UvA-DARE (Digital Academic Repository) Unexplained subfertility Tjon-Kon-Fat, R.I. Link to publication Citation for published version (APA): Tjon-Kon-Fat, R. I. (2017). Unexplained subfertility: Illuminating the path to treatment. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (http://dare.uva.nl) Download date: 05 Apr 2019
Unexplained subfertility: Illuminating the path to treatment Raïssa Ivanah Tjon-Kon-Fat
Unexplained subfertility: Illuminating the path to treatment PhD Thesis, University of Amsterdam, the Netherlands R.I. Tjon-Kon-Fat, 2017 No part of this thesis may be reproduced, stored or transmitted in any form or by any means, without prior permission of the author. The printing of this thesis was supported by: Stichting Gynaecologische Endocrinologie en Kunstmatige Voortplanting in Amsterdam. ISBN: 978-94-028-0664-9 Author: R.I. Tjon-Kon-Fat Cover design: Stefan Duikersloot Lay-out: Rozemarijn Klein-Heerenbrink, persoonlijkproefschrift.nl Printed by: Ipskamp Printing
Unexplained subfertility: Illuminating the path to treatment ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. ir. K.I.J. Maex ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Aula der Universiteit op vrijdag 30 juni 2017, te 13:00 uur door Raïssa Ivanah Tjon-Kon-Fat geboren te Paramaribo, Suriname
PROMOTIECOMMISSIE: Promotores: Prof. dr. B.W.J. Mol AMC-UvA Prof. dr. F. van der Veen AMC-UvA Copromotores: Dr. ir. M. van Wely AMC-UvA Prof. dr. M.J.C. Eijkemans Universiteit Utrecht Overige leden: Dr. ir. N. van Geloven Universiteit Leiden Prof. dr. S. Bhattacharya Prof. dr. T.M.S.H. D Hooghe Prof. dr. D.D.M. Braat Prof. dr. M. Goddijn University of Aberdeen Katholieke Universiteit Leuven Radboud Universiteit Nijmegen AMC-UvA Faculteit der Geneeskunde
CONTENTS Chapter 1 Introduction and outline of this thesis 9 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Chapter 8 IUI and IVF for unexplained subfertility: where did we go wrong? Human Reproduction 2016; 31:2665-2667 Prevention of multiple pregnancies in couples with unexplained or mild male subfertility: randomised controlled trial of in vitro fertilisation with single embryo transfer or in vitro fertilisation in a modified natural cycle compared with intrauterine insemination with controlled ovarian hyperstimulation British Medical Journal 2015; 350:g7771 Is IVF served two different ways more cost-effective than IUI with controlled ovarian hyperstimulation? Human Reproduction 2015: 30:2331-9 Can we identify subfertile couples that benefit from immediate in vitro fertilisation over intrauterine insemination? European Journal of Obstetrics & Gynecology and Reproductive Biology 2016; 202:36-40 IVF or IUI as first-line treatment in unexplained subfertility: the conundrum of treatment selection markers Human Reproduction 2017; in press The natural conception rate in couples with unexplained or mild male subfertility: a secondary analysis of arandomised controlled trial Submitted (under embargo) Inter-clinic variation in the chances of natural conception of subfertile couples Human Reproduction 2013; 28:1391-7 21 33 59 83 97 111 125
Chapter 9 Interventions for unexplained subfertility: a systematic review and network meta-analysis Protocol submitted, Cochrane Database of Systematic Reviews (under embargo) 143 Chapter 10 Summary, implications for practice and further research 163 Chapter 11 Appendices Nederlandse samenvatting, implicaties voor de klinische praktijk en toekomstig onderzoek List of co authors & affiliations Portfolio and list of publications Acknowledgements About the author 173 184 187 192 195