UvA-DARE (Digital Academic Repository) Dissecting Lyme borreliosis; Clinical aspects, pathogenesis and prevention Coumou, J. Link to publication Citation for published version (APA): Coumou, J. (2016). Dissecting Lyme borreliosis; Clinical aspects, pathogenesis and prevention. s- Hertogenbosch: Boxpress. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (http://dare.uva.nl) Download date: 05 Apr 2019
Clinical aspects, pathogenesis and prevention Dissecting Lyme borreliosis; Clinical aspects, pathogenesis and prevention Dissecting Lyme borreliosis; Jeroen Coumou Jeroen Coumou
Dissecting Lyme borreliosis; Clinical aspects, pathogenesis and prevention Jeroen Coumou
COLOFON Dissecting Lyme borreliosis; clinical aspects, pathogenesis and prevention Academic Thesis, University of Amsterdam, the Netherlands ISBN: 978-94-6295-350-5 Copyright 2016 by Jeroen Coumou, Amsterdam, the Netherlands. All rights reserved. No parts of this thesis may be reproduced, stored or transmitted in any form or by any means without the prior permission of the author or publishers of the included scientific papers. This thesis was prepared at the Center for Experimental Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. The authors report no conflicts of interest. Cover picture: Robert Voss, http://www.robertvoss-drawings.blogspot.com Printed by: Proefschriftmaken.nl Uitgeverij BOXPress Published by: Uitgeverij BOXpress, s-hertogenbosch Printing of this thesis was financially supported by: Academisch Medisch Centrum, Universiteit van Amsterdam, Chipsoft and Hycult Biotech.
Dissecting Lyme borreliosis; Clinical aspects, pathogenesis and prevention ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. D.C. van den Boom ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel op vrijdag 1 april 2016, te 14:00 uur door Jeroen Coumou geboren te Enkhuizen
Promotiecommissie: Promotores: Prof. dr. T. van der Poll Universiteit van Amsterdam Prof. dr. E. Fikrig Yale University Copromotores: Dr. J.W.R. Hovius Dr. S. Narasimhan Universiteit van Amsterdam Yale University Overige leden: Prof. dr. J.T. van Dissel Prof. dr. T.B.H. Geijtenbeek Prof. dr. L.A.B. Joosten Prof. dr. J.M. Prins Prof. dr. P. Speelman Dr. H. Sprong Universiteit Leiden Universiteit van Amsterdam Radboud Universiteit Nijmegen Universiteit van Amsterdam Universiteit van Amsterdam RIVM Bilthoven Faculteit der Geneeskunde
Table of contents Preface and thesis outline 10 Chapter 1 Introduction 18 PART I. CLINICAL ASPECTS Chapter 2 Chapter 3 Borrelia burgdorferi sensu lato serology in the Netherlands; contrasts between guidelines and actual practice Ticking the right boxes; classification of patients suspected of Lyme borreliosis at an academic referral center in the Netherlands 40 54 PART II. PATHOGENESIS Chapter 4 Chapter 5 Chapter 6 A tick mannose-binding lectin inhibits the vertebrate complement cascade to enhance transmission of the Lyme disease agent An Ixodes ricinus Tick Salivary Lectin Pathway Inhibitor protects Borrelia burgdorferi s.l. from human complement The role of Mannose Binding Lectin in the immune response against Borrelia burgdorferi sensu lato 76 104 114 PART III. PREVENTION Chapter 7 Chapter 8 Chapter 9 Vaccination against Bm86 homologues in rabbits does not impair Ixodes ricinus feeding or oviposition A Tick Gut protein with Fibronectin III domains Aids Borrelia burgdorferi Congregation to the Gut During Transmission Ixodes scapularis dystroglycan-like protein promotes Borrelia burgdorferi migration from the gut 136 148 172 Chapter 10 Summary and general discussion 188
Addendum Nederlandse samenvatting 202 References 216 PhD Portfolio 232 List of publications 234 Curriculum vitae 236 Dankwoord 238