infection Dolat Abadi, S. Link to publication Citation for published version (APA): Dolatabadi, S. (2015). Mucorales between food and infection General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (http://dare.uva.nl) Download date: 27 Feb 2019

Invitation Mucorales between food and infection You are cordially invited to attend the defense of the PhD thesis entitled: Mucorales between food and infection Mucorales between food and infection On Tuesday, 20 January 2015 at 12:00 in the Agnietenkapel of University van Amsterdam, Oudezijds Voorburgwal 231, Amsterdam, followed by a reception Somayeh99@gmail.com Paranymphs: Bert Gerrits van den Ende 2015 b.gerritsvandenende@cbs.knaw.nl Karolina Dukik k.dukik@cbs.knaw.nl

Mucorales between food and infection

ISBN 978-90-6464-836-6, 2015 All rights reserved. No part of this thesis may be reproduced or transmitted in any form or by any means without written permission of the author. Cover: Rhizopus arrhizus var. arrhizus Layout: S. Dolatabadi Printed at Ponsen & Looijen bv, Ede, The Netherlands

Mucorales between food and infection ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. D. C. van den Boom ten overstaan van een door het college voor promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel op dinsdag 20 Januari 2015, te 12.00 uur door geboren te Sabzevar, Iran

Promotiecommissie Promotores: Prof. dr. G. S. de Hoog Prof. dr. S. B. J. Menken Overige leden: Prof. dr. P. H. van Tienderen Prof. dr. A. M. Cleef Prof. dr. dr. h. c. R. A. Samson dr. K. Voigt dr. J. F. G. M. Meis Faculteit der Natuurwetenschappen, Wiskunde en Informatica.

Contents Chapter 1 General introduction: Mucorales between food and infection Chapter 2 Diversity and delimitation of Rhizopus microsporus 21 Chapter 3 Species boundaries and nomenclature of Rhizopus arrhizus (syn. R. oryzae) 55 Chapter 4 Rapid screening for human-pathogenic Mucorales using Rolling Circle Amplification 89 Chapter 5 Diagnostics of clinical Rhizopus species by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) 101 Chapter 6 Adaptation to thermotolerance in Rhizopus coincides with virulence as revealed by avian and invertebrate infection models, phylogeny, physiological and metabolic flexibility 115 Chapter 7 Virulence of Rhizopus species compared with two alternative model systems 135 Chapter 8 Food preparation with potentially unsafe fungi: a new biosafety issue? 151 Chapter 9 Summary and discussion 169 Chapter 10 Appendix 185 7

We raise in degrees of rank whomsoever We please; and over every possessor of knowledge is one, Most-Knowing. Holy Quran