Programme. TTS New Key Opinion Leader Meeting Thursday September 21 st Arrivals and Dinner at the Hotel. Friday September 22 nd

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TTS New Key Opinion Leader Meeting 2006 Programme Thursday September 21 st Arrivals and Dinner at the Hotel After dinner approx 9.00pm Pioneers in Transplantation Professor Josep Ma Caralps Heart transplantation in Spain Friday September 22 nd 8.30am 10.30am Session 1 "Regulatory T cells: are they really critical for graft acceptance?" Chairs Hans Schlitt and Kathryn Wood Presentation 1.1 KOL: Kathryn Wood Oxford, UK New KOL: Nick D. Jones Title: Regulatory T cells changing site of action and mechanisms Presentation 1.2 KOL: Josep Grinyo, Barcelona, Spain New KOL: Alberto Sanchez-Fueyo Title: "Immune characterization of operationally tolerant liver transplant recipients". Presentation 1.3 KOL: Zheng Xinxiao, Boston, USA New KOL: Wenda Gao Title : Wenda Gao : De novo generation of regulatory T cells in transplantation Presentation 1.4 KOL: Dr Irma Joosten - Nimegen, The Netherlands New KOL: Hans J.P.M. Koenen Title: A clinical approach to regulatory T cells 10.30am 11.00am TTS New KOL Meeting Barcelona September 21 st 23 rd, 2006 1

11.00am 1.00pm Session 2 Renal Allografts Factors influencing long term outcomes Chairs Josep Grinyo and Frederic Oppenheimer Presentation 2.1 KOL: Daniel Seron, Barcelona, Spain New KOL: Francesco Moreso Title: Glomerular adaptation and renal allograft outcome Presentation 2.2 KOL: José Medina Pestana, Sao Paolo, Brazil New KOL: Paula Goulart Machado Title: Jose Pestana: Renal allografts: long term effects of race and year of transplantation Paula Machado: Are we ready for a calcineurin inhibitor free-regimen Presentation 2.3 KOL: Yves VanRenterghem, Leuven, Belgium New KOL: Maarten Naesens Title: "Walking the tightrope between over- and underimmunosuppression: can therapeutic drug monitoring, protocol biopsies or both be helpful? Presentation 2.4 KOL: Christophe Legendre, Paris, France New KOL: Dany Anglicheau Title : Individualizing immunosuppression with pharmacogenetics to improve transplant results 1.15pm 2.30pm Lunch 2.30pm 4.00pm Session 3 Non-heart beating donors Chairs Blanca Miranda and Francis Delmonico Presentation 3.1 KOL: Stefan Tullius, Boston, USA New KOL: Christian Denecke Title: Stefan Tullius: Non-heart beating donors: Potential to solve the increasing demand for organ transplantation? Christian Denecke: Non-heart beating donors: Experimental models and the correspondence of immune and non-immune factors Presentation 3.2 KOL: Rutger Ploeg, Gronigen, The Netherlands New KOL: Cyril Moers Title: Non Heart Beating Donation: Possibilities and Limitations TTS New KOL Meeting Barcelona September 21 st 23 rd, 2006 2

Presentation 3.3 KOL: Marti Manyalich, Barcelona, Spain New KOL: Angel Ruiz Title: DCD Type I and II. Procedures and quality assessment 4.00pm 4.30pm 4.30pm 5.30pm Session 4 Cardiovascular diseases in Organ Transplantation Chairs José Morales and Fred Faendrich Presentation 4.1 KOL: Uwe Heemann, Munich, Germany New KOL: Jens Lutz Title: Factors influencing the cardiovascular system in organ transplantation. Presentation 4.2 KOL: Armando Torres, Canary Islands New KOL: Esteban Porrini Title: Armando Torres: Impact of glucose homeostasis alterations after renal transplantation on graft function and cardiovascular diseases. Esteban Porrini: Link between chronic subclinical inflammation, prediabetic glucose homeostasis alterations and atheromatosis in renal transplantation. 5.30pm Discussion and Summary Josep Grinyo, Josep Lloveras and Kathryn Wood 7.30pm Drinks 8.00pm Dinner TTS New KOL Meeting Barcelona September 21 st 23 rd, 2006 3

Saturday September 23rd 8.30am 10.30am Session 5 Towards tolerance translational studies exploring novel strategies Chairs Yves Vanrenterghem and Josep Lloveras Presentation 5.1 KOL: Robin Pierson, Baltimore, USA New KOL: Agnes Azimzadeh Title: Selective CD28 blockade to modulate alloimmunity Presentation 5.2 KOL: Margreet Jonker, Rijkswik, The Netherlands New KOL: Krista Haanstra Title: Margreet Jonker: The significance of non human primate studies in non-deletional tolerance induction Krista Haanstra: Development of a pre-clinical model for the evaluation of Treg inducing protocols Presentation 5.3 KOL: Fred Faendrich, Kiel, Germany New KOL: James A. Hutchinson Title: The use of in vitro modified monocytes in the clinical setting of tolerance induction 10.30am 11.00am 11.00am 1.00pm Session 6 Liver transplantation Factors influencing long term outcomes Chairs Rutger Ploeg and Juan Carlos García-Valdecasas Presentation 6.1 KOL: David Adams, Birmingham, UK New KOL:Edward Alabraba Title: Mechanisms of long term graft damage following liver transplantation Presentation 6.2 KOL: Hans Schlitt, Regensberg, Germany New KOL: Dr Martin Loss Title: Billiary problems after liver transplantation as a limiting factor of long-term success Presentation 6.3 KOL: Nigel Heaton, London, UK New KOL: Varuna Aluvihare Title: Factors influencing long term outcomes in Liver Transplantation: The Kings Experience TTS New KOL Meeting Barcelona September 21 st 23 rd, 2006 4

Presentation 6.4 KOL: Chung Mau Lo, Hong Kong New KOL: Dr See-Ching Chan Title: Long term outcome of adult-to-adult living donor liver transplantation 1.00pm Discussion and Summary Josep Lloveras, Josep Grinyo and Kathryn Wood Free Afternoon A series of activities will be planned 8.00 pm Gala Dinner Sunday September 24th - Departures TTS would like to thank Wyeth Pharmaceuticals for supporting the 2006 New Key Opinion Leader Meetings through an unrestricted educational grant TTS New KOL Meeting Barcelona September 21 st 23 rd, 2006 5