UvA-DARE (Digital Academic Repository) Finding the balance between overtreatment and undertreatment of ductal carcinoma in situ Elshof, L.E. Link to publication Citation for published version (APA): Elshof, L. E. (2017). Finding the balance between overtreatment and undertreatment of ductal carcinoma in situ. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (http://dare.uva.nl) Download date: 28 Mar 2019
FINDING THE BALANCE BETWEEN OVERTREATMENT AND UNDERTREATMENT OF DUCTAL CARCINOMA IN SITU Lotte Elisabeth Elshof
The work described in this thesis was performed at the Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands. In cooperation with the Netherlands Comprehensive Cancer Organization (IKNL), the nationwide network and registry of histo- and cytopathology in The Netherlands (PALGA foundation), the Dutch breast cancer screening facilities (BOB), Statistics Netherlands (CBS) and the European Organisation for Research and Treatment of Cancer (EORTC), Brussels, Belgium. The research was funded by grants from Pink Ribbon, A Sister s Hope and the Dutch Cancer Society (KWF Kankerbestrijding). Unrestricted financial support for publication of this thesis was kindly provided by Human Capital Care, Chipsoft and EURIN B.V. Copyright 2017 Lotte Elshof, Amsterdam, The Netherlands Design cover: Inspired by Golden Cosmos, Berlin, Germany and La cerise sur le gateau, Mulhouse, France / Designed by Hellen van Berge Henegouwen, E&H, Leiden, The Netherlands and Lotte Elshof Design inside: Bregje Jaspers, ProefschriftOntwerp, Nijmegen, The Netherlands Printed by: Gildeprint, Enschede, The Netherlands ISBN: 978-94-6233-740-4
FINDING THE BALANCE BETWEEN OVERTREATMENT AND UNDERTREATMENT OF DUCTAL CARCINOMA IN SITU ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. ir. K.I.J. Maex ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel op vrijdag 3 november 2017, te 14.00 uur door Lotte Elisabeth Elshof geboren te Leiden
Promotiecommissie: Promotores: prof. dr. E.J.T. Rutgers AMC-UvA prof. dr. ir. F.E. van Leeuwen Vrije Universiteit Amsterdam Copromotores: dr. J. Wesseling NKI-AvL dr. M. Schaapveld NKI-AvL Overige leden: prof. dr. M.J. van de Vijver AMC-UvA prof. dr. J.H.G. Klinkenbijl AMC-UvA prof. dr. R.M. Pijnappel Universiteit Utrecht prof. dr. L.V. van de Poll-Franse Universiteit van Tilburg dr. N. Bijker AMC-UvA dr. C.M. Ronckers AMC-UvA dr. H.A.O. Winter-Warnars NKI-AvL Faculteit der Geneeskunde
Voor mijn grootouders Robert van Zonneveld arts-epidemioloog Elisabeth Coco Limborgh Meijer Gerrit Elshof Anna Hulshof
Table of Contents Chapter 1 General introduction and outline of the thesis 9 Chapter 2 Finding the balance between overtreatment and undertreatment of ductal carcinoma in situ 21 Chapter 3 Ductaal carcinoma in situ: de balans tussen overbehandeling en onderbehandeling 47 Chapter 4 Subsequent risk of ipsilateral and contralateral invasive breast cancer after treatment for ductal carcinoma in situ: incidence and the effect of radiotherapy in a population-based cohort of 10,090 women 59 Chapter 5 Cause-specific mortality in a population-based cohort of 9,799 women treated for ductal carcinoma in situ 81 Chapter 6 The method of detection of ductal carcinoma in situ has no therapeutic implications: results of a population-based cohort study 109 Chapter 7 Feasibility of a prospective, randomised, open-label, international multicentre, phase III, non-inferiority trial to assess the safety of active surveillance for low risk ductal carcinoma in situ - The LORD study 137 Chapter 8 General discussion, ongoing research and future prospects 165 Chapter 9 Summary Samenvatting List of co-authors and their contributions PhD portfolio Dankwoord Curriculum Vitae 193 199 205 211 217 225