An Overview on the Global Market of Dietary Supplements

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An Overview on the Global Market of Dietary Supplements Abbas Kebriaeezadeh 1 and Alireza Yektadoost 2 Department of Pharmacoeconomics & Pharmaceutical Administration Faculty of Pharmacy, Tehran University of Medical Sciences 1- Pharm.D., PhD of Toxicology & Head of Department 2- Pharm.D., PhD Candidate of Pharmacoeconomics & Pharmaceutical Administration

Dietary Supplement Definition Food supplement or Nutritional supplement For supplementing the diet and supplying nutrients that may be absent in a person's diet or may not be consumed in sufficient quantities. A concoction of several vitamins, minerals, fiber, fatty acids, amino acids and other trace elements. Can be consumed in form of: pill, tablet, capsule, softgel, powder, or liquid.

Nutraceuticals Segments Nutraceuticals Functional /Medicinal Foods Functional Beverages Dietary Supplements Probiotic Fortified Foods Energy Drinks Vitamin & Mineral Supplements Omega FA Fortified Foods Sports Drinks Herbal Supplements Milk & Dairies, Wheat Flour, Iodinated Salt Fortified Juices Protein Supplements

Nutrition Supplement Requirement Lifestyle Wellbeing Vitality Beauty Energy Preventive & Proactive Age related Infant Nutrition Weight management Site specific Goal oriented Clinical Medical foods Nutrigenomics Food as dosage

Categories & Components of Dietary Supplements Categories Specialty Supplements Sports Nutrition Meal Replacements Components Herbs/Botanicals Vitamins Minerals Amino Acids

A Brief History of Dietary Supplements 1995: The Year of Melatonin 2004: The Year of Fish Oil 1996: The Year of Echinacea 2005: The Year of Vitamin E 1997: The Year of St. John s Wort 2006: The Year of Obesity 1998: The Year of Glucosamine 2007: The Year of Probiotics 1999: The Year of SAMe 2009: The Year of Vitamin D 2003: The Year of Ephedra

Global Nutrition Market In billion USD 400 350 300 250 285.18 305.14 325.89 350.01 372.76 2012: US$350.01 b 2013: US$372.76 b 200 150 6.5% Growth 100 50 0 2009 2010 2011 2012 2013 CAGR 2009-2013: 6.92% Source: KONCEPT ANALYTICS

Global Nutrition Industry Forecast 2014F 2018F CAGR = 6.87% 398.11 425.97 456.64 484.96 519.39 2014f 2015f 2016f 2017f 2018f Source: KONCEPT ANALYTICS

Global Nutrition Industry by Segments 2013 Infant Nutrition 24% Functional Food & Beverages 47% Dietary Supplements 29% Source: KONCEPT ANALYTICS

Global Dietary Supplements Market In billion USD 120 100 80 85.57 90.37 95.97 101.54 108.85 2012: US$101.54 b 2013: US$108.85 b 60 40 7.2% Growth 20 0 2009 2010 2011 2012 2013 CAGR 2009-2013: 6.2% Source: KONCEPT ANALYTICS

Global Nutrition Supplement Market by Segments Share - 2013 Meal Replacements 8% Others 19% Vitamins 34% Minerals 10% Sports Nutritions 12% Herbs & Botanical 17% Source: KONCEPT ANALYTICS

Global Nutrition Supplement Market by Segments 2013 Vitamins Herbs & Botanical Sports Nutrition Minerals Meal Replacements Others 36.79 (US$ Billion) 18.07 (US$ Billion) 13.17 (US$ Billion) 10.88 (US$ Billion) 9.25 (US$ Billion) 20.68 (US$ Billion)

Global Nutrition Supplement Market by Regional Share - 2013 Region Revenue (US$ b.) North America 38.10 21% 16% 35% Asia Pacific 30.48 28% Europe 22.86 Other 17.42 North America Asia Pacific Europe Other Source: KONCEPT ANALYTICS

Global Dietary Supplement Market Forecast 2014F 2018F 160 140 120 114.16 121.84 CAGR = 6.73% 130.04 138.8 148.14 100 80 60 40 20 0 2014f 2015f 2016f 2017f 2018f Source: KONCEPT ANALYTICS

Global Rx Pharmaceuticals vs. Nutraceuticals & Nutrition Supplement Market 1300 1000 +6.9% CAGR 2012-18 350 102 +6.8% CAGR 2012-18 520 149 Sources: IMS, EVALUATE-PHARMA, & KONCEPT ANALYTICS

Global Vitamin Market 2009 to 2013 & 2014 to 2018 forecast 50 45 40 35 30 25 20 15 10 5 CAGR = 3.24% CAGR = 4.1% 43.2 41.5 39.87 38.3 36.79 34.51 35.47 32.38 33.26 44.98 0 2009 2010 2011 2012 2013 2014f 2015f 2016f 2017f 2018f Source: KONCEPT ANALYTICS

Global Sports Nutrition Market Performance enhancers, metabolic/fat burners, muscle builders, meal replacements, weight gainers, and energy formulas. In tablet, powder or ready-to-drink forms. These products are targeted at athletes and gym-goers. They contain one or more of the following ingredients: Soy protein, whey protein, Creatine, L-Carnitine and Amino acids. While powders account for the majority of the market, protein bars and ready-to-drink protein beverages have been growing at a faster rate.

Global Sports Nutrition Market 2009 to 2013 & 2014 to 2018 forecast 25 CAGR = 12.82% CAGR = 10.4% 21.6 20 15 10 8.13 9.26 10.47 11.77 13.17 14.54 16.05 17.72 19.56 5 0 2009 2010 2011 2012 2013 2014f 2015f 2016f 2017f 2018f Source: KONCEPT ANALYTICS

Global Mineral Market 2009 to 2013 & 2014 to 2018 forecast 20 18 CAGR = 11.5% CAGR = 11.21% 16.64 18.51 16 14 12 10 8 7.04 7.91 8.83 9.78 10.88 12.1 13.46 14.97 6 4 2 0 2009 2010 2011 2012 2013 2014f 2015f 2016f 2017f 2018f Source: KONCEPT ANALYTICS

Nutrition Supplement Industry North America vs. Asia Pacific - 2013 2013: US$ 38.10 billion (CAGR: 5.43%) 2018: US$ 51.23 billion (CAGR: 6.1%) 2013: US$ 30.48 billion (CAGR: 5.55%) 2018: US$ 38.95 billion (CAGR: 4.89%) Minerals 9% Others 23% Meal Replacem ents 6% Herbs & Botanical 12% Vitamins 29% Sport nutritions 21% Meal Replacem ents 8% Minerals 13% Others 17% Herbs & Botanical 16% Sport nutritions 3% Vitamins 43%

Market of Dietary Supplements in Iran 2012 Tonics, 1.1% Co-Q10, 0.5% Fish Oils, 1.7% Protein DS, 1.8% Herbal DS, 4.9% Paediatric DS, 7.4% Glucosamine, 8.1% Other, 3.0% Multivitamins, 34.4% Single Vitamins, 15.7% Minerals, 21.5% Source: Euromonitor International

Targets of Supplement Use Iran Bone, 16% Joint, 10% Beauty, 5% Digestive, 2% Sexual Health, 2% Memory Health, 1% Other, 3% Immune System, 1% Energy, 1% General Health, 62% Source: Euromonitor International

Vitamin Market Iran vs. UK 0.5% 6.6% 1.0% Multivitamins Vitamin A 2.4% 2.4% 1.8% Multivitamins Vitamin A 8.8% Vitamin B 17.3% Vitamin B 13.8% Vitamin C Vitamin C 0.6% 68.8% Vitamin D Vitamin E 0.7% 8.8% 66.6% Vitamin D Vitamin E Other Single Vitamins Other Single Vitamins Source: Euromonitor International

Market Dynamics Growth Drivers Increasing Global Healthcare Expenditure Shift from Rural to Urban Regions Accelerating Aging Population Increasing Life Expectancy Rate Ameliorating Economic Conditions Rising Number of Vitamin D Tests

Increasing Global Healthcare Expenditure Per Capita (US$) CAGR: 4.56% 1200 1000 824.7 894.4 904.9 948.9 1012.7 1030.9 800 600 400 200 0 2007 2008 2009 2010 2011 2012 Source: World Bank

Shift from Rural to Urban Regions Billion CAGR: 2.14% 2012 3.69 2011 3.61 2010 3.54 2009 3.46 2008 3.39 2007 3.32 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Source: World Bank billion

Accelerating Aging Population (over 65 years) 7.9% 7.8% 7.8% 7.7% CAGR: 2.56% 7.7% 7.7% 7.8% 7.7% 7.6% 7.6% 7.6% 7.5% 7.5% 7.5% 7.4% 7.4% 2008 2009 2010 2011 2012 Source: World Bank

Increasing Life Expectancy Rate 70.8 70.6 CAGR: 0.34% 70.6 70.8 70.4 70.3 70.2 70.1 70 69.8 69.6 69.4 69.2 69.6 69.8 69 2007 2008 2009 2010 2011 2012 Source: World Bank

Ameliorating Economic Conditions Global GDP - US$ Trillion 80 70 60 55.7 61.3 CAGR: 5.24% 57.9 62.9 69.9 71.9 50 40 30 20 10 0 2007 2008 2009 2010 2011 2012 Source: World Bank

Rising Number of Vitamin D Tests Million of Test/Year 140 120 CAGR: 41.46% 124.7 100 100.23 80 75.56 80 60 50 40 31.11 20 15.56 0 2007 2008 2009 2010 2011 2012E 2013E 40% of the EU population, (~150 million) are Vitamin D deficient, but <5% of them get tested.

Trends and Developments Rising Prevalence of Dietary Supplements Increasing Demand for Liquid Dietary Supplements Increased Acceptance of Infant Nutrition Focus on Novel Nutrition Ingredients

Rising Prevalence of Dietary Supplements among Adult Population (2013) 60.0% 50.0% 56.7% 53.3% 40.0% 41.1% 34.4% 30.0% 20.0% 26.7% 24.4% 10.0% 11.1% 11.1% 4.4% 0.0% Denmark US UK Sweden Netherland Germany Italy Spain Greece

Dietary Supplements Use by Age Max: 3-5 years Min: 12-19 years >20 years 81% Pregnant women >50% of age >65 years Adapted from Dietary Supplement Barometer Survey

Dietary Supplements Use by Education Level Adapted from Dietary Supplement Barometer Survey

Dietary Supplements Use by Income Adapted from Dietary Supplement Barometer Survey

Dietary Supplements Use by Reason Autonomy Adapted from Dietary Supplement Barometer Survey

Increased Acceptance of Infant Nutrition Infant nutrition market is gaining popularity at a swift pace principally driven by increasing conscious of parents regarding the health of their offspring. Nucleotides Choline Taurine DHA Vitamins Minerals (e.g. Fe, Ca, Mg, Zn, I, Cu)

References & Acknowledgments Global Nutrition Supplement Market Report: May 2014 (KONCEPT ANALYTICS) VITAMINS AND DIETARY SUPPLEMENTS IN IRAN: August 2013 (Euromonitor International) And With acknowledgments to: LIVAR PHARMACEUTICAL & HYGIENIC COMPANY

Thanks For Your Kind Attention