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So-called cystadenoma of seminal vesicle.

Gross appearance of granulomatous orchitis.. The testis is increased in consistency, enlarged, and vaguely nodular.

Microscopic appearance of granulomatous orchitis.. The inflammatory infiltrate is centered in the seminiferous tubules.

Epidermoid cyst of testis. The lesion is sharply outlined and contains laminated layers of keratin.

Microscopic appearance of epidermoid cyst of testis. Keratin squames are laid down by well-differentiated squamous epithelium. There are no skin adnexal structures.

Gross appearance of combined tumor of testis. In both instances, the solid homogeneous gray areas correspond to the seminoma,, and the variegated foci with hemorrhage to the nonseminomatous component.

Gross appearance of seminoma.. The tumor in A is very small, whereas that in B has replaced most of the testis.

Classic seminoma of testis. Compact nests of large tumor cells are separated by fibrous septa heavily infiltrated by lymphocytes.

Plastic-embedded section of classical seminoma.. Notice the large nuclei, prominent nucleoli, abundant clear cytoplasm, sharply outlined cell membranes, and inflammatory infiltrate in the stroma.

Seminoma associated with marked granulomatous reaction. Only a few tumor cells are visible in this field.

Pagetoid extension of seminoma into rete testis. This should not be misinterpreted as a nonseminomatous component.

Abundant glycogen present in the cytoplasm of seminoma cells, evidenced by the PAS reaction and removed by diastase digestion.

CD117 immunoreactivity in classic seminoma.

Seminoma exhibiting pleomorphism and marked hyperchromasia.. Some authors designate this neoplasm as anaplastic seminoma.

Seminoma with trophoblastic giant cells. (Hematoxylin and eosin)

Seminoma with trophoblastic giant cells. (hcg( immunostain)

Gross appearance of spermatocytic seminoma.. A large tumor of myxoid appearance bulges on the cut surface.

Spermatocytic seminoma showing admixture of medium-sized cells (predominating), giant cells, and small lymphocyte-like like cells.

Typical chromatin pattern of spermatocytic seminoma.

Extensive intratubular growth of spermatocytic seminoma.

Sarcomatous focus in spermatocytic seminoma of testis, exhibiting rhabdomyoblastic differentiation. This section is from a lung metastasis.

Embryonal carcinoma showing solid nodular cut surface with numerous areas of necrosis and hemorrhage.

Embryonal carcinoma. The pattern of growth is diffuse but without the nesting seen in classic seminoma.. The high-power view shows the typical large, irregularly shaped, overlapping nuclei with multiple prominent nucleoli.

Gross appearance of mature (adult) teratoma of testis. There are multiple cystic areas, lobules of mature adipose tissue, and shiny solid nodules corresponding to well-differentiated cartilage.

Low-power microscopic view of mature teratoma. Large islands of cartilage are seen surrounding well-differentiated glandular structures.

Immature teratoma.. Gross appearance.

Immature teratoma.. Microscopic appearance. Hypercellular stroma is seen growing in a concentric fashion around glandular formations.

Microscopic appearance of intratubular germ cell neoplasia in routinely stained section. A row of atypical germ cells with clear cytoplasm is seen against a thickened basement membrane. No spermatogenesis is occurring in this tubule.

PAS stain of intratubular germ cell neoplasia showing abundant intracytoplasmic glycogen in the neoplastic cells.

PLAP immunoreactivity in the tumor cells of intratubular germ cell neoplasia.

Retroperitoneal metastasis of NSGCT. The mass is entirely composed of mature tissue, whereas the primary tumor had the features of a teratocarcinoma.

Entirely necrotic retroperitoneal metastasis of NSGCT following chemotherapy.

Lung metastasis of NSGCT following chemotherapy. The mass was entirely composed of mature tissues.

Gross appearance of Leydig cell tumor. The tumor, which has replaced most of the testis, has a granular yellowish appearance.

Gross appearance of Leydig cell tumor. This tumor, occurring in a child, is solid, well circumscribed, and dark brown.

Leydig cell tumor of testis. The neoplasm is characterized by solid growth of polygonal cells with abundant granular acidophilic cytoplasm.

Leydig cell tumor of testis. The tumor cells have a cytoplasmic clear quality, reminiscent of that seen in tumors of the adrenal cortex.

Leydig cell tumor with myxoid features.

So-called testicular tumor of the adrenogenital syndrome. Multiple nodules are present, having an appearance compatible with adrenal cortical origin.

Sertoli cell adenoma in a patient with testicular feminization syndrome.

Sertoli cell adenoma with sarcomatoid features. The Sertoli cell nature of the tumor is more apparent.

Sertoli cell adenoma with sarcomatoid features.

Microscopic appearance of sclerosing Sertoli cell tumor.

Gross appearance of large cell calcifying Sertoli cell tumor of testis. The tumor is distinctly multinodular.. The dark nodules had a prominent component of Leydig cells.

Large cell calcifying Sertoli cell tumor.

Adult form of granulosa cell tumor involving testis. Note the occasional longitudinal grooves, the oval to spindle shape of the tumor cells, and the high mitotic activity.

Gross appearance of a juvenile granulosa cell tumor involving the testis of an infant.

Mixed germ cell stromal tumor of the testis. This lesion is distinct from gonadoblastoma.

Gross appearance of malignant lymphoma of large cell type, which completely replaces the testis.

Malignant lymphoma of testis. There is diffuse infiltration of the interstitium by neoplastic lymphocytes, which surround and separate atrophic tubules.

Cases of large B-cell B lymphoma with pleomorphic features such as that depicted in this photograph can be misdiagnosed as anaplastic or spermatocytic seminoma.

Testicular involvement by granulocytic sarcoma. Most of the cells present in the interstitium are myeloid precursors.

Intratesticular carcinoid tumor showing the classic insular pattern.

Kaposi s s sarcoma of the testis in an HIV-infected individual.

Malignant melanoma metastatic to testis. The black color of the tumor is due to massive melanin deposition.

Prostatic adenocarcinoma metastatic to testis. This not too rare occurrence is sometimes misdiagnosed as sex cord stromal tumor.

Acute and chronic epididymitis.. The inflammation has not spread to the testicle.

Granulomatous epididymitis with focal extension into the testis. Some of the granulomas have a necrotic center. No microorganisms were identified on special stains.

Spermatic granuloma of epididymis.

Typical gross appearance of adenomatoid tumor of epididymis.

Low-power appearance of adenomatoid tumor, showing typical conglomerate of cystically dilated spaces.

On high power, some of the tubules of adenomatoid tumor are lined by cuboidal cells, whereas others are lined by flattened cells with the appearance of endothelial cells.

Strong immunoreactivity for keratin in an adenomatoid tumor.

Malignant mesothelioma involving the epididymis.

Bilateral papillary cystadenoma of epididymis.

Tumor interpreted as a primary papillary adenocarcinoma of the epididymis.

Leiomyosarcoma of epididymal region.

Vasitis nodosa.. Clumps of spermatozoa are present in the center of the granulomas.

Median raphe cyst. This probably results from cystic dilatation of accessory urethral canals or periurethral ducts.

Gross appearance of teratocarcinoma.. The solid granular areas correspond to foci of embryonal carcinoma, whereas the pearly nodules correspond to well-differentiated cartilage.

Gross appearance of pure choriocarcinoma.. The strikingly hemorrhagic appearance is characteristic of this tumor type.

Microscopic appearance of testicular choriocarcinoma. There is close intermingling of cytotrophoblast and syncytiotrophoblast,, which recapitulates that seen in normal chorionic villi.

Gross appearance of pure yolk sac tumor in an infant.

Schiller Duval body in yolk sac tumor of testis.

Pleomorphism and hyaline globules in yolk sac tumor of testis.