UvA-DARE (Digital Academic Repository) Pediatric inflammatory bowel disease Diederen, K. Link to publication Citation for published version (APA): Diederen, K. (2018). Pediatric inflammatory bowel disease: Monitoring, nutrition and surgery. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (http://dare.uva.nl) Download date: 11 Apr 2019
PEDIATRIC INFLAMMATORY BOWEL DISEASE MONITORING NUTRITION SURGERY KAY DIEDEREN
PEDIATRIC INFLAMMATORY BOWEL DISEASE MONITORING, NUTRITION AND SURGERY Kay Diederen
The printing of this thesis was financially supported by: Universiteit van Amsterdam, Nederlandse verreninging voor Gastroentorologie, Chipsoft, Coloplast B.V., Dr. Falk Pharma Benelux B.V., Fresenius, Laborie, Nutricia Advanced Medical Nutrition, Nutricia Early life Nutrition, Takeda Nederland B.V., TRAMEDICO B.V., Wellspect HealthCare, Yakult Nederland B.V. Cover design: Robert Glad Layout: Kay Diederen Pinting: Ridderprint B.V. ISBN: 978-94-6299-928-2 Copyright 2018 by Kay Diederen. All rights reserved. any unauthorized reprint or use of this material is prohibited. No part of this thesis may be reproduced, stored or transmitted in any form or by any means, without written permission of the author or, when appropriate, of the publishers of the publication.
PEDIATRIC INFLAMMATORY BOWEL DISEASE MONITORING, NUTRITION AND SURGERY ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. ir. K.I.J. Maex ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel op vrijdag 4 mei 2018, te 12:00 uur door Kay Diederen geboren te Sittard
PROMOTIECOMMISSIE Promotor: Prof. dr. M.A. Benninga Copromotores: Dr. A. Kindermann Dr. A.A. te Velde Overige leden: Prof. dr. I. de Blaauw Radboud Universiteit Nijmegen Prof. dr. G.R.A.M. D Haens Dr. E.H.H.M. Rings dr. J.N. Samsom Prof. dr. A.J.P.M. Smout Prof. dr. F.A. Wijburg Universiteit Leiden Erasmus Universiteit Rotterdam Faculteit der Geneeskunde
TABLE OF CONTENTS General introduction 9 PART I Chapter 1 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Monitoring disease course and psychosocial well-being Do children and adolescents with inflammatory bowel disease complete clinical disease indices similar to physicians? Relationship of clinical symptoms with biomarkers of inflammation in pediatric inflammatory bowel disease The prevalence of irritable bowel syndrome-type symptoms in pediatric inflammatory bowel disease and the relationship with biochemical markers of disease activity Raised faecal calprotectin in children and adolescent with inflammatory bowel disease in clinical remission is associated with subsequent symptomatic relapse Parental distress and quality of life in pediatric inflammatory bowel disease: implications for the outpatient clinic 33 53 71 87 107 PART II Chapter 6 Chapter 7 Nutrition and nutritional therapies Diet and anthropometrics of children with inflammatory bowel disease: a comparison with the general population Exclusive enteral nutrition mediates gut microbial and metabolic changes that induce remission in children with Crohn s disease 129 151 PART III Chapter 8 Chapter 9 Chapter 10 Outcome of surgical interventions Complications and disease recurrence after primary ileocecal resection in pediatric Crohn s disease: a multicenter cohort analysis Quality of life and colorectal function in Crohn s disease patients that underwent ileocecal resection during childhood Outcome after restorative proctocolectomy and ileal pouch anal anastomosis in children and adults 193 219 235 Summary, discussion and future perspectives 253 Addendum Nederlandse samenvatting 271 Contributing authors 277 List of publications 283 PhD portfolio 287 Dankwoord 291 About the author 295