Table of Contents Introduction...2 Vertical Integration...3-4 Locations of CBD Receptors...5 PCR Products...6 Phytocannabinoid-Rich Hemp Oil...7 Nanoemulsion-Based Platform...8 Water-Soluble Technology...9 0.0% THC PCR Hemp Oil (PDS)...10 Water-Soluble Powder (PDS)...11 Water-Soluble Liquid (PDS)...12 HydroPCR (PDS)...13 Advance Energy and Recovery Drink Powder (PDS)...14 PCR Softgels (PDS)...15 Advanced PCR Softgels With Curcumin (PDS)...16 Advanced PCR Softgels With Melatonin (PDS)...17 PCR Tinctures (PDS)...18 Advanced Nano-Tincture (PDS)...19 Vape & E-Liquids (PDS)...20 Balms (PDS)...21 Meet Our Chief Scientific Officer...22 Cosmeceuticals...23 Eye Serum (PDS)...24 Face Cream (PDS)...25 Body Lotion (PDS)...26 Cellulose Face Mask (PDS)...27 Animal Health Overview...28-29 K9 Chews (PDS)...30 Hemp Pellets (PDS)...31 Animal Health FAQ...32-33 Available Bottles & Containers...34 Disclaimer and Definitions All information in this document is property of Folium Biosciences and may not be reproduced or distributed without express written permission. Definitions: 0.0% THC*, THC-Free*, Zero-THC or 0 THC*, Non-Detectible THC*, THC Limits/Qualifications/Representations* *For purposes of representations, Folium Biosciences, when speaking to the above terms 0.0% THC, THC-Free or Zero-THC, is defining as being batch tested with every product's run cycle and tested, prior to release, with the use of Folium Biosciences laboratory and Agilent 1200 Series HPLC DAD (Diode-Array detector) equipment. Certificates of Analysis are provided with each order displaying levels of any THC detected or depicted from such equipment. Terms used not meant in the literal context. +/- ratios are associated with testing equipment. 1
Vertical Integration Extraction & Purification Farming On-site chromatography testing and 3rd party batch testing ensures accurate levels of phytocannabinoids and confirms the absence of THC through our proprietary processes Preserve the broad spectrum profile of non-psychoactive phytocannabinoids and synergistic compounds such as cannabigerol (CBG), cannabinol (CBN), cannabichromene (CBC), and over 40 naturally preserved terpenes The end result is the highest quality broad spectrum hemp derived phytocannabinoid-rich oil that contains no solvents, no heavy metals, no pesticides and 0.0% THC Located in La Junta, Colorado Our unique genetics provide our customers with a competitive advantage in the global hemp-derived phytocannabinoid industry Our plants are not genetically modified Proprietary high cannabidiol (CBD)/ low THC cultivar Phytocannabinoid and terpenoid rich strain Phytocannabinoid-Rich Hemp Full Plant Outdoor High CBD Harvest 3
Turn-Key Solution White label our products with your brand; ready to be sold direct to consumers We offer an array of formulated, tested and packaged finished products In-house product development team Unique and custom formulations Rigorous stability testing We ship domestically & internationally Formulation & Development Distribution 4
Locations of CBD Receptors Brain & central nervous system CANNABINOID RECEPTORS & NON-RECEPTOR PATHWAYS MODULATE HOMEOSTASIS Endocrine system Complete skeletal system Lungs & respiratory system Heart & circulatory system Digestive system Urinary system Reproductive system Muscular system Epidermis, dermis, & subcutaneous tissue Peripheral nervous system CANNABINOID RECEPTORS OF THE BRAIN ENDOCANNABINOID NEURO MODULATION Cerebral cortex Higher cognitive function Presynaptic Neuron Basal Ganglia Movement Cerebellum Hypothalamus Cannabinoid Receptors Appetite Movement Neurotransmitters Hippocampus Learning, memory and stress Medulla Nausea and vomiting chemoreceptor Neurotransmitter Receptors Endocannabinoid Lipid precursor Spinal cord Peripheral sensation including pain Postsynaptic Neuron 5
PCR Products White Label Products PCR Softgels PCR Formulated Tinctures PCR Balms Vape and E-Liquids Animal Health Products Cosmeceuticals Bulk Products PCR Hemp Oil HydroPCR Water-Soluble Powder Water-Soluble Liquid 6
Phytocannabinoid-Rich Hemp Oil CBD is 90% of all cannabinoids in the extract* H H OH Cannabidiol (CBD) Total terpenes range between 1 and 4% β-bisabolene β-farnesene β-caryophyllene α-humulene d-limonene Nerolidol Cannabidiol (CBD) Camphene E-Farnesene Cannabichromene (CBC) Linalool Myrcene Cannabigerol (CBG) Myrcene γ-terpinene Cannabidiolic Acid (CBDA) Guaiol β-maaliene Cannabinol (CBN) Cadinene α-gurjunene Minor Cannabinoids α-pinene Aristolene Farnesol α-bisabolol Phytol Isopulegol δ-3-carene Calarene HO *Minor cannabinoids are reduced to non detectable levels in the 0.0% THC PCR Hemp Oil Eucalyptol Terpinene P-Cymene Geraniol Understanding Different CBD in the Market Folium Biosciences PCR Oil PCR (Phytocannabinoid-Rich) Hemp Oil with 0.0% THC is golden amber in color and rich in phytocannabinoids, terpenes, and fatty acids, making it a broad spectrum oil. Our PCR oil has a high concentration of CBD, when combined with the other synergistic compounds makes it the most precious hemp-derived oil on the market. CBD Isolate CBD (cannabidiol) Isolate is a single molecule from the hemp plant that endures heavy processing to achieve its purity. All other beneficial cannabinoids, terpenes, etc. are destroyed in the process. The final product is a White / Off-white powder and used in many products to provide CBD. Hemp Seed Oil Hemp Seed Oil is Green in color and does not contain phytocannabinoids. This oil is a popular food source due to the high content of protein and omega fatty acids. It s also a beneficial emollient for skin. Cannabis Oil Cannabis Oil or Hash is an oil similar to PCR, however, cannabis oil is dark green or brown and is traditionally created with a high THC content; this oil has psychoactive effects. 7
Nanoemulsion-Based Platform Folium Biosciences nanoemulsions are patent pending formulas that use optimized composition and a unique process to manufacture. The average size of our hemp oil droplet in this form is 25 nanometers, compared with 100-5000 nanometers that is usually obtained by using the industry standard liposomal delivery method. The small size of the Folium nanoemulsion hemp oil leads to a much larger surface area of the hemp oil droplets leading to much higher absorption in the bloodstream. Hemp oil nanoemulsions can also be used in a number of consumer products, including the cosmetic, pharmaceutical and food industries. Due to their thermodynamic stability, nanoemulsions do not lead to phase separation (oil separating from water), thus enabling the formulation of stable products. Competitor 25 Nanometer (AVG) Folium Biosciences Patent Pending Nanoemulsion for Maximum Bioavailability 100-1000 719-574-2159 Nanometer info@foliumbiosciences.com Liposomal 615 Wooten Road, Suite 110 Colorado Springs, CO 80915 www.foliumbiosciences.com (Competitor) Microemulsion Superior >50% Absorption Only <20% Absorption H OH H HO 8
Water-Soluble Technology We have several proprietary and patent pending PCR water-soluble options for our customers to choose from. Our water-soluble technology is used to create a liquid or a powder that results in cannabidiol that is water-soluble and highly bioavailable. Pure phytocannabinoid-rich hemp oil that is added to water remains insoluble, and under physiological conditions, is not readily absorbed into the bloodstream. However, when our hemp oil is converted into a water-soluble liquid, it quickly goes into the solution, forming cannabinoid emulsion droplets with an average size of 25 nanometers, providing a high surface area for enhanced bioavailability. This results in a superior ingredient for our customers to formulate with. Our standard PCR water-soluble powder is a phytocannabinoid-rich (PCR) powder with 20% CBD, other minor phytocannabinoids, and terpenes. This proprietary formulation has been designed for optimum bioavailability and maximum absorption. It is intended for dissolution immediately prior to consumption and for manufacturing of semisolid/solid products. Our standard water-soluble liquid formula is made with PCR hemp oil and food grade emulsifiers. It contains 7.5% CBD for flavored beverage formulations and semisolid formulations, or 35% for cosmetic applications. Product Attributes Completely Water-Soluble Highly Bioavailable Water-Soluble Powder is 20% Cannabidiol Water-Soluble Liquid is 35% Cannabidiol for Cosmetic Products Broad Spectrum 9
0.0% THC PCR Hemp Oil PRODUCT DATA SHEET Product Description Active Ingredients Attributes Packaging Microbial Analysis Contaminant Analysis Our 0.0% THC Phytocannabinoid Hemp Oil has all cannabinoids and terpenes naturally found in hemp except Delta 9-Tetrahydrocannabinol (THC). This nonpsychoactive product allows for the global distribution of our hemp oil into international markets that have zero tolerance for any levels of THC. Our extraction & purification process uses a proprietary and patented technology that preserves all the phytocannabinoids, terpenes, and plant lipids while eliminating unwanted THC and chlorophyll. Customers can customize our hemp oils to the desired potency and specifications. A rigorous testing scheme using chromatography and 3rd party testing is followed to ensure that the critical attributes of taste, color, potency, and purity consistently meet quality control specifications for making finished products. Phytocannabinoid-Rich Hemp Oil Phytocannabinoids up to 85% Broad Spectrum Tetrahydrocannabinol (THC) Not Detected Bulk 24 Month Shelf Life Total Aerobic Count < 2,000 cfu/g Total Yeast and Mold < 200 cfu/g E. Coli = Negative Salmonella = Negative Heavy Metals: Not Detected (ND) Lead: ND Arsenic: ND Residual Solvents: ND Approved Terminology Non-GMO Manufactured in the USA Organically Grown Hemp Halal Kosher Infuse into your product line. This product is not intended to diagnose, treat, cure, or prevent any disease and has not been evaluated by the FDA. 10 Bulk Products
Water-Soluble Powder PRODUCT DATA SHEET Product Description Active Ingredients Inactive Ingredients Attributes Packaging Microbial Analysis Contaminant Analysis Our standard water-soluble PCR powder contains 20% CBD, other minor phytocannabinoids, and terpenes. This proprietary formulation has been designed for optimum bioavailability and maximum absorption. The product is broad spectrum water-soluble powder with a light herb taste. It is intended for dissolution immediately prior to consumption and for manufacturing of semisolid/solid products. 20% Phytocannabinoid-Rich Hemp Oil Dextrin, Acacia Gum, Sunflower Lecithin, Vitamin E Completely Water-Soluble Highly Bioavailable 0.0% THC Manufacturing Ready Broad Spectrum Bulk 18 Month Shelf Life Total Aerobic Count < 2,000 cfu/g Total Yeast and Mold < 200 cfu/g E. Coli = Negative Salmonella = Negative Heavy Metals: Not Detected (ND) Lead: ND Arsenic: ND Residual Solvents: ND Approved Terminology Manufactured in the USA Organically Grown Hemp Halal Kosher This product is not intended to diagnose, treat, cure, or prevent any disease and has not been evaluated by the FDA. 11 Water-Soluble Bulk Products
Water-Soluble Liquid Competitor Competitor Folium Biosciences PRODUCT DATA SHEET Standard Oil 100-1000 Nanometer Liposomal Microemulsion 25 Nanometer (AVG) Folium Biosciences Patent Pending Nanoemulsion for Maximum Bioavailability Product Description Active Ingredients Inactive Ingredients Attributes Packaging Microbial Analysis Contaminant Analysis Approved Terminology Nanoemulsion vs Liposomal Our patent pending water-soluble formulation is developed through our nanoemulsion technology platform. This technology transforms active compounds into nano-sized emulsions making them highly bioavailable and more permeable when applied to the skin. This proprietary formulation has been designed for optimum bioavailability and maximum absorption intended for cosmetics/personal care products. 35% Phytocannabinoid-Rich Hemp Oil Polysorbate Emulsifiers, Water Completely Water-Soluble Highly Bioavailable Zero-THC Manufacturing Ready Broad Spectrum Bulk 18 Month Shelf Life Total Aerobic Count < 2,000 cfu/g Total Yeast and Mold < 200 cfu/g E. Coli = Negative Salmonella = Negative Heavy Metals: Not Detected (ND) Lead: ND Arsenic: ND Residual Solvents: ND Manufactured in the USA Organically Grown Hemp Halal Kosher Folium Biosciences' nanoemulsions are patent pending formulas that use optimized composition and a unique process to manufacture. The average size of our hemp oil droplet is 25 nanometers, compared with 100-5000 nanometers that is usually obtained by using the industry standard liposomal delivery method. The small size of the Folium nanoemulsion leads to a much larger surface area of the hemp oil droplets, leading to much higher absorption in the bloodstream. Hemp oil nanoemulsions can also be used in a number of consumer products, including the cosmetic, pharmaceutical and food industries. Due to their thermodynamic stability, nanoemulsions do not lead to phase-separation (oil separating from water), and thus enable the formulation of stable products. This product is not intended to diagnose, treat, cure, or prevent any disease and has not been evaluated by the FDA. 12 Water-Soluble Bulk Products
HydroPCR PRODUCT DATA SHEET Product Description Active Ingredients Inactive Ingredients Attributes Packaging Approved Terminology Microbial Analysis Contaminant Analysis HydroPCR is a 4% PCR Hemp Oil Nanoemulsion from Folium Biosciences. Built with Nano-Enhanced Absorption Technology (NEAT), this fully water-soluble formula was designed to create ready-to- drink, shelf stable beverages and bottled water. It is made with broad spectrum 0.0% THC hemp oil rich in phytocannabinoids and contains substantially reduced amounts of natural surfactants compared to previous technologies. The manufacturing process uses a patented technology that breaks down cannabinoids into nanoemulsions 70 nm in size. This state-of-the-art solution was designed with the following in mind: (1) Shelf stability: The plant lipids in HydroPCR s 4% PCR Hemp Oil Nanoemulsion play a crucial role in ensuring that the beverage to which it is added, remains shelf stable. This makes it a superior product (compared to isolate) as the plant lipids in the hemp oil slow down Ostwald ripening, leading to 18 months of shelf life of the final product. (2) Bioavailability: Employing NEAT the nano-sized cannabinoid emulsion droplets lead to a much higher surface area, enhancing absorption through sublingual, topical or intestinal routes. Also, the broad spectrum hemp oil ensures that the carrier lipids do not break down in the small intestine, resulting in higher bioavailability of the cannabinoids. (3) Safety: The natural emulsifiers (Quillaja saponaria saponins) used in HydroPCR are derived from the soap bark tree, and are organic, preservative free and Generally Recognized as Safe, GRAS. The very low ratio of cannabinoids to surfactants (approximately 1:1) ensures that only a few milligrams of emulsifiers are consumed with the cannabinoids, resulting in an exceptionally safe and efficacious product. 4% Phytocannabinoid-Rich Hemp Oil Natural Emulsifier, Glycerin 0.0% THC Broad Spectrum Profile Water-Soluble Highly Bioavailable Manufacturing Ready Nano-Enhanced Absorption Technology Bulk 18 Month Shelf Life Temperature sensitive, should be stored at 60-85 F for maximum shelf life. Manufactured in the USA Organically Grown Hemp Halal Kosher Total Aerobic Count < 2,000 cfu/g Total Yeast and Mold < 200 cfu/g E. Coli = Negative Salmonella = Negative Heavy Metals: Not Detected (ND) Lead: ND Arsenic: ND Residual Solvents: ND Fish gelatin may be used as a processing aid. This product is not intended to diagnose, treat, cure, or prevent any disease and has not been evaluated by the FDA. 13 Water-Soluble Bulk Products
Advanced Energy + Recovery Drink Powder PRODUCT DATA SHEET Product Description Ingredients Attributes Packaging Directions Dosage Our Phytocannabinoid-Rich (PCR) Energy and Recovery Drink Powder is created with our broad spectrum 0.0% THC Water-Soluble Powder which contains cannabidiol (CBD), trace minor phytocannabinoids, and naturally present terpenes. This product contains a blend of amino acids, vitamins, and 20 mg of phytocannabinoids per serving. Our delicious powder is an excellent delivery system for Phytocannabinoid-Rich Hemp Oil when mixed with 16-20 ounces of cold water. This drink boosts energy, provides hydration, and assists with recovery. Vitamin A, Vitamin C, Vitamin D, Vitamin E, Vitamin K, Thiamine, Vitamin B2, Niacin, Vitamin B6, Vitamin B12, Panthothenic Acid, Phosphorous, Chromium, Potassium, Green Grown Vegan Glucosamine, N-Acetyl-L-Glutamine, L-Arginine-L-Pyroglutamate, Tyrosine, Taurine, L-Theanine, Bromelain, Aloe Vera Leaf Powder, Acetyl-L-Carnitine, Beta-Alanine, Asian Ginseng Root Powder, Maca Root Powder, Caffeine (120 mg), Water-Soluble Phytocannabinoid-Rich Hemp Powder (PCR Hemp Oil, Dextrin, Acacia Gum, Lecithin, Vitamin E), Glycine, Yohimbe Bark Extract, Leucine, Isoleucine, Valine, Citric Acid, Malic Acid, Red Beet Root Powder, Natural and Artificial Fruit Punch Flavor, Sucralose, Acesulfame Potassium, Stevia. Different Flavors Available 4.8 g per Serving Zero Sugar Aspartame Free 0.0% THC Bulk Container Mix one packet with 16-20 ounces of cold water, or to taste. Best to consume 30 minutes prior to physical activity. 1-2 servings daily Your Brand Here Made with Folium Biosciences Water-Water Soluble Powder that has been designed for optimum bioavailability and maximum absorption. This product is not intended to diagnose, treat, cure, or prevent any disease and has not been evaluated by the FDA. 14 White Label
PCR Softgels PRODUCT DATA SHEET 10 mg 25 mg Product Description Active Ingredients Inactive Ingredients Our Phytocannabinoid-Rich (PCR) Softgels are created with our patent pending water-soluble PCR hemp oil, along with other minor phytocannabinoids and naturally present terpenes. This product contains 10 mg or 25 mg of phytocannabinoids per dose and is designed to have optimum bioavailability. The patent-pending water-soluble formulation inside these softgels is composed of a nanoemulsion-based delivery system with cannabinoid emulsion droplets approximately 25 nanometers in size. The high surface area of cannabinoid droplets maximizes in-vivo absorption and the resulting bioavailability is 3-5 times higher than cannabinoids delivered in oil form. The enhanced and consistent absorption (despite fed vs. fasting state) leads to predictable biological response and improved efficacy. 10 mg or 25 mg Phytocannabinoid-Rich Hemp Oil 10 mg: Polysorbate Emulsifiers, Medium Chain Triglycerides, Beta Caryophyllene. Gelatin Shell: Bovine-derived Gelatin, Glycerin, Sorbitol, and Water 25 mg: Polysorbate Emulsifiers, Medium Chain Triglycerides (MCT), Beta-Caryophyllene. Gelatin Shell: Bovine-derived Gelatin, Glycerin, Sorbitol and Water, Artificial Coloring which includes Red 40, Red 3, Yellow 5, Yellow 6, Blue 1, Blue 2 Attributes Packaging Microbial Analysis Contaminant Analysis Approved Terminology Measurements 0.0% THC Broad Spectrum Profile Pharmaceutical Grade Bulk or Bottled 18 Month Shelf Life Total Aerobic Count < 2,000 cfu/g Total Yeast and Mold < 200 cfu/g E. Coli = Negative Salmonella = Negative Heavy Metals: Not Detected (ND) Lead: ND Arsenic: ND Residual Solvents: ND Manufactured in the USA Organically Grown Hemp Pharmaceutical Grade 5/16 1/2 Weight: 0.66 Grams This product is not intended to diagnose, treat, cure, or prevent any disease and has not been evaluated by the FDA. 15 White Label
Advanced PCR Softgels With Curcumin PRODUCT DATA SHEET Product Description Active Ingredients Inactive Ingredients Attributes Packaging Unique Claims Microbial Analysis Contaminant Analysis Approved Terminology Measurements Our Phytocannabinoid-Rich (PCR) Softgels with Curcumin are created with our patent pending water-soluble PCR hemp oil. This product contains 25 mg of phytocannabinoids and 10 mg of curcumin per dose and is designed to have maximum absorption and optimum bioavailability. The patent-pending water-soluble formulation inside these softgels is composed of a nanoemulsion-based delivery system with cannabinoid and curcumin emulsion droplets approximately 25 nanometers in size. The high surface area of cannabinoid and curcumin droplets maximizes in-vivo absorption and the resulting bioavailability is 3-5 times higher for CBD, and 100-times higher for curcumin than their natural oily form. The enhanced and consistent absorption (despite fed vs. fasting state) leads to predictable biological response. 25 mg Phytocannabinoid-Rich Hemp Oil & 10 mg Curcuminoids per Softgel Polysorbate Emulsifiers, Medium Chain Triglycerides (MCT) Oil, Beta-Caryophyllene. Gelatin Shell: Bovine-derived Gelatin, Glycerin, Sorbitol and Water and Artificial Coloring which includes Yellow 5, Yellow 6 0.0% THC Broad Spectrum Profile Pharmaceutical Grade Bulk or Bottled 18 Month Shelf Life CBD and curcumin are in water-soluble nanoemulsion form, increasing bioavailability. Made with broad spectrum oil. Total Aerobic Count < 2,000 cfu/g Total Yeast and Mold < 200 cfu/g E. Coli = Negative Salmonella = Negative Heavy Metals: Not Detected (ND) Lead: ND Arsenic: ND Residual Solvents: ND Manufactured in the USA Organically Grown Hemp Pharmaceutical Grade 5/16 1/2 Weight: 0.66 Grams This product is not intended to diagnose, treat, cure, or prevent any disease and has not been evaluated by the FDA. 16 White Label
Advanced PCR Softgels With Melatonin PRODUCT DATA SHEET Product Description Active Ingredients Inactive Ingredients Attributes Packaging Unique Claims Microbial Analysis Contaminant Analysis Approved Terminology Measurements The advanced water-soluble nanoemulsion softgels are designed to address specific conditions like insomnia and sleep disorders and is composed of water-soluble phytocannabinoid-rich hemp oil and melatonin in a microemulsion form. The nano-sized droplets of cannabidiol and melatonin make these botanical actives easy to absorb into the bloodstream. With 25 mg of PCR hemp oil and 1 mg of Melatonin per softgel, this formula is truly synergistic, leveraging multiple botanical actives through various pathways help accomplish better quality of sleep. 25 mg Phytocannabinoid-Rich Hemp Oil & 1 mg Melatonin per Softgel Polysorbate Emulsifiers, Medium Chain Triglycerides (MCT) Oil, Beta-Caryophyllene. Gelatin Shell: Bovine-derived Gelatin, Glycerin, Sorbitol and Water and Artificial Coloring which includes Blue 1, Yellow 5, Blue 2, Red 40 0.0% THC Broad Spectrum Profile Pharmaceutical Grade Bulk or Bottled 18 Month Shelf Life CBD and melatonin are in water-soluble nanoemulsion form, increasing bioavailability. Made with broad spectrum oil. Total Aerobic Count < 2,000 cfu/g Total Yeast and Mold < 200 cfu/g E. Coli = Negative Salmonella = Negative Heavy Metals: Not Detected (ND) Lead: ND Arsenic: ND Residual Solvents: ND Manufactured in the USA Organically Grown Hemp Pharmaceutical Grade 5/16 1/2 Weight: 0.66 Grams This product is not intended to diagnose, treat, cure, or prevent any disease and has not been evaluated by the FDA. 17 White Label
PCR Tinctures PRODUCT DATA SHEET Product Description Active Ingredients Inactive Ingredients Our Phytocannabinoid-Rich (PCR) Tincture products are created using our broad spectrum hemp oil and diluted with hemp seed oil, grape seed oil, or medium chain triglycerides and can be custom designed with any of our PCR Hemp oils. These products are designed for sublingual application. Our PCR tinctures can also be formulated with specific isolated terpenes, terpene blends, as well as our water-soluble liquid. Phytocannabinoid-Rich Hemp Oil Medium Chain Triglycerides (MCT) and/or Hemp Seed Oil and/or Grape Seed Oil, Orange Oil or Lemon Oil or Peppermint Oil for flavor Your Brand Here Attributes Packaging Microbial Analysis Contaminant Analysis Approved Terminology Available in 250 mg, 500 mg, 1000 mg, or 1500 mg Broad Spectrum Profile Standard Flavor Options: Peppermint, Orange, Lemon, No Flavor Customizations Available Bulk or Bottled 18 Month Shelf Life Total Aerobic Count < 2,000 cfu/g Total Yeast and Mold < 200 cfu/g E. Coli = Negative Salmonella = Negative Heavy Metals: Not Detected (ND) Lead: ND Arsenic: ND Residual Solvents: ND Manufactured in the USA All Natural Organically Grown Hemp Halal Kosher This product is not intended to diagnose, treat, cure, or prevent any disease and has not been evaluated by the FDA. 18 White Label
Advanced Nano-Tincture PRODUCT DATA SHEET Product Description Active Ingredients Inactive Ingredients Attributes Packaging The sublingual tinctures are made with water-soluble hemp extract in a nanoemulsion form. Compared with oil-based tinctures, the nano-tinctures have many benefits, most important of which are a quicker product response time (minutes vs. hours) and higher bioavailability. The nano-tinctures are available at 250 mg per oz potency in flavorless, caramel, and grape flavors, with custom flavors available upon request. Phytocannabinoid-Rich Hemp Oil No Flavor: Quillaja Extract, Glycerin Grape Flavor: Quillaja Extract, Glycerin, Artificial Flavor, FD&C Colors Red 40 and Blue 1 Salted Caramel Flavor: Quillaja Extract, Glycerin, Natural and Artificial Flavors, Caramel Color 0.0% THC Broad Spectrum Profile Water-Soluble Highly Bioavailable Nano-Enhanced Absorption Technology Bulk or Bottled 18 Month Shelf Life MOQ Bottled: 2000 Bottles Product Response Time of Phytocannabinoid-Rich Hemp Oil (CBD) in Oil Form vs. Water-Soluble Nanoemulsion Form CBD in Water-Soluble Nanoemulsion Form CBD in Oil Form 1 Hour 2 Hours (Advanced Nano-Tinctures have a faster Product Response Time than CBD in Oil Form) This product is not intended to diagnose, treat, cure, or prevent any disease and has not been evaluated by the FDA. 19 White Label
Vape & E-Liquids PRODUCT DATA SHEET Product Description Our Phytocannabinoid-Rich (PCR) Hemp Oil Vape products are created with VG or MCT oil, and have been designed to have accurate dosing delivery with our 0.0% THC oil. Our extraction process uses the entire plant for a broad spectrum oil, containing all phytocannabinoids and terpenes naturally found in hemp. Active Ingredients Attributes Packaging Microbial Analysis Contaminant Analysis 0.1-30% Phytocannabinoid-Rich Hemp Oil Custom Terpene Blends Broad Spectrum Profile Custom Products Available Different Flavors Available 1 oz VG in 250 mg, 500 mg, or 1000 mg 1 ml MCT in 150 mg, 200 mg, or 250 mg Bulk or Bottled 18 Month Shelf Life Total Aerobic Count < 2,000 cfu/g Total Yeast and Mold < 200 cfu/g E. Coli = Negative Salmonella = Negative Heavy Metals: Not Detected (ND) Lead: ND Arsenic: ND Residual Solvents: ND Approved Terminology Manufactured in the USA Organically Grown Hemp This product is not intended to diagnose, treat, cure, or prevent any disease and has not been evaluated by the FDA. 20 White Label
Balms Your Brand Here PRODUCT DATA SHEET Product Description Our Phytocannabinoid-Rich (PCR) Hemp Oil Balms, are created with beeswax and medium chain triglycerides as well as essential oils of your choice. Active Ingredients Inactive Ingredients Attributes Packaging Microbial Analysis Contaminant Analysis Approved Terminology 0.3-10% Phytocannabinoid-Rich Hemp Oil Beeswax, Medium Chain Triglycerides, Lavender Essential Oil and Eucalyptus Essential Oil Custom Formulations Available 1 oz available in 250 mg, 500 mg, or 1000 mg 2 oz available in 500 mg, 1000 mg, or 2000 mg 1 oz, & 2 oz Bulk 18 Month Shelf Life Total Aerobic Count < 2,000 cfu/g Total Yeast and Mold < 200 cfu/g E. Coli = Negative Salmonella = Negative Heavy Metals: Not Detected (ND) Lead: ND Arsenic: ND Residual Solvents: ND Manufactured in the USA Organically Grown Hemp This product is not intended to diagnose, treat, cure, or prevent any disease and has not been evaluated by the FDA. 21 White Label
Meet our Chief Scientific Officer Dr. Raj Gupta Chief Scientific Officer Folium Biosciences Dr. Raj Gupta is a pharmaceutical scientist, responsible for R&D and product development at Folium. His vision is to perfect the science of product development to a point where consumer experience can be predicted based on an accurate translation of research into product design. Before joining Folium Biosciences, he led the Technical Operations at Guthy-Renker (now Nestlé), overseeing product development and manufacturing, resulting in commercialization of billion dollar brands, such as, Proactiv+. Earlier, he had managed product development of orphan drugs like Kuvan (sapropterin dihydrochloride), Firdapse (amifampridine), Aldurazyme (laronidase), and Naglazyme (galsulfase) at BioMarin Pharmaceutical as well as category-leading brands; Clorox, Brita, Kingsford, Hidden Valley, and Fresh Step Scoop at The Clorox Company. Dr. Gupta has received a Ph.D. in Analytical Chemistry and an M.B.A., from University of Massachusetts, Amherst, and B.S./M.S. degrees from Indian Institute of Technology, Kharagpur. He has published multiple journal articles in the analytical chemistry and spectroscopy areas where his research has found applications in semiconductors. 22 16 Cosmeceuticals
Cosmeceuticals CBD Skincare and the Endocannabinoid System (ECS) The main physiological function of the cutaneous ECS is to constitutively control the proper and well-balanced proliferation, differentiation and survival, as well as immune competence and tolerance, of skin cells. The use of CBD internally or as a skin lotion, patch, or oil maintains this delicate balance and may prevent from pathological conditions and diseases of the skin (e.g. acne, seborrhea, allergic dermatitis, itch and pain, psoriasis, hair growth disorders, and systemic sclerosis). 23 Cosmeceuticals
Eye Serum with 1% CBD PRODUCT DATA SHEET Product Description Our Eye Serum is designed to help your skin feel soft, but not oily. Absorb within minutes, this formula delivers CBD topically as well as into the bloodstream. For best results, use around eyes in combination with our Face Cream and Body Lotion. The unique formula with skin permeation agents improves the retention of cannabidiol onto and enhance permeation through the skin. The unique ability of cannabidiol to bind with the skin s endocannabinoid system helps it modulate, control, and influence the desirable attributes; contrast, pigmentation, hair health, hydration, and oil production. Your Brand Here Active Ingredients Inactive Ingredients Attributes Directions Packaging Microbial Analysis Approved Terminology 1% Phytocannabinoid-Rich Hemp Oil Water/Aqua, Haloxyl (Aqua,Chrysin,Glycerin,N-Hydroxysuccinimide, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Steareth-20), Propanediol, Saccharomyces Cerevisiae Extract, Sodium Polyacrylate, Aloe Barbadensis Leaf Juice, Sandalwood extract, Cucumber5 extract, Niacinamide (Vitamin B3), Trisodium EDTA, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol 0.0% THC Bulk 18 Month Shelf Life Broad Spectrum Profile Use every morning and/or night after you cleanse and tone. Place a pea-sized amount of Eye Serum onto fingertips and spread evenly around eyes using upward circular motions. Total Aerobic Count < 2,000 cfu/g Total Yeast and Mold < 200 cfu/g E. Coli = Negative Salmonella = Negative Manufactured in the USA This product is not intended to diagnose, treat, cure, or prevent any disease and has not been evaluated by the FDA. 24 Cosmeceuticals
Face Cream with 0.5% CBD Your Brand Here PRODUCT DATA SHEET Product Description Our Phytocannabinoid-Rich (PCR) Face Cream with 0.5% CBD is perfect for all skin types. It is ph balanced and made with organic botanical ingredients to help the skin stay moisturized. The unique formula with skin permeation agents improves the retention of cannabidiol onto and enhance permeation through the skin. The unique ability of cannabidiol to bind with the skin s endocannabinoid system helps it modulate, control, and influence the desirable attributes; contrast, pigmentation, hair health, hydration, and oil production. Active Ingredients Inactive Ingredients Attributes Directions Packaging Microbial Analysis Approved Terminology 0.5% Phytocannabinoid-Rich Hemp Oil Water/Aqua, Sweet Almond oil, Glyceryl Stearate SE, Isopropyl Palmitate, C12-15 Alkyl Benzoate, Sucrose Acetate Isobutyrate, Cetyl Alcohol, Stearic Acid, Glyceryl Stearate, PEG-100 Stearate, Butyrospermum Parkii (Shea Butter) Fruit, Ashwagandha extract, Gotu Kola extract, Lotus extract, Panthenol (ProVitamin B5), Glycerin, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, Xanthan gum, Propanediol, Trisodium EDTA, Dimethicone, Carbomer, Triethanolamine, Fragrance 0.0% THC Bulk 18 Month Shelf Life Broad Spectrum Profile Apply to face and neck every morning and/or night after you cleanse and tone, using upward circular motions. Total Aerobic Count < 2,000 cfu/g Total Yeast and Mold < 200 cfu/g E. Coli = Negative Salmonella = Negative Manufactured in the USA This product is not intended to diagnose, treat, cure, or prevent any disease and has not been evaluated by the FDA. 25 Cosmeceuticals
PCR Body Lotion with 0.3% CBD Your Brand Here PRODUCT DATA SHEET Product Description Our Moisturizing Body Lotion is perfect for dry skin. The unique formula with skin permeation agents improve the retention of cannabidiol onto and enhance permeation through the skin. The unique ability of cannabidiol to bind with the skin s endocannabinoid system helps it modulate, control, and influence the desirable attributes; contrast, pigmentation, hair health, hydration, and oil production. Active Ingredients Inactive Ingredients Attributes Directions Packaging Microbial Analysis Approved Terminology 0.3% Phytocannabinoid-Rich Hemp Oil Water/Aqua, Isopropyl Palmitate, C12-15 Alkyl Benzoate, Sucrose Acetate Isobutyrate, C12-15 Alkyl Benzoate, Glycerin, Glyceryl Stearate, PEG-100 Stearate, Cetyl Alcohol, Triphala extract, Honey extract, Coconut extract, Tocopheryl Acetate (Vitamin E), Sodium PCA (NMF-Natural Moisturizing Factor), Stearic Acid, Xanthan gum, Trisodium EDTA, Dimethicone, Triethanolamine, Carbomer, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, Fragrance 0.0% THC Apply to full body including face, elbows and heels. Bulk 18 Month Shelf Life Broad Spectrum Profile Total Aerobic Count < 2,000 cfu/g Total Yeast and Mold < 200 cfu/g E. Coli = Negative Salmonella = Negative Manufactured in the USA This product is not intended to diagnose, treat, cure, or prevent any disease and has not been evaluated by the FDA. 26 Cosmeceuticals
Cellulose Face Mask TENCEL MASK (10 mg nanoemulsified CBD) PRODUCT DATA SHEET Product Description A super-charged sheet mask infused with 0.0% THC hemp oil elements and various plant extracts to promote healthy hydrated skin. Potent cannabinoid antioxidants work to undo skin damage from pollution, sun, and various environmental factors. Our proprietary mask wraps the skin, creating a reservoir of ingredients for continuous absorption and better retention. Phytocannabinoid-Rich Hemp Oil Inactive Ingredients Active Ingredients Water, Glycerin, Dipropylene Glycol, 1,2-Hexanediol, Carbomer, Triethanolamine, Sodium Benzoate, Chlorphenesin, Sodium Hyaluronate, PEG-60 Hydrogenated Castor Oil, Disodium EDTA, Butylene Glycol, Centella Asiatica Extract, Polygonum Cuspidatum Extract, Scutellaria Baicalensis Root Extract, Camellia Sinensis Leaf Extract, Quillaja Saponaria Bark Extract, Glycyrrhiza Uralensis (Licorice) Root Extract, Anthemis Nobilis Flower Extract, Rosmarinus Officinalis (Rosemary) Flower Extract, Fragrance Attributes 0.0% THC Directions 1. Cleanse face. For best results, apply toner. 2. Tear package and unfold two-piece mask. 3. Apply the mask to face and leave on for 20-30 minutes. 4. Remove mask and gently massage remaining serum into face and neck. For best results use 2-3 times a week. Packaging Bulk Quantity: Individual Pouch or Individual Hanger Pouch. Microbial Analysis Total Aerobic Count < 2,000 cfu/g Total Yeast and Mold < 200 cfu/g E. Coli = Negative Salmonella = Negative Broad Spectrum Profile TENCEL MASK (10 mg nanoemu Phytocannabino lsified CBD) id-rich Hemp Oil Infused Face Ma sk A super-charge d sheet mask infuse extracts to promo te healthy hydrat d with 0.0% THC * hemp oil damage from polluti elements and ed skin. Potent skin to prevent active on, sun, and various enviro cannabinoid antioxidants workvarious plant nmental factors. to undo skin improve the appea ingredients from evaporating Our rance of fine lines, allowing for complcellulose mask wraps the and pores. ete penetration to visibly HOW TO USE FOR ALL SKIN TYPES 30 STEP 1 STEP 2 1. Cleanse face. 2. Tear package For best results, apply toner. 3. Apply the maskand unfold two-piece mask. 4. Remove mask to face and leave on for 20-30 minute and For best results use gently massage remaining serum s. 2-3 times a week. into face and neck. STEP 3 STEP 4 INGREDIENTS 2 Piece Mask Hydrating Antioxidant 1.05 FL OZ 30G MADE IN KOREA Distributed by Folium Bioscienc es 615 Wooten Road, Colorado Springs, Suite 110 Colorado Water, Glycerin, Dipropylene Glycol, Benzoate, Chlorphe 1,2-Hexanediol, Disodium EDTA, nesin, Sodium Hyaluronate, Carbomer, Triethanolamine, Sodium PEG-60 Hydroge Extract, Scutellar Butylene Glycol, Centella Asiatica nated Castor Saponaria Bark ia Baicalensis Root Extract, CamelliaExtract, Polygonum CuspidatOil, um Sinensis Leaf Extract, (Licorice) Root Extract, Phytocannabinoid-Rich Quillaja (Rosemary) FlowerExtract, Anthemis Nobilis FlowerHemp Oil, Glycyrrhiza Uralensis Extract, Fragranc Extract, Rosmarin e us Officinalis STORE IN A COOL, DRY PLACE, AWAY ONLY. AVOID FROM DIRECT CONTACT SUNLIGHT. FOR WITH EYES DISCONTINUE EXTERNAL USE AND MOUTH. USE. KEEP OUT IF IRRITATI OF REACH OF ON OCCURS CHILDRE N., This mask is formulate oil, artificial fragrance d without parabens, sulfates, phthalate, artificial coloring, alcohol denat, and s, animal products, mineral benzophenone. 0.0% THC 80915 This product is not intended to diagnose, treat, cure, or prevent any disease and has not been evaluated by the FDA. Cosmeceuticals 27 V VEGAN Recycle *For purposes of defining as beingrepresentations, Folium Bioscienc es, when speaking with the use of batch tested with every product's to the above terms, Folium Bioscienc run cycle and tested, is (Diode-Array detector) es laborato equipment. Certificat ry and Agilent 1200 Seriesprior to release, displaying level of HPLC es of meant in the literal any THC detected or depicted Analysis are provided with each DAD from order context. +/- ratios are associated withsuch equipment. Terms used not testing equipment.
Animal Health Meet our Chief Veterinary Officer Dr. Robert Silver DVM, MS, CVA Chief Veterinary Officer, Folium Biosciences Dr. Robert Silver is a gifted veterinarian, researcher, and author who has been practicing medicine for over three decades. He graduated from Colorado State University s College of Veterinary Medicine in 1982. After working incolorado Springs, Dr. Silver moved to Boulder in 1993 to establish Boulder s Natural Animal, one of the first integrative veterinary medical practices in the US. For the past 12 years, Dr. Silver has been investigating and recording the influence of cannabis on his patients; leading him to be known as the veterinary authority on treating companion animals with medicinal cannabis. Literally writing the book on how cannabis works with animals, he has documented its effects in a wide variety of conditions found in companion animals. These observations resulted in the writing of his book entitled: Medical Marijuana and Your Pet. Currently, Dr. Silver is involved in ongoing studies detailing the benefits phytocannabinoids have on animals through a multi-centered approach that involves veterinarians from around the US. Dr. Silver came to Folium Biosciences originally in 2015 where he found the high-quality hemp extracts he had been looking for on behalf of an animal nutraceutical company and was recruited to join Team Folium in February of 2016. 28 Animal Health
K9 Soft Chews 0.0% THC Hemp Pellets 0.0% THC For Equine, Ruminants, Birds, & Pocket Pets Tinctures 0.0% THC For Mammals, Birds, & Reptiles Available in 250 mg, 500 mg, 1000 mg, or 1500 mg Broad Spectrum Profile 29
K9 Soft Chews PRODUCT DATA SHEET Product Description Active Ingredients Inactive Ingredients Recommended Dosage Attributes Packaging Microbial Analysis Contaminant Analysis Approved Terminology Our veterinarian formulated canine soft chews provide a broad spectrum profile of synergistic compounds that are naturally present in our 0.0% THC phytocannabinoid-rich organically grown hemp oil. Each soft chew is beef flavored and easy to digest. They are specially formulated to help canines, as a supplement. 2 mg Phytocannabinoid-Rich Hemp Oil Water, dried brewer s yeast, glycerin, gum arabic, sodium alginate, beef liver powder, natural bacon flavor, flaxseed oil, microcrystalline cellulose, organic sweet potato powder, sunflower lecithin (non-gmo), citrus pectin, vitamin E, sodium propionate, calcium sulfate dehydrate, natural mixed tocopherols (natural preservative), dextrin 0.25 mg/kg 1-2 Times Daily (1 mg for every 8.8 lbs) Broad Spectrum Profile Total Aerobic Count < 2,000 cfu/g Total Yeast and Mold < 200 cfu/g E. Coli = Negative Salmonella = Negative 0.0% THC 10-pound bulk sealed foil bags: contain approx 1000 soft chews. Shipping carton: 2 X 10-pound bags = 20 pounds per carton (about 2,000 chews) Pallets: 84 X 10-pound bags per pallet (about 84,000 chews per pallet) Bulk Only. Heavy Metals: Not Detected (ND) Lead: ND Arsenic: ND Residual Solvents: ND Manufactured in the USA Organically Grown Hemp Veterinarian Formulated Measurements 1/2 Weight: 4.5 Grams / per piece 5/8 This product is not intended to diagnose, treat, cure, or prevent any disease and has not been evaluated by the FDA. 30 Animal Health
Hemp Pellets For Equine, Large and Small Ruminants, Avian & Pocket Pets PRODUCT DATA SHEET Product Description Active Ingredients Inactive Ingredients Concentration Attributes Packaging Microbial Analysis Contaminant Analysis Approved Terminology Hemp Pellets are pressed from Folium Biosciences s Hemp Meal, which contains 0.0% THC and a guaranteed minimum cannabinoid content of 0.3% in dry matter. They have been assayed to contain 20% plant protein, 30% insoluble fiber and 50% complex carbohydrates. The hemp meal used to make the pellets has been sterilized, sieved, and blended for safety, efficacy, and consistency. A food-grade FDA approved mold inhibitor has been added to the pellets for additional shelf life. These pellets can be easily administered to a variety of species, including horses, donkeys, mules, goats, sheep, swine, poultry and pet caged birds, rabbits, and pocket pets. The minimum guaranteed amount, 0.3% phytocannabinoids, provides 25-30 mg of phytocannabinoids per 2 level teaspoons (10 cc). 0.3% Phytocannabinoids Myco Curb, Apple Ade 2 level Teaspoons (10 cc) = 25-30 mg phytocannabinoids 0.0% THC 25 Pound Sacks 18 Month Shelf Life Total Aerobic Count < 2,000 cfu/g Total Yeast and Mold < 200 cfu/g E. Coli = Negative Salmonella = Negative Heavy Metals: Not Detected (ND) Lead: ND Arsenic: ND Residual Solvents: ND Manufactured in the USA Organically Grown Hemp This product is not intended to diagnose, treat, cure, or prevent any disease and has not been evaluated by the FDA. 31 Animal Health
Frequently Asked Questions with our Chief Veterinary Officer Dr. Robert J. Silver, DVM, MS Phytocannabinoids and Pets: CBD and THC Q. How does CBD work in pets? A. It works the same way it works in people, by stimulating the endocannabinoid system to create balance in the body which helps to relieve pain, reduce neurological problems, reduce anxiety, and address problems with diseases like osteoarthritis, cancer, inflammatory bowel disease, epilepsy, asthma, etc. Q. Is THC necessary for CBD to work? A. No. This was a common belief before more research was done regarding hemp s other cannabinoids. New information has shown that THC and CBD can sufficiently function without the other. Broad spectrum products that are THC-free but still have several other cannabinoids present are the most beneficial as the cannabinoids are able to complement each other s individual effects. Q. Is THC safe to use in pets? A. Folium Biosciences does not recommend giving THC to animals. Every species will experience different reactions to the compound. Dogs have been found to be highly sensitive to its psychoactive properties, while cats have been shown to be less susceptible. THC in larger animals like horses can be potentially dangerous to both the animal and owner, due to THC causing excessive excitement or positive drug tests. Q. Is THC an important medicinal cannabinoid? A. THC does have clinical value when combined with CBD for severe pain and aggressive types of cancer. Other than those two applications, the other major and minor cannabinoids and terpenes found in broad spectrum hemp extracts are more than adequate to address most clinical conditions responsive to cannabinoids. 32
Phytocannabinoids and Animals: Dosing and Drug Testing Q. What is the recommended dosage for pets? A. We always suggest starting with a low dosage and seeing how it affects the animal before moving up. For the most common ailments, such as anxiety or mild pain, the lowest dose twice a day works very well. Even for more severe problems, the positive reaction to CBD can be profound enough at this low dosage to benefit the quality of life entirely. Every individual is unique and will process cannabinoids differently, meaning that there is no one-size-fits-all dose for all animals. The best way to make sure that the animal is receiving an adequate amount of CBD is to start low and monitor behavior for 5-10 days before increasing intake. RECOMMENDED DOSAGES FOR PETS Dosage per pound per 10 pounds low 0.05 mg 0.5 mg mid 0.10 mg 1.0 mg high 0.25 mg 2.5 mg Q. How was the recommended dose calculated? A. Several scientific studies were analyzed and compared with first-hand evidence to create the recommended dose. Study groups of neurology and oncology veterinary specialists were given Folium Biosciences Phytocannabinoid-rich (PCR) tinctures to administer to their patients and examine the outcomes. Through their results and overwhelming anecdotal evidence collected over the course of two years from other vets and pet owners, this was determined to be the most advantageous dose to begin with. Q. What is the recommended dosage for horses? A. Folium Biosciences had several equine veterinarians test CBD dosages on numerous horses to find the ideal amount needed for a given condition. Horses are very efficient at absorbing phytocannabinoids. For example, anxiety, a common occurrence when eventing or loading onto a trailer, was greatly reduced with the use of 25 mg once or twice a day. Mild lameness or pain was also remedied by that same dosage. For more serious conditions like laminitis, marked lameness, metabolic syndrome, or Cushing s disease, 50 mg twice daily made a notable improvement. Q. Will drug testing be a problem for equestrian events? A. Currently, in the US, horses are only being tested for THC, not CBD. Rules regarding CBD in these cases are subject to change, and we will be continually monitoring any development in this area. While the federal law on hemp allows small amounts of THC to be present, Folium Biosciences prides itself on creating 0.0% THC hemp products. Animals will not show a positive THC result on drug tests when using Folium Biosciences PCR hemp products, which very few hemp companies can promise. Animal Health 33
Available Bottles & Containers Tinctures, Vape & E-Juice 1 oz Glass Amber or Colbalt Dropper Bottle Softgels 2.5 oz Amber or Colbalt PET Packer Bottle With Glass Childproof Graduated Dropper Balm / Salve 1 oz and 2 oz Regular Wall Straight Side Jars With Heat Seal Induction Liner White Label
719-574-2159 info@foliumbiosciences.com 615 Wooten Road Suite 110 Colorado Springs, CO 80915 www.foliumbiosciences.com