FINAL PROGRAMME AND ABSTRACT BOOK

FINAL PROGRAMME AND ABSTRACT BOOK

General information Venue Melià Castilla Hotel Calle del Capitán Haya, 43 28020 Madrid, Spain Language Format Dedicated website The official language of this live educational conference will be English Using a highly innovative format and tools, this educational initiative will allow the audience to express their own views and opinions through debates, real-time surveys, discussion, voting system, question wall, questions cards, dedicated website and mobile application. Access http://www.2015rmannualconference.org to: 1. View the scientific programme 2. Get your certificate of attendance 3. Get your EACCME certificate 4. Fill in the Post-event surveys Mobile Application Download the conference application EXCEMEDRM and enjoy easy access to the: 1. Scientific programme 2. Faculty list 3. Meeting rooms map 4. Question wall 5. Tweets from the conference Any question? You can post your questions on: 1. Question card 2. Question wall on the mobile application 1

2015 Annual conference in reproductive medicine: Decoding the genomics of infertility and ART EXCEMED live educational conference on: 2015 Annual conference in reproductive medicine: Decoding the genomics of infertility and ART 22-23 May, 2015 - Madrid, Spain Aim Genetics plays a key role in human reproduction. Knowledge of the genetics of reproduction is useful to comprehend the successes and failures of human conception and fertility treatments. Embryologists and biologists have introduced genetics into assisted reproductive treatment (ART) with the aim of enhancing success in conception. Genetic application has certainly played a vital role in alleviating inherited disorders through pre-implantation genetic diagnosis (PGD). However, it is debated whether the application of pre-implantation genetic screening and pharmacogenomics is beyond the theory. Since the early application of genetics into ART there have been advances in the techniques and applications. The ultimate aim is to decode the genomics of infertility and ART and inform clinicians, biologists and scientists about strategies which will translate to patient success. This live educational conference, supported through working groups and lively discussion, will introduce approaches and technologies that can be used to improve patient outcomes. Learning objectives By attending this live educational conference, attendees will: Acquire knowledge of the key genetic aspects of human reproduction Apply an understanding of human genetics to improve IVF success Be able to apply current evidence-based recommendations to achieve the best outcomes from ART Target audience This programme is targeted at clinicians, embryologists, biologists and scientists working in ART who wish to update their knowledge of advanced techniques and scientific innovation. 2

Accreditation EXCEMED (www.excemed.org) is accredited by the European Accreditation Council for Continuing Medical Education (EACCME) to provide the following CME activity for medical specialists. The EACCME is an institution of the European Union of Medical Specialists (UEMS), www.uems.net. The CME activity Decoding the genomics of infertility and ART is designated for a maximum of 9 (nine) hours of European external CME credits. Each medical specialist should claim only those hours of credit that he/she actually spent in the educational activity. Through an agreement between the European Union of Medical Specialists and the American Medical Association, physicians may convert EACCME credits to an equivalent number of AMA PRA Category 1 Credits. Information on the process to convert EACCME credit to AMA credit can be found at www.amaassn.org/go/internationalcme. Live educational activities, occurring outside of Canada, recognized by the UEMS-EACCME for ECMEC credits are deemed to be Accredited Group Learning Activities (Section 1) as defined by the Maintenance of Certification Program of The Royal College of Physicians and Surgeons of Canada. EXCEMED adheres to the principles of the Good CME Practice group (gcmep) Share your opinion with us We are always looking for ways to bring our educational activities to the next level and meet your needs as a healthcare practitioner. You will be asked to answer a real-time survey during this event, followed by a post-event online survey on the dedicated website to find out if the experience met your educational expectations. Your views also help us tailor future initiatives. Thank you for taking the time to participate. Register to EXCEMED website: www.reproductive-medicine.excemed.org follow us on EXCEMED_Repro http://twitter.com/excemed_repro 3

Scientific committee Robert Fischer Fertility Centre Hamburg Hamburg, Germany Juan Antonio García-Velasco IVI Madrid Rey Juan Carlos University Madrid, Spain Laura Rienzi G.EN.E.R.A. Centre for Reproductive Medicine Rome, Italy Sesh Kamal Sunkara Aberdeen Fertility Centre Aberdeen Maternity Hospital University of Aberdeen Aberdeen, UK Filippo Maria Ubaldi G.EN.E.R.A. Centre for Reproductive Medicine Rome, Italy 4

Faculty members Natalia Basile Laboratorio FIV IVI Madrid Madrid, Spain Antonio Capalbo G.EN.E.R.A. Centre for Reproductive Medicine Rome, Italy Johannes L.H. Evers Maastricht University Medical Centre Maastricht, The Netherlands Alberto Ferlin Department of Medicine DIMED University of Padua Padua, Italy Robert Fischer Fertility Centre Hamburg Hamburg, Germany Juan Antonio García-Velasco IVI Madrid Rey Juan Carlos University Madrid, Spain Samir Hamamah Service of Reproductive Biology and IVF CHU Montpellier - Hôpital Arnauld de Villeneuve Montpellier, France Eva Hoffmann MRC Genome Damage and Stability Centre University of Sussex Falmer, UK Kui Liu Department of Chemistry & Molecular Biology University of Gothenburg Gothenburg, Sweden Alison Murdoch International Centre for Life Institute of Genetic Medicine Newcastle University Newcastle upon Tyne, UK Raoul Orvieto Infertility and IVF Unit Department of Obstetrics and Gynaecology The Chaim Sheba Medical Center Tel Hashomer, Israel Laura Rienzi G.EN.E.R.A. Centre for Reproductive Medicine Rome, Italy Gerald Phillip Schatten Pittsburgh Development Center Obstetrics, Gynecology & Reproductive Sciences Division of Developmental & Regenerative Medicine University of Pittsburgh School of Medicine Pittsburgh (PA), USA Richard T. Scott Jr. Reproductive Medicine Associates of New Jersey Division of Reproductive Endocrinology Department of Obstetrics and Gynecology and Reproductive Science Rutgers - Robert Wood Johnson Medical School New Brunswick (NJ), USA Manuela Simoni Unit of Endocrinology Department of Biomedicine, Metabolism and Neural Sciences University of Modena and Reggio Emilia Modena, Italy Sesh Kamal Sunkara Aberdeen Fertility Centre Aberdeen Maternity Hospital University of Aberdeen Aberdeen, UK Nathan Treff Department of Obstetrics, Gynecology & Reproductive Sciences Robert Wood Johnson Medical School (RWJMS) New Brunswick (NJ), USA and Molecular Biology Research Reproductive Medicine Associates of New Jersey Basking Ridge (NJ), USA Filippo Maria Ubaldi G.EN.E.R.A. Centre for Reproductive Medicine Rome, Italy Hakan Yarali Department of Obstetrics and Gynecology Hacettepe University, School of Medicine, Ankara, Turkey 5

Scientific secretariat EXCEMED - Excellence in Medical Education Salita di San Nicola da Tolentino, 1/b 00187 Rome, Italy Programme and Relations Manager: Flaminia Masprone T +39 06 420413 206 - F +39 06 420413 677 flaminia.masprone@excemed.org EXCEMED is a Swiss Foundation with headquarters in 14, Rue du Rhône 1204 Geneva, Switzerland Organising secretariat Meridiano Congress International Via Sapri, 6-00185 Rome, Italy Congress Coordinator: Titty Alvino T +39 06 88 595 310 - F +39 06 88595 234 titty.alvino@meridiano.it 6

Scientific Programme

Scientific programme Friday 22 May 8.45 8.55 EXCEMED Opening R. Fischer (Germany) Welcome and introduction F.M. Ubaldi (Italy) Real-time survey 9.00 9.25 9.50 10.15 10.35 L1: L2: L3: Session I: Genetics and infertility Chairmen: G.P. Schatten (USA) - A. Murdoch (UK) Genetic aspects of folliculogenesis K. Liu (Sweden) Genetics of male infertility: clinical implications A. Ferlin (Italy) Genetics of ageing gametes What is the mechanism? E. Hoffmann (UK) Let s talk Coffee break Experts meet-up 11.00 11.25 11.50 12.15 12.35 L4: L5: L6: Session II: Clinical genetics Chairmen: A. Capalbo (Italy) - S.K. Sunkara (UK) PGD for monogenic disease: where are we and where can we go? N. Treff (USA) PGS for aneuploidy screening in ART: who will benefit and what is the evidence? R.T. Scott Jr. (USA) Non invasive techniques for aneuploidy screening S. Hamamah (France) Let s talk Lunch Experts meet-up 8

13.30 13.55 14.15 14.35 15.00 15.20 L7: L8: L9: L10: Session III: icos Chairmen: F.M. Ubaldi (Italy) - R. Fischer (Germany) Pharmacogenomics and icos M. Simoni (Italy) Genetic ethiology of poor and hyper responders S.K. Sunkara (UK) Can we improve clinical results in poor responders? H. Yarali (Turkey) Hyper responders: safety while maximizing the results R. Orvieto (Israel) Revisiting real-time survey Let s talk Coffee Break Experts meet-up 15.45 Breakout Session Attendees will be divided into 4 groups and will attend 2 workshops: one on clinical genetics and a second on poor responders. Group A Group B Group C Group D 15.45-16.45 Q&A: clinical genetics Q&A: clinical genetics Q&A: poor responders Q&A: poor responders R.T. Scott Jr. (USA) N. Treff (USA) F.M. Ubaldi (Italy) H. Yarali (Turkey) Q&A: poor responders Q&A: poor responders 16.45-17.45 Q&A: clinical genetics Q&A: clinical genetics F.M. Ubaldi (Italy) H. Yarali (Turkey) R.T. Scott Jr. (USA) N. Treff (USA) 17.45 End of the day Legend: L: Lecture; KNL: Keynote lecture; 9

Scientific programme Saturday 23 May Session IV: Lab technology Chairmen: L. Rienzi (Italy) - S. Hamamah (France) 8.00 Highlights and summary from the first day R. Fischer (Germany) 8.10 8.35 9.00 9.25 9.40 10.00 10.25 11.00 L11: L12: L13: L14: KNL: Real-time survey Can time lapse technology predict embryo euploidy? Where are we today? N. Basile (Spain) Optimizing embryo biopsy (techniques and timing) A. Capalbo (Italy) Genetic technologies for PGS N. Treff (USA) Let s talk Coffee break Experts meet up The genetic role of mitochondria, clinical applications and prospective A. Murdoch (UK) The role of epigenetic and imprinting in extended embryo culture: would it affect the health of the child? G.P. Schatten (USA) Let s talk 11.10 Breakout session Attendees will be divided into 4 groups and will attend 2 workshops: one on normal & hyper responders and a second on lab technology Group A Group B Group C Group D Q&A: normal & hyper responders Q&A: normal & hyper responders 11.10-12.10 Q&A: lab technology - cryopreservation - media - biopsy - time lapse Q&A: lab technology - cryopreservation - media - biopsy - time lapse R. Fischer (Germany) R. Orvieto (Israel) L. Rienzi (Italy) N. Basile (Spain) Q&A: lab technology - cryopreservation - media - biopsy - time lapse Q&A: lab technology - cryopreservation - media - biopsy - time lapse 12.10-13.10 Q&A: normal & hyper responders Q&A: normal & hyper responders L. Rienzi (Italy) N. Basile (Spain) R. Fischer (Germany) R. Orvieto (Israel) 13.10 Back to plenary room 10

Session V: Scientific summary Chairmen: F.M. Ubaldi (Italy) - R. Fischer (Germany) Revisiting real-time survey 13.15 13.35 13.40 Scientific summary of the conference J.L.H. Evers (The Netherlands) Closing remarks R. Fischer (Germany) End of the conference Closing lunch 11

Disclosure of faculty relationships EXCEMED adheres to guidelines of the European Accreditation Council for Continuing Medical Education (EACCME ) and all other professional organizations, as applicable, which state that programmes awarding continuing education credits must be balanced, independent, objective, and scientifically rigorous. Investigative and other uses for pharmaceutical agents, medical devices, and other products (other than those uses indicated in approved product labeling/package insert for the product) may be presented in the programme (which may reflect clinical experience, the professional literature or other clinical sources known to the presenter). We ask all presenters to provide participants with information about relationships with pharmaceutical or medical equipment companies that may have relevance to their lectures. This policy is not intended to exclude faculty who have relationships with such companies; it is only intended to inform participants of any potential conflicts so that participants may form their own judgements, based on full disclosure of the facts. Further, all opinions and recommendations presented during the programme and all programme-related materials neither imply an endorsement nor a recommendation on the part of EXCEMED. All presentations represent solely the independent views of the presenters/authors. The following faculty provided information regarding significant commercial relationships and/or discussions of investigational or non-emea/fda approved (off-label) uses of drugs: Natalia Basile Antonio Capalbo Johannes L.H. Evers Alberto Ferlin Robert Fischer Juan Antonio García-Velasco Samir Hamamah Eva Hoffmann. Kiu Liu Alison Murdoch Raoul Orvieto Laura Rienzi Gerald Phillip Schatten Richard T. Scott Jr. Manuela Simoni Sesh Kamal Sunkara Nathan Treff Filippo Maria Ubaldi Hakan Yarali Declared receipt of the 2013 Grant for Fertility Innovation Declared receipt of grants from Merck, MSD and Ferring Declared receipt of grants and contracts from Ferring in 2013, 2014 and 2015 Declared receipt of the Medical Research Council (MRC), UK SNRF fellowship and the MRC funded project grant and that her presentation will include labelled use of the Illumina SNP array (Human CytoSNPv12) Declared receipt of honoraria from Ferring Declared receipt of grants and contracts from the National Institute of Health Declared to be member of Ferring Pharmaceutical advisory board and to be board member of the Foundation for the Assessment and Enhancement of Embryonic Competence, Inc. Declared receipt of grants and contracts from Merck Serono Declared receipt of the 2015 Grant for Fertility Innovation Declared receipt of honoraria and consultation fees from Merck Serono and that during his presentation off-labeled use of Letrozole/Testosterone gel/growth Hormone will be mentioned. 12

All EXCEMED programmes are organized solely to promote the exchange and dissemination of scientific and medical information. No forms of promotional activities are permitted. There may be presentations discussing investigational uses of various products. These views are the responsibility of the named speakers, and do not represent an endorsement or recommendation on the part of EXCEMED. This programme is made possible thanks to an educational grant from Merck Serono. 13