PRELIMINARY PROGRAMME

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PRELIMINARY PROGRAMME 26 May 2017 ITALIAN LANGUAGE SYMPOSIUM PHARMACOLOGY IN INTERVENTIONAL CARDIOLOGY DAPT AFTER PCI 10.00 CONTROVERSY 1 - P2Y12 INHIBITION AFTER PCI IN STABLE PATIENTS Clopidogrel remains the best option in real life Direct-acting P2Y12 inhibitors should be preferred 10.45 CONTROVERSY WHICH P2Y12 INHIBITOR SHOULD WE USE IN ACS? What guidelines suggest What real world registries show LONG-TERM MANAGEMENT OF PCI PATIENTS 11.30 CONTROVERSY 1 THERAPY IN HIGH RISK PATIENTS Medical therapy optimization with multiple drugs The newer Polypill is the solution 12.15 CONTROVERSY 2 ADHERENCE TO DRUGS Compliance to treatment as a major determinant of outcome Strategies to improve patient adherence to treatment 12.30 LUNCH

ANTICOAGULATION IN PCI PATIENTS WITH ATRIAL FIBRILLATION 14.00 CONTROVERSY 1 THE CHOICE OF NOACS AFTER PCI Phase 3 trials only must guide drug selection Real world data help physicians choice 14.45 CONTROVERSY 2 NOACS IN PCI AND SURGERY Should NOACs be interrupted in case of PCI? How NOACs should be used in case of surgery? THE FUTURE OF ANTIPLATELETS AND ANTICOAGULANTS AFTER PCI 15.30 CONTROVERSY 1 THE FUTURE OF P2Y12 INHIBITION Life long dual antiplatelet therapy Only ticagrelor without aspirin 16.15 CONTROVERSY 2 THE FUTURE OF NOACS Will NOACs and aspirin never be associated? Will NOACs become indicated also in patients with SCA? PARALLEL WORKSHOP ABOUT CLINICAL TRIALS 26 MAY 2017 08.45 Welcome introduction and course objectives Giuseppe Rosano (UK), Sven Wassmann (Germany) 08.55 Perspectives of an Editor-In-Chief Stefan Agewall (Norway) SESSION 1. HOW TO DESIGN AND RUN A CLINICAL TRIAL 09.10 An overview of the different aspects of clinical trials A. Niessner

09.50 Traditional versus novel trial designing Giuseppe Rosano (UK) 10.20 Planning and organising a clinical trial Basil Lewis (Israel) 10.40 The logistics of running a clinical trial Basil Lewis (Israel) 11.00 Refreshments and networking SESSION 2. REGULATORY ASPECTS 11.30 Requirements from regulatory agencies: endpoints, comparators, type of studies Giuseppe Rosano (UK) 12.00 Post marketing surveillance T. Walther 12.30 Lunch and networking SESSION 3. TRIAL CATEGORIES 13.30 Observational trials and registries G. L. Savarese (Italy) 13.50 Randomised controlled trials A. Niessner 14.10 Meta-analyses and systematic reviews G. L. Savarese (Italy) SESSION 4. WHAT S NEXT UPCOMING AND ONGOING CLINICAL TRIALS 14.30 ACS / Antithrombotics Basil Lewis (Israel) / S. Wassmann (Germany) 14.45 Lipidology H. Drexel (Austria) 15.00 Diabetes H. Drexel (Austria) 15.15 Heart Failure M. Lainscack (Slovenia) 15.30 Refreshments and networking

SESSION 5: GOOD CLINICAL PRACTICE 16.00 GCP for the busy investigator (certificate included) D. Rolfe 18.00 Close of day 1 27 MAY 2017 08.00 Welcome and objectives Giuseppe Rosano (UK), Sven Wassmann (Germany) 08.05 STATISTICAL ISSUES IN CLINICAL TRIALS BASIC NOTIONS Parallel groups (switch after 60 min): Randomised controlled trials and subgroup analyses - A. Niessner Registries and meta-analyses - G.L. Savarese 10.00 Refreshments and networking 10.30 HOW TO INTERPRET CLINICAL TRIAL DATA Examples from recent clinical trials S. Wassmann (Germany) + Panelists 12.00 THINGS TO KNOW FOR JUNIOR INVESTIGATORS Parallel groups: How to write a manuscript - S. Wassmann (Germany) What you need to know as junior investigator - G. Rosano (UK) 12.30 Closing remarks G. Rosano (UK), S. Wassmann (Germany) 12.45 Lunch and networking Close of day 2

26 May 2017 17.00 EuroCVP 2017 OPENING CEREMONY 18.00 END OF DAY 1 27 May 2017 NEW TARGETS IN THE PREVENTION OF CARDIOVASCULAR DISEASE Chairs: Basil Lewis (Israel), Stefan Agewall (Norway) 09.00 The pharmacological and non-pharmacological approach to cardiovascular prevention Massimo Piepoli (Italy) 09.45 The management of lipid profile according to the ESC Guidelines Heinz Drexel (Austria) 10.30 Management of altered glucose metabolism Itamar Raz (Israel) DIABETES MELLITUS: A CARDIOVASCULAR DISEASE Chairs: Stefan Anker (Germany), Massimo Piepoli (Italy) 11.00 Cardiovascular risk in diabetics Gianluigi Savarese (Sweden) 11.30 Lenient or intensive control of glycaemia? Itamar Raz (Israel) 12.00 Effective at last The new glucose-lowering drugs that reduce cardiovascular events Thomas Walther (Ireland)

12.30 LUNCHEON SYMPOSIUM PHARMACOLOGY OF ANTI-ISCHAEMIC THERAPY HOW TO TREAT THE DIFFICULT PATIENT? Chairs: Claudio Ceconi (Italy), Juan Carlos Kaski (UK) 14.30 Elderly patients with heart failure co-morbidities Andrew Coats (UK) 15.00 Patients with acute coronary syndromes receiving oral anticoagulants Torp Pederson (Denmark) 15.30 Ischaemic heart failure with renal and/or liver failure Claudio Ceconi (Italy) Joint Session with the HEART FAILURE ASSOCIATION PHARMACOTHERAPY OF HEART FAILURE Chairs: Petar Seferovic (Serbia), Thomas Walther (Ireland) 16.00 How to implement the pharmacological therapy of patients with HFrEF Stefan Anker (Germny) 16.30 Optimisation of RAASi How can we manage K+ Lars Lund (Sweden) 17.00 The treatment of patients with advanced heart failure Marco Metra (Italy) 17.30 END OF DAY 2

28 May 2017 UPDATE ON ORAL ANTICOAGULATION Chairs: Juan Tamargo (Spain), Thomas Schmidt (Denmark) 09.00 NOACs for patients with venous thromboembolism and atrial fibrillation Alexander Niessner (Austria) 09.30 How can we individualise NOACs in everyday practice? Giuseppe Rosano (UK) 10.00 Anticoagulation in the difficult patient: how to choose the right drug Sven Wassmann (Germany) 10:30 OPEN COFFEE BREAK WITH PANEL DISCUSSION NOAC antidotes. How relevant for clinical practice? Panel: Basil Lewis (Israel), Alexander Niessner (Austria), Giuseppe Rosano (UK), Sven Wassmann (Germany) Current status of antidotes and reversal agents for NOAC Juan Tamargo (Spain) MODERN MANAGEMENT OF CHRONIC ISCHAEMIC HEART DISEASE Chairs: Maurizio Volterrani (Italy) Dan Atar (Norway) 11.00 Targets for the modern pharmacologic treatment of chronic ischaemic heart disease Juan Carlos Kaski (UK) 11.30 Combination therapy for the optimal management of chronic stable angina Giuseppe Rosano (UK) 12.00 Heart rate and cardiac metabolism optimisation Maurizio Volterrani (Italy) 12.30 Closing discussion 13.00 END OF DAY 3

Organisers EUROPEAN SOCIETY OF CARDIOLOGY The European Heart House Les Templiers 2035 route des colles CS 80179 BIOT 06903 - Sophia Antipolis Cedex France MICOM Srl Via B. Verro, 12 20141 - Milan Italy Supported by: Società Italiana di Cardiologia (SIC) Societa' Italiana Cardiologia Ospedalita' Accreditata (SICOA) (Requests pending) Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO) Italian Heart Failure Association (ITAHFA) CME Provider and Secretariat MICOM Srl Via B. Verro, 12 20141 - Milan Italy Tel. +44 02 89 51 88 95 Fax +44 02 89 51 89 54 E-mail: info@eurocvp.com Website: www.eurocvp.com Location: NH Collection Roma Vittorio Veneto Corso D'Italia 1 00198 - Rome Italy