Global Cardio-Oncology Summit

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Wednesday, September 20, 2017 7:00 a.m. 7:30 p.m. Global Cardio-Oncology Summit September 20-21, 2017 Time Topic Speaker / Location 7:00 7:50 Breakfast & Registration 7:50 8:00 GCOS 2017 Welcome & Introduction Co-Chairs: Dr. Alexander Lyon & Dr. Susannah Stanway Session 1 Chairs: Dr. Sarah Clarke & Dr. Susan Dent 8:00 8:20 Opening Address Prof. Jane Dacre President, Royal College of Physicians, 8:20 8:40 Keynote Lecture The growing burden of cardiovascular disease the impact of cancer survivorship 8:40 9:00 Patient s Perspective Prof. Jane Maher Chief Medical Officer, Macmillan Cancer Support, 9:00 9:20 Session 1 Panel Discussion Session 2: Immunotherapy and Emerging Cardiotoxicity Chairs: Dr. Juan Carlos Plana & Dr. Ruth Plummer 9:20 9:40 The impact of immunotherapy in treating solid tumours Dr. James Larkin Consultant Medical Oncologist, The Royal Marsden NHS Foundation Trust, 9:40 10:00 Cardiotoxicity caused by immunotherapy Dr. Javid Moslehi Director, Vanderbilt Cardio- Oncology, Vanderbilt University Medical Centre, Nashville, TN, USA 10:00 10:30 Session 2 Case Review & Panel Discussion Case Presenter: 10:30 11:00 BREAK

Session 3: Hormonal Therapies and Cardiovascular Risk Chairs: Dr. Stuart Rosen & Dr. Christine Simmons 11:00 11:20 Cardiovascular risk with chronic oestrogen suppression is there a risk? 11:20 11:40 Novel pathophysiology of cardiovascular risk with estrogen antagonists Dr. Ann Partridge Director, Adult Survivorship Program, Dana-Farber Cancer Institute, Boston, MA, USA Dr. Anne Blaes Associate Professor of Medicine, University of Minnesota, Minneapolis, MN, USA 11:40 12:00 Cardiac outcomes of ADT in prostate cancer Dr. Derek Rosario Urologist, The University of Sheffield, Sheffield, UK 12:00 12:30 Session 3 Case Review & Panel Discussion Case Presenter: 12:30-13:30 LUNCH Chairs: Dr. Helena Earl & Dr. Sanjay Prasad 13:30 14:00 HER2 targeted therapies for breast cancer new insights and cardiac safety Prof. Ian Smith Consultant Medical Oncologist, Royal Marsden NHS Foundation Trust, Session 4: Radiation therapy and long-term cardiovascular complications Chairs: Dr. Mark Harbinson & Dr. Anna Kirby 14:00 14:15 Scale of radiation-induced cardiovascular disease in cancer survivors Prof. Sarah Darby Professor of Medical Statistics, Nuffield Department of Population Health, University of Oxford, Oxford, UK 14:15 14:30 How to minimize cardiac radiation doses? Dr. David Hodgson Associate Professor of Radiation Oncology, University of Toronto, Toronto, ON, Canada

14:30 14:45 How to treat radiation-induced coronary disease? Prevention & Treatment 14:45 15:00 Radiation-induced autonomic dysfunction and arrhythmias 15:00 15:30 Session 4 Case Review & Panel Discussion Dr. Martin Denvir Consultant Cardiologist, University of Edinburgh, Edinburgh, UK Dr. John Groarke Cardio-Oncologist, Dana- Farber Cancer Institute, Boston, MA, USA Case Presenter: Jutta Bergler-Klein 15:30 16:00 TEA BREAK Session 5: Coordinating Primary Care in Cardio-Oncology Chairs: Dr. Ana Barac & Dr. Simon Ray 16:00 16:15 Raising awareness of cardiotoxicity in primary care 16:15 16:30 Managing cardiovascular risk in cancer patients in primary care 16:30 16:45 Lessons from paediatric oncology how to organize long-term cardiovascular surveillance in cancer survivors Dr. Fiona Walter Principal Researcher in Primary Care Cancer Research, University of Cambridge, Cambridge, UK Prof. Mike Kirby Visiting Professor, University of Hertfordshire, Hertfordshire, UK Prof. Sara Faithful Professor of Cancer Nursing Practice, University of Surrey, Surrey, UK Prof. Gill Levitt Consultant Oncologist, Great Ormond Street for Sick Children NHS Trust, London, UK 16:45 17:00 Session 5 Panel Discussion 15-minute discussion period Chairs: Dr. Christopher Johnson & Dr. Bonnie Ky 17:00 17:30 e-health and cardio-oncology Dr. Karen Syrjala Co-Director of Survivorship Program, Fred Hutchinson Cancer Research Centre, Seattle, WA, USA

Session 6: Young Investigator Competition Judges: Joseph Carver, Zaza Iakobishvili, Daniel Lenihan, Teresa Lopez-Fernandez, Giorgio Minotti 17:30 17:45 Talk 1 17:45 18:00 Talk 2 18:00 18:15 Talk 3 10-minute presentation 5-minute discussion period 10-minute presentation 5-minute discussion period 10-minute presentation 5-minute discussion period 18:15 19:30 Special Event Wine & Cheese Reception Special Event & Reception

Thursday, September 21, 2017 7:00 a.m. 6:00 p.m. Time Topic Speaker / Location 7:00 7:50 Breakfast & Registration 7:50 8:00 Opening Remarks & Day 1 Review Co-Chairs: Alexander Lyon & Susannah Stanway Chairs: Dr. Daniel Lenihan & Dr. Alexander Lyon 8:00 8:30 Long-term cardiovascular outcomes in survivors of Hodgkin s Lymphoma Prof. John Radford Professor in Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK Session 7: Cardio-Oncology and Haemato-Oncology Chairs: Dr. Eric Harrison & Dr. Robert Marcus 8:30 8:45 How to manage cardiac problems in the bone marrow transplant patient 8:45 9:00 Modern advances in the treatment of cardiac amyloid 9:00 9:15 Proteosomal inhibitors and cardiac complications Dr. Charlotte Manisty Consultant Cardiologist, The Heart Hospital and Barts Health NHS Trust, London, UK Dr. Ashutosh Wechalekar Honorary Consultant Haematologist, Royal Free London NHS Foundation Trust, Dr. Douglas Sawyer Chief, Cardiovascular Services, Maine Medical Center, Scarborough, ME, USA 9:15 9:30 BCR-Abl inhibitors and cardiovascular toxicity Dr. Dragana Milojkovic Consultant Haematologist, Hammersmith Hospital, 9:30 10:00 Session 7 Case Review & Panel Discussion Case Presenter: 10:00 10:30 BREAK

Session 8: New Scientific Advances in Cardio-Oncology Chairs: Dr. Justin Stebbing & Dr. Thomas Suter 10:30 10:45 ipsc models to study cardiotoxicity Prof. Sian Harding Professor of Cardiac Pharmacology, National Heart and Lung Institute, Imperial College, London, UK 10:45 11:00 Novel insights into mechanism of dexrazoxanemediated cardioprotection 11:00 11:15 New strategies to protect the heart from cancer therapies Dr. Martin Szerba Czech Republic Prof. Denise Hilfiker- Kleiner Professor of Molecular Cardiology, Hannover Medical School, Hanover, Germany 11:15 11:30 Genetic susceptibility, genomics, etc. 11:30 12:00 Session 8 Panel Discussion 12:00 13:00 LUNCH Chairs: Dr. Susannah Stanway & Dr. Sean Virani 13:00 13:30 The Global Epidemic of Cancer and Cardiovascular Disease Prof. Richard Sullivan Director, Institute of Cancer Policy & Global Health, King s College London, Session 9: Arrhythmia management in cancer patients Chairs: Dr. John-Paul Carpenter & Dr. Kate Newbold 13:30 13:50 Practical matters in AF anticoagulation & rhythm management 13:50 14:10 How and why to measure QT and what to do about it? Dr. Dimitrios Farmakis Cardiologist, Thalassemia and Transfusion Unit, Ippokrateion General Hospital, Athens, Greece Dr. Chris Plummer Consultant Medical Oncologist, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK

14:10 14:30 How to manage patients with cardiac pacemakers or defibrillators undergoing cancer surgery or thoracic radiotherapy? 14:30 15:00 Session 9 Case Presentation & Panel Discussion Dr. Jay Wright Lead Clinician for Heart Failure and Cardiac Devices, Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool, UK Case Presenter: 15:00 15:30 TEA BREAK Session 10: How to deliver a successful cardio-oncology service Chairs: Dr. Theresa McDonagh & Dr. Rod Skinner 15:30 15:45 Toolkit for success real world options Dr. Joerg Herrmann Cardiologist, Mayo Clinic, Rochester, MN, USA 15:45 16:00 Role of the Cardio-Oncology Nurse Vicki Chambers Cardio-Oncology Nurse, Royal Brompton & Harefield NHS Foundation Trust, 16:00 16:15 Training and Cardio-Oncology Dr. John McGowan Hon. Cardiology Research Fellow, University College London Hatter Cardiovascular Institute, 16:15 16:30 How should we measure the quality of a cardiooncology service? Dr. Ronald Witteles Associate Professor of Medicine, Stanford University Medical Center, Stanford, CA, USA 16:30 16:50 (20) Session 10 Panel Discussion 16:50 17:00 Closing Statements Co-Chairs: Alexander Lyon & Susannah Stanway Session 11: Poster Presentation Session 17:00 18:30 General Poster Presentation Session 18:30 Adjourn