Arg-ADNI Gustavo E. Sevlever, Silvia Vázquez, Deborah R. Gustafson, Salvador M. Guinjoan, Ricardo F. Allegri(*) and Arg-ADNI group. Memory and Aging Center Institute for Neurological Research (FLENI) Buenos Aires, Argentina *speaker WW-ADNI update: Copenhagen, July 11, 2014
Argentine ADNI 2011-2014 1. Background 2. Work-Plan 3. Results 4. AAIC and other meetings 5. Publications 6. New Projects
Worldwide Life Expectancy 78a 62a 70a 81a 79a 79a 75a 74a Argentina 76a 72a 68a 73a 81a 76a Buenos Aires 78a 78a 77a 76a Font: CIA World Factbook / INDEC
Argentina
Institute for Neurological Research Memory and Aging Center Institute for Neurological Research FLENI Buenos Aires Argentina Institute for Neurological Rehabilitation www.fleni.org.ar/alzheimer
Argentine ADNI 2011-2014 1. Background 2. Work-Plan 3. Results 4. AAIC and other meetings 5. Publications 6. New Projects
Arg-ADNI 1 st Arg-ADNI: FLENI Cohort (2011-2014) Single-Center, Pilot Study-60pts Main Project 2 nd Arg-ADNI: Multicenter Cohort (2015-2018)
Arg-ADNI Management Committee Sevlever G, Allegri RF, Guinjoan S, Gustafson D, Vazquez S. Clinical Stream Neurologists Ricardo Allegri (*) Jorge Campos Alejandra Amengual Gabriela Cohen Neuroimaging Stream Silvia Vazquez S (*) Esteban Obenaus German Falasco Leandro Urrutia Fernando Ventrice Laboratory Stream Gustavo Sevlever (*) Horacio Martinetto Ezequiel Surace Miguel Riudavetz Epidemiological Stream Deb Gustafson (*) Marcos Fernández Suárez Patricio Chrem Julieta Russo Psychiatrists Salvador Guinjoan Griselda Russo Pablo Bagnati Lucas Drucaroff Neuropsychologists Liliana Sabe María Eugenia Martín Florencia Clarens Lucía Crivelli Paula Harris (*) Stream Chair
Arg-ADNI 1 st Cohort (FLENI) Study Timelines 11/20/2013 Last patient / first visit 1 06/08/2014 Copenhagen Study report 2 01/19/2012 First patient / first visit 02/10/2011 FLENI Review Board approval 1. Recruitment: 24 months 2. Follow-up: 24 months
Patients Invited to ADNI Nº= 73 Arg-ADNI 1st Cohort (FLENI) Patients Flowchart Patients Screened at FLENI Nº= 60 Screening Failure Nº= 7 2 Claustrophobia 1 Psychiatric Disease 1 Cancer 1 Adult ADHD 2 without informant Patients Followed (1 st year) Nº= 50 Dropout Nº= 3 2 removed inform.cons 1 by distance/caregiver Healthy Controls Nº= 10 Early MCI Nº=15 Late MCI Nº= 16 Dementia AD Nº=9
Arg-ADNI 1 st Cohort (FLENI) Table 1: Demographic Data Healthy Controls Early MCI Late MCI Dementia AD 10 15 16 9 Age (years) 68 70 75 75 Education (years) 14 12.9 13.6 12.1 Sex (%fem) 70% 40% 68.8% 44.4% MMSE 30 28.9 27.1 21.4
Arg-ADNI 1 st Cohort (FLENI) Methods: ADNI 1. Demographic and Neurological Exams 2. Neuropsychological Assessment 3. Cognitive Reserve Inventory 4. Blood sampling including DNA banking 5. Cerebro Spinal Fluid (AB42, tau and f-tau) 6. MRI (3.0T) 7. FDG PET-CT scan 8. 11 C-PiB PET-CT scan
Argentine ADNI 2011-2014 1. Background 2. Work-Plan 3. Results 4. AAIC and other meetings 5. Publications 6. New Projects
Arg-ADNI 1 st Cohort (FLENI) Results Baseline Follow-up Follow-up Total Nº NPS Ass MRI CSF Aβ-tau PET FDG PET PiB Follow-up 1 year Healthy Controls 10 10 10 7 10 9 6 Follow-up 2 year Early MCI 15 15 15 12 15 12 8 Late MCI 16 16 16 11 15 13 7 Dementia AD 9 9 9 8 9 9 2 TOTAL 50 50 50 38 (76%) 49 (98%) 43 (86%) 23
Brain 18 FDG PET scan Brain 11 C-PiB PET scan Uptake Map AD Healthy Hypometabolism Map AD
Arg-ADNI 1 st Cohort (FLENI) Results Table 3: PET Scanning as of June 2014 FDG-PET Normal FDG-PET Pathol PiB-PET Negative PiB-PET Possitive Healthy Control s 5 5 10 0 Early MCI 2 9 5 3 Late MCI 3 11 4 8 Dementia AD 0 9 1 8 Total 10 34 20 19
Brain Bank. FLENI houses the only brain bank in Argentina. ADNI participants are being asked to consent brain donation at the time of death. Brain banking: opportunities, challenges and meaning for the future Hans Kretzschmar Nature Reviews Neuroscience 10, 70-78 (January 2009)
Argentine ADNI 2011-2014 1. Background 2. Work-Plan 3. Results 4. AAIC and other meetings 5. Publications 6. New Projects
April 2014
POSTER in AAIC>14 Alzheimer s Imaging Consortium (AIC) pre-conference 1. Discrepancy between PiB amyloid imaging in typical and atypical clinical diagnosis. (nº: IC-P-005) 2. Hippocampal atrophy. Automated volumetry vs visual examination: Arg-ADNI cohort analysis (nº: IC-P-006)
Argentine ADNI 2011-2014 1. Background 2. Work-Plan 3. Results 4. AAIC and other meetings 5. Publications 6. New Projects
Papers submitted 1. Concordance between C 11 -PiB amyloid imaging and clinical diagnosis in a memory clinic. American Journal of Alzheimer s Disease and other Dementias. 2. Discriminability and Response bias Indices in recognition memory performance in amnestic mild cognitive impairment and Alzheimer s disease. Alzheimer & Dementia 3. Hippocampal atrophy. Automated volumetry vs visual examination: an ARG ADNI cohort analysis
Argentine ADNI 2011-2014 1. Background 2. Work-Plan 3. Results 4. AAIC and other meetings 5. Publications 6. New Projects
Future Tasks Arg-DIAN (Dominantly Inherited Alzheimer Network) National grant application (CONICET) June 2014 to study an Argentine DIAN cohort of 40 participant. Start-up October 2014
Future Tasks Arg-ADNI 2 nd Cohort (Argentine Multicenter Study) National grant application (2015-2018) to study larger Argentina ADNI 2 cohort of 180pts involving at least 8 new sites (AD Centers). Mendoza 9.-Univ. Mendoza Mar del Plata 7.- CEMA Córdoba 8.- Instituto Neuropsiquiátrico Kremer Buenos Aires 1.- FLENI 2.- Hospital Zubizarreta (GCBA) 3.- INEBA 4.- Hospital Fernandez (GCBA) 5.- Hospital Borda (GCBA) La Plata 6.- Instituto Neuropsiquiátrico Luria
Thank you ADNI Argentina