Personalized IBD and VEO-IBD: Genomics, Microbiome, Biologics and Beyond Friday, May 18, 2018 Ruth and Tristram Colket, Jr. Translational Research Building on the Raymond G. Perelman Campus 1
Course information This one-day course is designed to present the latest developments in research and clinical care for very-early-onset inflammatory bowel disease (VEO-IBD) and pediatric IBD. Participants will receive a comprehensive overview of the genomic, immunologic and microbiome discoveries in VEO-IBD and in pediatric IBD and of the advances in the diagnosis, management and therapy of the disease. This will include lectures by nationally and internationally recognized experts and interactive panel discussions. This activity has been designed for gastroenterologists, gastrointestinal surgeons, GI fellows and residents, physician assistants, clinical nurse specialists, radiologists, pathologists, nutritionists, and other healthcare professionals. General Information The conference will be held in the Ruth and Tristram Colket, Jr. Translational Research Building on the Raymond G. Perelman Campus at Children s Hospital of Philadelphia. The registration fee for physicians is $75 and the fee for nurses is $50. Residents, fellows and medical students may attend for free, however, they still need to register. This fee includes breakfast, lunch and program material. All attendees are invited to submit an abstract for poster or oral presentations. Course Objectives Review the genetics of VEO-IBD, new candidate genes and the relevance of these discoveries to disease development Review the role of the dysregulated immune system in VEO-IBD and pediatric IBD and how this can impact therapeutic strategies Manage difficult cases in VEO-IBD and pediatric IBD Practice appropriate therapy for patients with VEO-IBD and pediatric IBD, considering the both the patients phenotype and underlying genetics Explain the role for endoscopic intervention in pediatric IBD Identify the therapeutic targets in pediatric IBD and outcome measures of success of therapy Counsel patients about the role of diet in disease development and as therapy for patients with IBD Discuss the current role of fecal microbiome transplant in IBD 2
ACCME Accreditation Statement Children s Hospital of Philadelphia is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing education for physicians. AMA Credit Designation Statement Children s Hospital of Philadelphia designates this live activity for a maximum of 5.5 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Hotel Accommodations A block of rooms has been reserved at reduced rates at the Sheraton University City, located just a few blocks from Children s Hospital. The group overnight rate is $209 single and double occupancy plus a 15.2 percent room tax. Participants are required to make their own hotel reservations by calling the Sheraton directly at 215-387-8000. Please mention the name of the conference when making your reservation. The special room rate will be available until April 17, 2018. After that date, reservations will be accepted on a space and rate availability basis. Cancellation and Refund Policy Children s Hospital of Philadelphia reserves the right to cancel or postpone any course due to any unforeseen circumstances. In the event of cancellation or postponement, Children s Hospital of Philadelphia will refund any registration fees, less a $40 service charge, but is not responsible for any related costs, charges or expenses to participants, including cancellation charges assessed by airlines or travel agencies. In order to process refunds for course withdrawals, cancellation must be received in writing by Friday, May 4, 2018. No refunds will be issued thereafter. Services for People with Disabilities If special arrangements are required for an individual with a disability to attend this meeting, please contact the Continuing Medical Education Department at 215-590-5263. Register online at chop.cloud-cme.com 3
Program Friday, May 18, 2018 7:30 a.m. Registration and Continental Breakfast 8:15 a.m. Welcome and Introduction Joseph W. St. Geme, MD Bryan A. Wolf, MD, PhD VEO-IBD Moderator: David A. Piccoli, MD 8:30 a.m. Novel Mechanism of Immune Dysfunction in VEO-IBD Kathleen E. Sullivan, MD, PhD 8:50 a.m. Therapeutic Concepts in VEO-IBD Judith R. Kelsen, MD 9:10 a.m. A Novel Mechanism of Genetic Mutation in VEO-IBD Edward M. Behrens, MD 9:30 a.m. Panel Discussion: VEO-IBD Patient Case 10 a.m. Break Endoscopic Therapeutic Interventions and Mucosal Targets of Disease Moderator: Joel Rosh, MD 10:15 a.m. Therapeutic Intervention Petar Mamula, MD 10:35 a.m. Defining Remission: Lessons from the PROTECT Study Jeffrey S. Hyams, MD 10:55 a.m. Severe Colitis Andrew B. Grossman, MD 11:15 a.m. Panel: IBD Case 11:45 a.m. Lunch continued> 4
1 p.m. Targeted Therapy in IBD Marla C. Dubinsky, MD 1:20 p.m. Therapeutic Drug Monitoring Mark T. Osterman, MD 1:40 p.m. What Is the Target We Are Striving for and What Should We Be Striving for? Robert N. Baldassano, MD 2 p.m. Panel Discussion and Case 2:30 p.m. Coffee/Snack Break Microbiome Moderator: Frederic D. Bushman, PhD 3 p.m. Diet and IBD: What Works and What Is the Hype? Lindsey G. Albenberg, DO 3:20 p.m. Fecal Microbiota Transplant: Is There a Role in IBD? Stacy A. Kahn, MD 3:40 p.m. Panel 4 p.m. Adjourn 5
Faculty Unless otherwise noted, faculty are from Children s Hospital of Philadelphia and/or the Perelman School of Medicine at the University of Pennsylvania. Course Directors Robert N. Baldassano, MD Director, Center for Pediatric Inflammatory Bowel Disease Co-director, Penn/CHOP Microbiome Program Judith R. Kelsen, MD Director, Very Early Onset IBD Center Assistant Course Faculty Lindsay G. Albenberg, DO Program Director, IBD Fellowship Edward M. Behrens, MD Chief, Division of Rheumatology Associate Andrew B. Grossman, MD Co-director, Center for Pediatric Inflammatory Bowel Disease Associate Professor of Clinical Pediatrics Petar Mamula, MD Director, Kohl s GI Nutrition and Diagnostic Center, endoscopy suite Co-director, Center for Digestive, Liver and Pancreatic Medicine David A. Piccoli, MD Chief, Division of Gastroenterology, Hepatology and Nutrition Director, Fred and Suzanne Biesecker Pediatric Liver Center Fred and Suzanne Biesecker continued> 6
Joseph W. St. Geme, MD Physician-in-Chief Chair, Department of Pediatrics Kathleen E. Sullivan, MD, PhD Chief, Division of Allergy and Immunology Bryan A. Wolf, MD, PhD Chief Scientific Officer CHOP Research Institute Professor of Pathology and Laboratory Medicine Guest Faculty Frederic D. Bushman, PhD Chair, Department of Microbiology Co-Pl, Penn/CHOP Microbiome Program Hospital of the University of Pennsylvania Professor of Microbiology Marla C. Dubinsky, MD Chief, Pediatric Gastroenterology and Hepatology Director, IBD Center, Mount Sinai Medical Center Icahn School of Medicine at Mount Sinai Jeffery S. Hyams, MD Division Head, Gastroenterology Director, Inflammatory Bowel Disease Center Connecticut Children s Medical Center University of Connecticut School of Medicine Stacy A. Kahn, MD Boston Children s Hospital Assistant Harvard Medical School continued> 7
Mark T. Osterman, MD, MSCE Hospital of the University of Pennsylvania and The Presbyterian Medical Center of Philadelphia Associate Professor of Medicine Joel Rosh, MD Director, Pediatric Gastroenterology Vice Chairman, Clinical Development and Research Affairs Goryeb Children s Hospital/Atlantic Health System Mount Sinai Hospital Icahn School of Medicine 2018 The Children s Hospital of Philadelphia 18CME0211/WEB/04-18 8