HCC and the Hallmarks of Cancer: steps towards novel therapeutic strategies
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1 EASL HCC SUMMIT February 2017, Geneva, Switzerland Scientific Committee: Basic Programme: Tom Luedde, Germany Helen Reeves, United Kingdom Clinical Programme: Alejandro Forner, Spain Franco Trevisani, Italy HCC and the Hallmarks of Cancer: steps towards novel therapeutic strategies THURSDAY 2 FEBRUARY Welcome and Introduction Helen Reeves, (United Kingdom) Tom Luedde, (Germany) Opening Lecture: The Challenge - bridging the gap between basic science and clinical practice Peter Schirmacher, (Germany) Session 1: Models and Tools for identification and translation of novel candidates. Chair: Helen Reeves, (United Kingdom) Jessica Zucman Rossi, (France) Identifying candidates Omics & Next-generation Sequencing in HCC. Jessica Zucman Rossi, (France) Animal models of HCC: Which models mimic best human biology, pathology and genetics? Robert Eferl, (Austria) Molecular imaging: principles, progress and application to HCC. Twan Lammers, (Netherlands) Coffee break Session 2: Sustained Proliferative Signalling & Evasion of Growth Suppression Chair: Peter Schirmacher, (Germany) Robert Eferl, (Austria) MAPKinases in hepatocarcinogenesis Erwin Wagner, (Spain)
2 CAR and Beta catenin David Moore, (United States) The MDM2-p53 pathway in cancer Simone Fulda, (Germany) ABSTRACT X Coffee Break Session 3: The role of the inflammatory microenvironment in HCC Chair: Robert Thimme, (Germany) Frank Tacke, (Germany) The microenvironment and its contribution to outcome in HCC Xin Wei Wang, (United States) Granulocytes in liver Cancer Derek Mann, (United Kingdom) Tumour associated antigen responses in HCC Robert Thimme, (Germany) Cocktail Reception for all participants and poster session Authors of abstracts with odd poster numbers to be present at the poster session FRIDAY 3 FEBRUARY Session 4: Hallmark - Angiogenesis, Invasion and metastases Chair: Erwin Wagner, (Spain) Erica Villa, (Italy) Prognostic signatures from HCC biopsy Erica Villa, (Italy) Endothelial cell metabolism and angiogenesis Peter Carmeliet (Belgium) TGF beta in HCC progression Isabel Fabregat, (Spain) TWO ABSTRACTS Coffee Break Session 5: Enabling of replicative Immortality, Genomic Instability and mutation Chair: Josep Llovet, (Spain) Rudolph Lenhard, (Germany) Telomeres & Telomerase in HCC Rudolph, Lenhard (Germany) Mutations in SPRTN and genomic instability in HCC Christian Kubisch, (Germany) Transposable elements and genetic instability Ruchi Shukla, (United Kingdom)
3 Molecular classification and drivers of cholangiocarcinoma Josep Llovet, (Spain) :30 Poster session & lunch break :00 16: Session 6: Deregulation of cellular energetics Chair: Peter Jansen, (Netherlands) Matias Heikenwalder, (Germany) Mechanisms of NASH and NASH- triggered HCC M. Heikenwälder, (Germany) Obesity, the gut microbiome and liver cancer Herbet Tilg, (Austria) Endoplasmic reticulum stress Eric Chevet, (France) Metabolic Receptors in HCC/CCC Peter Jansen, (Netherlands) Coffee break Session 7: Cell Death Chair: Tom Luedde, (Germany) Derek Mann, (Germany) Regulated Cell Death pathways in Hepatocarcinogenesis Tom Luedde, (Germany) Cell death response pathways in liver cancer Robert Schwabe, (United States) Joint translational Key note lecture The Hallmarks of Cancer in Douglas Hanahan, (Switzerland) Joint Faculty Dinner
4 CLINICAL RESEARCH: Liver Cancer Management SATURDAY 4 FEBRUARY Opening address Franco Trevisani, (Italy) and Alejandro Forner, (Spain) Session 1 THE CHANGING EPIDEMIOLOGY Chair: Franco Trevisani, (Italy) and Jordi Bruix, (Spain) Epidemiology of HCC an introduction. Massimo Colombo, (Italy) How can we assess the risk of HCC development in alcoholic patients? Pierre Nahon, (France) Impact of new antiviral treatments on HCC risk. George Papatheodoridis, (Greece) NAFLD as a risk factor for HCC. Jean Francois Dufour, (Switzerland ) Coffee break Session 2: DIAGNOSTIC CHALLENGES Chairs: Valerie Vilgrain, (France) and Massimo Colombo, (Italy) Surveillance for HCC: whom, how, and how often? Alejandro Forner, (Spain) Diagnosis of HCC by imaging: Can we improve its accuracy? Carmen Ayuso, (Spain) Pathology of HCC: Can we improve the diagnostic accuracy? Valérie Paradis, (France) Refinement of staging and prognosis assessment of HCC: - Western point of view: Jordi Bruix, (Spain) - Eastern point of view: Ronnie Poon, (Hong Kong) ABSTRACT x 2 OR LONGER LUNCH BREAK Lunch BREAK AND POSTER VIEWING Session 3: SURGICAL THERAPY Chairs: Vincenzo Mazzaferro, (Italy) and Alejandro Forner, (Spain) Extending the boundaries for resection Daniel Cherqui, (France) Resection or RFA as first line treatment for early stage HCC? Fabio Piscaglia, (Italy) Resection vs. Liver Transplantation in HCC.
5 Pietro Majno, (Switzerland) Liver transplantation for HCC: Can extending criteria be applied in clinical practice? Vincenzo Mazzaferro, (Italy) COFFEE BREAK Session 4: LOCOREGIONAL THERAPY Chairs: Philippe L. Pereira (Germany) and Carmen Ayuso (Spain) TACE: Who should be treated, when to stop, how to be done? Markus Peck-Radosavljevic, (Austria) Which is the role of radioembolization in HCC? Sherrie Bhoori, (Italy) Imaging tumor response evaluation in HCC: Room for improvement? Valérie Vilgrain, (France) Can locoregional therapies be combined? Philippe L. Pereira, (Germany) SUNDAY 5 FEBRUARY Session 5: INTRAHEPATIC CHOLANGIOCARCINOMA: AN EMERGING PROBLEM. Chairs: Peter Galle, (Germany) and Bruno Sangro, (Spain) The changing epidemiology and diagnosis. Annika Bergquist, (Sweden) Surgical therapy in ICC: Resection and liver transplantation. Ulf P. Neumann, (Germany) The role of locoregional therapies in ICC Stephen Pereira, (United Kingdom) Systemic therapy. Arndt Vogel, (Germany) Coffee Break Session 6: Systemic treatments and beyond in HCC Chairs: Tim Meyer, (United Kingdom) and Josep Llovet (Spain) Sorafenib in HCC: Is the efficacy predictable? Maria Reig, (Spain) First-line and second-line trials on HCC: Why they have failed? Peter Galle, (Germany) Rationale basis and ongoing trial of immunotherapy. Bruno Sangro, (Spain) Ongoing trial.
6 Tim Meyer, (United Kingdom) End of the conference
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